BRPI0518205A - uso de (4'-trifluorometilfenil)-amida de ácido (z)-2-ciano-3-hidróxi-but-2-enóico para o tratamento de doença inflamatória do intestino - Google Patents
uso de (4'-trifluorometilfenil)-amida de ácido (z)-2-ciano-3-hidróxi-but-2-enóico para o tratamento de doença inflamatória do intestinoInfo
- Publication number
- BRPI0518205A BRPI0518205A BRPI0518205-0A BRPI0518205A BRPI0518205A BR PI0518205 A BRPI0518205 A BR PI0518205A BR PI0518205 A BRPI0518205 A BR PI0518205A BR PI0518205 A BRPI0518205 A BR PI0518205A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- inflammatory bowel
- bowel disease
- trifluoromethylphenyl
- cyano
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
USO DE (4'-TRIFLUOROMETILFENIL)-AMIDA DE áCIDO (Z)-2-CIANO-3-HIDRóXI-BUT-2-ENóICO PARA O TRATAMENTO DE DOENçA INFLAMATóRIA DO INTESTINO. A presente invenção refere-se ao uso de um composto de fórmula I no tratamento de pacientes para os sintomas de doença inflamatória do intestino, incluindo doença de Crohn e colíte ulcerativa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62025504P | 2004-10-19 | 2004-10-19 | |
PCT/US2005/037161 WO2006044741A1 (en) | 2004-10-19 | 2005-10-18 | Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating inflammatory bowel disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0518205A true BRPI0518205A (pt) | 2008-11-04 |
Family
ID=35636963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0518205-0A BRPI0518205A (pt) | 2004-10-19 | 2005-10-18 | uso de (4'-trifluorometilfenil)-amida de ácido (z)-2-ciano-3-hidróxi-but-2-enóico para o tratamento de doença inflamatória do intestino |
Country Status (13)
Country | Link |
---|---|
US (1) | US20070197643A1 (pt) |
EP (1) | EP1804782A1 (pt) |
JP (1) | JP2008517059A (pt) |
KR (1) | KR20070065888A (pt) |
CN (1) | CN101043883A (pt) |
AU (1) | AU2005295511A1 (pt) |
BR (1) | BRPI0518205A (pt) |
CA (1) | CA2584655A1 (pt) |
IL (1) | IL182591A0 (pt) |
MX (1) | MX2007004265A (pt) |
RU (1) | RU2007118691A (pt) |
SG (1) | SG142305A1 (pt) |
WO (1) | WO2006044741A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006268238A1 (en) | 2005-07-11 | 2007-01-18 | Medtronic Ablation Frontiers Llc | Low power tissue ablation system |
ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
EP2100881A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Pyrimidyl- or pyridinylaminobenzoic acid derivatives |
UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
EP2228367A1 (en) | 2009-03-13 | 2010-09-15 | Almirall, S.A. | Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors |
EP2230232A1 (en) | 2009-03-13 | 2010-09-22 | Almirall, S.A. | Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors |
EP2239256A1 (en) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor |
EP2277515A1 (en) * | 2009-07-10 | 2011-01-26 | Sanofi-Aventis | Use of the combination of teriflunomide and interferon beta for treating multiple sclerosis |
CA2772275A1 (en) * | 2009-09-18 | 2011-03-24 | Sanofi | (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluormethylphenyl)-amide tablet formulations with improved stability |
EP2314577A1 (en) | 2009-10-16 | 2011-04-27 | Almirall, S.A. | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
US8686048B2 (en) | 2010-05-06 | 2014-04-01 | Rhizen Pharmaceuticals Sa | Immunomodulator and anti-inflammatory compounds |
US20140031383A1 (en) | 2011-02-08 | 2014-01-30 | Dana-Farber Cancer Institute, Inc. | Methods for treatment of melanoma |
JOP20190207A1 (ar) * | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19547648A1 (de) * | 1995-12-20 | 1997-06-26 | Hoechst Ag | Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate |
KR20010042804A (ko) * | 1998-04-17 | 2001-05-25 | 파커 휴우즈 인스티튜트 | 비티케이 억제제와 그들의 동정 방법 및 용도 |
GB0005345D0 (en) * | 2000-03-06 | 2000-04-26 | Mathilda & Terence Kennedy Ins | Methods of treating sepsis septic shock and inflammation |
JP2004536786A (ja) * | 2001-03-02 | 2004-12-09 | メディミューン,インコーポレイテッド | インテグリンαvβ3拮抗薬を他の予防薬もしくは治療薬と組み合わせて投与することによる炎症性疾患または自己免疫疾患の予防または治療方法 |
ATE396719T1 (de) * | 2001-04-05 | 2008-06-15 | Aventis Pharma Inc | Verwendung von (z)-2-cyano-3-hydroxy-but-2- ensäure-(4'-trifluoromethylphenyl)-amid zur behandlung der multiplen sklerose |
EP1534666A1 (de) * | 2002-09-06 | 2005-06-01 | Schebo Biotech AG | Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes |
-
2005
- 2005-10-18 MX MX2007004265A patent/MX2007004265A/es not_active Application Discontinuation
- 2005-10-18 BR BRPI0518205-0A patent/BRPI0518205A/pt not_active IP Right Cessation
- 2005-10-18 KR KR1020077008909A patent/KR20070065888A/ko not_active Application Discontinuation
- 2005-10-18 RU RU2007118691/14A patent/RU2007118691A/ru not_active Application Discontinuation
- 2005-10-18 JP JP2007537944A patent/JP2008517059A/ja not_active Abandoned
- 2005-10-18 WO PCT/US2005/037161 patent/WO2006044741A1/en active Application Filing
- 2005-10-18 EP EP05812243A patent/EP1804782A1/en not_active Ceased
- 2005-10-18 AU AU2005295511A patent/AU2005295511A1/en not_active Abandoned
- 2005-10-18 CN CNA2005800357982A patent/CN101043883A/zh active Pending
- 2005-10-18 CA CA002584655A patent/CA2584655A1/en not_active Abandoned
- 2005-10-18 SG SG200802858-1A patent/SG142305A1/en unknown
-
2007
- 2007-03-29 US US11/693,358 patent/US20070197643A1/en not_active Abandoned
- 2007-04-16 IL IL182591A patent/IL182591A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2008517059A (ja) | 2008-05-22 |
IL182591A0 (en) | 2007-09-20 |
CN101043883A (zh) | 2007-09-26 |
MX2007004265A (es) | 2008-03-04 |
AU2005295511A1 (en) | 2006-04-27 |
US20070197643A1 (en) | 2007-08-23 |
KR20070065888A (ko) | 2007-06-25 |
SG142305A1 (en) | 2008-05-28 |
RU2007118691A (ru) | 2008-11-27 |
WO2006044741A1 (en) | 2006-04-27 |
EP1804782A1 (en) | 2007-07-11 |
CA2584655A1 (en) | 2006-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25G | Requested change of headquarter approved |
Owner name: AVENTIS PHARMACEUTICALS, INC. (US) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070165509/RJ DE 23/11/2007. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |