BRPI0715698B8 - produto, composição farmacêutica que o contém e uso de composto - Google Patents

produto, composição farmacêutica que o contém e uso de composto

Info

Publication number
BRPI0715698B8
BRPI0715698B8 BRPI0715698A BRPI0715698A BRPI0715698B8 BR PI0715698 B8 BRPI0715698 B8 BR PI0715698B8 BR PI0715698 A BRPI0715698 A BR PI0715698A BR PI0715698 A BRPI0715698 A BR PI0715698A BR PI0715698 B8 BRPI0715698 B8 BR PI0715698B8
Authority
BR
Brazil
Prior art keywords
compound
product
pharmaceutical composition
composition containing
pharmaceutically acceptable
Prior art date
Application number
BRPI0715698A
Other languages
English (en)
Inventor
Clozel Martine
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38954615&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0715698(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0715698A2 publication Critical patent/BRPI0715698A2/pt
Publication of BRPI0715698B1 publication Critical patent/BRPI0715698B1/pt
Publication of BRPI0715698B8 publication Critical patent/BRPI0715698B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

produto, composição farmacêutica que o contém e uso de composto a invenção refere-se a um produto que contém o composto da seguinte fórmula ( i) ou um sal farmaceuticamente aceitável deste composto, em combinação com pelo menos um composto dotado de propriedades inibidoras de pde5, ou um sal farmaceuticamente aceitável do mesmo, para uso terapêutico, simultaneamente, separadamente ou durante um período de tempo, no tratamento de uma enfermidade em que está envolvida vasoconstrição.
BRPI0715698A 2006-08-29 2007-08-28 produto, composição farmacêutica que o contém e uso de composto BRPI0715698B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IBPCT/IB06/052999 2006-08-29
IB2006052999 2006-08-29
IB2006053857 2006-10-19
IBPCT/IB06/053857 2006-10-19
PCT/IB2007/053448 WO2008026156A2 (en) 2006-08-29 2007-08-28 Therapeutic compositions comprising a specific endothelin receptor antagonist and a pde5 inhibitor

Publications (3)

Publication Number Publication Date
BRPI0715698A2 BRPI0715698A2 (pt) 2013-08-06
BRPI0715698B1 BRPI0715698B1 (pt) 2020-01-21
BRPI0715698B8 true BRPI0715698B8 (pt) 2021-05-25

Family

ID=38954615

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0715698A BRPI0715698B8 (pt) 2006-08-29 2007-08-28 produto, composição farmacêutica que o contém e uso de composto

Country Status (27)

Country Link
US (8) US8268847B2 (pt)
EP (1) EP2059246B1 (pt)
JP (1) JP5208113B2 (pt)
KR (1) KR101473022B1 (pt)
CN (1) CN101511365B (pt)
AR (1) AR062501A1 (pt)
AU (1) AU2007290099B2 (pt)
BR (1) BRPI0715698B8 (pt)
CA (1) CA2659770C (pt)
CL (1) CL2007002494A1 (pt)
CY (1) CY1114735T1 (pt)
DK (1) DK2059246T3 (pt)
ES (1) ES2438792T3 (pt)
HK (1) HK1133597A1 (pt)
HR (1) HRP20131233T1 (pt)
IL (1) IL197235A (pt)
MA (1) MA30704B1 (pt)
MX (1) MX2009002057A (pt)
MY (1) MY154591A (pt)
NO (1) NO342554B1 (pt)
NZ (1) NZ575702A (pt)
PL (1) PL2059246T3 (pt)
PT (1) PT2059246E (pt)
RU (1) RU2462249C2 (pt)
SI (1) SI2059246T1 (pt)
TW (1) TWI388556B (pt)
WO (1) WO2008026156A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2393117T3 (es) 2005-09-12 2012-12-18 Actelion Pharmaceuticals Ltd. Composición farmacéutica estable que comprende una pirimidina-sulfamida
MX2010001837A (es) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.
AU2009215329B2 (en) * 2008-02-20 2014-08-21 Actelion Pharmaceuticals Ltd Combination comprising paclitaxel for treating ovarian cancer
CN102099026B (zh) 2008-08-13 2012-08-29 埃科特莱茵药品有限公司 含美西特田的治疗组合物
TWI462739B (zh) * 2010-11-02 2014-12-01 Univ Kaohsiung Medical Ｓｉｌｄｅｎａｆｉｌ－同族物四級銨哌嗪鹽類之製備及醫療用途
CN102949395A (zh) * 2011-09-22 2013-03-06 荆志成 盐酸伐地那非片在制备治疗肺动脉高压药物中的应用
CN102839165B (zh) * 2012-09-26 2014-12-10 金普诺安生物科技（苏州）有限公司 基因突变型重组蛋白酶k及其工业化生产方法
CN105693624B (zh) * 2013-06-14 2018-05-18 杭州普晒医药科技有限公司 马西替坦晶体及其制备方法、其药物组合物和用途
KR20190030805A (ko) 2017-09-14 2019-03-25 경상대학교산학협력단 폐고혈압 예방 또는 치료용 흡입제, 및 이의 투여방법
KR20210109558A (ko) 2018-12-21 2021-09-06 액테리온 파마슈티칼 리미티드 폐동맥 고혈압의 치료를 위한 약제학적 조성물
TW202042818A (zh) 2019-01-25 2020-12-01 瑞士商艾克泰聯製藥有限公司 用於治療慢性血栓性肺高血壓之醫藥組成物

Family Cites Families (26)

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DE2801584A1 (de) * 1978-01-14 1979-07-19 Bayer Ag Halogensubstituierte pyrimidin (2)yl-thiono-thiol-phosphor(phosphon)- saeureester, verfahren zu ihrer herstellung und ihre verwendung als insektizide und akarizide
US5250534A (en) * 1990-06-20 1993-10-05 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
TW394761B (en) 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
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PT1049695E (pt) 1997-11-12 2002-07-31 Bayer Ag Imidazotriazinonas 2-fenil substituidas enquanto inibidores de fosfodiesterase
US6087368A (en) * 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase
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TWI284642B (en) 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides
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TW200400821A (en) 1999-11-02 2004-01-16 Pfizer Pharmaceutical composition (II) useful for treating or preventing pulmonary hypertension in a patient
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IL155805A0 (en) * 2000-12-18 2003-12-23 Actelion Pharmaceuticals Ltd Novel sulfamides and their use as endothelin receptor antagonists
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US20060205733A1 (en) * 2004-08-26 2006-09-14 Encysive Pharmaceuticals Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof
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ES2393117T3 (es) * 2005-09-12 2012-12-18 Actelion Pharmaceuticals Ltd. Composición farmacéutica estable que comprende una pirimidina-sulfamida
US20100022568A1 (en) * 2006-04-13 2010-01-28 Actelion Pharmaceeuticals Ltd. Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis

Also Published As

Publication number Publication date
CA2659770C (en) 2014-11-18
US8268847B2 (en) 2012-09-18
PL2059246T3 (pl) 2014-03-31
CA2659770A1 (en) 2008-03-06
AR062501A1 (es) 2008-11-12
KR20090057009A (ko) 2009-06-03
SI2059246T1 (sl) 2014-01-31
EP2059246A2 (en) 2009-05-20
US20140148460A1 (en) 2014-05-29
US20210177849A1 (en) 2021-06-17
WO2008026156A3 (en) 2008-10-16
HRP20131233T1 (hr) 2014-01-31
IL197235A0 (en) 2009-12-24
MA30704B1 (fr) 2009-09-01
CN101511365A (zh) 2009-08-19
IL197235A (en) 2014-04-30
WO2008026156A2 (en) 2008-03-06
BRPI0715698A2 (pt) 2013-08-06
US20180147205A1 (en) 2018-05-31
HK1133597A1 (en) 2010-04-01
PT2059246E (pt) 2013-12-16
MY154591A (en) 2015-06-30
KR101473022B1 (ko) 2014-12-15
CN101511365B (zh) 2011-08-17
US20130210830A9 (en) 2013-08-15
JP5208113B2 (ja) 2013-06-12
BRPI0715698B1 (pt) 2020-01-21
US20130005734A1 (en) 2013-01-03
NO342554B1 (no) 2018-06-11
ES2438792T3 (es) 2014-01-20
DK2059246T3 (da) 2013-12-02
CL2007002494A1 (es) 2008-04-04
EP2059246B1 (en) 2013-10-16
NZ575702A (en) 2011-11-25
TW200823198A (en) 2008-06-01
JP2010502588A (ja) 2010-01-28
US20200352944A1 (en) 2020-11-12
AU2007290099A1 (en) 2008-03-06
US20090318459A1 (en) 2009-12-24
US20190083494A1 (en) 2019-03-21
TWI388556B (zh) 2013-03-11
RU2009111378A (ru) 2010-10-10
NO20091254L (no) 2009-03-26
US20200038401A1 (en) 2020-02-06
CY1114735T1 (el) 2017-01-25
AU2007290099B2 (en) 2013-01-31
RU2462249C2 (ru) 2012-09-27
MX2009002057A (es) 2009-03-06

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Legal Events

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