SI1928409T1 - Stabilni farmacevtski sestavek, ki obsega pirimidin-sulfamid - Google Patents

Stabilni farmacevtski sestavek, ki obsega pirimidin-sulfamid

Info

Publication number
SI1928409T1
SI1928409T1 SI200631471T SI200631471T SI1928409T1 SI 1928409 T1 SI1928409 T1 SI 1928409T1 SI 200631471 T SI200631471 T SI 200631471T SI 200631471 T SI200631471 T SI 200631471T SI 1928409 T1 SI1928409 T1 SI 1928409T1
Authority
SI
Slovenia
Prior art keywords
sulfamide
pyrimidine
pharmaceutical composition
stable pharmaceutical
stable
Prior art date
Application number
SI200631471T
Other languages
English (en)
Inventor
Charles Tokunbo Adesuyi
Lovelace Holman
Olivier Lambert
Bruce Hamilton Lithgow
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37865339&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1928409(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of SI1928409T1 publication Critical patent/SI1928409T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI200631471T 2005-09-12 2006-09-11 Stabilni farmacevtski sestavek, ki obsega pirimidin-sulfamid SI1928409T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2005009775 2005-09-12
EP06809280A EP1928409B1 (en) 2005-09-12 2006-09-11 Stable pharmaceutical composition comprising a pyrimidine-sulfamide
PCT/IB2006/053210 WO2007031933A2 (en) 2005-09-12 2006-09-11 Stable pharmaceutical composition comprising a pyrimidine-sulfamide

Publications (1)

Publication Number Publication Date
SI1928409T1 true SI1928409T1 (sl) 2012-12-31

Family

ID=37865339

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200631471T SI1928409T1 (sl) 2005-09-12 2006-09-11 Stabilni farmacevtski sestavek, ki obsega pirimidin-sulfamid

Country Status (24)

Country Link
US (6) US20080233188A1 (sl)
EP (2) EP2292209A3 (sl)
JP (2) JP4955685B2 (sl)
KR (1) KR101313395B1 (sl)
CN (1) CN101262847B (sl)
AU (1) AU2006290309B2 (sl)
BR (1) BRPI0615898B8 (sl)
CA (1) CA2621273C (sl)
CY (1) CY1113395T1 (sl)
DK (1) DK1928409T3 (sl)
ES (1) ES2393117T3 (sl)
HK (1) HK1121950A1 (sl)
HR (1) HRP20120957T1 (sl)
IL (1) IL190072A (sl)
MY (1) MY151003A (sl)
NO (1) NO341325B1 (sl)
NZ (1) NZ567188A (sl)
PL (1) PL1928409T3 (sl)
PT (1) PT1928409E (sl)
RU (1) RU2424805C2 (sl)
SI (1) SI1928409T1 (sl)
TW (1) TWI323661B (sl)
WO (1) WO2007031933A2 (sl)
ZA (1) ZA200802947B (sl)

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US20080233188A1 (en) 2005-09-12 2008-09-25 Actelion Pharmaceuticals Ltd. Stable Pharmaceutical Compositions Comprising a Pyrimidine - Sulfamide
AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
TWI399223B (zh) * 2006-09-15 2013-06-21 Daiichi Sankyo Co Ltd 奧美沙坦酯及氨氯地平之固體劑型
MX2010001837A (es) * 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.
ES2446303T3 (es) 2008-02-20 2014-03-07 Actelion Pharmaceuticals Ltd. Combinación que comprende paclitaxel para el tratamiento del cáncer de ovarios
PL3300729T3 (pl) 2008-08-13 2020-04-30 Actelion Pharmaceuticals Ltd Kompozycje terapeutyczne zawierające macitentan
NZ598078A (en) * 2009-08-10 2013-07-26 Univ Texas Treatment of brain metastases with macitentan in combination with paclitacel and/or temozolomide and/or radiotherapy
WO2011074961A1 (en) 2009-12-18 2011-06-23 Frieslandcampina Nederland Holding B.V. Co-processed tablet excipient composition its preparation and use
IT1403248B1 (it) * 2010-11-12 2013-10-17 Scharper Therapeutics Srl Composizione per il trattamento di disfunzioni degli apparati fonatorio ed olfattorio
MA34952B1 (fr) 2011-02-04 2014-03-01 Actelion Pharmaceuticals Ltd Combinaisons comprenant du macitentan pour le traitement d'un glioblastome multiforme
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DK3172209T3 (da) 2014-07-25 2021-02-22 Novartis Ag Tabletformulering med 2-fluor-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamid
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WO2018153925A1 (en) 2017-02-22 2018-08-30 Amneal Pharmaceuticals Company Gmbh Stable pharmaceutical compositions comprising macitentan
MA54522A (fr) 2018-12-21 2022-03-23 Actelion Pharmaceuticals Ltd Composition pharmaceutique pour le traitement de l'hypertension artérielle pulmonaire
TW202042818A (zh) * 2019-01-25 2020-12-01 瑞士商艾克泰聯製藥有限公司 用於治療慢性血栓性肺高血壓之醫藥組成物
MX2022000267A (es) 2019-07-05 2022-02-03 Tecnimede Soc Tecnico Medicinal Sa Composiciones comprimidas de macitentan, metodos y usos de las mismas.
TW202133851A (zh) 2019-11-29 2021-09-16 瑞士商艾克泰聯製藥有限公司 治療肺動脈高血壓之方法
WO2022238375A1 (en) 2021-05-11 2022-11-17 Actelion Pharmaceuticals Ltd Methods of treating pulmonary hypertension
TW202317119A (zh) * 2021-06-11 2023-05-01 瑞士商艾克泰聯製藥有限公司 用於口服投予之分散錠
WO2023025672A1 (en) 2021-08-25 2023-03-02 Basf Se Direct tableting auxiliary composition
WO2023038600A1 (en) * 2021-09-07 2023-03-16 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi A capsule formulation comprising macitentan
EP4154873A1 (en) 2021-09-22 2023-03-29 Sanovel Ilac Sanayi Ve Ticaret A.S. The tablet comprising macitentan

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AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
ES2446303T3 (es) 2008-02-20 2014-03-07 Actelion Pharmaceuticals Ltd. Combinación que comprende paclitaxel para el tratamiento del cáncer de ovarios
PL3300729T3 (pl) 2008-08-13 2020-04-30 Actelion Pharmaceuticals Ltd Kompozycje terapeutyczne zawierające macitentan
MA34952B1 (fr) 2011-02-04 2014-03-01 Actelion Pharmaceuticals Ltd Combinaisons comprenant du macitentan pour le traitement d'un glioblastome multiforme

Also Published As

Publication number Publication date
ZA200802947B (en) 2009-12-30
US10946015B2 (en) 2021-03-16
US11648249B2 (en) 2023-05-16
JP5054061B2 (ja) 2012-10-24
IL190072A0 (en) 2008-08-07
EP1928409B1 (en) 2012-09-12
US20080233188A1 (en) 2008-09-25
US9265762B2 (en) 2016-02-23
AU2006290309A1 (en) 2007-03-22
HK1121950A1 (en) 2009-05-08
NO341325B1 (no) 2017-10-16
US20180263980A1 (en) 2018-09-20
HRP20120957T1 (hr) 2012-12-31
WO2007031933A3 (en) 2007-10-18
BRPI0615898B1 (pt) 2020-02-18
US20100004274A1 (en) 2010-01-07
TWI323661B (en) 2010-04-21
CA2621273A1 (en) 2007-03-22
AU2006290309B2 (en) 2012-04-05
DK1928409T3 (da) 2012-11-05
US20130190336A1 (en) 2013-07-25
NO20081724L (no) 2008-04-09
TW200803860A (en) 2008-01-16
CN101262847B (zh) 2010-11-24
US8367685B2 (en) 2013-02-05
RU2008113869A (ru) 2009-10-20
CN101262847A (zh) 2008-09-10
JP2009519893A (ja) 2009-05-21
ES2393117T3 (es) 2012-12-18
KR20080055897A (ko) 2008-06-19
RU2424805C2 (ru) 2011-07-27
EP2292209A2 (en) 2011-03-09
JP4955685B2 (ja) 2012-06-20
WO2007031933A2 (en) 2007-03-22
EP2292209A3 (en) 2011-05-04
IL190072A (en) 2013-08-29
MY151003A (en) 2014-03-31
NZ567188A (en) 2011-04-29
BRPI0615898B8 (pt) 2021-05-25
PL1928409T3 (pl) 2013-02-28
BRPI0615898A2 (pt) 2011-05-31
EP1928409A2 (en) 2008-06-11
US20210186966A1 (en) 2021-06-24
JP2009235073A (ja) 2009-10-15
PT1928409E (pt) 2012-11-27
US10117870B2 (en) 2018-11-06
CA2621273C (en) 2014-07-29
KR101313395B1 (ko) 2013-10-02
US20160136163A1 (en) 2016-05-19
CY1113395T1 (el) 2016-06-22

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