BRPI0518216C8 - ligante de cromatografia, métodos de preparação de uma matriz de separação, e de separação de um ou mais anticorpos de um ou mais outros compostos em uma amostra líquida, matriz de separação, e, coluna de cromatografia descartável. - Google Patents

ligante de cromatografia, métodos de preparação de uma matriz de separação, e de separação de um ou mais anticorpos de um ou mais outros compostos em uma amostra líquida, matriz de separação, e, coluna de cromatografia descartável.

Info

Publication number
BRPI0518216C8
BRPI0518216C8 BRPI0518216A BRPI0518216A BRPI0518216C8 BR PI0518216 C8 BRPI0518216 C8 BR PI0518216C8 BR PI0518216 A BRPI0518216 A BR PI0518216A BR PI0518216 A BRPI0518216 A BR PI0518216A BR PI0518216 C8 BRPI0518216 C8 BR PI0518216C8
Authority
BR
Brazil
Prior art keywords
separation matrix
chromatography
binder
compounds
antibodies
Prior art date
Application number
BRPI0518216A
Other languages
English (en)
Portuguese (pt)
Inventor
Forss Annika
Johansson Bo-Lennart
Engstrand Carina
Glad Gunnar
J Johansson Hans
Maloisel Jean-Luc
Original Assignee
Ge Healthcare Bio Sciences Ab
Ge Healthcare Bioprocess R&D Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0402558A external-priority patent/SE0402558D0/xx
Application filed by Ge Healthcare Bio Sciences Ab, Ge Healthcare Bioprocess R&D Ab filed Critical Ge Healthcare Bio Sciences Ab
Publication of BRPI0518216A publication Critical patent/BRPI0518216A/pt
Publication of BRPI0518216B1 publication Critical patent/BRPI0518216B1/pt
Publication of BRPI0518216B8 publication Critical patent/BRPI0518216B8/pt
Publication of BRPI0518216C8 publication Critical patent/BRPI0518216C8/pt
Publication of BRPI0518216C1 publication Critical patent/BRPI0518216C1/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/04—Processes using organic exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3253—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure not containing any of the heteroatoms nitrogen, oxygen or sulfur, e.g. aromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3285—Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI0518216A 2004-10-21 2005-10-21 ligante de cromatografia, métodos de preparação de uma matriz de separação, e de separação de um ou mais anticorpos de um ou mais outros compostos em uma amostra líquida, matriz de separação, e, coluna de cromatografia descartável. BRPI0518216C8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0402558A SE0402558D0 (sv) 2004-10-21 2004-10-21 A process for the purification of antibodies
SE0402910 2004-11-26
PCT/SE2005/001592 WO2006043896A1 (en) 2004-10-21 2005-10-21 Chromatography ligand
PCT/SE2005/001591 WO2006043895A1 (en) 2004-10-21 2005-10-21 A method of antibody purification

Publications (5)

Publication Number Publication Date
BRPI0518216A BRPI0518216A (pt) 2008-11-04
BRPI0518216B1 BRPI0518216B1 (pt) 2016-04-05
BRPI0518216B8 BRPI0518216B8 (pt) 2016-10-25
BRPI0518216C8 true BRPI0518216C8 (pt) 2017-03-21
BRPI0518216C1 BRPI0518216C1 (enExample) 2017-03-21

Family

ID=36203226

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0518216A BRPI0518216C8 (pt) 2004-10-21 2005-10-21 ligante de cromatografia, métodos de preparação de uma matriz de separação, e de separação de um ou mais anticorpos de um ou mais outros compostos em uma amostra líquida, matriz de separação, e, coluna de cromatografia descartável.
BRPI0518207-7A BRPI0518207B1 (pt) 2004-10-21 2005-10-21 Método de separação de um ou mais anticorpos de um ou mais outros compostos em uma amostra líquida

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0518207-7A BRPI0518207B1 (pt) 2004-10-21 2005-10-21 Método de separação de um ou mais anticorpos de um ou mais outros compostos em uma amostra líquida

Country Status (12)

Country Link
US (5) US7714112B2 (enExample)
EP (2) EP1807205B1 (enExample)
JP (2) JP4831436B2 (enExample)
KR (2) KR101243601B1 (enExample)
AU (2) AU2005296352B2 (enExample)
BR (2) BRPI0518216C8 (enExample)
CA (2) CA2583578C (enExample)
DK (1) DK1827691T3 (enExample)
ES (1) ES2612572T3 (enExample)
PL (1) PL1827691T3 (enExample)
RU (3) RU2541429C2 (enExample)
WO (2) WO2006043896A1 (enExample)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4801598B2 (ja) 2004-01-20 2011-10-26 ポール・コーポレーション 生理的イオン強度でタンパク質を吸着させるためのクロマトグラフィー材料
AU2005296352B2 (en) 2004-10-21 2011-01-06 Cytiva Bioprocess R&D Ab Chromatography ligand
US9910341B2 (en) 2005-01-31 2018-03-06 The Invention Science Fund I, Llc Shared image device designation
US20060174203A1 (en) 2005-01-31 2006-08-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Viewfinder for shared image device
US8606383B2 (en) 2005-01-31 2013-12-10 The Invention Science Fund I, Llc Audio sharing
US9082456B2 (en) 2005-01-31 2015-07-14 The Invention Science Fund I Llc Shared image device designation
US8902320B2 (en) 2005-01-31 2014-12-02 The Invention Science Fund I, Llc Shared image device synchronization or designation
US9124729B2 (en) 2005-01-31 2015-09-01 The Invention Science Fund I, Llc Shared image device synchronization or designation
US9325781B2 (en) 2005-01-31 2016-04-26 Invention Science Fund I, Llc Audio sharing
US9489717B2 (en) 2005-01-31 2016-11-08 Invention Science Fund I, Llc Shared image device
US20060170956A1 (en) 2005-01-31 2006-08-03 Jung Edward K Shared image devices
TW200639190A (en) * 2005-02-04 2006-11-16 Showa Denko Kk Packing material for ion chromatography
US9093121B2 (en) 2006-02-28 2015-07-28 The Invention Science Fund I, Llc Data management of an audio data stream
US9451200B2 (en) 2005-06-02 2016-09-20 Invention Science Fund I, Llc Storage access technique for captured data
US9942511B2 (en) 2005-10-31 2018-04-10 Invention Science Fund I, Llc Preservation/degradation of video/audio aspects of a data stream
US9819490B2 (en) 2005-05-04 2017-11-14 Invention Science Fund I, Llc Regional proximity for shared image device(s)
US9967424B2 (en) 2005-06-02 2018-05-08 Invention Science Fund I, Llc Data storage usage protocol
US8681225B2 (en) 2005-06-02 2014-03-25 Royce A. Levien Storage access technique for captured data
US10003762B2 (en) 2005-04-26 2018-06-19 Invention Science Fund I, Llc Shared image devices
US9001215B2 (en) 2005-06-02 2015-04-07 The Invention Science Fund I, Llc Estimating shared image device operational capabilities or resources
CN102887955A (zh) 2006-04-05 2013-01-23 艾博特生物技术有限公司 抗体纯化
EP2043767B1 (en) 2006-07-14 2020-03-25 Wisconsin Alumni Research Foundation Adsorptive membranes for trapping viruses
US7999085B2 (en) * 2007-01-09 2011-08-16 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
WO2008085116A1 (en) * 2007-01-10 2008-07-17 Ge Healthcare Bio-Sciences Ab Mult i -modal ion exchange chromotography resins
US10562007B2 (en) 2007-07-25 2020-02-18 Ge Healthcare Bioprocess R&D Ab Separation matrix
AU2008315124B2 (en) 2007-10-26 2012-06-21 Asahi Kasei Chemicals Corporation Method for purifying protein
WO2009058769A1 (en) * 2007-10-30 2009-05-07 Schering Corporation Purification of antibodies containing hydrophobic variants
EP2265129B1 (en) * 2008-04-08 2015-10-28 Bio-Rad Laboratories, Inc. Chromatography purification of antibodies
DE102008018732B4 (de) * 2008-04-14 2022-06-09 Sartorius Stedim Biotech Gmbh Verfahren zur Stofftrennung unter Verwendung einer Cellulosehydrat-Membran in der Größenausschlusschromatographie
DE102008018734B4 (de) * 2008-04-14 2013-03-21 Sartorius Stedim Biotech Gmbh Hydrophobe Cellulose-Membran, Verfahren zu ihrer Herstellung und ihre Verwendung in der hydrophoben Interaktionschromatographie
DE102008055821A1 (de) * 2008-04-14 2009-10-15 Sartorius Stedim Biotech Gmbh Cellulosehydrat-Membran, Verfahren zur ihrer Herstellung und Verwendung davon
FR2931838B1 (fr) * 2008-06-02 2010-06-11 Millipore Corp Installation pour traiter un liquide biologique.
WO2010030222A1 (en) * 2008-09-12 2010-03-18 Ge Healthcare Bio-Sciences Ab Enhanced protein aggregate removal with multimodal anion exchangers in the presence of protein-excluded zwitterions
WO2010071208A1 (ja) * 2008-12-19 2010-06-24 武田薬品工業株式会社 抗体の精製方法
FR2940145B1 (fr) 2008-12-24 2011-03-25 Millipore Corp Chariot et installation de traitement d'un liquide biologique
JP2010158624A (ja) * 2009-01-08 2010-07-22 Asahi Kasei Chemicals Corp 多孔質吸着膜、及び当該多孔質吸着膜を用いたたんぱく質の精製方法
FR2941385B1 (fr) 2009-01-23 2011-04-01 Millipore Corp Procede pour fournir un circuit pour liquide biologique et circuit obtenu.
WO2011001963A1 (ja) * 2009-07-03 2011-01-06 旭化成ケミカルズ株式会社 多孔質基材に固定されたグラフト鎖に結合しているアミノ基及びアルキル基を有する多孔膜を用いた抗体の精製方法
KR101866265B1 (ko) 2009-07-28 2018-06-11 인스트랙션 게엠베하 단백질 및 펩타이드 결합용 특정 흡착제, 및 이를 사용하는 분리방법
US8277649B2 (en) * 2009-12-14 2012-10-02 General Electric Company Membranes and associated methods for purification of antibodies
FR2955119B1 (fr) 2010-01-13 2012-12-28 Millipore Corp Circuit pour liquide biologique
HRP20241463T1 (hr) 2010-05-25 2025-01-03 F. Hoffmann - La Roche Ag Metode pročišćavanja polipeptida
FR2960794B1 (fr) 2010-06-08 2012-07-27 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2960795B1 (fr) 2010-06-08 2012-07-27 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2960796B1 (fr) 2010-06-08 2014-01-24 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2961713B1 (fr) 2010-06-23 2012-08-10 Millipore Corp Poche pour circuit d'une installation de traitement de liquide biologique
FR2961711B1 (fr) 2010-06-23 2012-08-17 Millipore Corp Poche pour circuit d'une installation de traitement de liquide biologique
KR101847405B1 (ko) 2010-07-30 2018-04-10 이엠디 밀리포어 코포레이션 크로마토그래피 매질 및 방법
FR2963573B1 (fr) 2010-08-03 2012-08-31 Millipore Corp Chariot de pompage pour une installation de traitement de liquide biologique
CN103201003B (zh) * 2010-09-20 2016-04-13 Abbvie公司 采用模拟移动床色谱纯化抗体
CA2820095C (en) 2010-12-21 2019-02-26 F. Hoffmann-La Roche Ag Isoform enriched antibody preparation and method for obtaining it
FR2973396B1 (fr) 2011-03-28 2013-05-10 Millipore Corp Installation de traitement de liquide biologique
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
EP2570185A1 (en) * 2011-09-15 2013-03-20 InstrAction GmbH Sorbent comprising an aromatic ring system on its surface for the purification of organic molecules
EP2570184A1 (en) * 2011-09-15 2013-03-20 InstrAction GmbH Sorbent comprising on its surface an aromatic ring system having an anionic or deprotonizable group for the purification of organic molecules
US8802448B2 (en) 2011-07-27 2014-08-12 Pall Corporation Mixed mode ligands
EP2578286A1 (en) * 2011-10-04 2013-04-10 Merck Patent GmbH Method and apparatus for chromatographic purification
US9309282B2 (en) * 2011-10-19 2016-04-12 Bio-Rad Laboratories, Inc. Solid phase for mixed-mode chromatographic purification of proteins
AU2012351751B2 (en) * 2011-10-19 2017-09-07 Novimmune S.A. Methods of purifying antibodies
US20140288278A1 (en) * 2011-10-31 2014-09-25 Joseph Nti-Gyabaah Chromatography process for resolving heterogeneous antibody aggregates
WO2013075740A1 (en) * 2011-11-23 2013-05-30 Sanofi Antibody purification method
EP2782925B1 (en) * 2011-11-23 2024-03-06 Sanofi Protein purification using bis-tris buffer
WO2013134251A2 (en) 2012-03-08 2013-09-12 Bio-Rad Laboratories, Inc. Anionic exchange-hydrophobic mixed mode
SG10201701224UA (en) * 2012-03-12 2017-04-27 Merck Patent Gmbh Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
RU2501008C1 (ru) * 2012-06-14 2013-12-10 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт клинической иммунологии" Сибирского отделения Российской академии медицинских наук (ФГБУ "НИИКИ" СОРАМН) СПОСОБ АФФИННОГО ВЫДЕЛЕНИЯ АУТОАНТИТЕЛ КЛАССА IgG К ИММУНОРЕГУЛЯТОРНОМУ ЦИТОКИНУ TNF
FR2993572B1 (fr) 2012-07-23 2016-04-15 Emd Millipore Corp Circuit pour liquide biologique comportant une vanne a pincement
EP2890782A1 (en) 2012-09-02 2015-07-08 AbbVie Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
US9890191B2 (en) 2012-09-03 2018-02-13 Kaneka Corporation Mixed-mode antibody affinity separation matrix and purification method using the same, and the target molecules
MY178616A (en) 2012-09-17 2020-10-19 Grace W R & Co Chromatography media and devices
CN104797332B (zh) * 2012-11-13 2018-05-29 通用电气医疗集团生物工艺研发股份公司 多元阴离子交换基质
US20140238935A1 (en) 2013-02-26 2014-08-28 Natrix Separations Inc. Mixed-Mode Chromatography Membranes
EP2964663A2 (en) 2013-03-08 2016-01-13 Genzyme Corporation Continuous purification of therapeutic proteins
SG11201507230PA (en) 2013-03-12 2015-10-29 Abbvie Inc Human antibodies that bind human tnf-alpha and methods of preparing the same
US10023608B1 (en) * 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
DK2970378T3 (da) 2013-03-15 2021-08-23 Biogen Ma Inc Hydrofob interaktionsproteinkromatografi under saltfrie betingelser
HUE038741T2 (hu) * 2013-05-06 2018-11-28 Sanofi Sa Folyamatos többlépéses eljárás antitestek tisztítására
CN105555795A (zh) 2013-09-17 2016-05-04 株式会社钟化 新抗体纯化方法和由该方法得到的抗体、以及使用了阳离子交换基团的新抗体纯化法和由该方法得到的抗体
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
KR101891522B1 (ko) 2013-12-12 2018-08-24 이엠디 밀리포어 코포레이션 아크릴아미드 함유 필터를 사용한 단백질 분리
SG11201605712SA (en) 2014-01-16 2016-08-30 Grace W R & Co Affinity chromatography media and chromatography devices
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
US10610807B2 (en) 2014-01-17 2020-04-07 Repligen Corporation Sterilizing chromatography columns
US20240100450A9 (en) * 2014-01-17 2024-03-28 Repligen Corporation Sterilizing chromatography columns
TWI709569B (zh) * 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
CN105579463B (zh) 2014-03-14 2020-01-31 生物辐射实验室股份有限公司 混合模式配体
US11389783B2 (en) 2014-05-02 2022-07-19 W.R. Grace & Co.-Conn. Functionalized support material and methods of making and using functionalized support material
EP3171888B1 (en) * 2014-07-21 2022-12-28 Merck Sharp & Dohme LLC Chromatography process for purification of inlsulin and insulin analogs
TW201628649A (zh) 2014-10-09 2016-08-16 再生元醫藥公司 減少醫藥調配物中微可見顆粒之方法
CN107001410A (zh) 2014-12-08 2017-08-01 Emd密理博公司 混合床离子交换吸附剂
KR102566292B1 (ko) 2015-06-05 2023-08-10 더블유.알. 그레이스 앤드 캄파니-콘. 흡착성 바이오프로세싱 정화제와 이의 제조 및 사용 방법
EP4371663A3 (en) * 2016-04-06 2024-08-14 Cytiva BioProcess R&D AB Chromatography matrix
CA3031742A1 (en) 2016-08-16 2018-02-22 Regeneron Pharmaceuticals, Inc. Methods for quantitating individual antibodies from a mixture
EP4071469B1 (en) 2016-10-25 2025-04-09 Regeneron Pharmaceuticals, Inc. Methods for chromatography data analysis
WO2018092691A1 (ja) * 2016-11-18 2018-05-24 Jnc株式会社 抗体の精製方法
IL299270B2 (en) 2017-01-30 2024-10-01 Regeneron Pharma Compositions and methods for reducing bioburden in chromatography
CA3073935A1 (en) 2017-09-19 2019-03-28 Regeneron Pharmaceuticals, Inc. Methods of reducing particle formation and compositions formed thereby
US11161128B2 (en) 2017-11-14 2021-11-02 General Electric Company Spray nozzle device for delivering a restorative coating through a hole in a case of a turbine engine
US11534780B2 (en) 2017-11-14 2022-12-27 General Electric Company Spray nozzle device for delivering a restorative coating through a hole in a case of a turbine engine
EP3749697A4 (en) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE
JP7344232B2 (ja) 2018-03-05 2023-09-13 キラル テクノロジーズ ヨーロッパ エスアーエス バイオセパレーションのための複合材料
EP3762121B1 (en) 2018-03-05 2024-04-24 Chiral Technologies Europe SAS Composite material for bioseparations
US12343702B2 (en) 2018-03-08 2025-07-01 Bio-Rad Laboratories, Inc. Anionic exchange-hydrophobic mixed mode chromatography resin
WO2019175412A2 (en) * 2018-03-15 2019-09-19 Klawego Gmbh & Co. Kg Composite materials for the depletion of contaminants from solutions
EP3546475A1 (en) 2018-03-27 2019-10-02 Sanofi Full flow-through process for purifying recombinant proteins
TW202448568A (zh) 2018-07-02 2024-12-16 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
US11045773B2 (en) 2018-08-31 2021-06-29 Pall Corporation Salt tolerant porous medium
CA3110666A1 (en) 2018-08-31 2020-03-05 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
US10737259B2 (en) 2018-08-31 2020-08-11 Pall Corporation Salt tolerant anion exchange medium
AU2020246969A1 (en) * 2019-03-27 2021-09-16 Cytiva Sweden Ab A method for separating biomolecules
JP7570344B2 (ja) * 2019-03-29 2024-10-21 ブリストル－マイヤーズ スクイブ カンパニー クロマトグラフィー樹脂の疎水性を測定する方法
EP4025336A4 (en) * 2019-09-05 2024-01-17 Bio-Rad Laboratories, Inc. ANION EXCHANGE/HYDROPHOBIC RESINS FOR MIXED MODE CHROMATOGRAPHY
EP4019125A1 (en) 2020-12-22 2022-06-29 Sartorius Stedim Biotech GmbH Chromatographic material and method of producing same
GB202110014D0 (en) 2021-07-12 2021-08-25 Cytiva Bioprocess R & D Ab A method for separating adeno-associated virus capsids, compositions obtained by said method and uses thereof
CA3236293A1 (en) 2021-12-07 2023-06-15 Cytiva Bioprocess R&D Ab Separation matrix and methods for separating target molecules
GB202202777D0 (en) 2022-03-01 2022-04-13 Cytiva Bioprocess R & D Ab A method for separating supercoiled plasmid DNA
GB202206123D0 (en) 2022-04-27 2022-06-08 Cytiva Bioprocess R & D Ab A pre-screening method and a method for separating adeno-associated virus capsids
GB202214280D0 (en) 2022-09-29 2022-11-16 Cytiva Vioprocess R&D Ab Chromatography ligand and chromatography material, and uses thereof
GB202215814D0 (en) 2022-10-26 2022-12-07 Cytiva Bioprocess R & D Ab A chromatography device, system, and use thereof for analytic separation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2405555A (en) * 1946-08-13 Manufacture of heterocyclic bases
US3467656A (en) * 1967-09-06 1969-09-16 Hoffmann La Roche 4-aryl-3,1-benzoxazine-2-thione
SE8204810L (sv) 1982-08-23 1984-02-24 Pharmacia Fine Chemicals Ab Hybrid-dna-molekyl, transformerad mikroorganism och sett att framstella protein a
US5151350A (en) 1982-10-27 1992-09-29 Repligen Corporation Cloned genes encoding recombinant protein a
US4983722A (en) 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
US5322859A (en) * 1993-02-08 1994-06-21 University Of Iowa Research Foundation Antiglaucoma drug composition and method
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5652348A (en) * 1994-09-23 1997-07-29 Massey University Chromatographic resins and methods for using same
GB9519197D0 (en) * 1995-09-20 1995-11-22 Affinity Chromatography Ltd Novel affinity ligands and their use
US6117996A (en) 1995-09-20 2000-09-12 Novo Nordisk A/S Triazine based ligands and use thereof
SE9601368D0 (sv) * 1996-04-11 1996-04-11 Pharmacia Biotech Ab Process for the production of a porous cross-linked polysaccharide gel
ES2332893T3 (es) * 1996-08-30 2010-02-15 Upfront Chromatography A/S Aislamiento de inmunoglobulinas.
SE9700383D0 (sv) 1997-02-04 1997-02-04 Pharmacia Biotech Ab An adsorption/separation method and a medium for adsorption/separation
US5908960A (en) * 1997-05-07 1999-06-01 Smithkline Beecham Corporation Compounds
AU6069800A (en) * 1999-07-07 2001-01-30 Zymogenetics Inc. Human cytokine receptor
SE9904197D0 (sv) 1999-11-22 1999-11-22 Amersham Pharm Biotech Ab A method for anion exchange adsorption on matrices carrying mixed mode ligands
AU1550201A (en) * 2000-06-08 2001-12-17 Kaneka Corporation Process for the production of sulfonic esters
SE0004932D0 (sv) 2000-12-31 2000-12-31 Apbiotech Ab A method for mixed mode adsorption and mixed mode adsorbents
JP2004517310A (ja) * 2001-01-05 2004-06-10 プロ・ケム インク 精製器具及び方法
US6652853B2 (en) * 2001-03-08 2003-11-25 Ludwig Institute For Cancer Research Method for treating cancer using A33 specific antibodies and chemotherapeutic agents
DE10155984A1 (de) 2001-11-15 2003-05-28 Boehringer Ingelheim Pharma Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices
AU2004215653B2 (en) * 2003-02-28 2011-03-17 Lonza Biologics Plc. Antibody purification by protein A and ion exchange chromatography
CA2552639C (en) * 2004-02-27 2012-05-01 Ge Healthcare Bio-Sciences Ab A process for the purification of antibodies
EP1793926B1 (en) 2004-09-22 2016-11-23 GE Healthcare BioProcess R&D AB Method of preparing a chromatography matrix
US9266041B2 (en) * 2004-10-21 2016-02-23 Ge Healthcare Bio-Sciences Ab Chromatography ligand
AU2005296352B2 (en) * 2004-10-21 2011-01-06 Cytiva Bioprocess R&D Ab Chromatography ligand
US7691980B2 (en) * 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers

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