BRPI0111220B1 - conjugados de fármacos com etilenodicisteína (ec) - Google Patents

conjugados de fármacos com etilenodicisteína (ec)

Info

Publication number
BRPI0111220B1
BRPI0111220B1 BRPI0111220A BR0111220A BRPI0111220B1 BR PI0111220 B1 BRPI0111220 B1 BR PI0111220B1 BR PI0111220 A BRPI0111220 A BR PI0111220A BR 0111220 A BR0111220 A BR 0111220A BR PI0111220 B1 BRPI0111220 B1 BR PI0111220B1
Authority
BR
Brazil
Prior art keywords
drug conjugates
ethylenedicistein
chelated
specific
diseases
Prior art date
Application number
BRPI0111220A
Other languages
English (en)
Other versions
BRPI0111220B8 (pt
BR0111220A (pt
Inventor
Chun-Wei Liu
David J Yang
Dong-Fang Yu
E Edmund Kim
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/599,152 external-priority patent/US7067111B1/en
Application filed by Univ Texas filed Critical Univ Texas
Publication of BR0111220A publication Critical patent/BR0111220A/pt
Publication of BRPI0111220B1 publication Critical patent/BRPI0111220B1/pt
Publication of BRPI0111220B8 publication Critical patent/BRPI0111220B8/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/087—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being an annexin, e.g. annexin V
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"conjugados de fármacos de etilenodicisteína (ec)". a invenção fornece, num sentido geral, uma nova estratégia de rotulação com emprego de 99tc quelado com etilenodicisteína (ec). ec é conjugada com uma variedade de ligantes e quelada ao ^ 99m^tc para uso em um agente de geração de imagem para doenças específicas de tecido. os conjugados do fármaco da invenção podem também ser usados como uma ferramenta de prognóstico ou como uma ferramenta para entregar compostos terapêuticos a sítios específicos num corpo de mamífero. estojos para uso na geração de imagem de doenças específicas de tecido são também providos.
BRPI0111220A 2000-06-02 2001-06-01 conjugados de fármacos com etilenodicisteína (ec) BRPI0111220B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58758300A 2000-06-02 2000-06-02
US09/599,152 US7067111B1 (en) 1999-10-25 2000-06-21 Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
PCT/US2001/018060 WO2001091807A2 (en) 2000-06-02 2001-06-01 Ethylenedicysteine (ec)-drug conjugates

Publications (3)

Publication Number Publication Date
BR0111220A BR0111220A (pt) 2003-06-24
BRPI0111220B1 true BRPI0111220B1 (pt) 2016-10-11
BRPI0111220B8 BRPI0111220B8 (pt) 2021-07-27

Family

ID=27080078

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0111220A BRPI0111220B8 (pt) 2000-06-02 2001-06-01 conjugados de fármacos com etilenodicisteína (ec)

Country Status (16)

Country Link
US (4) US7615208B2 (pt)
EP (2) EP1286704B1 (pt)
JP (3) JP5448284B2 (pt)
KR (1) KR100784120B1 (pt)
CN (1) CN1292798C (pt)
AU (2) AU2001275210B2 (pt)
BR (1) BRPI0111220B8 (pt)
CA (1) CA2410906C (pt)
DK (1) DK1286704T3 (pt)
ES (1) ES2518926T3 (pt)
HK (1) HK1056682A1 (pt)
HU (1) HU230437B1 (pt)
IL (2) IL153218A0 (pt)
NO (1) NO332574B1 (pt)
PL (1) PL212211B1 (pt)
WO (1) WO2001091807A2 (pt)

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EP1286704B1 (en) 2014-07-23
US20130165631A1 (en) 2013-06-27
HK1056682A1 (en) 2004-02-27
JP2008208138A (ja) 2008-09-11
US20070297976A1 (en) 2007-12-27
BRPI0111220B8 (pt) 2021-07-27
PL212211B1 (pl) 2012-08-31
IL153218A0 (en) 2003-07-06
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US20100055035A1 (en) 2010-03-04
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IL153218A (en) 2010-02-17
AU7521001A (en) 2001-12-11
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HU230437B1 (hu) 2016-06-28
CA2410906A1 (en) 2001-12-06
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