BRPI0016184B8 - precursores de vitamina d, processo e intermediários - Google Patents
precursores de vitamina d, processo e intermediáriosInfo
- Publication number
- BRPI0016184B8 BRPI0016184B8 BRPI0016184A BR0016184A BRPI0016184B8 BR PI0016184 B8 BRPI0016184 B8 BR PI0016184B8 BR PI0016184 A BRPI0016184 A BR PI0016184A BR 0016184 A BR0016184 A BR 0016184A BR PI0016184 B8 BRPI0016184 B8 BR PI0016184B8
- Authority
- BR
- Brazil
- Prior art keywords
- intermediates
- vitamin
- precursors
- preparing
- compounds
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 3
- 239000002243 precursor Substances 0.000 title abstract 3
- 229940046008 vitamin d Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UYEMGAFJOZZIFP-UHFFFAOYSA-N 3,5-dihydroxybenzoic acid Chemical class OC(=O)C1=CC(O)=CC(O)=C1 UYEMGAFJOZZIFP-UHFFFAOYSA-N 0.000 abstract 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/78—Benzoic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/40—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing six carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cephalosporin Compounds (AREA)
Abstract
"precursores de vitamina d, processo e intermediários". a invenção se refere aos precursores de anel-a da vitamina d da fórmula (i): onde: a, r, r~ 1~ e r~ 2~ são conforme definidos no relatório descritivo. a invenção também se refere a um processo para preparação dos compostos (1) compreendendo uma assimetrização enzimática de derivados de ácido 3,5-diidroxibenzóicos, bem como intermediários para preparação dos compostos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99403065A EP1106618A1 (en) | 1999-12-08 | 1999-12-08 | Precursors of the A-ring of vitamin D, and method and intermediates for the preparation thereof |
| US09/456,509 US6191292B1 (en) | 1999-12-08 | 1999-12-08 | Precursors of the A-ring of vitamin D and method and intermediates for the preparation thereof |
| PCT/EP2000/012225 WO2001042251A1 (en) | 1999-12-08 | 2000-12-04 | Vitamin d precursors, method and intermediates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0016184A BR0016184A (pt) | 2002-08-20 |
| BRPI0016184B1 BRPI0016184B1 (pt) | 2015-07-14 |
| BRPI0016184B8 true BRPI0016184B8 (pt) | 2021-05-25 |
Family
ID=26153704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0016184A BRPI0016184B8 (pt) | 1999-12-08 | 2000-12-04 | precursores de vitamina d, processo e intermediários |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6191292B1 (pt) |
| EP (2) | EP1106618A1 (pt) |
| CN (1) | CN1210282C (pt) |
| AT (1) | ATE254623T1 (pt) |
| AU (1) | AU782089B2 (pt) |
| BR (1) | BRPI0016184B8 (pt) |
| CA (1) | CA2393617C (pt) |
| CZ (1) | CZ303421B6 (pt) |
| DE (1) | DE60006714T2 (pt) |
| DK (1) | DK1235832T3 (pt) |
| EE (1) | EE05326B1 (pt) |
| ES (1) | ES2210022T3 (pt) |
| HU (1) | HU229508B1 (pt) |
| IL (1) | IL150089A0 (pt) |
| MX (1) | MXPA01012904A (pt) |
| NO (1) | NO327848B1 (pt) |
| NZ (1) | NZ519391A (pt) |
| PL (1) | PL201691B1 (pt) |
| PT (1) | PT1235832E (pt) |
| RU (1) | RU2247710C2 (pt) |
| TW (1) | TWI290928B (pt) |
| WO (1) | WO2001042251A1 (pt) |
| ZA (1) | ZA200204594B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE550318T1 (de) | 2010-01-26 | 2012-04-15 | Hybrigenics Sa | Neues verfahren zur isomerisierung kondensierter bicyclischer strukturen und herstellung von diese enthaltenden vitamin d analoga |
| USRE46698E1 (en) | 2011-12-21 | 2018-02-06 | Merck Patent Gmbh | Use of cyclohexanol derivatives as antimicrobial active compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2153491C2 (ru) * | 1993-07-09 | 2000-07-27 | Лаборатуар Терамекс С.А. | Аналоги витамина d, соединения, способы их получения и фармацевтическая композиция |
-
1999
- 1999-12-08 US US09/456,509 patent/US6191292B1/en not_active Expired - Lifetime
- 1999-12-08 EP EP99403065A patent/EP1106618A1/en not_active Withdrawn
-
2000
- 2000-10-30 TW TW089122845A patent/TWI290928B/zh not_active IP Right Cessation
- 2000-12-04 IL IL15008900A patent/IL150089A0/xx active IP Right Grant
- 2000-12-04 DK DK00983224T patent/DK1235832T3/da active
- 2000-12-04 CZ CZ20021977A patent/CZ303421B6/cs not_active IP Right Cessation
- 2000-12-04 CA CA2393617A patent/CA2393617C/en not_active Expired - Lifetime
- 2000-12-04 WO PCT/EP2000/012225 patent/WO2001042251A1/en active IP Right Grant
- 2000-12-04 MX MXPA01012904A patent/MXPA01012904A/es active IP Right Grant
- 2000-12-04 EP EP00983224A patent/EP1235832B1/en not_active Expired - Lifetime
- 2000-12-04 BR BRPI0016184A patent/BRPI0016184B8/pt not_active IP Right Cessation
- 2000-12-04 HU HU0204521A patent/HU229508B1/hu unknown
- 2000-12-04 NZ NZ519391A patent/NZ519391A/en not_active IP Right Cessation
- 2000-12-04 AU AU20051/01A patent/AU782089B2/en not_active Expired
- 2000-12-04 ES ES00983224T patent/ES2210022T3/es not_active Expired - Lifetime
- 2000-12-04 EE EEP200200294A patent/EE05326B1/xx unknown
- 2000-12-04 RU RU2002118103/04A patent/RU2247710C2/ru active
- 2000-12-04 AT AT00983224T patent/ATE254623T1/de active
- 2000-12-04 DE DE60006714T patent/DE60006714T2/de not_active Expired - Lifetime
- 2000-12-04 PL PL356389A patent/PL201691B1/pl unknown
- 2000-12-04 PT PT00983224T patent/PT1235832E/pt unknown
- 2000-12-04 CN CNB008184984A patent/CN1210282C/zh not_active Expired - Lifetime
-
2002
- 2002-06-06 NO NO20022690A patent/NO327848B1/no not_active IP Right Cessation
- 2002-06-07 ZA ZA200204594A patent/ZA200204594B/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 14/07/2015, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/12/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 04/12/2020 |