BR0306149A - Composto, processo para a preparação do mesmo, composição farmacêutica, e, usos do composto, e de um inibidor de enzima degradadora da neurotensina - Google Patents

Composto, processo para a preparação do mesmo, composição farmacêutica, e, usos do composto, e de um inibidor de enzima degradadora da neurotensina

Info

Publication number
BR0306149A
BR0306149A BR0306149-3A BR0306149A BR0306149A BR 0306149 A BR0306149 A BR 0306149A BR 0306149 A BR0306149 A BR 0306149A BR 0306149 A BR0306149 A BR 0306149A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
neurotensin
enzyme inhibitor
degrading enzyme
Prior art date
Application number
BR0306149-3A
Other languages
English (en)
Inventor
Roelof W Feenstra
Josephus H M Lange
Maria L Pras-Raves
Cornelis G Kruse
Herman H Van Stuivenberg
Tinka Tuinstra
Hiskias G Keizer
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of BR0306149A publication Critical patent/BR0306149A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTO, PROCESSO PARA A PREPARAçãO DO MESMO, COMPOSIçãO FARMACêUTICA, E, USOS DO COMPOSTO, E DE UM INIBIDOR DE ENZIMA DEGRADADORA DA NEUROTENSINA". A invenção refere-se a um grupo de novos derivados de 2,3 diaril-piperazolidina tendo a fórmula (1) Os símbolos usados na fórmula (1) têm os significados dados no relatório. Os compostos têm atividade inibidora sobre as enzimas que degradam a neurotensina neuropeptídica e podem ser usados para o tratamento de afecções e doenças causadas por perturbações da transmissão mediadas pela neurotensina.
BR0306149-3A 2002-03-18 2003-03-17 Composto, processo para a preparação do mesmo, composição farmacêutica, e, usos do composto, e de um inibidor de enzima degradadora da neurotensina BR0306149A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02076482 2002-03-18
PCT/EP2003/050064 WO2003078400A1 (en) 2002-03-18 2003-03-17 Neurotensin active 2,3-diaryl-pyrazolidine derivatives

Publications (1)

Publication Number Publication Date
BR0306149A true BR0306149A (pt) 2004-10-19

Family

ID=27838122

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0306149-3A BR0306149A (pt) 2002-03-18 2003-03-17 Composto, processo para a preparação do mesmo, composição farmacêutica, e, usos do composto, e de um inibidor de enzima degradadora da neurotensina

Country Status (25)

Country Link
US (1) US7186741B2 (pt)
EP (1) EP1487802B1 (pt)
JP (1) JP4484525B2 (pt)
KR (1) KR20040106290A (pt)
CN (1) CN100509788C (pt)
AR (1) AR038967A1 (pt)
AT (1) ATE493390T1 (pt)
AU (1) AU2003219165B2 (pt)
BR (1) BR0306149A (pt)
CA (1) CA2462694C (pt)
DE (1) DE60335525D1 (pt)
DK (1) DK1487802T3 (pt)
ES (1) ES2358894T3 (pt)
HK (1) HK1070646A1 (pt)
HR (1) HRP20040275A2 (pt)
IL (1) IL160944A0 (pt)
MX (1) MXPA04004743A (pt)
NO (1) NO20044405L (pt)
PL (1) PL371440A1 (pt)
PT (1) PT1487802E (pt)
RU (1) RU2304578C2 (pt)
SI (1) SI1487802T1 (pt)
UA (1) UA77775C2 (pt)
WO (1) WO2003078400A1 (pt)
ZA (1) ZA200404741B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1801098A1 (en) 2005-12-16 2007-06-27 Merck Sante 2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors
CN102241678B (zh) 2011-04-26 2014-10-29 辽宁利锋科技开发有限公司 含有脂环结构化合物的抗肿瘤作用与应用
US10377718B2 (en) 2014-06-06 2019-08-13 Research Triangle Institute Apelin receptor (APJ) agonists and uses thereof
EP3386976A1 (en) 2015-12-09 2018-10-17 Research Triangle Institute, International Improved apelin receptor (apj) agonists and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3712365A1 (de) 1987-04-11 1988-10-27 Hoechst Ag Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2711140B1 (fr) * 1993-10-12 1996-01-05 Sanofi Sa 1-Naphtylpyrazole-3-carboxamides substitués actifs sur la neurotensine, leur préparation, les compositions pharmaceutiques en contenant.

Also Published As

Publication number Publication date
MXPA04004743A (es) 2004-08-02
CA2462694A1 (en) 2003-09-25
CN100509788C (zh) 2009-07-08
NO20044405L (no) 2004-10-15
PT1487802E (pt) 2011-03-11
AU2003219165B2 (en) 2008-03-13
ES2358894T3 (es) 2011-05-16
JP2005527528A (ja) 2005-09-15
CN1592742A (zh) 2005-03-09
RU2304578C2 (ru) 2007-08-20
EP1487802B1 (en) 2010-12-29
DE60335525D1 (de) 2011-02-10
EP1487802A1 (en) 2004-12-22
AU2003219165A1 (en) 2003-09-29
HK1070646A1 (en) 2005-06-24
AR038967A1 (es) 2005-02-02
CA2462694C (en) 2010-08-10
ZA200404741B (en) 2005-08-29
PL371440A1 (en) 2005-06-13
HRP20040275A2 (en) 2004-08-31
JP4484525B2 (ja) 2010-06-16
SI1487802T1 (sl) 2011-04-29
DK1487802T3 (da) 2011-04-04
IL160944A0 (en) 2004-08-31
UA77775C2 (en) 2007-01-15
US20040242493A1 (en) 2004-12-02
US7186741B2 (en) 2007-03-06
ATE493390T1 (de) 2011-01-15
KR20040106290A (ko) 2004-12-17
WO2003078400A1 (en) 2003-09-25
RU2004114262A (ru) 2005-09-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 8A E 9A ANUIDADES.