BR9809456A - Molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, processo para produzir umaa partìcula de piv infeccioso de uma ou mais moléculas isoladas de polinucleotìdeo, partìcula isolada de piv infecioso, e, composição imunogênica - Google Patents

Molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, processo para produzir umaa partìcula de piv infeccioso de uma ou mais moléculas isoladas de polinucleotìdeo, partìcula isolada de piv infecioso, e, composição imunogênica

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Publication number
BR9809456A
BR9809456A BR9809456-4A BR9809456A BR9809456A BR 9809456 A BR9809456 A BR 9809456A BR 9809456 A BR9809456 A BR 9809456A BR 9809456 A BR9809456 A BR 9809456A
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BR
Brazil
Prior art keywords
isolated
cell
produce
piv
isolated polynucleotide
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Application number
BR9809456-4A
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English (en)
Other versions
BR9809456B1 (pt
Inventor
Brian R Murphy
Peter L Collins
Anna P Durbin
Mario H Skiadopoulos
Tao Tao
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Us Gov Health & Human Serv
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Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Publication of BR9809456A publication Critical patent/BR9809456A/pt
Publication of BR9809456B1 publication Critical patent/BR9809456B1/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
    • C12N2760/18622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
    • C12N2760/18634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Communicable Diseases (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"MOLéCULA ISOLADA DE POLINUCLEOTìDEO, COMPOSIçãO DE CéLULA OU ISENTA DE CéLULA, PROCESSO PARA PRODUZIR UMA PARTìCULA DE PIV INFECCIOSO DE UMA OU MAIS MOLéCULAS ISOLADAS DE POLINUCLEOTìDEO, PARTìCULA ISOLADA DE PIV INFECIOSO, E, COMPOSIçãO IMUNOGêNICA". Moléculas isoladas de polinucleotídeo fornecem genomas e antigenomas de PIV recombinantes para a produção de vacinas de PIV recombinantes. O genoma ou o antigenoma recombinante podem ser expressos por uma nucleoproteína (N), uma fosfoproteína (P) e uma proteína de polimerase grande (L), para produzir partículas infecciosas de PIV isoladas. O genoma e o antigenoma PIV recombinantes podem ser modificados para produzir as mudanças desejadas, por exemplo, para incorporarem mutações atenuadas de mutantes PIV biologicamente derivadas ou para criar clones PIV quiméricos, para gerar vírus imunogênicos, atenuados, para o uso em vacinas.
BRPI9809456-4A 1997-05-23 1998-05-22 molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, partìcula de piv infeciosa, atenuada e imunogênica, e, composição imunogênica. BR9809456B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4757597P 1997-05-23 1997-05-23
UA60/047575 1997-05-23
US5938597P 1997-09-19 1997-09-19
US60/059385 1997-09-19
PCT/US1998/010551 WO1998053078A1 (en) 1997-05-23 1998-05-22 Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences

Publications (2)

Publication Number Publication Date
BR9809456A true BR9809456A (pt) 2000-06-13
BR9809456B1 BR9809456B1 (pt) 2011-06-28

Family

ID=26725195

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9809456-4A BR9809456B1 (pt) 1997-05-23 1998-05-22 molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, partìcula de piv infeciosa, atenuada e imunogênica, e, composição imunogênica.

Country Status (10)

Country Link
EP (1) EP0994949B1 (pt)
JP (2) JP4237268B2 (pt)
KR (1) KR100702523B1 (pt)
CN (1) CN1250725C (pt)
AT (1) ATE501259T1 (pt)
AU (1) AU7797798A (pt)
BR (1) BR9809456B1 (pt)
CA (1) CA2291216A1 (pt)
DE (1) DE69842165D1 (pt)
WO (1) WO1998053078A1 (pt)

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CN1250725C (zh) 2006-04-12
CA2291216A1 (en) 1998-11-26
CN1306575A (zh) 2001-08-01
ATE501259T1 (de) 2011-03-15
EP0994949A1 (en) 2000-04-26
JP4237268B2 (ja) 2009-03-11
BR9809456B1 (pt) 2011-06-28
AU7797798A (en) 1998-12-11
DE69842165D1 (de) 2011-04-21
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JP2002502241A (ja) 2002-01-22
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