BR9809456A - Molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, processo para produzir umaa partìcula de piv infeccioso de uma ou mais moléculas isoladas de polinucleotìdeo, partìcula isolada de piv infecioso, e, composição imunogênica - Google Patents
Molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, processo para produzir umaa partìcula de piv infeccioso de uma ou mais moléculas isoladas de polinucleotìdeo, partìcula isolada de piv infecioso, e, composição imunogênicaInfo
- Publication number
- BR9809456A BR9809456A BR9809456-4A BR9809456A BR9809456A BR 9809456 A BR9809456 A BR 9809456A BR 9809456 A BR9809456 A BR 9809456A BR 9809456 A BR9809456 A BR 9809456A
- Authority
- BR
- Brazil
- Prior art keywords
- isolated
- cell
- produce
- piv
- isolated polynucleotide
- Prior art date
Links
- 102000040430 polynucleotide Human genes 0.000 title abstract 5
- 108091033319 polynucleotide Proteins 0.000 title abstract 5
- 239000002157 polynucleotide Substances 0.000 title abstract 5
- 208000015181 infectious disease Diseases 0.000 title abstract 4
- 230000002458 infectious effect Effects 0.000 title abstract 4
- 239000002245 particle Substances 0.000 title abstract 4
- 230000002163 immunogen Effects 0.000 title abstract 2
- 230000002238 attenuated effect Effects 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 102000011931 Nucleoproteins Human genes 0.000 abstract 1
- 108010061100 Nucleoproteins Proteins 0.000 abstract 1
- 102000007982 Phosphoproteins Human genes 0.000 abstract 1
- 108010089430 Phosphoproteins Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
"MOLéCULA ISOLADA DE POLINUCLEOTìDEO, COMPOSIçãO DE CéLULA OU ISENTA DE CéLULA, PROCESSO PARA PRODUZIR UMA PARTìCULA DE PIV INFECCIOSO DE UMA OU MAIS MOLéCULAS ISOLADAS DE POLINUCLEOTìDEO, PARTìCULA ISOLADA DE PIV INFECIOSO, E, COMPOSIçãO IMUNOGêNICA". Moléculas isoladas de polinucleotídeo fornecem genomas e antigenomas de PIV recombinantes para a produção de vacinas de PIV recombinantes. O genoma ou o antigenoma recombinante podem ser expressos por uma nucleoproteína (N), uma fosfoproteína (P) e uma proteína de polimerase grande (L), para produzir partículas infecciosas de PIV isoladas. O genoma e o antigenoma PIV recombinantes podem ser modificados para produzir as mudanças desejadas, por exemplo, para incorporarem mutações atenuadas de mutantes PIV biologicamente derivadas ou para criar clones PIV quiméricos, para gerar vírus imunogênicos, atenuados, para o uso em vacinas.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4757597P | 1997-05-23 | 1997-05-23 | |
UA60/047575 | 1997-05-23 | ||
US5938597P | 1997-09-19 | 1997-09-19 | |
US60/059385 | 1997-09-19 | ||
PCT/US1998/010551 WO1998053078A1 (en) | 1997-05-23 | 1998-05-22 | Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9809456A true BR9809456A (pt) | 2000-06-13 |
BR9809456B1 BR9809456B1 (pt) | 2011-06-28 |
Family
ID=26725195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9809456-4A BR9809456B1 (pt) | 1997-05-23 | 1998-05-22 | molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, partìcula de piv infeciosa, atenuada e imunogênica, e, composição imunogênica. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0994949B1 (pt) |
JP (2) | JP4237268B2 (pt) |
KR (1) | KR100702523B1 (pt) |
CN (1) | CN1250725C (pt) |
AT (1) | ATE501259T1 (pt) |
AU (1) | AU7797798A (pt) |
BR (1) | BR9809456B1 (pt) |
CA (1) | CA2291216A1 (pt) |
DE (1) | DE69842165D1 (pt) |
WO (1) | WO1998053078A1 (pt) |
Families Citing this family (99)
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---|---|---|---|---|
US7465574B2 (en) | 1994-09-30 | 2008-12-16 | Medimmune, Llc | Recombinant RSV virus expression systems and vaccines |
US7485440B2 (en) | 1995-09-27 | 2009-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
US6699476B1 (en) | 1996-07-15 | 2004-03-02 | Peter L. Collins | Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules |
JP4413999B2 (ja) | 1996-07-15 | 2010-02-10 | アメリカ合衆国 | クローニングされたヌクレオチド配列からの弱毒化呼吸シンシチウムウィルスワクチンの製造 |
US7314631B1 (en) | 1997-05-23 | 2008-01-01 | The United States Of America As Represented By The Department Of Health And Human Services | Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV) |
US7192593B2 (en) | 1997-05-23 | 2007-03-20 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens |
US6410023B1 (en) | 1997-05-23 | 2002-06-25 | United States Of America | Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene |
US20030082209A1 (en) | 2000-07-05 | 2003-05-01 | Skiadopoulos Mario H. | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
US7951383B2 (en) | 1997-05-23 | 2011-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated parainfluenza virus (PIV) vaccines |
US7201907B1 (en) | 1997-05-23 | 2007-04-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines |
US7632508B2 (en) | 1997-05-23 | 2009-12-15 | The United States Of America | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
US7250171B1 (en) | 1997-05-23 | 2007-07-31 | United States Of America As Represented By The Dept. Of Health & Human Services | Construction and use of recombinant parainfluenza viruses expressing a chimeric glycoprotein |
US6830748B1 (en) | 1997-09-26 | 2004-12-14 | Medimmune Vaccines, Inc. | Recombinant RSV virus expression systems and vaccines |
JP4531255B2 (ja) | 1998-06-12 | 2010-08-25 | マウント シナイ スクール オブ メディシン オブ ニューヨーク ユニバーシティー | ワクチンおよび医薬として使用される、改変されたインターフェロン拮抗活性を有する弱毒(−)鎖ウイルス |
ES2301241T3 (es) | 1998-06-12 | 2008-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Virus de influenza a atenuados, y composiciones inmunogenicas y formulaciones de vacunas que los contienen. |
US6544785B1 (en) | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
US6146642A (en) | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
US8715940B2 (en) | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
CA2369200A1 (en) | 1999-04-13 | 2000-10-19 | Peter L. Collins | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
KR100940776B1 (ko) * | 1999-07-09 | 2010-02-11 | 더 가버먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 리프리젠티드 바이 더 디파트먼트 오브 헬스 앤 휴먼 서비씨즈 | 약독화된 사람-소 키메라 파라인플루엔자바이러스(piv) 백신 |
US7820182B2 (en) | 1999-07-09 | 2010-10-26 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions |
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AU7007491A (en) * | 1990-02-02 | 1991-08-08 | Schweiz. Serum- & Impfinstitut Bern | Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses |
PT702085E (pt) * | 1994-07-18 | 2004-04-30 | Karl Klaus Conzelmann | Virus de arn de cadeia negativa nao segmentada infeccioso recombinante |
BR9610590A (pt) * | 1995-09-22 | 2000-10-24 | Connaught Lab | Glicoproteìnas e vacinas de vìrus parainfluenza |
US5869036A (en) * | 1995-12-08 | 1999-02-09 | St. Louis University | Live attenuated vaccines based on CP45 HPIV-3 strain and method to ensure attenuation in such vaccine |
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1998
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- 1998-05-22 AU AU77977/98A patent/AU7797798A/en not_active Abandoned
- 1998-05-22 AT AT98926055T patent/ATE501259T1/de not_active IP Right Cessation
- 1998-05-22 EP EP98926055A patent/EP0994949B1/en not_active Expired - Lifetime
- 1998-05-22 BR BRPI9809456-4A patent/BR9809456B1/pt not_active IP Right Cessation
- 1998-05-22 JP JP55070498A patent/JP4237268B2/ja not_active Expired - Fee Related
- 1998-05-22 CA CA002291216A patent/CA2291216A1/en not_active Abandoned
- 1998-05-22 WO PCT/US1998/010551 patent/WO1998053078A1/en active IP Right Grant
- 1998-05-22 DE DE69842165T patent/DE69842165D1/de not_active Expired - Lifetime
- 1998-05-22 KR KR1019997010859A patent/KR100702523B1/ko not_active IP Right Cessation
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CN1306575A (zh) | 2001-08-01 |
ATE501259T1 (de) | 2011-03-15 |
JP2002502241A (ja) | 2002-01-22 |
EP0994949A1 (en) | 2000-04-26 |
CA2291216A1 (en) | 1998-11-26 |
JP4237268B2 (ja) | 2009-03-11 |
JP2008307055A (ja) | 2008-12-25 |
AU7797798A (en) | 1998-12-11 |
DE69842165D1 (de) | 2011-04-21 |
BR9809456B1 (pt) | 2011-06-28 |
JP4384244B2 (ja) | 2009-12-16 |
CN1250725C (zh) | 2006-04-12 |
WO1998053078A1 (en) | 1998-11-26 |
EP0994949B1 (en) | 2011-03-09 |
KR20010012893A (ko) | 2001-02-26 |
KR100702523B1 (ko) | 2007-04-04 |
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