BRPI0612268A2 - Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrus - Google Patents
Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrusInfo
- Publication number
- BRPI0612268A2 BRPI0612268A2 BRPI0612268-0A BRPI0612268A BRPI0612268A2 BR PI0612268 A2 BRPI0612268 A2 BR PI0612268A2 BR PI0612268 A BRPI0612268 A BR PI0612268A BR PI0612268 A2 BRPI0612268 A2 BR PI0612268A2
- Authority
- BR
- Brazil
- Prior art keywords
- virus
- influenza
- producing
- generating
- cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Pulmonology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
ÁCIDO NUCLEICO ISOLADO, VETOR DE EXPRESSçO, MÉTODOS PARA PRODUZIR UM RNA GENâMICO DA INIFLUENZA, PARA PRODUZIR UM VÍRUS DA INFLUENZA RECOMBINANTE, PARA GERAR UM VÍRUS DE RNA SEGMENTADO DE FILAMENTO NEGATIVO RECOMBINANTE NAS CÉLULAS CANINAS CULTIVADAS E PARA GERAR PARTÍCULAS VIRAIS DA INFLUENZA INFECCIOSA EM CÉLULAS CANiNAS CULTIVADAS, CÉLULA, E, VÍRUS. A presente invenção fornece novas sequências de ácido nucleico reguladoras da polimerase 1 canina, úteis para a expressão das sequências de ácido nucleico em células caninas tais como as células MDCK. A invenção ainda fornece vetores de expressão e células compreendendo tais ácidos nucleicos, bem como métodos de uso de tais ácidos nucleicos para produzir vírus da influenza, incluindo os vírus da influenza infecciosa.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69296505P | 2005-06-21 | 2005-06-21 | |
US69297805P | 2005-06-21 | 2005-06-21 | |
US69955505P | 2005-07-15 | 2005-07-15 | |
US69955605P | 2005-07-15 | 2005-07-15 | |
US70200605P | 2005-07-22 | 2005-07-22 | |
US79352506P | 2006-04-19 | 2006-04-19 | |
US79352206P | 2006-04-19 | 2006-04-19 | |
PCT/US2006/023867 WO2007002008A2 (en) | 2005-06-21 | 2006-06-20 | Methods and compositions for expressing negative-sense viral rna in canine cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0612268A2 true BRPI0612268A2 (pt) | 2009-01-27 |
Family
ID=37595721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0612268-0A BRPI0612268A2 (pt) | 2005-06-21 | 2006-06-20 | Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrus |
Country Status (11)
Country | Link |
---|---|
US (4) | US20060286591A1 (pt) |
EP (2) | EP1917361A4 (pt) |
JP (2) | JP2008543331A (pt) |
KR (2) | KR20080024212A (pt) |
AU (2) | AU2006262381A1 (pt) |
BR (1) | BRPI0612268A2 (pt) |
CA (2) | CA2613283A1 (pt) |
IL (1) | IL188202A0 (pt) |
NO (1) | NO20080358L (pt) |
RU (1) | RU2008101367A (pt) |
WO (2) | WO2007002007A2 (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
US7790434B2 (en) | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
EP1917361A4 (en) | 2005-06-21 | 2009-07-29 | Medimmune Vaccines Inc | METHODS AND COMPOSITIONS FOR EXPRESSING NEGATIVE SENSE RNA VIRUS IN CANINE CELLS |
US7682619B2 (en) | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
AU2007240448B8 (en) * | 2006-04-19 | 2014-03-06 | Medimmune Llc. | Methods and compositions for expressing negative-sense viral RNA in canine cells |
ES2694805T7 (es) | 2006-09-11 | 2021-10-21 | Seqirus Uk Ltd | Fabricación de vacunas contra virus de la gripe sin usar huevos |
US9163053B2 (en) * | 2007-05-18 | 2015-10-20 | Fluidigm Corporation | Nucleotide analogs |
MY152175A (en) | 2007-06-26 | 2014-08-15 | Japan Health Science Found | Vaccine antigen capable of inducing cross-reacting and neutralizing antibody againts high-risk-type human papillomavirus |
GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
JP5548207B2 (ja) | 2008-09-24 | 2014-07-16 | メディミューン,エルエルシー | ウイルスの精製方法 |
USH2284H1 (en) | 2009-04-27 | 2013-09-03 | Novartis Ag | Vaccines for protecting against influenza |
KR101800245B1 (ko) * | 2009-05-21 | 2017-11-22 | 노파르티스 아게 | 비-내인성 pol i 프로모터를 사용하는 역 유전학 |
WO2011012999A1 (en) | 2009-07-31 | 2011-02-03 | Novartis Ag | Reverse genetics systems |
CN102220437B (zh) * | 2011-04-27 | 2014-04-23 | 贵州省烟草科学研究所 | 部分接种鉴定烟草病毒病抗性的方法 |
JP6054883B2 (ja) | 2012-03-02 | 2016-12-27 | ノバルティス アーゲー | インフルエンザウイルスの再集合 |
GB201220119D0 (en) * | 2012-11-08 | 2012-12-26 | Univ Cork | Vector |
AU2013354219A1 (en) | 2012-12-03 | 2015-07-02 | Novartis Ag | Reassortant influenza a viren |
AU2014229255B2 (en) | 2013-03-13 | 2018-12-13 | Novartis Ag | Influenza B virus reassortment |
DE202013005100U1 (de) | 2013-06-05 | 2013-08-26 | Novartis Ag | Influenza Virus Reassortierung |
DE202013005130U1 (de) | 2013-06-05 | 2013-09-10 | Novartis Ag | Influenza Virus Reassortierung |
CA2914604A1 (en) | 2013-06-06 | 2014-12-11 | Novartis Ag | Influenza virus reassortment |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
WO2016148195A1 (ja) * | 2015-03-17 | 2016-09-22 | 一般財団法人阪大微生物病研究会 | インフルエンザウイルス作出用細胞 |
CN106520700B (zh) * | 2016-11-10 | 2019-12-27 | 中国食品药品检定研究院 | 稳定表达牛胰蛋白酶原的mdck细胞系及其用途 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
JPWO2020004425A1 (ja) * | 2018-06-27 | 2021-07-08 | 一般財団法人阪大微生物病研究会 | インフルエンザウイルスの培養方法 |
CN109762938B (zh) * | 2019-02-01 | 2022-06-10 | 中国水产科学研究院珠江水产研究所 | 用于区分鳜鱼弹状病毒vRNA、cRNA和mRNA的引物组合及试剂盒 |
CN109652384B (zh) * | 2019-02-21 | 2021-10-26 | 昆明理工大学 | 一种体外培养戊型肝炎病毒的方法 |
BR102020010208A2 (pt) | 2020-05-21 | 2022-04-12 | Fundação Oswaldo Cruz | Construção de ácido nucleico, virus influenza recombinante, método para preparar um virus influenza recombinante, composição, e, uso. |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6001634A (en) * | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
US6887699B1 (en) * | 1990-05-22 | 2005-05-03 | Medimmune Vaccines, Inc. | Recombinant negative strand RNA virus expression systems and vaccines |
US6348327B1 (en) * | 1991-12-06 | 2002-02-19 | Genentech, Inc. | Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells |
EP1394259A3 (en) | 1994-07-18 | 2004-04-14 | Karl-Klaus Prof. Dr. Conzelmann | Recombinant infectious non-segmented negative strand RNA virus |
FR2723104B1 (fr) * | 1994-07-27 | 1996-09-13 | Rhone Poulenc Rorer Sa | Nouvelle topoisomerase iv, sequences nucleotiques correspondantes et leurs utilisations |
US5824536A (en) * | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
US5789229A (en) * | 1994-09-30 | 1998-08-04 | Uab Research Foundation | Stranded RNA virus particles |
US5753489A (en) * | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
AU694592B2 (en) | 1994-11-16 | 1998-07-23 | St. Jude Children's Research Hospital | Novel replication process |
US7153510B1 (en) | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
US5690937A (en) * | 1995-06-05 | 1997-11-25 | Aviron | Temperature sensitive clustered changed-to-alanine mutants of influenza virus PB2 gene |
DE69510207T3 (de) | 1995-08-09 | 2007-02-15 | Schweiz. Serum- & Impfinstitut Bern | Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren |
WO1997012032A1 (en) | 1995-09-27 | 1997-04-03 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Production of infectious respiratory syncytial virus from cloned nucleotide sequences |
KR100894670B1 (ko) | 1996-07-15 | 2009-04-22 | 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 에즈 레프리젠티드 바이 더 디파트먼트 오브 헬쓰 앤드 휴먼 서비시즈 | 클론닝된 뉴클레오타이드 서열로부터 약독화된 호흡기 세포융합 바이러스 백신의 생산 |
CN1232504A (zh) | 1996-09-27 | 1999-10-20 | 美国氰胺公司 | 在单链负义病毒目病毒内引起减毒的3'基因组启动子区和聚合酶基因中的突变 |
KR100702523B1 (ko) | 1997-05-23 | 2007-04-04 | 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 에즈 레프리젠티드 바이 더 디파트먼트 오브 헬쓰 앤드 휴먼 서비시즈 | 클로닝된 뉴클레오타이드 서열로부터 약독화된파라인플루엔자 바이러스를 제조하는 방법 |
PT1012244E (pt) | 1997-07-11 | 2007-08-21 | Univ Yale | ''rabdovírus com revestimentos remanipulados'' |
US6946291B2 (en) * | 1998-04-24 | 2005-09-20 | University Hospitals Of Cleveland | Mixed cell diagnostic systems |
US6544785B1 (en) * | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
DK1194580T4 (da) | 1999-07-14 | 2011-01-03 | Sinai School Medicine | In-vitro rekonstitution af segmenterede negativstrengede RNA-virus |
US6951754B2 (en) | 2000-04-28 | 2005-10-04 | St. Jude Children's Research Hospital | DNA transfection system for the generation of infectious influenza virus |
WO2002006453A2 (en) * | 2000-07-18 | 2002-01-24 | Bayer Aktiengesellschaft | Regulation of human desc1-like serine protease |
US20040241139A1 (en) * | 2000-07-20 | 2004-12-02 | Gerd Hobom | Recombinant influenza viruses with bicistronic vRNAs coding for two genes in tandem arrangement |
ES2563402T3 (es) * | 2002-02-13 | 2016-03-15 | Wisconsin Alumni Research Foundation | Señal para el empaquetamiento de vectores del virus de la gripe |
WO2003072725A2 (en) * | 2002-02-21 | 2003-09-04 | Mount Sinai School Of Medicine | Recombinant negative strand virus rna expression systems and vaccines |
US7465456B2 (en) * | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
WO2003091401A2 (en) | 2002-04-26 | 2003-11-06 | Medimmune Vaccines, Inc. | Multi plasmid system for the production of influenza virus |
US7132523B2 (en) * | 2002-07-03 | 2006-11-07 | Ortho-Mcneil Pharmaceutical, Inc. | Human PRSS11-Like S2 serine protease and uses thereof |
AU2003287105A1 (en) * | 2002-10-10 | 2004-05-04 | Verenium Corporation | Proteases, nucleic acids encoding them and methods for making and using them |
JP4617300B2 (ja) * | 2003-02-25 | 2011-01-19 | メディミューン,エルエルシー | インフルエンザワクチン組成物を生成する方法 |
CA2421086A1 (fr) * | 2003-02-28 | 2004-08-28 | Institut Pasteur | Promoteur de l'arn polymerase i de poulet et son utilisation |
WO2004112831A2 (en) * | 2003-05-28 | 2004-12-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines and gene therapy |
CA2526834A1 (en) * | 2003-05-28 | 2005-03-31 | Wisconsin Alumni Research Foundation | Recombinant influenza vectors with a polii promoter and ribozymes |
JP4771959B2 (ja) * | 2003-12-23 | 2011-09-14 | メディミューン,エルエルシー | インフルエンザウイルス作製のための多重プラスミド系 |
JP5620048B2 (ja) * | 2004-12-24 | 2014-11-05 | アボツト・バイオロジカルズ・ベー・ブイAbbott Biologicals B.V. | インフルエンザウイルスの救済(rescue) |
EP1917361A4 (en) | 2005-06-21 | 2009-07-29 | Medimmune Vaccines Inc | METHODS AND COMPOSITIONS FOR EXPRESSING NEGATIVE SENSE RNA VIRUS IN CANINE CELLS |
US7790434B2 (en) * | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
AU2007240448B8 (en) * | 2006-04-19 | 2014-03-06 | Medimmune Llc. | Methods and compositions for expressing negative-sense viral RNA in canine cells |
-
2006
- 2006-06-20 EP EP06773570A patent/EP1917361A4/en not_active Withdrawn
- 2006-06-20 CA CA002613283A patent/CA2613283A1/en not_active Abandoned
- 2006-06-20 RU RU2008101367/13A patent/RU2008101367A/ru not_active Application Discontinuation
- 2006-06-20 JP JP2008518287A patent/JP2008543331A/ja active Pending
- 2006-06-20 AU AU2006262381A patent/AU2006262381A1/en not_active Abandoned
- 2006-06-20 WO PCT/US2006/023866 patent/WO2007002007A2/en active Application Filing
- 2006-06-20 KR KR1020087001609A patent/KR20080024212A/ko not_active Application Discontinuation
- 2006-06-20 US US11/455,734 patent/US20060286591A1/en not_active Abandoned
- 2006-06-20 KR KR1020087001669A patent/KR20080025171A/ko not_active Application Discontinuation
- 2006-06-20 AU AU2006262380A patent/AU2006262380A1/en not_active Abandoned
- 2006-06-20 WO PCT/US2006/023867 patent/WO2007002008A2/en active Application Filing
- 2006-06-20 BR BRPI0612268-0A patent/BRPI0612268A2/pt not_active IP Right Cessation
- 2006-06-20 CA CA002613284A patent/CA2613284A1/en not_active Abandoned
- 2006-06-20 JP JP2008518286A patent/JP2008546408A/ja active Pending
- 2006-06-20 EP EP06773569A patent/EP1917352A4/en not_active Withdrawn
-
2007
- 2007-12-17 IL IL188202A patent/IL188202A0/en unknown
-
2008
- 2008-01-18 NO NO20080358A patent/NO20080358L/no not_active Application Discontinuation
-
2010
- 2010-02-17 US US12/706,994 patent/US20100203641A1/en not_active Abandoned
- 2010-07-23 US US12/842,854 patent/US8278433B2/en not_active Expired - Fee Related
-
2012
- 2012-08-31 US US13/601,401 patent/US8742089B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20100203641A1 (en) | 2010-08-12 |
NO20080358L (no) | 2008-03-03 |
US8278433B2 (en) | 2012-10-02 |
WO2007002007A3 (en) | 2007-06-21 |
EP1917361A4 (en) | 2009-07-29 |
US8742089B2 (en) | 2014-06-03 |
US20110045586A1 (en) | 2011-02-24 |
WO2007002007A2 (en) | 2007-01-04 |
AU2006262381A1 (en) | 2007-01-04 |
CA2613284A1 (en) | 2007-01-04 |
JP2008546408A (ja) | 2008-12-25 |
RU2008101367A (ru) | 2009-08-10 |
KR20080024212A (ko) | 2008-03-17 |
KR20080025171A (ko) | 2008-03-19 |
EP1917352A4 (en) | 2009-03-25 |
EP1917361A2 (en) | 2008-05-07 |
WO2007002007A8 (en) | 2007-05-10 |
WO2007002008A2 (en) | 2007-01-04 |
WO2007002008A3 (en) | 2007-12-27 |
JP2008543331A (ja) | 2008-12-04 |
EP1917352A2 (en) | 2008-05-07 |
IL188202A0 (en) | 2008-03-20 |
CA2613283A1 (en) | 2007-01-04 |
AU2006262380A1 (en) | 2007-01-04 |
US20060286591A1 (en) | 2006-12-21 |
US20120329150A1 (en) | 2012-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0612268A2 (pt) | Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrus | |
ES2526191T3 (es) | Método para producir virus influenza B infeccioso en cultivo celular | |
ATE460473T1 (de) | Immortalisierte entezelllinien zur viruserzeugung | |
EP1697521A4 (en) | PLASMID MULTIPLE SYSTEM FOR PRODUCING INFLUENZA VIRUS | |
DE122007000070I1 (de) | In Vitro-rekonstitution von segmentierten Negativstrang-Rna-Viren | |
AU2007240448A8 (en) | Methods and compositions for expressing negative-sense viral RNA in canine cells | |
BRPI0518568A2 (pt) | mÉtodo para produzir uma partÍcula do vÍrus da influenza replicativo sem o uso de vÍrus auxiliar, partÍcula de vÍrus da influenza replicativo, cÉlula, composiÇço, uso de uma composiÇço, mÉtodo para gerar proteÇço imunolàgica contra infecÇço de um indivÍduo com um vÍrus da influenza, e, Ácido nuclÉico | |
EA201692359A1 (ru) | Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса | |
BR112013007862A2 (pt) | ácidos nucleicos manipulados e métodos de uso dos mesmos. | |
MX2007005132A (es) | Medios libres de proteina animal para cultivo de celulas. | |
JP2015119730A5 (pt) | ||
FI971998A (fi) | Menetelmä biologisten tuotteiden tuottamiseksi proteiinittomassa viljelmässä | |
NO20054124L (no) | Dyre-fri celle kultur metode | |
NZ609903A (en) | Expression vector for high level expression of recombinant proteins | |
CY1111378T1 (el) | Προερχομενα απο κυτταρα ιικα εμβολια με χαμηλα επιπεδα υπολειμματικου κυτταρικου dna | |
EA200801756A1 (ru) | Противогриппозные вакцины, содержащие гемагглютинин и белки матрикса | |
WO2005115448A8 (en) | Multi plasmid system for the production of influenza virus | |
EA201001045A1 (ru) | Модифицированный вирус гриппа | |
EA200500547A1 (ru) | Конструкции нуклеиновых кислот для экспрессии генов | |
BR112013024346A2 (pt) | técnica de interferência de tra-2 rna do mosquito culicinae para geneticamente produzir populações de machos | |
AR090810A1 (es) | Agentes para el control de la glycaspis brimblecombei | |
EA201201620A1 (ru) | Способ получения рнк-вируса | |
Dormitzer | Synthetic vaccinology at Novartis | |
van Wielink et al. | Effect of natural and chimeric haemagglutinin genes on influenza A virus replication in baby hamster kidney cells | |
Yasmon et al. | Five Unique Amino Acid Residues of Hemagglutinin (HA) Proteins of Swine Influenza A (H1N1) Detected in 2009 in Jakarta, Indonesia |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: MEDIMMUNE, INC. (US) Free format text: TRANSFERIDO POR INCORPORACAO DE: MEDIMMUNE VACCINES, INC. |
|
B25D | Requested change of name of applicant approved |
Owner name: MEDIMMUNE, LLC (US) Free format text: ALTERADO DE: MEDIMMUNE, INC. |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 7A. ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2213 DE 04/06/2013. |