BRPI0518568A2 - mÉtodo para produzir uma partÍcula do vÍrus da influenza replicativo sem o uso de vÍrus auxiliar, partÍcula de vÍrus da influenza replicativo, cÉlula, composiÇço, uso de uma composiÇço, mÉtodo para gerar proteÇço imunolàgica contra infecÇço de um indivÍduo com um vÍrus da influenza, e, Ácido nuclÉico - Google Patents
mÉtodo para produzir uma partÍcula do vÍrus da influenza replicativo sem o uso de vÍrus auxiliar, partÍcula de vÍrus da influenza replicativo, cÉlula, composiÇço, uso de uma composiÇço, mÉtodo para gerar proteÇço imunolàgica contra infecÇço de um indivÍduo com um vÍrus da influenza, e, Ácido nuclÉicoInfo
- Publication number
- BRPI0518568A2 BRPI0518568A2 BRPI0518568-8A BRPI0518568A BRPI0518568A2 BR PI0518568 A2 BRPI0518568 A2 BR PI0518568A2 BR PI0518568 A BRPI0518568 A BR PI0518568A BR PI0518568 A2 BRPI0518568 A2 BR PI0518568A2
- Authority
- BR
- Brazil
- Prior art keywords
- influenza virus
- composition
- cell
- replicative
- nucleic acid
- Prior art date
Links
- 108020004707 nucleic acids Proteins 0.000 title abstract 5
- 150000007523 nucleic acids Chemical class 0.000 title abstract 5
- 102000039446 nucleic acids Human genes 0.000 title abstract 5
- 239000002245 particle Substances 0.000 title abstract 5
- 241000712461 unidentified influenza virus Species 0.000 title abstract 5
- 241000700605 Viruses Species 0.000 title abstract 4
- 230000003362 replicative effect Effects 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- -1 Cell Substances 0.000 title abstract 2
- 230000001900 immune effect Effects 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 229960003971 influenza vaccine Drugs 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 241001515965 unidentified phage Species 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18651—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
MÉTODO PARA PRODUZIR UMA PARTÍCULA DO VÍRUS DA INFLUENZA REPLICATIVO SEM O USO DE VÍRUS AUXILIAR, PARTÍCULA DE VÍRUS DA INFLUENZA REPLICATIVO, CÉLULA, COMPOSIÇçO, USO DE UMA COMPOSIÇçO, MÉTODO PARA GERAR PROTEÇçO IMUNOLàGICA CONTRA INFECÇçO DE UM INDIVÍDUO COM UM VÍRUS DA INFLUENZA, E, ÁCIDO NUCLÉICO. A invenção diz respeito ao campo da produção de vacinas da influenza. As vacinas da influenza têm sido produzidas em ovos de galinhas embrionados por mais de 50 anos, mas recentemente têm sido feitos consideráveis esforços para se desenvolver sistemas de cultura celular para a produção de vacina. A invenção proporciona um ácido nucleico compreendendo um segmento de gene da influenza e um promotor bacteriófago da polimerase ou um filamento complementar do referido ácido nucleico, e uma célula compreendendo um tal ácido nucleico capaz de produzir o desejado virus da influenza. Além do mais, a invenção provê uma composição compreendendo uma célula ou material derivado de uma célula de acordo com a invenção, e um vírus ou material derivado de uma partícula viral, de acordo com a invenção.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04078527 | 2004-12-24 | ||
| US64100305P | 2005-01-04 | 2005-01-04 | |
| PCT/EP2005/057092 WO2006067211A1 (en) | 2004-12-24 | 2005-12-22 | Rescue of influenza virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0518568A2 true BRPI0518568A2 (pt) | 2008-11-25 |
Family
ID=34928779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518568-8A BRPI0518568A2 (pt) | 2004-12-24 | 2005-12-22 | mÉtodo para produzir uma partÍcula do vÍrus da influenza replicativo sem o uso de vÍrus auxiliar, partÍcula de vÍrus da influenza replicativo, cÉlula, composiÇço, uso de uma composiÇço, mÉtodo para gerar proteÇço imunolàgica contra infecÇço de um indivÍduo com um vÍrus da influenza, e, Ácido nuclÉico |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7959930B2 (pt) |
| EP (2) | EP1831357B1 (pt) |
| JP (2) | JP5620048B2 (pt) |
| KR (1) | KR101272487B1 (pt) |
| CN (1) | CN101379183B (pt) |
| AU (1) | AU2005318087B2 (pt) |
| BR (1) | BRPI0518568A2 (pt) |
| CA (1) | CA2592439C (pt) |
| DK (1) | DK1831357T3 (pt) |
| ES (1) | ES2395813T3 (pt) |
| HK (1) | HK1125674A1 (pt) |
| IL (1) | IL183888A (pt) |
| MX (1) | MX2007007889A (pt) |
| NO (1) | NO20073737L (pt) |
| NZ (1) | NZ556061A (pt) |
| PT (1) | PT1831357E (pt) |
| RU (2) | RU2435855C2 (pt) |
| TW (2) | TWI495724B (pt) |
| WO (1) | WO2006067211A1 (pt) |
| ZA (1) | ZA200705145B (pt) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL213926B1 (pl) | 2001-01-19 | 2013-05-31 | Vironovative Bv | Wyizolowany ssaczy metapneumowirus o ujemnej pojedynczej nici RNA (MPV), kompozycja immunogenna, wyizolowane kwasy nukleinowe, sposoby wykrywania ssaczego metapneumowirusa, wektor, komórka gospodarza, wyizolowane bialko, przeciwcialo, sposób wirologicznego diagnozowania infekcji MPV, sposób serologicznego diagnozowania infekcji MPV, kompozycja farmaceutyczna, zestaw diagnostyczny oraz zastosowanie kompozycji farmaceutycznej |
| CN101098958A (zh) | 2002-02-21 | 2008-01-02 | 免疫医疗疫苗公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途 |
| RU2435855C2 (ru) * | 2004-12-24 | 2011-12-10 | Солвей Байолоджикалз Б.В. | Способ продуцирования репликативной частицы вируса гриппа, композиция клеток (варианты), композиция клеточной культуры и ее применение |
| US7790434B2 (en) | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
| US20060286591A1 (en) | 2005-06-21 | 2006-12-21 | Medimmune Vaccines, Inc. | Methods and compositions for expressing negative-sense viral RNA in canine cells |
| ATE539765T1 (de) | 2005-11-04 | 2012-01-15 | Novartis Vaccines & Diagnostic | Grippeimpfstoffe mit kombinationen aus teilchenförmigen adjuvantien und immunverstärkern |
| US10842867B2 (en) | 2005-11-04 | 2020-11-24 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| NZ567978A (en) | 2005-11-04 | 2011-09-30 | Novartis Vaccines & Diagnostic | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
| BRPI0618254A2 (pt) | 2005-11-04 | 2011-08-23 | Novartis Vaccines & Diagnostic | emulsões com agente tensoativo de fase aquosa livre para fornecer adjuvante às vacinas contra influenza dividido |
| AU2006310337B9 (en) | 2005-11-04 | 2013-11-28 | Novartis Ag | Adjuvanted influenza vaccines including cytokine-inducing agents |
| EP1976559B3 (en) | 2006-01-27 | 2020-02-19 | Seqirus UK Limited | Influenza vaccines containing hemagglutinin and matrix proteins |
| JP2009534303A (ja) | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
| CN101472941B (zh) | 2006-03-31 | 2017-08-08 | 沃弗-威斯康星校友研究基金会 | 用于疫苗的高滴度重组流感病毒 |
| US7682619B2 (en) | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| CA3016948A1 (en) | 2006-09-11 | 2008-03-20 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| EA200900784A1 (ru) | 2006-12-06 | 2009-12-30 | Новартис Аг | Вакцины, включающие антиген из четырех штаммов вируса гриппа |
| WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| EP2185191B1 (en) | 2007-06-27 | 2012-09-12 | Novartis AG | Low-additive influenza vaccines |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| EP2889042A3 (en) | 2008-03-18 | 2015-10-14 | Novartis AG | Improvements in preparation of influenza virus vaccine antigens |
| WO2010092477A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccines with increased amounts of h3 antigen |
| ES2608841T3 (es) | 2009-02-10 | 2017-04-17 | Seqirus UK Limited | Vacunas contra la gripe con cantidades reducidas de escualeno |
| WO2010092476A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccine regimens for pandemic-associated strains |
| WO2010125461A1 (en) | 2009-04-27 | 2010-11-04 | Novartis Ag | Adjuvanted vaccines for protecting against influenza |
| KR20120039047A (ko) | 2009-07-31 | 2012-04-24 | 노파르티스 아게 | 역유전학 시스템 |
| ES2813347T3 (es) | 2009-10-26 | 2021-03-23 | Wisconsin Alumni Res Found | Virus recombinantes de la influenza de alto título con replicación mejorada en células Vero |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| CA2801268A1 (en) * | 2010-06-02 | 2011-12-08 | Avir Green Hills Biotechnology Research Development Trade Ag | Novel method for generation of rna virus |
| FR2962739B1 (fr) * | 2010-07-13 | 2014-01-31 | Univ Claude Bernard Lyon | Souches virales modifiees et procede pour ameliorer la production de semences vaccinales de virus influenza |
| US20140248320A1 (en) | 2011-10-20 | 2014-09-04 | Novartis Ag | Adjuvanted influenza b virus vaccines for pediatric priming |
| GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
| WO2014145287A2 (en) * | 2013-03-15 | 2014-09-18 | University Of Maryland | Swine influenza viruses and constructs and uses thereof |
| WO2015009743A1 (en) | 2013-07-15 | 2015-01-22 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| CN108290932A (zh) | 2015-06-09 | 2018-07-17 | 圣诺菲·帕斯图尔公司 | 优化编码工程改造的流感蛋白的核苷酸序列的方法 |
| KR20180035807A (ko) | 2015-06-26 | 2018-04-06 | 세퀴러스 유케이 리미티드 | 항원적으로 매치된 인플루엔자 백신 |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| KR20230132628A (ko) | 2015-07-07 | 2023-09-15 | 세퀴러스 유케이 리미티드 | 인플루엔자 효능 검정 |
| EP3417056A1 (en) | 2016-02-19 | 2018-12-26 | Wisconsin Alumni Research Foundation (WARF) | Improved influenza b virus replication for vaccine development |
| EP3914295A2 (en) | 2019-01-23 | 2021-12-01 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5854037A (en) * | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US6001634A (en) * | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
| US6887699B1 (en) * | 1990-05-22 | 2005-05-03 | Medimmune Vaccines, Inc. | Recombinant negative strand RNA virus expression systems and vaccines |
| US6544785B1 (en) * | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
| AU4073300A (en) | 1999-04-06 | 2000-10-23 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses for vaccines and gene therapy |
| US8715940B2 (en) * | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
| EP1194580B2 (en) | 1999-07-14 | 2010-08-25 | Mount Sinai School of Medicine of New York University | In vitro reconstitution of segmented negative-strand rna viruses |
| EP1218499A2 (en) * | 1999-08-02 | 2002-07-03 | Wyeth | RESCUE OF MUMPS VIRUS FROM cDNA |
| US6764685B1 (en) * | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
| KR100862758B1 (ko) | 2000-04-28 | 2008-10-13 | 세인트 쥬드 칠드런즈 리써치 호스피탈 | 감염성 인플루엔자 바이러스 생성용 ｄｎａ 트랜스펙션시스템 |
| WO2002000884A2 (en) * | 2000-06-23 | 2002-01-03 | American Cyanamid Company | Nucleotide sequence of influenza a/udorn/72 (h3n2) genome |
| CN101098958A (zh) * | 2002-02-21 | 2008-01-02 | 免疫医疗疫苗公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途 |
| JP2005523698A (ja) * | 2002-04-26 | 2005-08-11 | メディミューン・ヴァクシンズ・インコーポレーテッド | インフルエンザウイルスの生産用多重プラスミドシステム |
| US7037707B2 (en) * | 2003-09-04 | 2006-05-02 | St. Jude Children's Research Hospital | Method for generating influenza viruses and vaccines |
| RU2435855C2 (ru) * | 2004-12-24 | 2011-12-10 | Солвей Байолоджикалз Б.В. | Способ продуцирования репликативной частицы вируса гриппа, композиция клеток (варианты), композиция клеточной культуры и ее применение |
-
2005
- 2005-12-22 RU RU2007128336/10A patent/RU2435855C2/ru not_active IP Right Cessation
- 2005-12-22 BR BRPI0518568-8A patent/BRPI0518568A2/pt not_active IP Right Cessation
- 2005-12-22 KR KR1020077017093A patent/KR101272487B1/ko not_active IP Right Cessation
- 2005-12-22 CA CA2592439A patent/CA2592439C/en not_active Expired - Fee Related
- 2005-12-22 PT PT58252875T patent/PT1831357E/pt unknown
- 2005-12-22 JP JP2007547535A patent/JP5620048B2/ja not_active Expired - Fee Related
- 2005-12-22 EP EP05825287A patent/EP1831357B1/en active Active
- 2005-12-22 AU AU2005318087A patent/AU2005318087B2/en not_active Ceased
- 2005-12-22 DK DK05825287.5T patent/DK1831357T3/da active
- 2005-12-22 CN CN2005800447512A patent/CN101379183B/zh not_active Expired - Fee Related
- 2005-12-22 EP EP10182258A patent/EP2295542B1/en not_active Not-in-force
- 2005-12-22 NZ NZ556061A patent/NZ556061A/en not_active IP Right Cessation
- 2005-12-22 MX MX2007007889A patent/MX2007007889A/es active IP Right Grant
- 2005-12-22 WO PCT/EP2005/057092 patent/WO2006067211A1/en active Application Filing
- 2005-12-22 ES ES05825287T patent/ES2395813T3/es active Active
- 2005-12-22 US US11/722,769 patent/US7959930B2/en not_active Expired - Fee Related
- 2005-12-23 TW TW101113590A patent/TWI495724B/zh not_active IP Right Cessation
- 2005-12-23 TW TW094146438A patent/TWI402344B/zh not_active IP Right Cessation
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2007
- 2007-06-13 IL IL183888A patent/IL183888A/en not_active IP Right Cessation
- 2007-06-21 ZA ZA200705145A patent/ZA200705145B/xx unknown
- 2007-07-18 NO NO20073737A patent/NO20073737L/no not_active Application Discontinuation
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2009
- 2009-04-30 HK HK09104018.1A patent/HK1125674A1/xx not_active IP Right Cessation
-
2011
- 2011-04-15 US US13/088,120 patent/US20120156241A1/en not_active Abandoned
- 2011-05-31 RU RU2011122117/10A patent/RU2011122117A/ru not_active Application Discontinuation
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2012
- 2012-03-22 JP JP2012065345A patent/JP5702321B2/ja not_active Expired - Fee Related
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