HK1125674A1 - Rescue of influenza virus - Google Patents
Rescue of influenza virusInfo
- Publication number
- HK1125674A1 HK1125674A1 HK09104018.1A HK09104018A HK1125674A1 HK 1125674 A1 HK1125674 A1 HK 1125674A1 HK 09104018 A HK09104018 A HK 09104018A HK 1125674 A1 HK1125674 A1 HK 1125674A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- influenza
- cell
- nucleic acid
- virus
- provides
- Prior art date
Links
- 241000712461 unidentified influenza virus Species 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 229960003971 influenza vaccine Drugs 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 241001515965 unidentified phage Species 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18651—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04078527 | 2004-12-24 | ||
| PCT/EP2005/057092 WO2006067211A1 (en) | 2004-12-24 | 2005-12-22 | Rescue of influenza virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1125674A1 true HK1125674A1 (en) | 2009-08-14 |
Family
ID=34928779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK09104018.1A HK1125674A1 (en) | 2004-12-24 | 2009-04-30 | Rescue of influenza virus |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7959930B2 (pt) |
| EP (2) | EP2295542B1 (pt) |
| JP (2) | JP5620048B2 (pt) |
| KR (1) | KR101272487B1 (pt) |
| CN (1) | CN101379183B (pt) |
| AU (1) | AU2005318087B2 (pt) |
| BR (1) | BRPI0518568A2 (pt) |
| CA (1) | CA2592439C (pt) |
| DK (1) | DK1831357T3 (pt) |
| ES (1) | ES2395813T3 (pt) |
| HK (1) | HK1125674A1 (pt) |
| IL (1) | IL183888A (pt) |
| MX (1) | MX2007007889A (pt) |
| NO (1) | NO20073737L (pt) |
| NZ (1) | NZ556061A (pt) |
| PT (1) | PT1831357E (pt) |
| RU (2) | RU2435855C2 (pt) |
| TW (2) | TWI402344B (pt) |
| WO (1) | WO2006067211A1 (pt) |
| ZA (1) | ZA200705145B (pt) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1351981T3 (da) | 2001-01-19 | 2012-11-26 | Vironovative Bv | Et virus, der forårsager luftvejssygdom hos modtagelige pattedyr |
| US20040005545A1 (en) | 2002-02-21 | 2004-01-08 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| CN101379183B (zh) * | 2004-12-24 | 2013-07-03 | 雅培生物学有限责任公司 | 流感病毒的拯救 |
| US7790434B2 (en) | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
| CA2613283A1 (en) | 2005-06-21 | 2007-01-04 | Medimmune Vaccines, Inc. | Methods and compositions for expressing a heterologous protease |
| PT1951299E (pt) | 2005-11-04 | 2012-02-28 | Novartis Vaccines & Diagnostic | Vacinas contra a gripe que incluem combinações de adjuvantes particulados e imuno-potenciadores |
| JP2009514850A (ja) | 2005-11-04 | 2009-04-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | アジュバントとして減少した量の水中油型エマルションを有するインフルエンザワクチン |
| DK2368572T3 (da) | 2005-11-04 | 2020-05-25 | Seqirus Uk Ltd | Adjuvansvacciner med ikke-virionantigener fremstillet fra influenza-virusser dyrket i cellekultur |
| US20090220541A1 (en) | 2005-11-04 | 2009-09-03 | Novartis Vaccines And Diagnostics Srl | Emulsions with free aqueous-phase surfactant for adjuvanting split influenza vaccines |
| NZ592713A (en) | 2005-11-04 | 2012-12-21 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9 |
| EP2478916B1 (en) | 2006-01-27 | 2020-04-01 | Seqirus UK Limited | Influenza vaccines containing hemagglutinin and matrix proteins |
| EP2382987A1 (en) | 2006-03-24 | 2011-11-02 | Novartis Vaccines and Diagnostics GmbH | Storage of influenza vaccines without refrigeration |
| US9254318B2 (en) | 2006-03-31 | 2016-02-09 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| US7682619B2 (en) | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| AU2007297178B2 (en) | 2006-09-11 | 2014-07-24 | Novartis Ag | Making influenza virus vaccines without using eggs |
| CN101553252A (zh) | 2006-12-06 | 2009-10-07 | 诺华有限公司 | 包含来自于四株流感病毒的抗原的疫苗 |
| WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| NZ582595A (en) | 2007-06-27 | 2012-07-27 | Novartis Ag | Low-additive influenza vaccines |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| AU2009227674C1 (en) | 2008-03-18 | 2015-01-29 | Seqirus UK Limited | Improvements in preparation of influenza virus vaccine antigens |
| DK2396032T3 (en) | 2009-02-10 | 2016-12-19 | Seqirus Uk Ltd | Influenza vaccines with reduced amounts of squalene |
| CA2752039A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccine regimens for pandemic-associated strains |
| EP2396031A1 (en) | 2009-02-10 | 2011-12-21 | Novartis AG | Influenza vaccines with increased amounts of h3 antigen |
| FR2949344A1 (fr) | 2009-04-27 | 2011-03-04 | Novartis Ag | Vaccins de protection contre la grippe |
| WO2011012999A1 (en) | 2009-07-31 | 2011-02-03 | Novartis Ag | Reverse genetics systems |
| JP2013507990A (ja) | 2009-10-26 | 2013-03-07 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| EP2576773A2 (en) * | 2010-06-02 | 2013-04-10 | Avir Green Hills Biotechnology Research Development Trade AG | Methods and helper viruses for the generation of rna virus |
| FR2962739B1 (fr) * | 2010-07-13 | 2014-01-31 | Univ Claude Bernard Lyon | Souches virales modifiees et procede pour ameliorer la production de semences vaccinales de virus influenza |
| AU2012324398A1 (en) | 2011-10-20 | 2014-05-01 | Seqirus UK Limited | Adjuvanted influenza B virus vaccines for pediatric priming |
| GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
| US10080794B2 (en) | 2013-03-15 | 2018-09-25 | University Of Maryland, College Park | Swine influenza viruses and constructs and uses thereof |
| WO2015009743A1 (en) | 2013-07-15 | 2015-01-22 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| CA2986701A1 (en) | 2015-06-09 | 2016-12-15 | Sanofi Pasteur, Inc. | Methods of optimizing nucleotide sequences encoding engineered influenza proteins |
| WO2016207853A2 (en) | 2015-06-26 | 2016-12-29 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| AU2016290603B2 (en) | 2015-07-07 | 2022-06-02 | Seqirus UK Limited | Influenza potency assays |
| EP3417056A1 (en) | 2016-02-19 | 2018-12-26 | Wisconsin Alumni Research Foundation (WARF) | Improved influenza b virus replication for vaccine development |
| WO2020167432A2 (en) | 2019-01-23 | 2020-08-20 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| JP2022551805A (ja) | 2019-08-27 | 2022-12-14 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5854037A (en) | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US6001634A (en) | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
| US6887699B1 (en) | 1990-05-22 | 2005-05-03 | Medimmune Vaccines, Inc. | Recombinant negative strand RNA virus expression systems and vaccines |
| US6544785B1 (en) | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
| US8715940B2 (en) * | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
| BRPI0009580B8 (pt) | 1999-04-06 | 2021-05-25 | Wisconsin Alumni Res Found | processo para preparar vírus influenza infecciosos na ausência de um vírus auxiliar, preparação de vírus influenza infeccioso recombinante, e, composição. |
| DK1194580T4 (da) | 1999-07-14 | 2011-01-03 | Sinai School Medicine | In-vitro rekonstitution af segmenterede negativstrengede RNA-virus |
| AU6514900A (en) * | 1999-08-02 | 2001-02-19 | Wyeth | Rescue of mumps virus from cdna |
| US6764685B1 (en) * | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
| ATE420189T1 (de) | 2000-04-28 | 2009-01-15 | St Jude Childrens Res Hospital | Dna-transfektionssystem zur erzeugung von infektiösen negativsträngigen rna virus |
| BR0111819A (pt) * | 2000-06-23 | 2004-01-06 | American Cyanamid Co | Moléculas de ácido nucléico isoladas, e, seq ência de aminoácido isolada |
| US20040005545A1 (en) * | 2002-02-21 | 2004-01-08 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| EP1499348B1 (en) * | 2002-04-26 | 2014-10-01 | MedImmune, LLC | Method for producing infectious influenza b virus in cell culture |
| US7037707B2 (en) * | 2003-09-04 | 2006-05-02 | St. Jude Children's Research Hospital | Method for generating influenza viruses and vaccines |
| CN101379183B (zh) * | 2004-12-24 | 2013-07-03 | 雅培生物学有限责任公司 | 流感病毒的拯救 |
-
2005
- 2005-12-22 CN CN2005800447512A patent/CN101379183B/zh not_active Expired - Fee Related
- 2005-12-22 WO PCT/EP2005/057092 patent/WO2006067211A1/en active Application Filing
- 2005-12-22 US US11/722,769 patent/US7959930B2/en not_active Expired - Fee Related
- 2005-12-22 ES ES05825287T patent/ES2395813T3/es active Active
- 2005-12-22 BR BRPI0518568-8A patent/BRPI0518568A2/pt not_active IP Right Cessation
- 2005-12-22 EP EP10182258A patent/EP2295542B1/en not_active Not-in-force
- 2005-12-22 EP EP05825287A patent/EP1831357B1/en active Active
- 2005-12-22 MX MX2007007889A patent/MX2007007889A/es active IP Right Grant
- 2005-12-22 NZ NZ556061A patent/NZ556061A/en not_active IP Right Cessation
- 2005-12-22 DK DK05825287.5T patent/DK1831357T3/da active
- 2005-12-22 PT PT58252875T patent/PT1831357E/pt unknown
- 2005-12-22 AU AU2005318087A patent/AU2005318087B2/en not_active Ceased
- 2005-12-22 RU RU2007128336/10A patent/RU2435855C2/ru not_active IP Right Cessation
- 2005-12-22 JP JP2007547535A patent/JP5620048B2/ja not_active Expired - Fee Related
- 2005-12-22 KR KR1020077017093A patent/KR101272487B1/ko not_active IP Right Cessation
- 2005-12-22 CA CA2592439A patent/CA2592439C/en not_active Expired - Fee Related
- 2005-12-23 TW TW094146438A patent/TWI402344B/zh not_active IP Right Cessation
- 2005-12-23 TW TW101113590A patent/TWI495724B/zh not_active IP Right Cessation
-
2007
- 2007-06-13 IL IL183888A patent/IL183888A/en not_active IP Right Cessation
- 2007-06-21 ZA ZA200705145A patent/ZA200705145B/xx unknown
- 2007-07-18 NO NO20073737A patent/NO20073737L/no not_active Application Discontinuation
-
2009
- 2009-04-30 HK HK09104018.1A patent/HK1125674A1/xx not_active IP Right Cessation
-
2011
- 2011-04-15 US US13/088,120 patent/US20120156241A1/en not_active Abandoned
- 2011-05-31 RU RU2011122117/10A patent/RU2011122117A/ru not_active Application Discontinuation
-
2012
- 2012-03-22 JP JP2012065345A patent/JP5702321B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1125674A1 (en) | Rescue of influenza virus | |
| Rauch et al. | New vaccine technologies to combat outbreak situations | |
| Chen et al. | Advances in development and application of influenza vaccines | |
| CN1826407B (zh) | 用于疫苗和基因治疗的高滴度重组流感病毒 | |
| EP2010557B1 (en) | High titer recombinant influenza viruses for vaccines | |
| WO2003072720A3 (en) | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus | |
| AU2012204138B2 (en) | High titer recombinant influenza viruses for vaccines | |
| DE60139026D1 (de) | Lebender influenza impfstoff und verfahren zu seiner herstellung | |
| Le Nouën et al. | Attenuation of human respiratory viruses by synonymous genome recoding | |
| HK1159188A1 (zh) | 重組的新城疫病毒 表達系統及疫苗 | |
| AU2014202470B2 (en) | High titer recombinant influenza viruses for vaccines | |
| WO2007052163A3 (en) | Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment | |
| WO2005027825A3 (en) | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus | |
| UA85371C2 (ru) | Модифицированный вирус коровьей оспы ankara для вакцинации новорожденных | |
| EP2527445A3 (en) | Treatment and prevention of influenza | |
| IL147447A0 (en) | Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines | |
| WO2006136448A3 (en) | Attenuated sars and use as a vaccine | |
| EP1989316A4 (en) | METHOD FOR THE PRODUCTION OF RECOMBINANT VIRUS, DNA CONSTRUCTS, RECOMBINANT VIRUS AND VACCINE COMPOSITIONS | |
| WO2006045532A3 (en) | Virosome particles comprising antigens from influenza virus and hepatitis b virus | |
| WO2003072725A3 (en) | Recombinant negative strand virus rna expression systems and vaccines | |
| WO2008024413A3 (en) | Tissue culture system for production of hepatitis c virus | |
| CN102875660A (zh) | 一种病毒诱导蛋白Mig1及其应用 | |
| TH110151B (th) | "กรรมวิธีการผลิตไวรัสสังเคราะห์ชนิดที่ดัดแปลงยีนเฉพาะตำแหน่งและยีนสังเคราะห์ที่ดัดแปลงแล้ว" | |
| TH60798A (th) | ชีวมวลที่เป็นอนุภาคเอมบริโอของสัตว์ปีกสำหรับการผลิตแอนติเจนของไวรัส |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20171222 |