BR9713494A - Sondas de adn especìficas para espécies, especìficas para gênero e universais e primers de amplificação para rapidamente detectar e identificar patógenos bacterianos e fúngicos comuns e genes com resistência antibiótica associados a partir de espécimes para diagnose em laboratórios de microbiologia - Google Patents

Sondas de adn especìficas para espécies, especìficas para gênero e universais e primers de amplificação para rapidamente detectar e identificar patógenos bacterianos e fúngicos comuns e genes com resistência antibiótica associados a partir de espécimes para diagnose em laboratórios de microbiologia

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Publication number
BR9713494A
BR9713494A BR9713494-5A BR9713494A BR9713494A BR 9713494 A BR9713494 A BR 9713494A BR 9713494 A BR9713494 A BR 9713494A BR 9713494 A BR9713494 A BR 9713494A
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BR
Brazil
Prior art keywords
species
specific
resistance genes
diagnosis
amplification primers
Prior art date
Application number
BR9713494-5A
Other languages
English (en)
Inventor
Michel G Bergeron
Francois J Picard
Marc Ouellette
Paul H Roy
Original Assignee
Infectio Diagnostic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infectio Diagnostic Inc filed Critical Infectio Diagnostic Inc
Publication of BR9713494A publication Critical patent/BR9713494A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C07K14/212—Moraxellaceae, e.g. Acinetobacter, Moraxella, Oligella, Psychrobacter
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/26—Klebsiella (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Parte da Invenção: <B>"SONDAS DE ADN ESPECìFICAS PARA ESPéCIES, ESPECìFICAS PARA GêNERO E UNIVERSAIS E PRIMERS DE AMPLIFICAçãO PARA RAPIDAMENTE DETECTAR E IDENTIFICAR PATóGENOS BACTERIANOS E FúNGICOS COMUNS E GENES COM RESISTêNCIA ANTIBIóTICA ASSOCIADOS A APARTIR DE ESPéCIMES PARA DIAGNOSE EM LABORATóRIOS DE MICROBIOLOGIA"<D>. Processos baseados em DNA empregando primers de amplificação ou sondas para detecção, identificação, e quatificação em um DNA de amostra teste de (i)qualquer bactéria, (ii)as espécies Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes e Candida albicans, e (iii) algumas espécies do gênero Streptococcus, Staphylococcus, Enterococcus, Neisseria e Candida são mostrados. Processo baseados em DNA empregando primers ou sondas de amplificação para detecção, identificação, e quatificação em uma amostra teste genes de resistência a antibiótico selecionados do grupo de bla~ tem~, bla~ rob~, bla~ oxa, blaZ, aadB, aacC1, aacC2, aacC3, aacA4, aa6'-lla, ermA, ermB, ermlC, mecA, vanA, vanB, vanC, satA, aac(6')-aph(2"), aad(6'), vat, vga, nsrAm sul e int também são mostrados. As espécies microbiais acima, gêneros e genes de resistência são todos clinicamente relevantes e comumente encontrados em uma variedade de espécimes clínicos. Estes ensaios baseados em DNA são rápidos, precisos e podem ser usados em laboratórios de microbiologia para diagnóstico de rotina. Estas novas ferramentas diagnósticas devem ser úteis para aperfeiçoamento da velocidade e precisão de diagnóstico de infecções microbiais, pelo que permitindo tratamentos mais eficazes,. Kistas diagnósticos para (i)a detecção e quatificação univesal de bactérias, e/ou (ii)a detecção, identificação e quatificação das espécies e/ou gêneros de fungos e bactérias mencionadas acima e/ou (iii)a detecção, identificação e quantificação dos genes de resistência a antibiótico mencionados acima também são reivindicados.
BR9713494-5A 1996-11-04 1997-11-04 Sondas de adn especìficas para espécies, especìficas para gênero e universais e primers de amplificação para rapidamente detectar e identificar patógenos bacterianos e fúngicos comuns e genes com resistência antibiótica associados a partir de espécimes para diagnose em laboratórios de microbiologia BR9713494A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/743,637 US5994066A (en) 1995-09-11 1996-11-04 Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
PCT/CA1997/000829 WO1998020157A2 (en) 1996-11-04 1997-11-04 Species-specific, genus-specific and universal dna probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories

Publications (1)

Publication Number Publication Date
BR9713494A true BR9713494A (pt) 2000-02-29

Family

ID=24989560

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713494-5A BR9713494A (pt) 1996-11-04 1997-11-04 Sondas de adn especìficas para espécies, especìficas para gênero e universais e primers de amplificação para rapidamente detectar e identificar patógenos bacterianos e fúngicos comuns e genes com resistência antibiótica associados a partir de espécimes para diagnose em laboratórios de microbiologia

Country Status (14)

Country Link
US (1) US5994066A (pt)
EP (8) EP2339034A1 (pt)
JP (3) JP2001504330A (pt)
CN (1) CN1248295A (pt)
AT (2) ATE552352T1 (pt)
AU (1) AU731850B2 (pt)
BR (1) BR9713494A (pt)
CA (4) CA2789369C (pt)
DE (1) DE69739473D1 (pt)
DK (1) DK0943009T3 (pt)
ES (1) ES2329202T3 (pt)
NO (1) NO991976L (pt)
NZ (1) NZ335548A (pt)
WO (1) WO1998020157A2 (pt)

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EP2336366A1 (en) 2011-06-22
DE69739473D1 (de) 2009-08-06
CA2790915A1 (en) 1998-05-14
EP2339034A1 (en) 2011-06-29
EP2336364A1 (en) 2011-06-22
EP2336365B1 (en) 2014-10-15
JP2010094133A (ja) 2010-04-30
CA2715575C (en) 2012-12-18
DK0943009T3 (da) 2009-10-05
ATE552352T1 (de) 2012-04-15
ES2329202T3 (es) 2009-11-23
CA2715575A1 (en) 1998-05-14
EP2345746A1 (en) 2011-07-20
AU731850B2 (en) 2001-04-05
JP2008289493A (ja) 2008-12-04
WO1998020157A3 (en) 1998-08-13
ATE434669T1 (de) 2009-07-15
JP5221507B2 (ja) 2013-06-26
US5994066A (en) 1999-11-30
EP2128268A1 (en) 2009-12-02
CA2789369A1 (en) 1998-05-14
EP2336364B1 (en) 2015-04-08
CA2789369C (en) 2013-05-07
AU4859897A (en) 1998-05-29
CA2790915C (en) 2013-12-24
EP2128268B1 (en) 2012-04-04
WO1998020157A2 (en) 1998-05-14
EP2336365A1 (en) 2011-06-22
EP2336366B1 (en) 2015-04-15
EP0943009A2 (en) 1999-09-22
CA2270281A1 (en) 1998-05-14
EP2339033A1 (en) 2011-06-29
NZ335548A (en) 2001-03-30
NO991976L (no) 1999-07-02
NO991976D0 (no) 1999-04-26
CN1248295A (zh) 2000-03-22

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