BR8907642A - Matriz tridimensional de estroma,culturas tridimensionais de celulas,sistema de cultura tridimensional,processos para cultura de celulas,processo para transplante de implante de celulas,processo para implante de celulas de estroma in vivo,processo para teste de citotoxicidade de uma substancia,processo para teste do efeito de um medicamento,processo para diagnostico ou monitoracao demalignidade,processo para cultura de celulas de engenharia genetica,processo para analise de doenca ou condicao de um paciente,processo para estudo de mecanismos de doenca,processo para testar a capacidade de uma substancia de a - Google Patents

Matriz tridimensional de estroma,culturas tridimensionais de celulas,sistema de cultura tridimensional,processos para cultura de celulas,processo para transplante de implante de celulas,processo para implante de celulas de estroma in vivo,processo para teste de citotoxicidade de uma substancia,processo para teste do efeito de um medicamento,processo para diagnostico ou monitoracao demalignidade,processo para cultura de celulas de engenharia genetica,processo para analise de doenca ou condicao de um paciente,processo para estudo de mecanismos de doenca,processo para testar a capacidade de uma substancia de a

Info

Publication number
BR8907642A
BR8907642A BR898907642A BR8907642A BR8907642A BR 8907642 A BR8907642 A BR 8907642A BR 898907642 A BR898907642 A BR 898907642A BR 8907642 A BR8907642 A BR 8907642A BR 8907642 A BR8907642 A BR 8907642A
Authority
BR
Brazil
Prior art keywords
dimensional
culture
cell
cells
disease
Prior art date
Application number
BR898907642A
Other languages
English (en)
Inventor
Gail K Naughton
Brian A Naughton
Original Assignee
Marrow Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/242,096 external-priority patent/US4963489A/en
Application filed by Marrow Tech Inc filed Critical Marrow Tech Inc
Publication of BR8907642A publication Critical patent/BR8907642A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0669—Bone marrow stromal cells; Whole bone marrow
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
    • C12N2502/081—Coculture with; Conditioned medium produced by cells of the nervous system neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
    • C12N2502/086—Coculture with; Conditioned medium produced by cells of the nervous system glial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/091—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells melanocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/097—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells oral mucosa cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1305—Adipocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/30—Coculture with; Conditioned medium produced by tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/04—Screening or testing on artificial tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BR898907642A 1988-09-08 1989-09-07 Matriz tridimensional de estroma,culturas tridimensionais de celulas,sistema de cultura tridimensional,processos para cultura de celulas,processo para transplante de implante de celulas,processo para implante de celulas de estroma in vivo,processo para teste de citotoxicidade de uma substancia,processo para teste do efeito de um medicamento,processo para diagnostico ou monitoracao demalignidade,processo para cultura de celulas de engenharia genetica,processo para analise de doenca ou condicao de um paciente,processo para estudo de mecanismos de doenca,processo para testar a capacidade de uma substancia de a BR8907642A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/242,096 US4963489A (en) 1987-04-14 1988-09-08 Three-dimensional cell and tissue culture system
US07/402,104 US5032508A (en) 1988-09-08 1989-09-01 Three-dimensional cell and tissue culture system
PCT/US1989/003853 WO1990002796A1 (en) 1988-09-08 1989-09-07 Three-dimensional cell and tissue culture system

Publications (1)

Publication Number Publication Date
BR8907642A true BR8907642A (pt) 1991-08-20

Family

ID=26934819

Family Applications (1)

Application Number Title Priority Date Filing Date
BR898907642A BR8907642A (pt) 1988-09-08 1989-09-07 Matriz tridimensional de estroma,culturas tridimensionais de celulas,sistema de cultura tridimensional,processos para cultura de celulas,processo para transplante de implante de celulas,processo para implante de celulas de estroma in vivo,processo para teste de citotoxicidade de uma substancia,processo para teste do efeito de um medicamento,processo para diagnostico ou monitoracao demalignidade,processo para cultura de celulas de engenharia genetica,processo para analise de doenca ou condicao de um paciente,processo para estudo de mecanismos de doenca,processo para testar a capacidade de uma substancia de a

Country Status (11)

Country Link
US (1) US5032508A (pt)
EP (1) EP0358506A3 (pt)
JP (3) JPH04501657A (pt)
BR (1) BR8907642A (pt)
CA (1) CA1335657C (pt)
DK (1) DK40591A (pt)
FI (1) FI911142A0 (pt)
HU (2) HUT56393A (pt)
NZ (1) NZ230572A (pt)
PT (1) PT91676A (pt)
WO (1) WO1990002796A1 (pt)

Families Citing this family (293)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5567612A (en) * 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US5496722A (en) * 1988-06-30 1996-03-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom
US6117674A (en) * 1988-06-30 2000-09-12 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Pathogen propagation in cultured three-dimensional tissue mass
US5851816A (en) * 1988-06-30 1998-12-22 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Cultured high-fidelity three-dimensional human urogenital tract carcinomas and process
US5175092A (en) * 1989-05-04 1992-12-29 Millipore Corporation Vitro toxicology kit and method therefor
US5705732A (en) * 1989-06-12 1998-01-06 Oklahoma Medical Research Foundation Universal donor cells
US5437994A (en) * 1989-06-15 1995-08-01 Regents Of The University Of Michigan Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5605822A (en) * 1989-06-15 1997-02-25 The Regents Of The University Of Michigan Methods, compositions and devices for growing human hematopoietic cells
US5763266A (en) * 1989-06-15 1998-06-09 The Regents Of The University Of Michigan Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells
US5399493A (en) * 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
ES2097149T3 (es) * 1989-06-15 1997-04-01 Univ Michigan Procedimientos, composiciones y dispositivos para desarrollar celulas.
US5635386A (en) * 1989-06-15 1997-06-03 The Regents Of The University Of Michigan Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5256418A (en) * 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
US5242806A (en) * 1990-05-07 1993-09-07 Baxter Diagnostics Inc. Method for conducting the cytotoxicity assays on tumor cells
IT1248934B (it) * 1990-06-01 1995-02-11 Fidia Spa Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle
EP0470681A3 (en) * 1990-08-08 1992-04-22 W.R. Grace & Co.-Conn. Cell clusters or sheets comprising a plurality of cell species and preparations thereof
US5618531A (en) * 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
ATE233809T1 (de) * 1990-10-19 2003-03-15 Univ New York Eine methode zur transplantation von zellen in das gehirn und ihre therapeutische verwendung
EP0499932A1 (en) * 1991-02-16 1992-08-26 W.R. Grace & Co.-Conn. Cancer cell cluster comprising cancer cells and normal cells and preparation thereof
US5192312A (en) * 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
US6967086B2 (en) * 1991-04-18 2005-11-22 Becton Dickinson And Company Method for determining the presence or absence of respiring cells on a three-dimensional scaffold
EP0513803A2 (en) * 1991-05-17 1992-11-19 Japan Vilene Company, Ltd. Carrier for immobilization of animal cells, process for manufacture thereof, and methods for cultivation
US6069005A (en) 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
EP1559778A1 (en) * 1991-08-07 2005-08-03 Albert Einstein College Of Medicine Of Yeshiva University Proliferation of hepatocyte precursors
WO1993007913A1 (en) * 1991-10-24 1993-04-29 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
CA2122473C (en) 1991-10-31 2001-01-23 Lee Anne Beausang Nuclear matrix protein fluid assay
EP0620939A4 (en) * 1991-11-25 1996-05-29 Cornell Res Foundation Inc Automated multicompartmental cell culture system.
WO1993012805A1 (en) * 1992-01-02 1993-07-08 Regents Of The University Of Michigan Methods for regulatory lineages of human hematopoietic cells
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
IT1255657B (it) * 1992-05-29 1995-11-09 Colture di tessuto di mucosa congiuntivale differenziata, procedimentoper la loro preparazione e supporti per il loro uso.
EP1002538A3 (en) * 1992-06-25 2000-07-19 SCHEER, David Stem cell and lymphocyte storage
AU4657993A (en) * 1992-06-29 1994-01-24 Alexion Pharmaceuticals, Inc. Matrix for universal donor microvascular endothelial cells
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
WO1994003584A1 (en) * 1992-08-07 1994-02-17 Tissue Engineering, Inc. Production of graft tissue from extracellular matrix
US5478739A (en) * 1992-10-23 1995-12-26 Advanced Tissue Sciences, Inc. Three-dimensional stromal cell and tissue culture system
US5888720A (en) * 1992-10-27 1999-03-30 Yissum Research And Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs
EP0673433A1 (en) * 1992-11-25 1995-09-27 Merck & Co. Inc. Hepatic model
US5610007A (en) * 1993-01-21 1997-03-11 Universite Laval Chimeric sheets of epithelial cells
US5656492A (en) * 1993-02-12 1997-08-12 Brigham And Women's Hospital, Inc. Cell induction device
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
GB9306449D0 (en) 1993-03-29 1993-05-19 Nat Heart Research Fund Tissue equivalents
AU687386B2 (en) * 1993-04-08 1998-02-26 Human Cell Cultures, Inc. Cell culturing method and medium
US6008047A (en) * 1993-04-08 1999-12-28 Livercell L.L.C. Cell culturing method and medium
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5858783A (en) * 1993-05-25 1999-01-12 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Production of normal mammalian organ culture using a medium containing mem-alpha, leibovitz L-15, glucose galactose fructose
AU5116593A (en) * 1993-10-08 1995-05-04 Martin Rosdy In vitro human epidermal sun-tanning test
JPH07298876A (ja) * 1994-03-09 1995-11-14 Res Dev Corp Of Japan 通液性細胞培養担体と、この担体を用いる培養方法お よび培養装置
US5656450A (en) * 1994-05-27 1997-08-12 Board Of Regents, The University Of Texas System Activation of latent transforming growth factor β by matrix vesicles
US20020055786A1 (en) * 1994-08-16 2002-05-09 Anthony Atala Reconstruction of urological structures with polymeric matrices
SE506164C2 (sv) 1995-10-09 1997-11-17 Medscand Medical Ab Instrumentarium för behandling av urininkontinens hos kvinnor
US5899909A (en) * 1994-08-30 1999-05-04 Medscand Medical Ab Surgical instrument for treating female urinary incontinence
JPH10511563A (ja) * 1994-09-12 1998-11-10 アドバンスド ティシュー サイエンシズ，インコーポレーテッド 心臓弁枠組み上での三次元ヒト細胞培養物およびその使用
US5562946A (en) * 1994-11-02 1996-10-08 Tissue Engineering, Inc. Apparatus and method for spinning and processing collagen fiber
US7001328B1 (en) * 1994-11-15 2006-02-21 Kenton W. Gregory Method for using tropoelastin and for producing tropoelastin biomaterials
US20030152909A1 (en) * 1994-11-16 2003-08-14 Mitrani Eduardo N. In vitro micro-organs, and uses related thereto
US5709934A (en) * 1994-11-22 1998-01-20 Tissue Engineering, Inc. Bipolymer foams having extracellular matrix particulates
US5891558A (en) * 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US6485723B1 (en) * 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US7008634B2 (en) * 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
US6123727A (en) 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6284284B1 (en) * 1995-06-06 2001-09-04 Advanced Tissue Sciences, Inc. Compositions and methods for production and use of an injectable naturally secreted extracellular matrix
US5830708A (en) * 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5716413A (en) * 1995-10-11 1998-02-10 Osteobiologics, Inc. Moldable, hand-shapable biodegradable implant material
JP3452366B2 (ja) * 1995-10-20 2003-09-29 トランスティッシュウ テクノロジーズ ゲーエムベーハー 新規人工組織、その製法およびその使用
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
US5965125A (en) 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
US5911942A (en) * 1995-11-02 1999-06-15 Tissue Engineering, Inc. Method for spinning and processing collagen fiber
US5800539A (en) * 1995-11-08 1998-09-01 Emory University Method of allogeneic hematopoietic stem cell transplantation without graft failure or graft vs. host disease
US6482231B1 (en) * 1995-11-20 2002-11-19 Giovanni Abatangelo Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative
FR2743817B1 (fr) * 1996-01-23 1998-03-13 Oreal Equivalent de peau comprenant des cellules de langerhans
US5842477A (en) * 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
CN1061812C (zh) * 1996-04-01 2001-02-14 胡杰 制备皮肤移植体的方法
US6497875B1 (en) * 1996-04-26 2002-12-24 Case Western Reserve University Multilayer skin or dermal equivalent having a layer containing mesenchymal stem cells
AU3214797A (en) * 1996-05-28 1998-01-05 Regents Of The University Of Michigan, The Engineering oral tissues
US6213127B1 (en) 1996-07-29 2001-04-10 Emory University Methods for treating cancer using allogeneic lymphocytes without graft vs host disease activity
US5925510A (en) * 1996-10-11 1999-07-20 Cornell Research Foundation, Inc. Medium for preserving tissue without tissue culturing occurring
US6033896A (en) 1996-11-15 2000-03-07 The Ohio State University Process of separation of cells from liquid by adsorption onto fiber
FR2757635B1 (fr) * 1996-12-24 1999-02-05 Oreal Procede d'evaluation des dommages induits dans la peau par les uv-a
FR2759381B1 (fr) * 1997-02-11 1999-04-16 Oreal Procede d'evaluation du potentiel sensibilisant et/ou irritant et/ou allergene d'un produit
US6039686A (en) 1997-03-18 2000-03-21 Kovac; S. Robert System and a method for the long term cure of recurrent urinary female incontinence
CA2207882A1 (en) 1997-06-17 1998-12-17 Joel Claveau Assessment of human skin damage following exposure to harmful agents
AU9111698A (en) * 1997-09-04 1999-03-22 Pharmacia & Upjohn Company A method for the evaluation of antiviral drugs
US6440734B1 (en) 1998-09-25 2002-08-27 Cytomatrix, Llc Methods and devices for the long-term culture of hematopoietic progenitor cells
GB9720987D0 (en) * 1997-10-01 1997-12-03 Biocure Ltd A multicellular in vitro assay of angiogenesis
US6225118B1 (en) 1997-10-01 2001-05-01 Biocure Limited Multicellular in vitro assay of angiogenesis
EP1042019B1 (en) * 1997-10-31 2006-06-07 Children's Medical Center Corporation Penile reconstruction
WO1999022781A2 (en) * 1997-10-31 1999-05-14 Children's Medical Center Corporation Bladder reconstruction
US6080579A (en) * 1997-11-26 2000-06-27 Charlotte-Mecklenburg Hospital Authority Method for producing human intervertebral disc cells
US7101545B1 (en) 1997-11-26 2006-09-05 Charlotte-Mecklenburg Hospital Authority Method for using human intervertebral disc cells
DE19752900A1 (de) * 1997-11-28 1999-06-02 Biotechnolog Forschung Gmbh Knochenmatrix und/oder osteogene Zellen, deren Verwendung, therapeutische Zubereitung und Kit
US7687057B2 (en) * 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US6291240B1 (en) 1998-01-29 2001-09-18 Advanced Tissue Sciences, Inc. Cells or tissues with increased protein factors and methods of making and using same
US20020034819A1 (en) * 1998-02-23 2002-03-21 Alan K. Smith Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses
DE19811114C2 (de) * 1998-03-14 2003-08-21 Hellmut Augustin Verfahren zur definierten Herstellung multizellulärer sphäroidaler Aggregate lebender Blutgefäßwandzellen
US6143293A (en) * 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US6382214B1 (en) 1998-04-24 2002-05-07 American Medical Systems, Inc. Methods and apparatus for correction of urinary and gynecological pathologies including treatment of male incontinence and female cystocele
CN1115407C (zh) * 1998-11-05 2003-07-23 四川大学华西医院 复合场三维细胞培养装置
CA2351889A1 (en) * 1998-11-12 2000-05-18 Cell Science Therapeutics, Inc. Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices
US6548299B1 (en) 1999-11-12 2003-04-15 Mark J. Pykett Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices
CN1333818A (zh) * 1998-11-19 2002-01-30 奥加诺吉尼西斯公司 生物工程化的组织构建物、其制备方法及其应用
ES2338405T3 (es) * 1999-02-04 2010-05-07 Pluristem Ltd. Metodo y aparato para mantenimiento y expasion de celulas madre hemopoyeticas y/o celulas progenitoras.
US20030007954A1 (en) 1999-04-12 2003-01-09 Gail K. Naughton Methods for using a three-dimensional stromal tissue to promote angiogenesis
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
US20040167634A1 (en) * 1999-05-26 2004-08-26 Anthony Atala Prosthetic kidney and its use for treating kidney disease
US7121997B2 (en) * 1999-06-09 2006-10-17 Ethicon, Inc. Surgical instrument and method for treating female urinary incontinence
KR100684489B1 (ko) 1999-06-09 2007-02-22 에디컨인코포레이티드 가요성 면적 폴리머 이식기의 조정 장치
US7226407B2 (en) 1999-06-09 2007-06-05 Ethicon, Inc. Surgical instrument and method for treating female urinary incontinence
US6932759B2 (en) 1999-06-09 2005-08-23 Gene W. Kammerer Surgical instrument and method for treating female urinary incontinence
JP2001037472A (ja) * 1999-07-28 2001-02-13 Bio Quest:Kk 三次元細胞培養基材及びそれを用いた細胞培養方法
WO2001014527A1 (en) * 1999-08-23 2001-03-01 Organogenesis Inc. Skin care compositions and treatments
JP2001120582A (ja) 1999-10-22 2001-05-08 Gunze Ltd 人工心臓弁およびその作製方法
US20080267923A2 (en) * 1999-11-05 2008-10-30 Donald Kleinsek Hair undifferentiated cells
US7799325B2 (en) * 1999-11-05 2010-09-21 Kleinsek Donald A Removal of hypertrophic scars
US6428802B1 (en) 1999-12-29 2002-08-06 Children's Medical Center Corp. Preparing artificial organs by forming polylayers of different cell populations on a substrate
US6376244B1 (en) 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US6368859B1 (en) 1999-12-29 2002-04-09 Children's Medical Center Corporation Methods and compositions for producing a fascial sling
US6479064B1 (en) * 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
US6828111B2 (en) 2000-01-13 2004-12-07 Wayne State University Three-dimensional in vitro model of human preneoplastic breast disease
DE10002803A1 (de) * 2000-01-24 2001-08-02 Conbio Lizenzverwertungsgesell System zur internen qualitativen und quantitativen Validierung von Markerindices
US7131943B2 (en) * 2000-03-09 2006-11-07 Ethicon, Inc. Surgical instrument and method for treating organ prolapse conditions
JP4876275B2 (ja) * 2000-03-31 2012-02-15 独立行政法人農業・食品産業技術総合研究機構 生物の組織を薄切した切片からなる動物細胞の培養担体と、この担体を用いる動物細胞の培養方法および移植方法
GB2365443B (en) * 2000-04-04 2004-12-22 Denis Eon Solomon A surgical-medical dressing for the treatment of body burns and for wound healing
DE10019604C2 (de) * 2000-04-20 2002-06-27 Ethicon Gmbh Implantat
JP3421741B2 (ja) * 2000-05-18 2003-06-30 筑波大学長 人工骨髄、血球細胞の増殖方法
EP1290144A2 (de) * 2000-05-31 2003-03-12 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. In vitro-gewebetestsystem
JP4426064B2 (ja) * 2000-05-31 2010-03-03 独立行政法人科学技術振興機構 脊椎動物の膵臓のインビトロ形成方法
CN1130971C (zh) * 2000-07-13 2003-12-17 胡杰 制备用作细胞种植框架和植入体的生物细胞外基质的方法
CN1116794C (zh) * 2000-07-13 2003-08-06 胡杰 制备软骨移植体的方法
CN1115957C (zh) * 2000-07-13 2003-07-30 胡杰 制备血管移植体的方法
US7025063B2 (en) 2000-09-07 2006-04-11 Ams Research Corporation Coated sling material
US7229453B2 (en) * 2001-01-23 2007-06-12 Ams Research Corporation Pelvic floor implant system and method of assembly
US6612977B2 (en) 2001-01-23 2003-09-02 American Medical Systems Inc. Sling delivery system and method of use
US6802807B2 (en) 2001-01-23 2004-10-12 American Medical Systems, Inc. Surgical instrument and method
US6641525B2 (en) 2001-01-23 2003-11-04 Ams Research Corporation Sling assembly with secure and convenient attachment
US20020161382A1 (en) * 2001-03-29 2002-10-31 Neisz Johann J. Implant inserted without bone anchors
US20020147382A1 (en) * 2001-01-23 2002-10-10 Neisz Johann J. Surgical articles and methods
US20040247567A1 (en) * 2001-05-07 2004-12-09 Gurtner Geoffrey C. Microvascular free flaps for local or systemic delivery
US6923939B1 (en) * 2001-07-05 2005-08-02 Uop Llc Heat activated membrane introduction apparatus and method for screening materials
DE60237455D1 (de) * 2001-07-12 2010-10-07 Kyowa Medex Co Ltd Verfahren zur quantifizierung von denaturiertem lipoprotein
US7407480B2 (en) * 2001-07-27 2008-08-05 Ams Research Corporation Method and apparatus for correction of urinary and gynecological pathologies, including treatment of incontinence cystocele
US6648921B2 (en) 2001-10-03 2003-11-18 Ams Research Corporation Implantable article
US7087065B2 (en) * 2001-10-04 2006-08-08 Ethicon, Inc. Mesh for pelvic floor repair
JP2005509495A (ja) * 2001-11-16 2005-04-14 チルドレンズ メディカル センター コーポレーション 臓器の機能の増強
CA2466903A1 (en) * 2001-11-19 2003-05-30 Amniotec Inc. Ectocornea-like sheet and method of constructing the same
WO2003054171A1 (en) * 2001-12-06 2003-07-03 The Regents Of The University Of California Method for differentiating islet precursor cells into beta cells
JP4241389B2 (ja) 2002-03-01 2009-03-18 エチコン、インコーポレイテッド 女性患者の骨盤器官脱出症処置のための方法および装置
WO2003092546A2 (en) * 2002-04-30 2003-11-13 Cook Urological Inc. Sling for supporting tissue
US6943021B2 (en) * 2002-06-07 2005-09-13 Mattek Corporation Three dimensional vaginal tissue model containing immune cells
WO2004001023A2 (de) * 2002-06-20 2003-12-31 Bionethos Holding Gmbh Verfahren und vorrichtung zur vermehrung und differenzierung von zellen in anwesenheit von wachstumsfaktoren und einer biologischen matrix oder trägerstruktur
AU2003242967A1 (en) * 2002-07-12 2004-02-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method and device for inducing biological processes by micro-organs
IL151660A0 (en) * 2002-09-09 2003-04-10 Univ Ben Gurion Method for isolating and culturing unculturable microorganisms
DE10253066A1 (de) * 2002-11-07 2004-05-27 Co.Don Aktiengesellschaft Gewebeersatzstruktur, Verfahren zur Modifikation einer Gewebeläsion und Verwendung von vorgeformtem dreidimensionalem Gewebe als Lieferant von Botenstoffen und/oder Strukturbausteinen
WO2004046337A2 (en) * 2002-11-19 2004-06-03 The Board Of Trustees Of The University Of Illinois Multilayered microcultures
FR2847268B1 (fr) * 2002-11-19 2006-09-29 Coletica Procede d'identification d'une modification eventuelle d'au moins un parametre biologique mettant en oeuvre des cellules vivantes soumises a un stress et des cellules vivantes non soumises a ce meme stress
US20040126405A1 (en) * 2002-12-30 2004-07-01 Scimed Life Systems, Inc. Engineered scaffolds for promoting growth of cells
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7744869B2 (en) * 2003-08-20 2010-06-29 Ebi, Llc Methods of treatment using electromagnetic field stimulated mesenchymal stem cells
EP2338442B1 (en) 2003-12-11 2013-01-30 Isto Technologies Inc. Particulate cartilage system
WO2005062868A2 (en) * 2003-12-19 2005-07-14 Osteotech, Inc. Tissue-derived mesh for orthopedic regeneration
US7785883B2 (en) 2004-04-28 2010-08-31 Vax Design Corp. Automatable artificial immune system (AIS)
US7855074B2 (en) 2004-04-28 2010-12-21 Vaxdesign Corp. Artificial immune system: methods for making and use
US8030070B2 (en) 2004-04-28 2011-10-04 Sanofi Pasteur Vaxdesign Corp. Artificial lymphoid tissue equivalent
US8298824B2 (en) 2004-04-28 2012-10-30 Sanofi Pasteur Vaxdesign Corporation Methods of evaluating a test agent in a diseased cell model
US7785806B2 (en) 2004-04-28 2010-08-31 Vaxdesign Corporation Method for determining the immunogenicity of an antigen
US7771999B2 (en) 2004-04-28 2010-08-10 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US8071373B2 (en) 2004-04-28 2011-12-06 Sanofi Pasteur Vaxdesign Corp. Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)
US20060275270A1 (en) * 2004-04-28 2006-12-07 Warren William L In vitro mucosal tissue equivalent
US7709256B2 (en) 2004-04-28 2010-05-04 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US8047982B2 (en) * 2004-05-07 2011-11-01 Ethicon, Inc. Mesh tape with wing-like extensions for treating female urinary incontinence
US20050288796A1 (en) * 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
KR101259770B1 (ko) * 2004-07-28 2013-05-03 에디컨인코포레이티드 최소 침습성 의료용 임플란트 및 삽입 장치와 그 사용 방법
JP2008511672A (ja) * 2004-08-30 2008-04-17 セレゲン，インコーポレーテッド 培養三次元組織およびその使用
US20080226604A9 (en) * 2005-06-17 2008-09-18 Theregen Company Methods for treating ischemic tissue
US7527588B2 (en) * 2004-09-15 2009-05-05 Ethicon, Inc. System and method for surgical implant placement
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20060165667A1 (en) * 2004-12-03 2006-07-27 Case Western Reserve University Novel methods, compositions and devices for inducing neovascularization
US7481314B2 (en) * 2005-02-02 2009-01-27 Ethicon, Inc. Packaging assembly for surgical mesh implants
JP4262695B2 (ja) * 2005-04-25 2009-05-13 独立行政法人海洋研究開発機構 膜状バイオデバイス及びバイオリアクター
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
WO2007016083A1 (en) 2005-07-26 2007-02-08 Ams Research Corporation Methods and systems for treatment of prolapse
FR2889808B1 (fr) 2005-08-17 2011-07-22 Oreal Utilisation de l'acide 8-hexadecene-1,16-dicarboxylique comme agent de soin destine a favoriser la cohesion de la couche cornee
WO2007025290A2 (en) 2005-08-26 2007-03-01 Isto Technologies, Inc. Implants and methods for repair, replacement and treatment of joint disease
US20080207989A1 (en) * 2005-08-29 2008-08-28 Ams Research Corporation System For Positioning Support Mesh in a Patient
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
US20090221867A1 (en) * 2005-11-11 2009-09-03 Ams Research Corporation Integral Sling Connection System and Method
JP5113332B2 (ja) * 2005-12-19 2013-01-09 正美 丹羽 血液脳関門インヴィトロ・モデル、病態血液脳関門インヴィトロ・モデル、及びこれを用いた薬物スクリーニング方法、病態血液脳関門機能解析方法、病因解析方法
EP1969366B1 (en) 2005-12-21 2015-10-21 Sanofi Pasteur VaxDesign Corporation In vitro germinal centers
ES2572214T3 (es) * 2006-03-23 2016-05-30 Pluristem Ltd Métodos para expansión celular y usos de células y medios acondicionados producidos de este modo para terapia
EP2019648A4 (en) 2006-05-19 2017-06-07 AMS Research Corporation Method and articles for treatment of stress urinary incontinence
WO2008012696A2 (en) * 2006-06-15 2008-01-31 Penelope Costello Methods and kits for testing the efficacy of therapeutica compounds and other therapies in a three-dimensional matrix with respect to tumorous cells and tissue
BRPI0712194A2 (pt) 2006-06-16 2012-03-06 Ams Research Corporation Implantes pélvico e cirúrgico combinação ferramenta cirúrgica útil para implantar um implante pélvico métodos de tratamento de uma condição pélvica, e de prolapso vaginal, e, método para manipular um implante cirúrgico
WO2007149555A2 (en) 2006-06-22 2007-12-27 Ams Research Corporation Adjustable tension incontinence sling assemblies
EP2409714A1 (en) 2006-06-27 2012-01-25 Sanofi Pasteur VaxDesign Corporation Models for vaccine assessment
JP2010505580A (ja) * 2006-10-13 2010-02-25 リライアンス ライフ サイエンシーズ ピーヴィーティー． リミテッド 生体高分子上での培養メラニン細胞
CN101626781B (zh) * 2006-11-22 2011-10-12 刘华 制备具有抗肿瘤免疫应答反应的细胞群的方法
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
SG10201509679XA (en) 2007-05-29 2015-12-30 Christopher B Reid Methods for production and uses of multipotent cell populations
EP2162529B1 (en) * 2007-06-08 2019-03-27 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
US10590391B2 (en) * 2007-06-08 2020-03-17 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
WO2009048661A1 (en) 2007-07-16 2009-04-16 Vaxdesign Corporation Artificial tissue constructs comprising alveolar cells and methods for using the same
JPWO2009050965A1 (ja) * 2007-10-19 2011-02-24 国立成育医療センター総長 細胞凍結物固定化基材及び初代肝細胞培養ツール、並びに初代肝細胞培養ツールの製造方法
US8623034B2 (en) * 2007-10-19 2014-01-07 Ethicon, Gmbh Soft tissue repair implant
US8535913B2 (en) * 2008-01-30 2013-09-17 Histogen, Inc. Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells
US8530415B2 (en) * 2008-01-30 2013-09-10 Histogen, Inc. Repair and/or regeneration of cells with a composition produced by culturing fibroblast cells under hypoxic conditions
US8524494B2 (en) 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
US20100166824A1 (en) * 2008-01-30 2010-07-01 Histogen, Inc. Extracellular matrix compositions
KR101650957B1 (ko) * 2008-01-30 2016-08-24 히스토젠, 인코포레이티드 세포외 기질 조성물
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US9095569B2 (en) 2008-04-18 2015-08-04 Collplant Ltd. Methods of generating and using procollagen
WO2009157585A1 (ja) * 2008-06-24 2009-12-30 独立行政法人海洋研究開発機構 動物細胞の凍結保存用担体、それを用いた凍結保存用バイオデバイス及び凍結保存方法
US8727963B2 (en) 2008-07-31 2014-05-20 Ams Research Corporation Methods and implants for treating urinary incontinence
KR101739304B1 (ko) 2008-08-25 2017-05-24 에이엠에스 리서치 코포레이션 최소 침수성 임플란트 조합
US9017243B2 (en) 2008-08-25 2015-04-28 Ams Research Corporation Minimally invasive implant and method
JP5307489B2 (ja) * 2008-09-19 2013-10-02 株式会社クラレ 三次元細胞構造体の作製方法
NZ601862A (en) 2008-11-12 2014-07-25 Tengion Inc Isolated renal cells and uses thereof
WO2010057015A1 (en) * 2008-11-14 2010-05-20 Wake Forest University Health Sciences Kidney structures and methods of forming the same
CN102497871B (zh) 2008-11-14 2014-10-15 希斯托金公司 用于癌症治疗的胞外基质组合物
US8449573B2 (en) 2008-12-05 2013-05-28 Boston Scientific Scimed, Inc. Insertion device and method for delivery of a mesh carrier
US20100274362A1 (en) * 2009-01-15 2010-10-28 Avner Yayon Cartilage particle tissue mixtures optionally combined with a cancellous construct
JP5436905B2 (ja) * 2009-03-26 2014-03-05 テルモ株式会社 シート状細胞培養物の製造方法
US8968334B2 (en) 2009-04-17 2015-03-03 Boston Scientific Scimed, Inc. Apparatus for delivering and anchoring implantable medical devices
US9301750B2 (en) * 2009-11-03 2016-04-05 Boston Scientific Scimed, Inc. Device and method for delivery of mesh-based devices
US9060837B2 (en) 2009-11-23 2015-06-23 Ams Research Corporation Patterned sling implant and method
KR101694742B1 (ko) * 2009-11-23 2017-01-11 에이엠에스 리서치 코포레이션 패턴화된 임플란트 및 방법
JP5667357B2 (ja) * 2009-11-30 2015-02-12 テルモ株式会社 シート状細胞培養物の製造方法
US8622886B2 (en) * 2010-03-16 2014-01-07 Ethicon, Inc. Surgical instrument and method for the treatment of urinary incontinence
JP5974215B2 (ja) 2010-05-12 2016-08-24 リージェンメド（ケイマン）エルティーディー． 生理活性腎臓細胞
JP5884218B2 (ja) * 2010-06-17 2016-03-15 国立大学法人大阪大学 腫瘍組織モデルの製造方法
US10028813B2 (en) 2010-07-22 2018-07-24 Boston Scientific Scimed, Inc. Coated pelvic implant device and method
CA2813599A1 (en) 2010-10-06 2012-04-12 Ams Research Corporation Implants with absorbable and non-absorbable features for the treatment of female pelvic conditions
FR2967163A1 (fr) 2010-11-05 2012-05-11 Centre Nat Rech Scient Procede in vitro ou ex vivo pour la maintenance en survie et la generation ou reconstruction d'un epiderme
WO2012064369A1 (en) 2010-11-10 2012-05-18 Tengion, Inc. Injectable formulations for organ augmentation
EP2799077A1 (en) 2010-11-12 2014-11-05 Allergan, Inc. Metabolized conditioned growth medium and methods of use
US9572648B2 (en) 2010-12-21 2017-02-21 Justin M. Crank Implantable slings and anchor systems
US8597948B2 (en) 2011-03-10 2013-12-03 First Principles, Inc. Cloned biological material medical device and method thereof
US8808162B2 (en) 2011-03-28 2014-08-19 Ams Research Corporation Implants, tools, and methods for treatment of pelvic conditions
US9750590B2 (en) 2011-03-28 2017-09-05 Andrew P. VanDeWeghe Implants, tools, and methods for treatment of pelvic conditions
US9492259B2 (en) 2011-03-30 2016-11-15 Astora Women's Health, Llc Expandable implant system
FR2976001B1 (fr) 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
US10058240B2 (en) 2011-06-29 2018-08-28 Boston Scientific Scimed, Inc. Systems, implants, tools, and methods for treatments of pelvic conditions
US9351723B2 (en) 2011-06-30 2016-05-31 Astora Women's Health, Llc Implants, tools, and methods for treatments of pelvic conditions
US9414903B2 (en) 2011-07-22 2016-08-16 Astora Women's Health, Llc Pelvic implant system and method
EP2734148B1 (en) 2011-07-22 2019-06-05 Boston Scientific Scimed, Inc. Pelvic implant system
US9492191B2 (en) 2011-08-04 2016-11-15 Astora Women's Health, Llc Tools and methods for treatment of pelvic conditions
US20130035555A1 (en) 2011-08-05 2013-02-07 Alexander James A Systems, implants, tools, and methods for treatment of pelvic conditions
CN102614547B (zh) * 2012-03-13 2015-04-15 中山大学中山眼科中心 一种快速构建复层细胞的方法
WO2013163358A1 (en) 2012-04-24 2013-10-31 Harvard Bioscience, Inc. Engineered tissue scaffolds and supports therefor
JP5977580B2 (ja) * 2012-05-24 2016-08-24 秀実 高橋 ランゲルハンス細胞の調製方法
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
WO2014110300A1 (en) 2013-01-09 2014-07-17 Harvard Apparatus Regenerative Technology Synthetic scaffolds
WO2015005349A1 (ja) * 2013-07-09 2015-01-15 国立大学法人東京大学 細胞培養支持体、細胞培養装置、細胞培養キット、及び細胞シート
AU2014296053B2 (en) 2013-08-01 2018-09-06 Cook Biotech Incorporated Tissue adjustment implant
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
JP5813074B2 (ja) * 2013-10-21 2015-11-17 テルモ株式会社 シート状細胞培養物の製造方法
JP6277684B2 (ja) * 2013-11-18 2018-02-14 大日本印刷株式会社 細胞積層体の製造方法
CN104877953B (zh) * 2014-02-28 2018-06-01 上海尚瑞生物医药科技有限公司 促进黑色素细胞色素产生的皮肤制剂的制备方法
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
JP5727665B2 (ja) * 2014-12-11 2015-06-03 テルモ株式会社 シート状細胞培養物の製造方法
JP5893786B2 (ja) * 2015-04-02 2016-03-23 テルモ株式会社 シート状細胞培養物の製造方法
US11919941B2 (en) 2015-04-21 2024-03-05 Purdue Research Foundation Cell-collagen-silica composites and methods of making and using the same
RU2587755C1 (ru) * 2015-06-10 2016-06-20 Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный Медицинский биофизический центр имени А.И. Бурназяна Федерального Медико-биологического агентства" (ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России) Способ получения действующего вещества из пантов марала
GB201510913D0 (en) * 2015-06-22 2015-08-05 Nat University Of Singapore And Agency For Science Technology And Res Vascularized tissue, skin or mucosa quivalent
KR102078602B1 (ko) * 2015-07-23 2020-02-19 한국화학연구원 지방세포와 마크로파지의 3차원 공동 배양 방법
JP6710211B2 (ja) * 2015-08-03 2020-06-17 富士フイルム株式会社 細胞構造体、非ヒトモデル動物、非ヒトモデル動物の製造方法、及び被験物質の評価方法
JP6140322B2 (ja) * 2016-02-24 2017-05-31 テルモ株式会社 シート状細胞培養物の製造方法
WO2017183673A1 (ja) * 2016-04-19 2017-10-26 凸版印刷株式会社 抗がん剤の評価方法
KR20190020654A (ko) * 2016-06-24 2019-03-04 가부시키가이샤 시세이도 3차원 배양 피부 시트, 그 제조에 사용하기 위한 세포 배양 용기 및 그 제조 방법
US11123372B2 (en) 2016-07-29 2021-09-21 Prokidney Bioactive renal cells for the treatment of chronic kidney disease
US11739291B2 (en) 2017-04-25 2023-08-29 Purdue Research Foundation 3-dimensional (3D) tissue-engineered muscle for tissue restoration
JP6490738B2 (ja) * 2017-04-28 2019-03-27 テルモ株式会社 シート状細胞培養物の製造方法
EP3674706A4 (en) * 2017-08-21 2020-08-12 Toppan Printing Co., Ltd. METHODS OF EVALUATING ANTI-CANCER EFFECTIVENESS AND METHODS OF PREDICTING EFFECTIVENESS OF ANTI-CANCER IMMUNOTHERAPY
WO2019108756A1 (en) * 2017-11-29 2019-06-06 Figene, Llc Interaction of fibroblasts and immune cells for activation and uses thereof
JP2018078906A (ja) * 2018-01-17 2018-05-24 大日本印刷株式会社 細胞積層体の製造方法
JP2019180354A (ja) * 2018-04-16 2019-10-24 国立研究開発法人理化学研究所 細胞シートの製造方法及び細胞シート
JP6657452B2 (ja) * 2019-02-27 2020-03-04 テルモ株式会社 シート状細胞培養物の製造方法
JP7002497B2 (ja) * 2019-06-20 2022-01-20 テルモ株式会社 シート状細胞培養物の製造方法
JP6872051B2 (ja) * 2020-02-05 2021-05-19 テルモ株式会社 シート状細胞培養物の製造方法
CN112625193B (zh) * 2020-12-31 2022-06-14 青岛科技大学 极性改性凡士林及其制备方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997396A (en) * 1973-07-02 1976-12-14 Monsanto Company Method for the in vitro propagation and maintenance of cells
US4144126A (en) * 1975-05-21 1979-03-13 Beecham Group Limited Cell culture method
US4280954A (en) * 1975-07-15 1981-07-28 Massachusetts Institute Of Technology Crosslinked collagen-mucopolysaccharide composite materials
US4016036A (en) * 1975-11-14 1977-04-05 Massachusetts Institute Of Technology Process for serially culturing keratinocytes
US4024020A (en) * 1975-12-15 1977-05-17 Monsanto Company Method of cell culture on polyacrylonitrile surface
DE2557870A1 (de) * 1975-12-22 1977-06-23 Linde Ag Verfahren und vorrichtung zum tiefgefrieren von biologischen substanzen
US4087327A (en) * 1976-04-12 1978-05-02 Monsanto Company Mammalion cell culture process
US4117881A (en) * 1977-06-14 1978-10-03 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration System for and method of freezing biological tissue
US4135975A (en) * 1977-12-14 1979-01-23 Lichtman Marshall A Obtaining human cell lines that elaborate colony stimulating activity for marrow cells of man and other species and methods of preparing same
US4228243A (en) * 1978-07-13 1980-10-14 Toray Industries, Inc. Cell culture propagation apparatus
US4299819A (en) * 1979-01-02 1981-11-10 Sloan-Kettering Institute For Cancer Research Process for treating burn victims
US4342828A (en) * 1979-07-20 1982-08-03 Morinaga Milk Industry Co., Ltd. Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells
US4642292A (en) * 1979-10-29 1987-02-10 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method for isolation of connective tissue biomatrix
US4481946A (en) * 1980-08-14 1984-11-13 Altshuler John H Bone marrow transplant method and apparatus
US4486188A (en) * 1980-08-14 1984-12-04 Applied Medical Devices, Inc. Bone marrow transplant method and apparatus
US4553272A (en) * 1981-02-26 1985-11-19 University Of Pittsburgh Regeneration of living tissues by growth of isolated cells in porous implant and product thereof
US4539716A (en) * 1981-03-19 1985-09-10 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4546500A (en) * 1981-05-08 1985-10-15 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4489710A (en) * 1981-06-23 1984-12-25 Xoma Corporation Composition and method for transplantation therapy
US4621100A (en) * 1981-09-25 1986-11-04 The Upjohn Company Treatment of osteoporosis with prostaglandins
DE3138597A1 (de) * 1981-09-29 1983-04-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur zuechtung von humanen fibrolasten und fibroblastenartigen zellen
US4458678A (en) * 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
JPS5881781A (ja) * 1981-11-11 1983-05-17 Ajinomoto Co Inc 動物細胞の培養方法
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
US4520821A (en) * 1982-04-30 1985-06-04 The Regents Of The University Of California Growing of long-term biological tissue correction structures in vivo
US4485097A (en) * 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
US4645669A (en) * 1982-10-04 1987-02-24 Albert Einstein College Of Medicine Of Yeshiva University Culturing and emplacement of differentiated cells in vivo
JPS60123884A (ja) * 1983-12-09 1985-07-02 三菱電機株式会社 英語学習機
IL74715A0 (en) * 1984-03-27 1985-06-30 Univ New Jersey Med Biodegradable matrix and methods for producing same
EP0163543A3 (en) * 1984-06-01 1987-08-12 VXR, Inc. Marrow cell stimulator
JPS61227526A (ja) * 1984-07-25 1986-10-09 Chugai Pharmaceut Co Ltd 新規なコロニー刺激因子
US4604346A (en) * 1984-10-09 1986-08-05 Massachusetts Institute Of Technology Skin-equivalent prepared by the use of punch biopsy
AU589438B2 (en) * 1985-08-26 1989-10-12 Hana Biologics, Inc. Transplantable artificial tissue and process
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US4835102A (en) * 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems

Also Published As

Publication number Publication date
JP2000189158A (ja) 2000-07-11
FI911142A0 (fi) 1991-03-07
HU895973D0 (en) 1991-07-29
WO1990002796A1 (en) 1990-03-22
EP0358506A2 (en) 1990-03-14
HUT56393A (en) 1991-08-28
PT91676A (pt) 1990-03-30
NZ230572A (en) 1993-12-23
DK40591A (da) 1991-05-07
JP2001258555A (ja) 2001-09-25
EP0358506A3 (en) 1990-05-23
DK40591D0 (da) 1991-03-07
US5032508A (en) 1991-07-16
HU910750D0 (en) 1991-09-30
CA1335657C (en) 1995-05-23
JPH04501657A (ja) 1992-03-26

Similar Documents

Publication Publication Date Title
BR8907642A (pt) Matriz tridimensional de estroma,culturas tridimensionais de celulas,sistema de cultura tridimensional,processos para cultura de celulas,processo para transplante de implante de celulas,processo para implante de celulas de estroma in vivo,processo para teste de citotoxicidade de uma substancia,processo para teste do efeito de um medicamento,processo para diagnostico ou monitoracao demalignidade,processo para cultura de celulas de engenharia genetica,processo para analise de doenca ou condicao de um paciente,processo para estudo de mecanismos de doenca,processo para testar a capacidade de uma substancia de a
Mobini et al. Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering
Bornstein Organotypic mammalian central and peripheral nerve tissue
Dunnett et al. Functional consequences of embryonic neocortex transplanted to rats with prefrontal cortex lesions.
Longo et al. Delayed nerve regeneration in streptozotocin diabetic rats
CA2612269C (en) Method of producing organotypic cell cultures
CN101802174A (zh) 细胞增殖方法以及用于组织修复及再生的药物
WO2019182358A1 (en) Method and system for hair regrowth using 3d organoid system of hair follicle stem cell
ES2755096T3 (es) Sistema que permite el mantenimiento de la supervivencia y el transporte de biopsias de piel y sus aplicaciones
Zhao et al. Multiscale brain research on a microfluidic chip
Aas et al. The RG2 rat glioma model
Drucker-Colín et al. Adrenal medullary tissue transplants in the caudate nucleus of Parkinson's patients
Sharma et al. Considerations for the bioengineering of advanced cardiac in vitro models of myocardial infarction
Pagella et al. Bioengineered tooth emulation systems for regenerative and pharmacological purposes
Turner et al. Nerve growth factor stimulates neurite outgrowth from goldfish retinal explants: the influence of a prior lesion
ES2632930T3 (es) Biorreactor rotatorio de cámara doble: métodos y usos del mismo
Spielvogel et al. Mononuclear cell stimulation of fibroblast collagen synthesis
CN116254180A (zh) 一种脑缺血再灌注损伤芯片及其在开发新药中的应用
Bloom et al. Metabolic requirements for differentiation of embryonic sympathetic ganglia cultured in the absence of exogenous nerve growth factor
Polley et al. Cystic fibrosis: current concepts.
Isaac Temperature alteration of monoamine metabolites in cerebrospinal fluid
CN105911096A (zh) 一种可以体外进行药物药理毒理筛查的人工心脏系统
Eder et al. Introducing the concept of the 3Rs into tissue engineering research
Elliott et al. Growth of human muscle spindles in vitro
McGee Jr et al. A new capillary tube system for measuring the uptake and release of materials from cultured cells