BR112019009911A2 - molécula de ligação de antígeno biespecífica, composição farmacêutica, métodos para tratar um câncer e para preparar um conjugado de anticorpo-fármaco, e, conjugado de anticorpo-fármaco - Google Patents
molécula de ligação de antígeno biespecífica, composição farmacêutica, métodos para tratar um câncer e para preparar um conjugado de anticorpo-fármaco, e, conjugado de anticorpo-fármacoInfo
- Publication number
- BR112019009911A2 BR112019009911A2 BR112019009911A BR112019009911A BR112019009911A2 BR 112019009911 A2 BR112019009911 A2 BR 112019009911A2 BR 112019009911 A BR112019009911 A BR 112019009911A BR 112019009911 A BR112019009911 A BR 112019009911A BR 112019009911 A2 BR112019009911 A2 BR 112019009911A2
- Authority
- BR
- Brazil
- Prior art keywords
- antigen binding
- antibody
- drug conjugate
- bispecific
- bispecific antigen
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 11
- 102000036639 antigens Human genes 0.000 title abstract 11
- 108091007433 antigens Proteins 0.000 title abstract 11
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 3
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000556 agonist Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 abstract 1
Classifications
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
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- C07—ORGANIC CHEMISTRY
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
são aqui providos anticorpos e moléculas de ligação de antígeno biespecíficas que ligam met e métodos de uso dos mesmos. as moléculas de ligação de antígeno biespecíficas compreendendo um primeiro e um segundo domínios de ligação de antígeno, em que o primeiro e segundo domínios de ligação de antígeno se ligam a dois epítopos diferentes (preferivelmente não sobrepostos) do domínio extracelular de met humano. as moléculas de ligação de antígeno biespecíficas são capazes de bloquear a interação entre met humano e seu ligante hgf. as moléculas de ligação de antígeno biespecíficas podem exibir mínima ou nenhuma atividade agonista de met, por exemplo, quando comparadas com moléculas de ligação de antígeno monovalentes que compreendem apenas um dos domínios de ligação de antígeno da molécula biespecífica, que tendem a exercer atividade agonista de met não desejada. também incluídos são conjugados de anticorpo-fármaco (adcs) compreendendo os anticorpos ou moléculas de ligação de antígeno biespecíficas providos aqui ligados a um agente citotóxico, radionuclídeo, ou outra porção, assim como métodos de tratar câncer em um sujeito pela administração ao sujeito de uma molécula de ligação de antígeno biespecífica ou um adc do mesmo.
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US201662423068P | 2016-11-16 | 2016-11-16 | |
US201762479516P | 2017-03-31 | 2017-03-31 | |
PCT/US2017/061757 WO2018093866A1 (en) | 2016-11-16 | 2017-11-15 | Anti-met antibodies, bispecific antigen binding molecules that bind met, and methods of use thereof |
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BR112019009911A2 true BR112019009911A2 (pt) | 2019-08-13 |
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BR112019009911A BR112019009911A2 (pt) | 2016-11-16 | 2017-11-15 | molécula de ligação de antígeno biespecífica, composição farmacêutica, métodos para tratar um câncer e para preparar um conjugado de anticorpo-fármaco, e, conjugado de anticorpo-fármaco |
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US (3) | US11142578B2 (pt) |
EP (1) | EP3541842A1 (pt) |
JP (3) | JP7084938B2 (pt) |
KR (2) | KR20230110825A (pt) |
CN (2) | CN110177806B (pt) |
AU (1) | AU2017362967A1 (pt) |
BR (1) | BR112019009911A2 (pt) |
CA (1) | CA3042950A1 (pt) |
CL (1) | CL2019001324A1 (pt) |
CO (1) | CO2019004955A2 (pt) |
IL (1) | IL266599B2 (pt) |
MA (1) | MA46917A (pt) |
MX (1) | MX2019005770A (pt) |
MY (1) | MY191146A (pt) |
PH (1) | PH12019501014A1 (pt) |
TW (1) | TWI782930B (pt) |
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CN118047832A (zh) | 2024-05-17 |
MX2019005770A (es) | 2019-11-18 |
AU2017362967A1 (en) | 2019-06-13 |
MA46917A (fr) | 2019-09-25 |
JP2020509027A (ja) | 2020-03-26 |
CA3042950A1 (en) | 2018-05-24 |
US20230416376A1 (en) | 2023-12-28 |
IL266599A (en) | 2019-07-31 |
PH12019501014A1 (en) | 2019-09-02 |
CO2019004955A2 (es) | 2019-07-31 |
IL266599B2 (en) | 2023-12-01 |
US20220049001A1 (en) | 2022-02-17 |
TWI782930B (zh) | 2022-11-11 |
EP3541842A1 (en) | 2019-09-25 |
MY191146A (en) | 2022-06-01 |
JP7084938B2 (ja) | 2022-06-15 |
KR102556241B1 (ko) | 2023-07-19 |
KR20190090386A (ko) | 2019-08-01 |
CL2019001324A1 (es) | 2019-11-29 |
TW201831514A (zh) | 2018-09-01 |
KR20230110825A (ko) | 2023-07-25 |
US11142578B2 (en) | 2021-10-12 |
WO2018093866A1 (en) | 2018-05-24 |
IL266599B1 (en) | 2023-08-01 |
JP2024023568A (ja) | 2024-02-21 |
US20180134794A1 (en) | 2018-05-17 |
CN110177806A (zh) | 2019-08-27 |
JP2022044698A (ja) | 2022-03-17 |
CN110177806B (zh) | 2024-03-15 |
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