BR112016008010A2 - uso de moléculas de ligação de semaforina-4d para tratamento de aterosclerose - Google Patents

uso de moléculas de ligação de semaforina-4d para tratamento de aterosclerose

Info

Publication number
BR112016008010A2
BR112016008010A2 BR112016008010A BR112016008010A BR112016008010A2 BR 112016008010 A2 BR112016008010 A2 BR 112016008010A2 BR 112016008010 A BR112016008010 A BR 112016008010A BR 112016008010 A BR112016008010 A BR 112016008010A BR 112016008010 A2 BR112016008010 A2 BR 112016008010A2
Authority
BR
Brazil
Prior art keywords
semaphorin
binding molecules
atherosclerosis
atherosclerosis treatment
patient
Prior art date
Application number
BR112016008010A
Other languages
English (en)
Inventor
Zauderer Maurice
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Publication of BR112016008010A2 publication Critical patent/BR112016008010A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

resumo “uso de moléculas de ligação de semaforina-4d para tratamento de aterosclerose” provido aqui são métodos para reduzir, inibir, suprimir e/ou atrasar o crescimento da placa aterosclerótica ou neovascularização em um paciente tendo aterosclerose, compreendendo administração ao paciente de uma quantidade efetiva de uma molécula de ligação isolada que especificamente liga a semaforina-4d (sema4d) ou ao seu receptor plexina-b1 de alta afinidade.
BR112016008010A 2013-10-10 2014-10-10 uso de moléculas de ligação de semaforina-4d para tratamento de aterosclerose BR112016008010A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361889421P 2013-10-10 2013-10-10
PCT/US2014/060129 WO2015054628A1 (en) 2013-10-10 2014-10-10 Use of semaphorin-4d binding molecules for treatment of atherosclerosis

Publications (1)

Publication Number Publication Date
BR112016008010A2 true BR112016008010A2 (pt) 2017-09-26

Family

ID=52809873

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016008010A BR112016008010A2 (pt) 2013-10-10 2014-10-10 uso de moléculas de ligação de semaforina-4d para tratamento de aterosclerose

Country Status (18)

Country Link
US (1) US9512224B2 (pt)
EP (1) EP3054976B1 (pt)
JP (2) JP6760840B2 (pt)
KR (1) KR102366682B1 (pt)
CN (1) CN105848679A (pt)
AU (1) AU2014331683B2 (pt)
BR (1) BR112016008010A2 (pt)
CA (1) CA2926944C (pt)
DK (1) DK3054976T3 (pt)
EA (1) EA037551B1 (pt)
ES (1) ES2821814T3 (pt)
IL (1) IL244976B (pt)
MX (1) MX2016004551A (pt)
NZ (1) NZ630881A (pt)
PT (1) PT3054976T (pt)
SG (1) SG11201602807PA (pt)
WO (1) WO2015054628A1 (pt)
ZA (1) ZA201602577B (pt)

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MX2015017485A (es) 2013-06-25 2016-03-31 Vaccinex Inc Uso de moleculas inhibidoras de semaforina-4d en combinacion con una terapia de modulacion inmune para inhibir crecimiento tumoral y metastasis.
NZ630881A (en) 2013-10-10 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treatment of atherosclerosis
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
RU2759846C2 (ru) 2016-04-22 2021-11-18 Вэксинекс, Инк. Дисплей интегрального мембранного белка на внеклеточных оболочечных вирионах поксвируса
WO2018026715A1 (en) 2016-08-02 2018-02-08 Vaccinex, Inc. Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells
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JP2020510845A (ja) * 2017-02-22 2020-04-09 バクシネックス インコーポレーティッド 神経変性疾患または神経炎症性疾患におけるグリア細胞活性化の早期検出方法
CN106983919B (zh) * 2017-03-06 2019-07-12 西南交通大学 一种Sema 4D-VEGF涂层的构建方法及应用
KR20200004324A (ko) 2017-05-05 2020-01-13 백시넥스 인코포레이티드 인간 항-세마포린 4d 항체
CN108499220B (zh) * 2018-04-25 2020-07-31 山东纯江环境科技有限公司 石墨烯/聚丙烯非织造布过滤网制备方法及其应用
CN109125731B (zh) * 2018-10-22 2019-10-25 华中科技大学同济医学院附属协和医院 Sema4D/PlexinB1抑制剂在制备治疗及预防眼底血管疾病药物中的应用
KR20230135556A (ko) * 2020-06-25 2023-09-25 백시넥스 인코포레이티드 레트 증후군의 치료를 위한 세마포린-4d 결합 분자의 용도
CN116949097B (zh) * 2023-09-20 2023-12-12 江苏集萃药康生物科技股份有限公司 一种sema4d人源化小鼠模型的构建方法及其应用

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MX2015017485A (es) 2013-06-25 2016-03-31 Vaccinex Inc Uso de moleculas inhibidoras de semaforina-4d en combinacion con una terapia de modulacion inmune para inhibir crecimiento tumoral y metastasis.
NZ630881A (en) 2013-10-10 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treatment of atherosclerosis
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders

Also Published As

Publication number Publication date
EP3054976A1 (en) 2016-08-17
AU2014331683B2 (en) 2019-07-11
DK3054976T3 (da) 2020-09-28
ZA201602577B (en) 2020-11-25
AU2014331683A1 (en) 2016-04-28
IL244976A0 (en) 2016-05-31
CN105848679A (zh) 2016-08-10
SG11201602807PA (en) 2016-05-30
MX2016004551A (es) 2016-07-22
EA037551B1 (ru) 2021-04-13
EP3054976B1 (en) 2020-07-08
CA2926944A1 (en) 2015-04-16
EP3054976A4 (en) 2017-05-17
KR102366682B1 (ko) 2022-02-22
CA2926944C (en) 2023-08-08
JP2019108359A (ja) 2019-07-04
US20150104462A1 (en) 2015-04-16
US9512224B2 (en) 2016-12-06
KR20160062167A (ko) 2016-06-01
EA201690728A1 (ru) 2016-08-31
PT3054976T (pt) 2020-08-05
IL244976B (en) 2020-07-30
NZ630881A (en) 2016-03-31
JP2016539089A (ja) 2016-12-15
JP6760840B2 (ja) 2020-09-23
WO2015054628A1 (en) 2015-04-16
ES2821814T3 (es) 2021-04-27

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