BR112018016842A2 - compostos de piridona tetracíclica como antivirais - Google Patents
compostos de piridona tetracíclica como antiviraisInfo
- Publication number
- BR112018016842A2 BR112018016842A2 BR112018016842A BR112018016842A BR112018016842A2 BR 112018016842 A2 BR112018016842 A2 BR 112018016842A2 BR 112018016842 A BR112018016842 A BR 112018016842A BR 112018016842 A BR112018016842 A BR 112018016842A BR 112018016842 A2 BR112018016842 A2 BR 112018016842A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- antivirals
- pyridone compounds
- tetracyclic pyridone
- tetracyclic
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- 229940121357 antivirals Drugs 0.000 title 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662297590P | 2016-02-19 | 2016-02-19 | |
| US201662434658P | 2016-12-15 | 2016-12-15 | |
| PCT/EP2017/053568 WO2017140821A1 (en) | 2016-02-19 | 2017-02-16 | Tetracyclic pyridone compounds as antivirals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018016842A2 true BR112018016842A2 (pt) | 2018-12-26 |
Family
ID=58046696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018016842A BR112018016842A2 (pt) | 2016-02-19 | 2017-02-16 | compostos de piridona tetracíclica como antivirais |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20200270265A1 (enExample) |
| EP (1) | EP3416946B1 (enExample) |
| JP (1) | JP7016809B2 (enExample) |
| KR (1) | KR20180110131A (enExample) |
| CN (1) | CN109071447B (enExample) |
| AU (1) | AU2017219216B2 (enExample) |
| BR (1) | BR112018016842A2 (enExample) |
| CA (1) | CA3014369A1 (enExample) |
| CO (1) | CO2018008589A2 (enExample) |
| EA (1) | EA038098B1 (enExample) |
| EC (1) | ECSP18069924A (enExample) |
| ES (1) | ES2897913T3 (enExample) |
| IL (1) | IL261158B (enExample) |
| JO (1) | JOP20170045B1 (enExample) |
| MX (1) | MX384799B (enExample) |
| PH (1) | PH12018501736A1 (enExample) |
| SG (1) | SG11201806863WA (enExample) |
| TW (1) | TWI747879B (enExample) |
| UY (1) | UY37128A (enExample) |
| WO (1) | WO2017140821A1 (enExample) |
| ZA (1) | ZA201805032B (enExample) |
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| US10179131B2 (en) | 2015-07-13 | 2019-01-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2017017042A1 (en) * | 2015-07-27 | 2017-02-02 | F. Hoffmann-La Roche Ag | Novel tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection |
| US20200270265A1 (en) * | 2016-02-19 | 2020-08-27 | Novartis Ag | Tetracyclic pyridone compounds as antivirals |
| SG11201807543YA (en) | 2016-03-07 | 2018-09-27 | Enanta Pharm Inc | Hepatitis b antiviral agents |
| BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
| CA3028228A1 (en) | 2016-06-10 | 2017-12-14 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| CN107759585A (zh) * | 2016-07-29 | 2018-03-06 | 银杏树药业(苏州)有限公司 | 一种异喹啉类化合物及其药用组合物和作为抗病毒药物的应用 |
| EP3490987B1 (en) | 2016-07-29 | 2022-09-21 | Guangzhou Lupeng Pharmaceutical Company Ltd. | Novel therapeutic agents for the treatment of hbv infection |
| IL308894A (en) | 2016-10-14 | 2024-01-01 | Prec Biosciences Inc | Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome |
| US10821103B2 (en) | 2016-11-07 | 2020-11-03 | Arbutus Biopharma Corporation | Substituted pyridinone-containing trycyclic compounds, and methods using same |
| JOP20180008A1 (ar) | 2017-02-02 | 2019-01-30 | Gilead Sciences Inc | مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b |
| CN106928215B (zh) * | 2017-03-06 | 2019-03-22 | 河南春风医药科技有限公司 | 一种喹嗪酮类化合物的制备方法 |
| WO2018172852A1 (en) | 2017-03-21 | 2018-09-27 | Arbutus Biopharma Corporation | Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same |
| AR111419A1 (es) * | 2017-04-27 | 2019-07-10 | Novartis Ag | Compuestos fusionados de indazol piridona como antivirales |
| CN110066278B (zh) * | 2017-06-01 | 2021-06-08 | 广东东阳光药业有限公司 | 稠合三环类化合物及其在药物中的应用 |
| AU2018326474B2 (en) | 2017-08-28 | 2024-07-25 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| EP3694856B1 (en) * | 2017-11-22 | 2023-10-25 | Sunshine Lake Pharma Co., Ltd. | Fused tricyclic compounds and uses thereof in medicine |
| GB201720163D0 (en) * | 2017-12-04 | 2018-01-17 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of hepatitis B |
| US10428070B2 (en) | 2017-12-06 | 2019-10-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10723733B2 (en) | 2017-12-06 | 2020-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2019123340A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019123339A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019123285A1 (en) | 2017-12-20 | 2019-06-27 | Novartis Ag | Fused tricyclic pyrazolo-dihydropyrazinyl-pyridone compounds as antivirals |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| KR102526964B1 (ko) | 2018-02-26 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 복제 억제제로서의 치환된 피롤리진 화합물 |
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| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| AU2019252441A1 (en) | 2018-04-12 | 2020-10-22 | Arbutus Biopharma Corporation | Methods for preparing substituted pyridinone-containing tricyclic compounds |
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| TW202014193A (zh) | 2018-05-03 | 2020-04-16 | 捷克科學院有機化學與生物化學研究所 | 包含碳環核苷酸之2’3’－環二核苷酸 |
| TWI869058B (zh) | 2018-07-27 | 2025-01-01 | 加拿大商愛彼特生物製藥公司 | 經取代四氫環戊[c]吡咯、經取代二氫吡咯，其類似物及使用其之方法 |
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| CN110862390B (zh) | 2018-08-28 | 2023-05-09 | 广东东阳光药业有限公司 | 稠合三环类化合物及其在药物中的应用 |
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| CN113271946A (zh) | 2018-11-21 | 2021-08-17 | 英安塔制药有限公司 | 官能化杂环化合物作为抗病毒剂 |
| TWI827760B (zh) | 2018-12-12 | 2024-01-01 | 加拿大商愛彼特生物製藥公司 | 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法 |
| CN111410653B (zh) * | 2019-01-08 | 2021-12-17 | 苏州爱科百发生物医药技术有限公司 | 一种二氢异喹啉类化合物 |
| TW202033523A (zh) * | 2019-01-17 | 2020-09-16 | 美商愛彼特生物製藥股份有限公司 | 經取代的多環羧酸、其類似物及使用其之方法 |
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Family Cites Families (58)
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-
2017
- 2017-02-16 US US15/999,664 patent/US20200270265A1/en not_active Abandoned
- 2017-02-16 US US15/435,137 patent/US9845325B2/en active Active
- 2017-02-16 JP JP2018543679A patent/JP7016809B2/ja active Active
- 2017-02-16 CA CA3014369A patent/CA3014369A1/en not_active Abandoned
- 2017-02-16 BR BR112018016842A patent/BR112018016842A2/pt not_active Application Discontinuation
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- 2017-02-16 WO PCT/EP2017/053568 patent/WO2017140821A1/en not_active Ceased
- 2017-02-16 CN CN201780024193.6A patent/CN109071447B/zh active Active
- 2017-02-16 MX MX2018010010A patent/MX384799B/es unknown
- 2017-02-16 UY UY0001037128A patent/UY37128A/es not_active Application Discontinuation
- 2017-02-16 AU AU2017219216A patent/AU2017219216B2/en not_active Ceased
- 2017-02-16 SG SG11201806863WA patent/SG11201806863WA/en unknown
- 2017-02-16 JO JOP/2017/0045A patent/JOP20170045B1/ar active
- 2017-02-16 KR KR1020187026639A patent/KR20180110131A/ko not_active Withdrawn
- 2017-02-16 EP EP17705425.1A patent/EP3416946B1/en active Active
- 2017-02-16 EA EA201891876A patent/EA038098B1/ru unknown
- 2017-02-18 TW TW106105419A patent/TWI747879B/zh active
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- 2018-08-15 CO CONC2018/0008589A patent/CO2018008589A2/es unknown
- 2018-08-16 PH PH12018501736A patent/PH12018501736A1/en unknown
- 2018-09-14 EC ECSENADI201869924A patent/ECSP18069924A/es unknown
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| JOP20170045B1 (ar) | 2021-08-17 |
| EA201891876A1 (ru) | 2019-01-31 |
| US20170240548A1 (en) | 2017-08-24 |
| ZA201805032B (en) | 2019-08-28 |
| ES2897913T3 (es) | 2022-03-03 |
| UY37128A (es) | 2017-09-29 |
| EA038098B1 (ru) | 2021-07-06 |
| CA3014369A1 (en) | 2017-08-24 |
| CO2018008589A2 (es) | 2018-08-21 |
| IL261158A (en) | 2018-10-31 |
| MX2018010010A (es) | 2018-11-09 |
| US10093673B2 (en) | 2018-10-09 |
| JP2019509276A (ja) | 2019-04-04 |
| IL261158B (en) | 2020-10-29 |
| KR20180110131A (ko) | 2018-10-08 |
| US20200270265A1 (en) | 2020-08-27 |
| US20180030053A1 (en) | 2018-02-01 |
| MX384799B (es) | 2025-03-14 |
| SG11201806863WA (en) | 2018-09-27 |
| US9845325B2 (en) | 2017-12-19 |
| AU2017219216A1 (en) | 2018-08-30 |
| ECSP18069924A (es) | 2018-09-30 |
| TW201804995A (zh) | 2018-02-16 |
| EP3416946A1 (en) | 2018-12-26 |
| TWI747879B (zh) | 2021-12-01 |
| JP7016809B2 (ja) | 2022-02-07 |
| AU2017219216B2 (en) | 2019-12-19 |
| CN109071447A (zh) | 2018-12-21 |
| EP3416946B1 (en) | 2021-09-15 |
| WO2017140821A1 (en) | 2017-08-24 |
| CN109071447B (zh) | 2022-04-22 |
| PH12018501736A1 (en) | 2019-06-17 |
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