PH12018501736A1 - Tetracyclic pyridone compounds as antivirals - Google Patents
Tetracyclic pyridone compounds as antiviralsInfo
- Publication number
- PH12018501736A1 PH12018501736A1 PH12018501736A PH12018501736A PH12018501736A1 PH 12018501736 A1 PH12018501736 A1 PH 12018501736A1 PH 12018501736 A PH12018501736 A PH 12018501736A PH 12018501736 A PH12018501736 A PH 12018501736A PH 12018501736 A1 PH12018501736 A1 PH 12018501736A1
- Authority
- PH
- Philippines
- Prior art keywords
- compounds
- antivirals
- pyridone compounds
- tetracyclic pyridone
- tetracyclic
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- 229940121357 antivirals Drugs 0.000 title 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662297590P | 2016-02-19 | 2016-02-19 | |
| US201662434658P | 2016-12-15 | 2016-12-15 | |
| PCT/EP2017/053568 WO2017140821A1 (en) | 2016-02-19 | 2017-02-16 | Tetracyclic pyridone compounds as antivirals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12018501736A1 true PH12018501736A1 (en) | 2019-06-17 |
Family
ID=58046696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12018501736A PH12018501736A1 (en) | 2016-02-19 | 2018-08-16 | Tetracyclic pyridone compounds as antivirals |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20200270265A1 (enExample) |
| EP (1) | EP3416946B1 (enExample) |
| JP (1) | JP7016809B2 (enExample) |
| KR (1) | KR20180110131A (enExample) |
| CN (1) | CN109071447B (enExample) |
| AU (1) | AU2017219216B2 (enExample) |
| BR (1) | BR112018016842A2 (enExample) |
| CA (1) | CA3014369A1 (enExample) |
| CO (1) | CO2018008589A2 (enExample) |
| EA (1) | EA038098B1 (enExample) |
| EC (1) | ECSP18069924A (enExample) |
| ES (1) | ES2897913T3 (enExample) |
| IL (1) | IL261158B (enExample) |
| JO (1) | JOP20170045B1 (enExample) |
| MX (1) | MX384799B (enExample) |
| PH (1) | PH12018501736A1 (enExample) |
| SG (1) | SG11201806863WA (enExample) |
| TW (1) | TWI747879B (enExample) |
| UY (1) | UY37128A (enExample) |
| WO (1) | WO2017140821A1 (enExample) |
| ZA (1) | ZA201805032B (enExample) |
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| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
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| US20200270265A1 (en) * | 2016-02-19 | 2020-08-27 | Novartis Ag | Tetracyclic pyridone compounds as antivirals |
| MX384836B (es) | 2016-03-07 | 2025-03-14 | Enanta Pharm Inc | Agentes antivirales contra la hepatitis b |
| BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
| EP3468561A4 (en) | 2016-06-10 | 2019-12-04 | Enanta Pharmaceuticals, Inc. | ANTIVIRAL AGENTS AGAINST HEPATITIS B |
| CN107759585A (zh) * | 2016-07-29 | 2018-03-06 | 银杏树药业(苏州)有限公司 | 一种异喹啉类化合物及其药用组合物和作为抗病毒药物的应用 |
| CN109715624B (zh) | 2016-07-29 | 2022-08-16 | 广州麓鹏制药有限公司 | 用于治疗hbv感染的新颖治疗剂 |
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| EA202090514A1 (ru) | 2017-08-28 | 2020-06-24 | Энанта Фармасьютикалс, Инк. | Противовирусное средство против гепатита в |
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| TW201936192A (zh) | 2017-12-06 | 2019-09-16 | 美商因那塔製藥公司 | B 型肝炎抗病毒試劑 |
| US10428070B2 (en) | 2017-12-06 | 2019-10-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| CN111566120B (zh) | 2017-12-20 | 2023-09-29 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸 |
| EP3728282B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| US11234977B2 (en) | 2017-12-20 | 2022-02-01 | Novartis Ag | Fused tricyclic pyrazolo-dihydropyrazinyl-pyridone compounds as antivirals |
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| WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
| TWI826492B (zh) | 2018-07-27 | 2023-12-21 | 加拿大商愛彼特生物製藥公司 | 經取代四氫環戊[c]吡咯、經取代二氫吡咯，其類似物及使用其之方法 |
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| CN111410653B (zh) * | 2019-01-08 | 2021-12-17 | 苏州爱科百发生物医药技术有限公司 | 一种二氢异喹啉类化合物 |
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-
2017
- 2017-02-16 US US15/999,664 patent/US20200270265A1/en not_active Abandoned
- 2017-02-16 KR KR1020187026639A patent/KR20180110131A/ko not_active Withdrawn
- 2017-02-16 BR BR112018016842A patent/BR112018016842A2/pt not_active Application Discontinuation
- 2017-02-16 ES ES17705425T patent/ES2897913T3/es active Active
- 2017-02-16 US US15/435,137 patent/US9845325B2/en active Active
- 2017-02-16 CA CA3014369A patent/CA3014369A1/en not_active Abandoned
- 2017-02-16 MX MX2018010010A patent/MX384799B/es unknown
- 2017-02-16 JP JP2018543679A patent/JP7016809B2/ja active Active
- 2017-02-16 SG SG11201806863WA patent/SG11201806863WA/en unknown
- 2017-02-16 EA EA201891876A patent/EA038098B1/ru unknown
- 2017-02-16 WO PCT/EP2017/053568 patent/WO2017140821A1/en not_active Ceased
- 2017-02-16 UY UY0001037128A patent/UY37128A/es not_active Application Discontinuation
- 2017-02-16 AU AU2017219216A patent/AU2017219216B2/en not_active Ceased
- 2017-02-16 EP EP17705425.1A patent/EP3416946B1/en active Active
- 2017-02-16 JO JOP/2017/0045A patent/JOP20170045B1/ar active
- 2017-02-16 CN CN201780024193.6A patent/CN109071447B/zh active Active
- 2017-02-18 TW TW106105419A patent/TWI747879B/zh active
- 2017-10-12 US US15/782,722 patent/US10093673B2/en active Active
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2018
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- 2018-08-14 IL IL261158A patent/IL261158B/en active IP Right Grant
- 2018-08-15 CO CONC2018/0008589A patent/CO2018008589A2/es unknown
- 2018-08-16 PH PH12018501736A patent/PH12018501736A1/en unknown
- 2018-09-14 EC ECSENADI201869924A patent/ECSP18069924A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20180030053A1 (en) | 2018-02-01 |
| CA3014369A1 (en) | 2017-08-24 |
| ECSP18069924A (es) | 2018-09-30 |
| EA201891876A1 (ru) | 2019-01-31 |
| IL261158A (en) | 2018-10-31 |
| EP3416946A1 (en) | 2018-12-26 |
| UY37128A (es) | 2017-09-29 |
| TW201804995A (zh) | 2018-02-16 |
| JP2019509276A (ja) | 2019-04-04 |
| KR20180110131A (ko) | 2018-10-08 |
| AU2017219216A1 (en) | 2018-08-30 |
| EP3416946B1 (en) | 2021-09-15 |
| JP7016809B2 (ja) | 2022-02-07 |
| ZA201805032B (en) | 2019-08-28 |
| US20200270265A1 (en) | 2020-08-27 |
| CO2018008589A2 (es) | 2018-08-21 |
| ES2897913T3 (es) | 2022-03-03 |
| MX2018010010A (es) | 2018-11-09 |
| EA038098B1 (ru) | 2021-07-06 |
| AU2017219216B2 (en) | 2019-12-19 |
| WO2017140821A1 (en) | 2017-08-24 |
| CN109071447B (zh) | 2022-04-22 |
| JOP20170045B1 (ar) | 2021-08-17 |
| US20170240548A1 (en) | 2017-08-24 |
| TWI747879B (zh) | 2021-12-01 |
| IL261158B (en) | 2020-10-29 |
| US9845325B2 (en) | 2017-12-19 |
| SG11201806863WA (en) | 2018-09-27 |
| US10093673B2 (en) | 2018-10-09 |
| CN109071447A (zh) | 2018-12-21 |
| MX384799B (es) | 2025-03-14 |
| BR112018016842A2 (pt) | 2018-12-26 |
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