BR112017011941A2 - compostos 5-amino-6h-tiazol [4,5-d] pirimidina-2,7-diona substituídos 3 para o tratamento e profilaxia de infecção viral - Google Patents
compostos 5-amino-6h-tiazol [4,5-d] pirimidina-2,7-diona substituídos 3 para o tratamento e profilaxia de infecção viralInfo
- Publication number
- BR112017011941A2 BR112017011941A2 BR112017011941A BR112017011941A BR112017011941A2 BR 112017011941 A2 BR112017011941 A2 BR 112017011941A2 BR 112017011941 A BR112017011941 A BR 112017011941A BR 112017011941 A BR112017011941 A BR 112017011941A BR 112017011941 A2 BR112017011941 A2 BR 112017011941A2
- Authority
- BR
- Brazil
- Prior art keywords
- prophylaxis
- treatment
- thiazol
- pyrimidine
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
a presente invenção se refere aos compostos da fórmula (i), em que, r1, r2 e r3 são descritos no presente documento e seus pró-fármacos ou sal farmaceuticamente aceitável, enantiômero ou diastereômeros dos mesmos e composições incluindo os compostos e métodos de uso dos compostos como agonistas de tlr7 para o tratamento e profilaxia de infecções por vírus.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2014093224 | 2014-12-08 | ||
CNPCT/CN2014/093224 | 2014-12-08 | ||
CN2015086987 | 2015-08-14 | ||
CNPCT/CN2015/086987 | 2015-08-14 | ||
PCT/EP2015/078439 WO2016091698A1 (en) | 2014-12-08 | 2015-12-03 | 3-substituted 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017011941A2 true BR112017011941A2 (pt) | 2017-12-26 |
BR112017011941B1 BR112017011941B1 (pt) | 2023-02-28 |
Family
ID=54771116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017011941-2A BR112017011941B1 (pt) | 2014-12-08 | 2015-12-03 | Compostos 5-amino-6h-tiazol [4,5-d] pirimidina-2,7-diona 3-substituídos para o tratamento e profilaxia de infecção viral |
Country Status (31)
Country | Link |
---|---|
US (4) | US9441008B2 (pt) |
EP (1) | EP3230298B1 (pt) |
JP (1) | JP6817217B2 (pt) |
KR (2) | KR20230113824A (pt) |
CN (2) | CN106164079B (pt) |
AU (1) | AU2015359692B2 (pt) |
BR (1) | BR112017011941B1 (pt) |
CA (1) | CA2963717C (pt) |
CL (1) | CL2017001426A1 (pt) |
CR (1) | CR20170237A (pt) |
DK (1) | DK3230298T3 (pt) |
EA (1) | EA038744B1 (pt) |
ES (1) | ES2864223T3 (pt) |
HK (1) | HK1245764A1 (pt) |
HR (1) | HRP20210454T1 (pt) |
HU (1) | HUE053704T2 (pt) |
IL (1) | IL251285B (pt) |
LT (1) | LT3230298T (pt) |
MA (1) | MA41134B1 (pt) |
MX (1) | MX2017007044A (pt) |
MY (1) | MY194002A (pt) |
PE (1) | PE20170679A1 (pt) |
PH (1) | PH12017501061A1 (pt) |
PL (1) | PL3230298T3 (pt) |
PT (1) | PT3230298T (pt) |
RS (1) | RS61612B1 (pt) |
SG (1) | SG11201704512PA (pt) |
SI (1) | SI3230298T1 (pt) |
TW (1) | TWI733656B (pt) |
UA (1) | UA124184C2 (pt) |
WO (1) | WO2016091698A1 (pt) |
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KR102139708B1 (ko) * | 2015-03-16 | 2020-07-31 | 에프. 호프만-라 로슈 아게 | Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료 |
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KR102139708B1 (ko) | 2015-03-16 | 2020-07-31 | 에프. 호프만-라 로슈 아게 | Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료 |
EP3294746B1 (en) | 2015-05-12 | 2021-10-06 | F. Hoffmann-La Roche AG | Substituted aminothiazolopyrimidinedione derivatives for the treatment and prophylaxis of virus infection |
EP3317289B1 (en) | 2015-06-30 | 2021-10-27 | F. Hoffmann-La Roche AG | Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection |
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