BR112015002945B1 - Formulações farmacêuticas contendo derivados de 3-(4-cinamil-1-piperazinil)-amino de 3- formil-rifamicina sv e 3-formil-rifamicina s e um processo para sua preparação - Google Patents

Formulações farmacêuticas contendo derivados de 3-(4-cinamil-1-piperazinil)-amino de 3- formil-rifamicina sv e 3-formil-rifamicina s e um processo para sua preparação Download PDF

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Publication number
BR112015002945B1
BR112015002945B1 BR112015002945-0A BR112015002945A BR112015002945B1 BR 112015002945 B1 BR112015002945 B1 BR 112015002945B1 BR 112015002945 A BR112015002945 A BR 112015002945A BR 112015002945 B1 BR112015002945 B1 BR 112015002945B1
Authority
BR
Brazil
Prior art keywords
rifamycin
compound
formyl
cinnamyl
piperazinyl
Prior art date
Application number
BR112015002945-0A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112015002945A8 (pt
BR112015002945A2 (pt
Inventor
Rumyana Gueorguieva Konstantinova
Kiril Asenov Ninov
Velichka Ilieva Apostolovadimova
Evtimia Ivanova Stefanova
Rossen Krumov Koytchev
Original Assignee
Adipharm Ead
Bozhidar Lyubenov Fudulov
Lyibomir Bozhidarov Fudulov
Ditchev Consulting Ood
Kiril Asenov Ninov
Velichka Llieva Apostolova -Dimova
Evtimia Ivanova STEFANOVA
Rossen Krumov KOYTCHEV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adipharm Ead, Bozhidar Lyubenov Fudulov, Lyibomir Bozhidarov Fudulov, Ditchev Consulting Ood, Kiril Asenov Ninov, Velichka Llieva Apostolova -Dimova, Evtimia Ivanova STEFANOVA, Rossen Krumov KOYTCHEV filed Critical Adipharm Ead
Publication of BR112015002945A2 publication Critical patent/BR112015002945A2/pt
Publication of BR112015002945A8 publication Critical patent/BR112015002945A8/pt
Publication of BR112015002945B1 publication Critical patent/BR112015002945B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Chemistry (AREA)
BR112015002945-0A 2012-08-13 2013-08-09 Formulações farmacêuticas contendo derivados de 3-(4-cinamil-1-piperazinil)-amino de 3- formil-rifamicina sv e 3-formil-rifamicina s e um processo para sua preparação BR112015002945B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BG11128812 2012-08-13
BG111288 2012-08-13
PCT/BG2013/000041 WO2014026254A1 (en) 2012-08-13 2013-08-09 Pharmaceutical formulations containing 3-(4-cinnamyl-l-piperazinyl) amino derivatives of 3-formylrifamycin sv and 3-formylrifamycin s and a process of their preparation

Publications (3)

Publication Number Publication Date
BR112015002945A2 BR112015002945A2 (pt) 2017-12-05
BR112015002945A8 BR112015002945A8 (pt) 2018-01-16
BR112015002945B1 true BR112015002945B1 (pt) 2021-08-31

Family

ID=50101135

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015002945-0A BR112015002945B1 (pt) 2012-08-13 2013-08-09 Formulações farmacêuticas contendo derivados de 3-(4-cinamil-1-piperazinil)-amino de 3- formil-rifamicina sv e 3-formil-rifamicina s e um processo para sua preparação

Country Status (18)

Country Link
US (2) US9682997B2 (https=)
EP (1) EP2882435B8 (https=)
JP (2) JP6400580B2 (https=)
KR (1) KR102210848B1 (https=)
CN (2) CN104736152B (https=)
BR (1) BR112015002945B1 (https=)
CA (1) CA2881958C (https=)
EA (1) EA029363B1 (https=)
ES (1) ES2876004T3 (https=)
HK (1) HK1248691A1 (https=)
HU (1) HUE054955T2 (https=)
IN (1) IN2015DN02009A (https=)
MX (1) MX380259B (https=)
PL (1) PL2882435T3 (https=)
PT (1) PT2882435T (https=)
UA (1) UA120030C2 (https=)
WO (1) WO2014026254A1 (https=)
ZA (1) ZA201501268B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX386622B (es) * 2017-06-26 2025-03-19 Biofer Spa Derivados de pirido-imidazo rifamicina como agente antibacteriano
TWI731295B (zh) * 2019-01-24 2021-06-21 宏碁股份有限公司 顯示裝置以及控制顯示裝置的方法
CN119243181B (zh) * 2024-10-14 2025-10-10 河北欣港药业有限公司 一种微尺度下由利福霉素sv连续流电化学合成利福霉素s的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1478563A (en) 1975-03-05 1977-07-06 Lepetit Spa Rifamycin derivatives
GR64108B (en) 1977-04-15 1980-01-24 Dso Pharmachim Method for the preparation of azomethine-derivatives of rifamycin s.v
US4179439A (en) * 1977-07-01 1979-12-18 Intreprinderea De Antibiotice Iasi Rifamycins and method for their preparation
US4193020A (en) 1978-05-22 1980-03-11 Sperry Rand Corporation Phase lock control system with trajectory correction
JPS5738742A (en) * 1980-08-21 1982-03-03 Kawasaki Kasei Chem Ltd Preparation of 1,4-dihydroanthraquinone
JPS5695190A (en) * 1980-09-17 1981-08-01 Intorepurinderea De Anteibiote Manufacture of rifamycin derivative
IT1201963B (it) * 1983-03-24 1989-02-02 Prodotti Antibiotici Spa Derivati delle rifamicine e procedimento per la loro preparazione
JPS6143132A (ja) * 1984-08-06 1986-03-01 Takeda Chem Ind Ltd キノン誘導体，その製造法およびそれを含んでなる医薬組成物
MC1819A1 (fr) * 1985-10-18 1988-03-18 Ciba Geigy Ag Composes 4-benzyl-piperazinyl substitues
IT1202424B (it) * 1987-01-26 1989-02-09 Prodotti Antibiotici Spa Sali di un derivato rifamicinico
EP0284552A1 (de) * 1987-03-06 1988-09-28 Ciba-Geigy Ag 4-Benzyl-piperazinyl-Hydrazone
BG48618A1 (en) 1988-02-23 1991-04-15 Nauchen Inst Promishlena Mikro Method for preparing riphampycin
JPH02215716A (ja) * 1989-02-08 1990-08-28 Farmitalia Carlo Erba Spa ３―（ｎ―ピペリジノメチル―アジノ）メチルリファマイシンｓを活性成分として含有する薬剤組成物
US5095108A (en) * 1990-08-28 1992-03-10 Technologichen Kombinat Za Promishlena Microbiologia Non-solvated crystalline form "A" of 3-(4-cynnamyl-1-piperazinyl)iminomethylrifamycine SV and a method of its production
BG64021B1 (bg) 1998-11-04 2003-10-31 КОНСТАНТИНОВА Румяна Натриева сол на 3-(4-цинамил-1-пиперазинил)-иминометил рифамицин и метод за получаването й
DE10015814A1 (de) * 2000-03-30 2001-10-11 Max Planck Gesellschaft Arzneimittel zur Stimulierung der Leukopoese, zur Behandlung von Tumor- und Protozoenerkrankungen und Verfahren zu seiner Herstellung
DE10038101A1 (de) * 2000-08-04 2002-02-14 Degussa Verfahren zur Herstellung von 2-(4-Methyl-3-pentenyl)-anthrachinon
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
EP1781670A1 (en) * 2004-07-22 2007-05-09 Cumbre Pharmaceuticals Inc. Rifamycin derivatives for treating microbial infections
GB0505909D0 (en) * 2005-03-23 2005-04-27 Univ Leeds Formulations

Also Published As

Publication number Publication date
US9981985B2 (en) 2018-05-29
CA2881958C (en) 2019-08-27
MX2015001963A (es) 2015-06-04
BR112015002945A8 (pt) 2018-01-16
US20170283433A1 (en) 2017-10-05
EP2882435A4 (en) 2017-05-03
CN104736152B (zh) 2018-01-23
CA2881958A1 (en) 2014-02-20
US20150368263A1 (en) 2015-12-24
PT2882435T (pt) 2021-06-18
US9682997B2 (en) 2017-06-20
EA029363B1 (ru) 2018-03-30
UA120030C2 (uk) 2019-09-25
KR20150042275A (ko) 2015-04-20
JP6400580B2 (ja) 2018-10-03
KR102210848B1 (ko) 2021-02-02
ES2876004T3 (es) 2021-11-11
PL2882435T3 (pl) 2021-10-04
IN2015DN02009A (https=) 2015-08-14
HK1248691A1 (zh) 2018-10-19
JP2018199718A (ja) 2018-12-20
JP2015528823A (ja) 2015-10-01
HUE054955T2 (hu) 2021-10-28
CN107840854A (zh) 2018-03-27
JP6694029B2 (ja) 2020-05-13
ZA201501268B (en) 2016-01-27
CN104736152A (zh) 2015-06-24
EP2882435A1 (en) 2015-06-17
WO2014026254A1 (en) 2014-02-20
EA201590278A1 (ru) 2015-07-30
EP2882435B8 (en) 2024-01-03
HK1206980A1 (en) 2016-01-22
MX380259B (es) 2025-03-12
BR112015002945A2 (pt) 2017-12-05
EP2882435B1 (en) 2021-03-17

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/08/2013, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 12A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2845 DE 15-07-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.