BR112014027374A2 - receptores de células t com afinidade aumentada e método de produção dos mesmos - Google Patents

receptores de células t com afinidade aumentada e método de produção dos mesmos

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Publication number
BR112014027374A2
BR112014027374A2 BR112014027374A BR112014027374A BR112014027374A2 BR 112014027374 A2 BR112014027374 A2 BR 112014027374A2 BR 112014027374 A BR112014027374 A BR 112014027374A BR 112014027374 A BR112014027374 A BR 112014027374A BR 112014027374 A2 BR112014027374 A2 BR 112014027374A2
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Brazil
Prior art keywords
cell receptors
increased affinity
production method
methods
delta
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BR112014027374A
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English (en)
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BR112014027374B1 (pt
Inventor
D Greenberg Philip
M Schmitt Thomas
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Hutchinson Fred Cancer Res
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Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
Publication of BR112014027374A2 publication Critical patent/BR112014027374A2/pt
Publication of BR112014027374B1 publication Critical patent/BR112014027374B1/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K39/0011—Cancer antigens
    • A61K39/001152—Transcription factors, e.g. SOX or c-MYC
    • A61K39/001153—Wilms tumor 1 [WT1]
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    • A61K39/0011—Cancer antigens
    • A61K39/001166—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
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    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
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    • A61K39/464452—Transcription factors, e.g. SOX or c-MYC
    • A61K39/464453—Wilms tumor 1 [WT1]
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex

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Abstract

resumo “receptores de células t com afinidade aumentada e método de produção dos mesmos” a presente descrição refere-se a métodos para gerar receptores de células t com alta afinidade por seleção de agonista de células progenitoras hematopoiéticas que expressam um tcra antígeno-específico cultivado com células estromais que expressam delta-like-1 ou delta-like-4, composições preparadas a partir desses métodos, e usos desses.
BR112014027374-0A 2012-05-03 2013-05-02 Método para gerar um receptor de células t (tcr) com afinidade aumentada BR112014027374B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261642358P 2012-05-03 2012-05-03
US61/642,358 2012-05-03
PCT/US2013/039316 WO2013166321A1 (en) 2012-05-03 2013-05-02 Enhanced affinity t cell receptors and methods for making the same

Publications (2)

Publication Number Publication Date
BR112014027374A2 true BR112014027374A2 (pt) 2017-06-27
BR112014027374B1 BR112014027374B1 (pt) 2022-05-31

Family

ID=49514896

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Application Number Title Priority Date Filing Date
BR112014027374-0A BR112014027374B1 (pt) 2012-05-03 2013-05-02 Método para gerar um receptor de células t (tcr) com afinidade aumentada

Country Status (18)

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US (2) US9751928B2 (pt)
EP (1) EP2844743B1 (pt)
JP (2) JP6251734B2 (pt)
KR (2) KR20150009556A (pt)
CN (2) CN104395462B (pt)
AU (2) AU2013256159B2 (pt)
BR (1) BR112014027374B1 (pt)
CA (1) CA2872471C (pt)
ES (1) ES2858248T3 (pt)
HK (1) HK1208050A1 (pt)
IL (1) IL235355B (pt)
IN (1) IN2014DN09787A (pt)
MX (1) MX361760B (pt)
NZ (1) NZ702108A (pt)
PH (1) PH12014502418A1 (pt)
RU (2) RU2018130123A (pt)
SG (2) SG10201609210SA (pt)
WO (1) WO2013166321A1 (pt)

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