BR112014018961A2 - - Google Patents

Info

Publication number
BR112014018961A2
BR112014018961A2 BR112014018961A BR112014018961A BR112014018961A2 BR 112014018961 A2 BR112014018961 A2 BR 112014018961A2 BR 112014018961 A BR112014018961 A BR 112014018961A BR 112014018961 A BR112014018961 A BR 112014018961A BR 112014018961 A2 BR112014018961 A2 BR 112014018961A2
Authority
BR
Brazil
Application number
BR112014018961A
Other languages
Portuguese (pt)
Other versions
BR112014018961A8 (pt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR112014018961A2 publication Critical patent/BR112014018961A2/pt
Publication of BR112014018961A8 publication Critical patent/BR112014018961A8/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7153Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for colony-stimulating factors [CSF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243Colony Stimulating Factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112014018961A 2012-02-06 2013-02-06 Anticorpo isolado, anticorpo biespecífico, fragmento, ácido nucleico isolado, vetor, célula hospedeira, método de produção de anticorpos, composição farmacêutica, uso do anticorpo, método de tratamento, método de inibição e artigo industrializado BR112014018961A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261595658P 2012-02-06 2012-02-06
US201261680674P 2012-08-07 2012-08-07
PCT/US2013/024998 WO2013119716A1 (fr) 2012-02-06 2013-02-06 Compositions et procédés d'utilisation d'inhibiteurs de csf1r

Publications (2)

Publication Number Publication Date
BR112014018961A2 true BR112014018961A2 (fr) 2017-06-20
BR112014018961A8 BR112014018961A8 (pt) 2017-07-11

Family

ID=48947977

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014018961A BR112014018961A8 (pt) 2012-02-06 2013-02-06 Anticorpo isolado, anticorpo biespecífico, fragmento, ácido nucleico isolado, vetor, célula hospedeira, método de produção de anticorpos, composição farmacêutica, uso do anticorpo, método de tratamento, método de inibição e artigo industrializado

Country Status (10)

Country Link
EP (1) EP2812355A4 (fr)
JP (2) JP6416630B2 (fr)
KR (1) KR20140127855A (fr)
CN (1) CN104093740B (fr)
BR (1) BR112014018961A8 (fr)
CA (1) CA2861122A1 (fr)
HK (1) HK1202879A1 (fr)
MX (1) MX2014008961A (fr)
RU (1) RU2014136332A (fr)
WO (1) WO2013119716A1 (fr)

Families Citing this family (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011070024A1 (fr) 2009-12-10 2011-06-16 F. Hoffmann-La Roche Ag Anticorps se liant de façon préférentielle au domaine extracellulaire 4 de csf1r humain et leur utilisation
CN104159921B (zh) 2011-12-15 2018-05-04 霍夫曼-拉罗奇有限公司 针对人csf-1r的抗体及其用途
US9580486B2 (en) 2013-03-14 2017-02-28 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
AR095882A1 (es) 2013-04-22 2015-11-18 Hoffmann La Roche Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9
GB201315486D0 (en) * 2013-08-30 2013-10-16 Ucb Pharma Sa Antibodies
AR097584A1 (es) 2013-09-12 2016-03-23 Hoffmann La Roche Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano
MA39211B1 (fr) 2013-12-24 2019-01-31 Bristol Myers Squibb Co Composés tricycliques comme agents anti-cancers
US10987322B2 (en) 2014-06-06 2021-04-27 Flexus Biosciences, Inc. Immunoregulatory agents
EA037006B1 (ru) 2014-06-06 2021-01-26 Бристол-Майерс Сквибб Компани Антитела к индуцируемому глюкокортикоидами рецептору фактора некроза опухолей (gitr) и их применения
MX2017001293A (es) * 2014-07-28 2017-05-23 Nogra Pharma Ltd Metodos y composiciones para diagnosticar y tratar trastornos inflamatorios del intestino.
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
UY36391A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
CN107205970A (zh) 2014-11-05 2017-09-26 弗莱塞斯生物科学公司 免疫调节剂
ME03806B (fr) 2014-11-21 2021-04-20 Bristol Myers Squibb Co Anticorps anti-cd73 et leurs utilisations
CA2971517A1 (fr) * 2014-12-19 2016-06-23 Universite De Nantes Anticorps anti-il-34
AR103232A1 (es) 2014-12-22 2017-04-26 Bristol Myers Squibb Co ANTAGONISTAS DE TGFbR
SG11201705063VA (en) 2014-12-23 2017-07-28 Bristol Myers Squibb Co Antibodies to tigit
JP6490419B2 (ja) * 2014-12-24 2019-03-27 学校法人関西医科大学 制御性t細胞分化誘導剤
US10983128B2 (en) 2015-02-05 2021-04-20 Bristol-Myers Squibb Company CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy
MY186133A (en) 2015-03-02 2021-06-24 Rigel Pharmaceuticals Inc Tgf-? inhibitors
AU2016242973A1 (en) 2015-04-03 2017-11-23 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase for the treatment of cancer
WO2016162505A1 (fr) 2015-04-08 2016-10-13 F-Star Biotechnology Limited Thérapies d'agent de liaison à her2
BR112017021696A2 (pt) 2015-04-10 2018-07-10 Amgen Inc muteínas de interleucina-2 para a expansão de células t regulatórias
WO2016183114A1 (fr) 2015-05-11 2016-11-17 Bristol-Myers Squibb Company Composés tricycliques utilisés en tant qu'agents anticancéreux
EP3307740B1 (fr) 2015-05-12 2019-12-18 Bristol-Myers Squibb Company Composés 5h-pyrido[3,2-b]indole en tant qu'agents anticancéreux
WO2016180948A1 (fr) * 2015-05-12 2016-11-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et kits pour marquer, détecter et isoler des lymphocytes t régulateurs foxp3+, population isolée de lymphocytes t régulateurs foxp3+ ainsi obtenus et ses utilisations
US9725449B2 (en) 2015-05-12 2017-08-08 Bristol-Myers Squibb Company Tricyclic compounds as anticancer agents
EP3297672B1 (fr) 2015-05-21 2021-09-01 Harpoon Therapeutics, Inc. Protéines trispécifiques de liaison et méthodes d'utilisation
WO2016189045A1 (fr) * 2015-05-27 2016-12-01 Ucb Biopharma Sprl Méthode pour le traitement d'une maladie neurologique
US9644032B2 (en) 2015-05-29 2017-05-09 Bristol-Myers Squibb Company Antibodies against OX40 and uses thereof
EP3302552A1 (fr) 2015-06-02 2018-04-11 H. Hoffnabb-La Roche Ag Compositions et méthodes d'utilisation d'anticorps anti-il -34 pour traiter des maladies neurologiques
JP6621252B2 (ja) * 2015-06-17 2019-12-18 国立大学法人北海道大学 治療耐性がんに対する治療耐性低減剤
WO2017004016A1 (fr) 2015-06-29 2017-01-05 The Rockefeller University Anticorps anti-cd40 présentant une activité agoniste renforcée
EP3328861A1 (fr) 2015-07-28 2018-06-06 Bristol-Myers Squibb Company Antagonistes des récepteurs du tgf bêta
EP3341372A1 (fr) 2015-08-25 2018-07-04 Bristol-Myers Squibb Company Antagonistes du récepteur tgf bêta
KR20180057657A (ko) 2015-09-23 2018-05-30 브리스톨-마이어스 스큅 컴퍼니 글리피칸-3-결합 피브로넥틴 기반 스캐폴드 분자
ES2926969T3 (es) 2015-11-19 2022-10-31 Bristol Myers Squibb Co Anticuerpos contra el receptor de factor de necrosis de tumor inducido por glucocorticoides (gitr) y usos de los mismos
JP6856648B2 (ja) 2015-12-15 2021-04-07 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Cxcr4受容体アンタゴニスト
IL295230A (en) 2016-03-04 2022-10-01 Bristol Myers Squibb Co Combination therapy with anti-cd73 antibodies
EP3445783A2 (fr) 2016-04-18 2019-02-27 Celldex Therapeutics, Inc. Anticorps agonistes se liant au cd40 humain et leurs utilisations
WO2017192844A1 (fr) 2016-05-04 2017-11-09 Bristol-Myers Squibb Company Inhibiteurs d'indoleamine 2,3-dioxygénase et leurs méthodes d'utilisation
KR20190004742A (ko) 2016-05-04 2019-01-14 브리스톨-마이어스 스큅 컴퍼니 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법
KR20190003686A (ko) 2016-05-04 2019-01-09 브리스톨-마이어스 스큅 컴퍼니 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법
WO2017192815A1 (fr) 2016-05-04 2017-11-09 Bristol-Myers Squibb Company Inhibiteurs d'indoleamine 2,3-dioxygénase et leurs méthodes d'utilisation
WO2017192811A1 (fr) 2016-05-04 2017-11-09 Bristol-Myers Squibb Company Inhibiteurs d'indoleamine 2,3-dioxygénase et leurs méthodes d'utilisation
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
WO2017210335A1 (fr) 2016-06-01 2017-12-07 Bristol-Myers Squibb Company Méthodes d'imagerie faisant intervenir des substances biologiques radiomarquées au 18f
UY37325A (es) 2016-07-14 2018-01-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Anticuerpos monoclonales que se enlazan a tim3 para estimular respuestas inmunitarias y composiciones que los contienen
WO2018017633A1 (fr) 2016-07-21 2018-01-25 Bristol-Myers Squibb Company ANTAGONISTES DU RÉCEPTEUR TGF-β
EP3504239B1 (fr) 2016-08-25 2024-05-29 F. Hoffmann-La Roche AG Dosage intermittent d'un anticorps anti-csf-1r en combinaison avec un agent d'activation de macrophages
KR20190040990A (ko) 2016-08-26 2019-04-19 브리스톨-마이어스 스큅 컴퍼니 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법
EP3503891A1 (fr) 2016-08-26 2019-07-03 Bristol-Myers Squibb Company Inhibiteurs d'indoleamine 2,3-dioxygénase et leurs méthodes d'utilisation
US10660909B2 (en) 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
EP3558360A1 (fr) 2016-12-22 2019-10-30 F. Hoffmann-La Roche AG Traitement de tumeurs par un anticorps anti-csf1r en association avec un anticorps anti-pd-l1 après l'échec d'un traitement anti-pd-l1/pd1
WO2018132279A1 (fr) 2017-01-05 2018-07-19 Bristol-Myers Squibb Company ANTAGONISTES DU RÉCEPTEUR TGF-β
PT3570844T (pt) 2017-01-20 2023-11-15 Arcus Biosciences Inc Azolopirimidina para o tratamento de doenças relacionadas com o cancro
TWI788340B (zh) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 抗icos促效劑抗體及其用途
TWI778050B (zh) 2017-04-21 2022-09-21 美商醫肯納腫瘤學公司 吲哚ahr抑制劑及其用途
WO2018209049A1 (fr) 2017-05-12 2018-11-15 Bristol-Myers Squibb Company Inhibiteurs d'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
CA3063359A1 (fr) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Proteines de liaison a la mesotheline
US11220492B2 (en) 2017-05-17 2022-01-11 Arcus Biosciences, Inc. Quinazoline-pyrazole derivatives for the treatment of cancer-related disorders
IL271601B2 (en) 2017-06-30 2024-05-01 Bristol Myers Squibb Co Amorphous and crystalline forms of IDO inhibitors
EP3658565B1 (fr) 2017-07-28 2022-11-09 Bristol-Myers Squibb Company Dinucléotides cycliques utilisés en tant qu'agents anticancéreux
JP2020529427A (ja) 2017-08-04 2020-10-08 バイスクルテクス・リミテッド Cd137に対して特異的な二環式ペプチドリガンド
WO2019036657A1 (fr) 2017-08-17 2019-02-21 Kyn Therapeutics Inhibiteurs d'ahr et leurs utilisations
JP7316263B2 (ja) 2017-08-31 2023-07-27 ブリストル-マイヤーズ スクイブ カンパニー 抗癌剤としての環状ジヌクレオチド
CN111051327B (zh) 2017-08-31 2023-11-03 百时美施贵宝公司 作为抗癌剂的环二核苷酸
US10953032B2 (en) 2017-08-31 2021-03-23 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
JP7366031B2 (ja) 2017-09-22 2023-10-20 カイメラ セラピューティクス, インコーポレイテッド タンパク質分解剤およびそれらの使用
WO2019060693A1 (fr) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. Ligands crbn et utilisations de ces derniers
WO2019074824A1 (fr) 2017-10-09 2019-04-18 Bristol-Myers Squibb Company Inhibiteurs d'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
US11649212B2 (en) 2017-10-09 2023-05-16 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
EP3694552A1 (fr) 2017-10-10 2020-08-19 Tilos Therapeutics, Inc. Anticorps anti-lap et leurs utilisations
US11660311B2 (en) 2017-10-10 2023-05-30 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
JP7066837B2 (ja) 2017-10-13 2022-05-13 ハープーン セラピューティクス,インク. B細胞成熟抗原結合タンパク質
JP7254821B2 (ja) 2017-10-16 2023-04-10 ブリストル-マイヤーズ スクイブ カンパニー 抗がん剤としての環状ジヌクレオチド
EP3704159A1 (fr) 2017-11-01 2020-09-09 Bristol-Myers Squibb Company Anticorps agonistes immunostimulateurs destinés à être utilisés dans le traitement du cancer
JP7167146B2 (ja) 2017-11-06 2022-11-08 ブリストル-マイヤーズ スクイブ カンパニー Hpk1阻害剤として有用なイソフラノン化合物
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc IRAK joints and used in them
KR20200103761A (ko) 2017-12-27 2020-09-02 브리스톨-마이어스 스큅 컴퍼니 항-cd40 항체 및 그의 용도
US11447449B2 (en) 2018-01-05 2022-09-20 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
JP7358361B2 (ja) 2018-01-12 2023-10-10 ブリストル-マイヤーズ スクイブ カンパニー Tim3に対する抗体およびその使用
WO2019140380A1 (fr) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Agents de dégradation de protéines et utilisations associées
WO2019147982A1 (fr) 2018-01-26 2019-08-01 Celldex Therapeutics, Inc. Méthodes de traitement du cancer à l'aide d'agents mobilisateur de cellules dendritiques
CN111918651B (zh) 2018-01-29 2024-01-30 默克专利股份有限公司 Gcn2抑制剂及其用途
AU2019212969A1 (en) 2018-01-29 2020-08-13 Merck Patent Gmbh GCN2 inhibitors and uses thereof
US10519187B2 (en) 2018-02-13 2019-12-31 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
WO2019165315A1 (fr) 2018-02-23 2019-08-29 Syntrix Biosystems Inc. Méthode de traitement du cancer à l'aide d'antagonistes de chimiokine seuls ou en combinaison
GB201803226D0 (en) * 2018-02-28 2018-04-11 Ultrahuman Twelve Ltd CSF1R Binding agents
WO2019169291A1 (fr) * 2018-03-02 2019-09-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Utilisation de l'il-34 pour traiter l'inflammation rétinienne et la neurodégénérescence
WO2019173211A1 (fr) * 2018-03-05 2019-09-12 Massachusetts Eye And Ear Infirmary Atténuation de l'uvéite auto-immune par le blocage du csf1r
US11945834B2 (en) 2018-03-08 2024-04-02 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
WO2019183040A1 (fr) 2018-03-21 2019-09-26 Five Prime Therapeutics, Inc. Anticorps se liant à vista à ph acide
TW202003565A (zh) 2018-03-23 2020-01-16 美商必治妥美雅史谷比公司 抗mica及/或micb抗體及其用途
CN112154153A (zh) 2018-03-28 2020-12-29 百时美施贵宝公司 白介素-2/白介素-2受体α融合蛋白以及使用方法
AU2019252795A1 (en) 2018-04-12 2020-10-29 Bristol-Myers Squibb Company Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody
US10973834B2 (en) 2018-04-16 2021-04-13 Arrys Therapeutics, Inc. EP4 inhibitors and use thereof
WO2019213340A1 (fr) 2018-05-03 2019-11-07 Bristol-Myers Squibb Company Dérivés d'uracile en tant qu'inhibiteurs de mer-axl
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
HUE064531T2 (hu) 2018-06-27 2024-04-28 Bristol Myers Squibb Co Szubsztituált naftiridinon vegyületek mint T-sejt aktivátorok
PT3814347T (pt) 2018-06-27 2023-07-18 Bristol Myers Squibb Co Compostos de naftiridinona úteis como ativadores de células t
EP3817748A4 (fr) 2018-07-06 2022-08-24 Kymera Therapeutics, Inc. Ligands crbn tricycliques et leurs utilisations
TW202428604A (zh) 2018-07-09 2024-07-16 美商戊瑞治療有限公司 結合至ilt4的抗體
CN112638948A (zh) 2018-07-11 2021-04-09 戊瑞治疗有限公司 在酸性pH下结合至VISTA的抗体
WO2020018680A1 (fr) 2018-07-18 2020-01-23 Arcus Biosciences, Inc. Formes solides d'un composé azolopyrimidine
WO2020023355A1 (fr) 2018-07-23 2020-01-30 Bristol-Myers Squibb Company Inhibiteurs de l'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
US20210355113A1 (en) 2018-07-23 2021-11-18 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US11253525B2 (en) 2018-08-29 2022-02-22 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US10959986B2 (en) 2018-08-29 2021-03-30 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
EP3846793B1 (fr) 2018-09-07 2024-01-24 PIC Therapeutics, Inc. Inhibiteurs d'eif4e et leurs utilisations
WO2020069028A1 (fr) 2018-09-25 2020-04-02 Harpoon Therapeutics, Inc. Protéines de liaison à dll3 et méthodes d'utilisation
US11130802B2 (en) 2018-10-10 2021-09-28 Tilos Therapeutics, Inc. Anti-lap antibody variants
WO2020102501A1 (fr) 2018-11-16 2020-05-22 Bristol-Myers Squibb Company Anticorps anti-nkg2a et leurs utilisations
MX2021006154A (es) 2018-11-30 2021-08-24 Kymera Therapeutics Inc Degradadores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos.
WO2020123444A1 (fr) 2018-12-11 2020-06-18 Celldex Therapeutics, Inc. Procédés d'utilisation d'anticorps cd27 en tant que traitement de conditionnement pour une thérapie cellulaire adoptive
EP3670659A1 (fr) 2018-12-20 2020-06-24 Abivax Biomarqueurs et leurs utilisations dans le traitement d'infections virales, d'inflammations ou du cancer
MX2021011320A (es) 2019-03-19 2021-12-10 Fundacio Privada Inst Dinvestigacio Oncològica De Vall Hebron Terapia de combinacion con omomyc y un anticuerpo que se une a pd-1 o a ctla-4 para el tratamiento del cancer.
AU2020253990A1 (en) 2019-04-02 2021-10-28 Bicycletx Limited Bicycle toxin conjugates and uses thereof
US11485750B1 (en) 2019-04-05 2022-11-01 Kymera Therapeutics, Inc. STAT degraders and uses thereof
US20230295087A1 (en) 2019-05-13 2023-09-21 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
US12012374B2 (en) 2019-05-13 2024-06-18 Bristol-Myers Squibb Company Agonists of ROR GAMMAt
JP2022534425A (ja) 2019-05-31 2022-07-29 イケナ オンコロジー, インコーポレイテッド Tead阻害剤およびその使用
WO2021024020A1 (fr) 2019-08-06 2021-02-11 Astellas Pharma Inc. Polythérapie impliquant des anticorps dirigés contre la claudine 18.2 et inhibiteurs de point de contrôle immunitaire pour le traitement du cancer
WO2021026179A1 (fr) 2019-08-06 2021-02-11 Bristol-Myers Squibb Company Agonistes de ror gammat
AR119821A1 (es) 2019-08-28 2022-01-12 Bristol Myers Squibb Co Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t
BR112022004451A2 (pt) 2019-09-13 2022-06-21 Nimbus Saturn Inc Antagonistas de hpk1 e usos dos mesmos
CA3149719A1 (fr) 2019-09-19 2021-03-25 Bristol-Myers Squibb Company Anticorps se liant a vista a un ph acide
IL293027A (en) 2019-11-19 2022-07-01 Bristol Myers Squibb Co Compounds useful as inhibitors of Helios protein
IL293357A (en) 2019-11-26 2022-07-01 Bristol Myers Squibb Co Salts/crystals of (r)-n-(4-chlorophenyl)-2-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide
MX2022006308A (es) 2019-11-26 2022-06-22 Ikena Oncology Inc Derivados de carbazol polimorfos y usos de los mismos.
US11591332B2 (en) 2019-12-17 2023-02-28 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
KR20220145325A (ko) 2019-12-17 2022-10-28 카이메라 쎄라퓨틱스 인코포레이티드 Irak 분해제 및 이의 용도
AU2020414688A1 (en) 2019-12-23 2022-08-18 Bristol-Myers Squibb Company Substituted quinolinonyl piperazine compounds useful as T cell activators
CN115175907B (zh) 2019-12-23 2024-08-02 百时美施贵宝公司 可用作t细胞激活剂的经取代的哌嗪衍生物
AR120823A1 (es) 2019-12-23 2022-03-23 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos útiles como activadores de células t
CN114846015B (zh) 2019-12-23 2024-07-30 百时美施贵宝公司 用作t细胞激活剂的经取代的杂芳基化合物
KR20220119454A (ko) 2019-12-23 2022-08-29 브리스톨-마이어스 스큅 컴퍼니 T 세포 활성화제로서 유용한 치환된 퀴나졸리닐 화합물
CN115297931A (zh) 2019-12-23 2022-11-04 凯麦拉医疗公司 Smarca降解剂和其用途
CA3166898A1 (fr) 2020-01-06 2021-07-15 Hifibio (Hk) Limited Anticorps anti-tnfr2 et ses utilisations
IL294466A (en) 2020-01-07 2022-09-01 Hifibio Hk Ltd Anti-galectin-9 antibody and uses thereof
WO2021178488A1 (fr) 2020-03-03 2021-09-10 PIC Therapeutics, Inc. Inhibiteurs d'eif4e et leurs utilisations
US20230140384A1 (en) 2020-03-09 2023-05-04 Bristol-Myers Squibb Company Antibodies to cd40 with enhanced agonist activity
JP2023518423A (ja) 2020-03-19 2023-05-01 カイメラ セラピューティクス, インコーポレイテッド Mdm2分解剤およびそれらの使用
CN115298165B (zh) 2020-03-19 2024-09-17 艾库斯生物科学有限公司 作为HIF-2α抑制剂的四氢化萘和四氢喹啉化合物
TW202140441A (zh) 2020-03-23 2021-11-01 美商必治妥美雅史谷比公司 經取代之側氧基異吲哚啉化合物
EP4132971A1 (fr) 2020-04-09 2023-02-15 Merck Sharp & Dohme LLC Anticorps anti-lap à maturation d'affinité et leurs utilisations
TWI799840B (zh) 2020-04-30 2023-04-21 美商美國禮來大藥廠 靶向介白素-34之化合物及方法
US20230192867A1 (en) 2020-05-15 2023-06-22 Bristol-Myers Squibb Company Antibodies to garp
US11820824B2 (en) 2020-06-02 2023-11-21 Arcus Biosciences, Inc. Antibodies to TIGIT
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
KR20230026312A (ko) 2020-06-17 2023-02-24 아르커스 바이오사이언시즈 인코포레이티드 Cd73 억제제의 결정형 및 이의 용도
MX2023000197A (es) 2020-07-07 2023-02-22 BioNTech SE Arn terapeutico para el cancer positivo para vph.
BR112023001638A2 (pt) 2020-07-30 2023-02-23 Kymera Therapeutics Inc Métodos de tratamento de linfomas mutantes
WO2022033419A2 (fr) 2020-08-10 2022-02-17 Shanghai Xbh Biotechnology Co., Ltd. Compositions et méthodes pour traiter des maladies auto-immunes et des cancers par ciblage de l'igsf8
WO2022038158A1 (fr) 2020-08-17 2022-02-24 Bicycletx Limited Conjugués "bicycle" spécifiques de la nectine-4 et leurs utilisations
WO2022120353A1 (fr) 2020-12-02 2022-06-09 Ikena Oncology, Inc. Inhibiteurs de tead et leurs utilisations
CA3200814A1 (fr) 2020-12-02 2022-06-09 Alfredo C. Castro Inhibiteurs de tead et utilisations associees
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性rna
WO2022135667A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Arn thérapeutique pour le traitement du cancer
WO2022135666A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Programme de traitement faisant intervenir des protéines cytokines
US20240325554A1 (en) 2021-01-11 2024-10-03 Bicycle TX Limited Methods for treating cancer
US20230091528A1 (en) 2021-02-02 2023-03-23 Liminal Biosciences Limited Gpr84 antagonists and uses thereof
EP4288427A1 (fr) 2021-02-02 2023-12-13 Liminal Biosciences Limited Antagonistes de gpr84 et leurs utilisations
US20240109899A1 (en) 2021-02-04 2024-04-04 Bristol-Myers Squibb Company Benzofuran compounds as sting agonists
CN116867494A (zh) 2021-02-15 2023-10-10 凯麦拉医疗公司 Irak4降解剂和其用途
WO2022187856A1 (fr) 2021-03-05 2022-09-09 Nimbus Saturn, Inc. Antagonistes de hpk1 et leurs utilisations
WO2022197641A1 (fr) 2021-03-15 2022-09-22 Rapt Therapeutics, Inc. Dérivés de 1h-pyrazolo[3,4-d]pyrimidin-6-yl-amine servant de modulateurs et/ou d'inhibiteurs de kinase progénitrice hématopoïétique 1 (hpk1) pour traiter le cancer et d'autres maladies
JP2024513011A (ja) 2021-03-29 2024-03-21 ニンバス サターン, インコーポレイテッド Hpk1アンタゴニスト及びその使用
WO2022212876A1 (fr) 2021-04-02 2022-10-06 The Regents Of The University Of California Anticorps dirigés contre un cdcp1 clivé et leurs utilisations
AU2022253450A1 (en) 2021-04-05 2023-11-16 Bristol-Myers Squibb Company Pyridinyl substituted oxoisoindoline compounds for the treatment of cancer
WO2022216644A1 (fr) 2021-04-06 2022-10-13 Bristol-Myers Squibb Company Composés oxoisoindoline substitués par pyridinyle
AU2022258968A1 (en) 2021-04-16 2023-10-19 Ikena Oncology, Inc. Mek inhibitors and uses thereof
TW202309030A (zh) 2021-05-07 2023-03-01 美商凱麥拉醫療公司 Cdk2降解劑及其用途
US20240269282A1 (en) 2021-05-10 2024-08-15 Institut Curie Methods for the Treatment of Cancer, Inflammatory Diseases and Autoimmune Diseases
CA3177291A1 (fr) 2021-05-17 2022-11-17 Nogra Pharma Limited Agents d'anti-sens il-34 et methodes d'utilisation
US20240246967A1 (en) 2021-05-21 2024-07-25 Arcus Biosciences, Inc. Axl compounds
TW202313603A (zh) 2021-05-21 2023-04-01 美商阿克思生物科學有限公司 Axl抑制劑化合物
KR20240046323A (ko) 2021-07-13 2024-04-08 비온테크 에스이 암에 대한 병용 요법에 있어서 cd40 및 cd137에 대한 다중특이 결합제
JP2024532276A (ja) 2021-08-25 2024-09-05 ピク セラピューティクス, インコーポレイテッド eIF4E阻害剤及びその使用
TW202315621A (zh) 2021-08-25 2023-04-16 美商皮克醫療公司 Eif4e抑制劑及其用途
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
IL312380A (en) 2021-10-29 2024-06-01 Lilly Co Eli Compounds and methods targeting interleukin-34
WO2023077046A1 (fr) 2021-10-29 2023-05-04 Arcus Biosciences, Inc. Inhibiteurs d'hif-2alpha et leurs procédés d'utilisation
TW202334210A (zh) * 2021-10-29 2023-09-01 美商美國禮來大藥廠 靶向介白素-34之化合物及方法
WO2023114984A1 (fr) 2021-12-17 2023-06-22 Ikena Oncology, Inc. Inhibiteurs de tead et leurs utilisations
AU2023214044A1 (en) 2022-01-31 2024-08-08 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2023150186A1 (fr) 2022-02-01 2023-08-10 Arvinas Operations, Inc. Composés de ciblage de dgk et utilisations associées
WO2023173057A1 (fr) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Inhibiteurs de mek et leurs utilisations
WO2023173053A1 (fr) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Inhibiteurs de mek et leurs utilisations
WO2023211889A1 (fr) 2022-04-25 2023-11-02 Ikena Oncology, Inc. Composés polymorphes et leurs utilisations
TW202409083A (zh) 2022-05-02 2024-03-01 美商阿克思生物科學有限公司 抗-tigit抗體及其用途
WO2023230205A1 (fr) 2022-05-25 2023-11-30 Ikena Oncology, Inc. Inhibiteurs de mek et leurs utilisations
WO2024015251A1 (fr) 2022-07-15 2024-01-18 Arcus Biosciences, Inc. Inhibiteurs de hpk1 et leurs méthodes d'utilisation
WO2024020034A1 (fr) 2022-07-20 2024-01-25 Arcus Biosciences, Inc. Inhibiteurs de cbl-b et leurs procédés d'utilisation
TW202416950A (zh) 2022-08-02 2024-05-01 英商利米那生物科技有限公司 雜芳基甲醯胺及相關gpr84拮抗劑及其用途
WO2024028365A1 (fr) 2022-08-02 2024-02-08 Liminal Biosciences Limited Antagonistes de gpr84 contenant de la pyridone substituée et leurs utilisations
TW202415650A (zh) 2022-08-02 2024-04-16 英商利米那生物科技有限公司 芳基-三唑基及相關gpr84拮抗劑及其用途
WO2024036100A1 (fr) 2022-08-08 2024-02-15 Bristol-Myers Squibb Company Composés tétrazolyles substitués utiles comme activateurs de lymphocytes t
WO2024036101A1 (fr) 2022-08-09 2024-02-15 Bristol-Myers Squibb Company Composés bicycliques substitués par amine tertiaire utiles comme activateurs de lymphocytes t
WO2024081385A1 (fr) 2022-10-14 2024-04-18 Arcus Biosciences, Inc. Inhibiteurs de hpk1 et leurs procédés d'utilisation
TW202428286A (zh) 2022-10-20 2024-07-16 美商阿克思生物科學有限公司 Cd73化合物之凍乾配方
US20240208961A1 (en) 2022-11-22 2024-06-27 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
WO2024126457A1 (fr) 2022-12-14 2024-06-20 Astellas Pharma Europe Bv Polythérapie impliquant des agents de liaison bispécifiques se liant à cldn18.2 et cd3 et des inhibiteurs de point de contrôle immunitaire

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2547586C2 (ru) * 2008-03-14 2015-04-10 Трансжене С.А. Антитело против csf-1r
AR080698A1 (es) * 2010-04-01 2012-05-02 Imclone Llc Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e
BR112012027994B1 (pt) * 2010-05-04 2021-10-13 Five Prime Therapeutics, Inc Anticorpo, composição farmacêutica e uso de um anticorpo

Also Published As

Publication number Publication date
EP2812355A1 (fr) 2014-12-17
RU2014136332A (ru) 2016-03-27
JP2017200482A (ja) 2017-11-09
HK1202879A1 (en) 2015-10-09
CA2861122A1 (fr) 2013-08-15
WO2013119716A8 (fr) 2014-08-07
KR20140127855A (ko) 2014-11-04
JP6416630B2 (ja) 2018-10-31
BR112014018961A8 (pt) 2017-07-11
CN104093740B (zh) 2018-01-09
EP2812355A4 (fr) 2016-03-02
JP2015510510A (ja) 2015-04-09
MX2014008961A (es) 2014-10-14
WO2013119716A1 (fr) 2013-08-15
CN104093740A (zh) 2014-10-08

Similar Documents

Publication Publication Date Title
BR112014029417A2 (fr)
BR112014018961A2 (fr)
BR112014017592A2 (fr)
BR112014017659A2 (fr)
BR112014017646A2 (fr)
AR092201A1 (fr)
BR112014020209A2 (fr)
BR112013027865A2 (fr)
BR112014017644A2 (fr)
BR112014017588A2 (fr)
BR112014017647A2 (fr)
BR112014013184A8 (fr)
BR112014017652A2 (fr)
BR112014019416A2 (fr)
BR112014017621A2 (fr)
BR112014017622A2 (fr)
BR112014017623A2 (fr)
BR112014018498A2 (fr)
BR112014017641A2 (fr)
BR112014018505A2 (fr)
BR112014018913A2 (fr)
BR112014017816A2 (fr)
BR112014017667A2 (fr)
BR112014017600A2 (fr)
BR112014021772A2 (fr)

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2500 DE 04-12-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.