BR112014001520A2 - processo para a produção de composto de benzo[b]tiofeno - Google Patents

processo para a produção de composto de benzo[b]tiofeno

Info

Publication number
BR112014001520A2
BR112014001520A2 BR112014001520A BR112014001520A BR112014001520A2 BR 112014001520 A2 BR112014001520 A2 BR 112014001520A2 BR 112014001520 A BR112014001520 A BR 112014001520A BR 112014001520 A BR112014001520 A BR 112014001520A BR 112014001520 A2 BR112014001520 A2 BR 112014001520A2
Authority
BR
Brazil
Prior art keywords
compound
formula
benzo
production
thiophene compound
Prior art date
Application number
BR112014001520A
Other languages
English (en)
Other versions
BR112014001520B1 (pt
Inventor
Shinhama Koichi
Sota Masahiro
Utsumi Naoto
Fujieda Shigeo
Ogasawara Shin
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BR112014001520A2 publication Critical patent/BR112014001520A2/pt
Publication of BR112014001520B1 publication Critical patent/BR112014001520B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

resumo patente de invenção: "processo para a produção de composto de benzo[b]tiofeno". a presente invenção refere-se a um processo para a produção de um composto de fórmula (4): em que r1 é um átomo de hidrogênio etc. por reação de um composto de fórmula (2): em que x1 é um grupo de saída, com um composto de fórmula (3): em que r1 é como definido acima, na presença de (a) um com-posto de paládio e uma fosfina terciária ou (b) um complexo de paládio car-beno, em um solvente inerte ou sem um solvente. a presente invenção pode produzir o composto de fórmula (4), com grande pureza com alto rendimento e por uma operação simples.
BR112014001520-1A 2011-07-28 2012-07-27 Processo para a produção de composto de benzo[b]tiofeno BR112014001520B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011-165724 2011-07-28
JP2011165724 2011-07-28
PCT/JP2012/069784 WO2013015456A1 (en) 2011-07-28 2012-07-27 Method for producing benzo[b]thiophene compound

Publications (2)

Publication Number Publication Date
BR112014001520A2 true BR112014001520A2 (pt) 2017-02-14
BR112014001520B1 BR112014001520B1 (pt) 2022-05-10

Family

ID=46690663

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014001520-1A BR112014001520B1 (pt) 2011-07-28 2012-07-27 Processo para a produção de composto de benzo[b]tiofeno

Country Status (12)

Country Link
US (1) US9206169B2 (pt)
EP (1) EP2736894B1 (pt)
JP (1) JP5832558B2 (pt)
KR (1) KR101911121B1 (pt)
CN (1) CN103717587B (pt)
BR (1) BR112014001520B1 (pt)
CA (1) CA2843241C (pt)
ES (1) ES2601457T3 (pt)
IL (1) IL230600A (pt)
RU (1) RU2601420C2 (pt)
TW (1) TWI546299B (pt)
WO (1) WO2013015456A1 (pt)

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CN104529998A (zh) * 2014-12-23 2015-04-22 杭州新博思生物医药有限公司 一种制备4-(1-哌嗪基)苯并[b]噻吩的新方法
CN105461703B (zh) * 2014-12-29 2019-05-17 深圳市泛谷药业股份有限公司 一种brexpiprazole的制备方法
CN104829602A (zh) * 2015-04-15 2015-08-12 重庆医药工业研究院有限责任公司 一种依匹哌唑的制备方法
CN104844585B (zh) * 2015-04-15 2021-05-11 重庆医药工业研究院有限责任公司 一种制备依匹哌唑的方法
CN104829588B (zh) * 2015-04-30 2017-03-29 苏州苏旺森生物医药科技有限公司 一种苯并[b]噻吩的制备方法及其中间体
CN104829603A (zh) * 2015-05-19 2015-08-12 杭州新博思生物医药有限公司 A晶型依匹唑派盐酸盐及其制备方法
CN105061414B (zh) * 2015-07-21 2019-01-01 杭州新博思生物医药有限公司 一锅法制备Brexpiprazole
EP3150591A1 (en) 2015-10-02 2017-04-05 Crystal Pharma S.A.U Process and intermediates for the preparation of benzo[b]thiophene compounds
CN105175401A (zh) * 2015-10-16 2015-12-23 北京康立生医药技术开发有限公司 一种依匹哌唑的制备方法
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CN105461704A (zh) * 2015-12-15 2016-04-06 南京艾德凯腾生物医药有限责任公司 一种依匹哌唑的制备方法
WO2017106641A1 (en) * 2015-12-17 2017-06-22 Assia Chemical Industries Ltd. Solid state forms of brexpiprazole
CN106916148B (zh) * 2015-12-25 2021-07-06 上海科胜药物研发有限公司 一种合成依匹哌唑的方法
EP3397636B1 (en) * 2015-12-28 2021-08-04 Honour (R&D) Process for the preparation of quinoline-2(1h)-one derivatives
CN106938982A (zh) * 2016-01-05 2017-07-11 连云港皓海医药科技有限公司 布瑞哌唑的制备方法及用于制备布瑞哌唑的化合物
CN105399736B (zh) * 2016-01-07 2018-10-19 安徽省逸欣铭医药科技有限公司 一种依匹哌唑新的制备方法
CN105541819B (zh) * 2016-02-04 2018-09-14 浙江永宁药业股份有限公司 一种依匹唑派的制备方法及其中间体和中间体的制备方法
US20170320862A1 (en) 2016-05-03 2017-11-09 Cadila Healthcare Limited Process for the preparation of brexpiprazole and intermediates thereof
CN107365305A (zh) 2016-05-12 2017-11-21 上海奥博生物医药技术有限公司 一种依匹哌唑新晶型及其制备方法
WO2017208251A1 (en) * 2016-05-31 2017-12-07 Cipla Limited A new stable polymorph of brexpiprazole and process for preparation thereof
WO2017216661A1 (en) 2016-06-17 2017-12-21 Jubilant Generics Limited Process for the preparation of brexpiprazole from 7-(4-chlorobutoxy)quinolin-2(1h)-one and 1-(benzo[b]thiophen-4-yl)piperazine
PL233778B1 (pl) 2016-07-19 2019-11-29 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu
CN106432179A (zh) * 2016-07-26 2017-02-22 江苏兢业制药有限公司 一种4‑氯‑1‑苯并噻吩‑2‑羧酸的制备方法
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CN111004211B (zh) * 2019-12-29 2021-04-02 苏州诚和医药化学有限公司 一种依匹哌唑中间体4-溴苯并［b］噻吩的合成方法

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Also Published As

Publication number Publication date
JP5832558B2 (ja) 2015-12-16
CA2843241C (en) 2021-01-26
IL230600A (en) 2017-05-29
CN103717587B (zh) 2016-02-10
JP2014523852A (ja) 2014-09-18
KR20140054116A (ko) 2014-05-08
RU2601420C2 (ru) 2016-11-10
IL230600A0 (en) 2014-03-31
BR112014001520B1 (pt) 2022-05-10
US9206169B2 (en) 2015-12-08
KR101911121B1 (ko) 2018-10-23
WO2013015456A1 (en) 2013-01-31
ES2601457T3 (es) 2017-02-15
CA2843241A1 (en) 2013-01-31
EP2736894A1 (en) 2014-06-04
TW201309679A (zh) 2013-03-01
RU2014107545A (ru) 2015-09-10
US20140187782A1 (en) 2014-07-03
CN103717587A (zh) 2014-04-09
EP2736894B1 (en) 2016-08-31
TWI546299B (zh) 2016-08-21

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 333/54 , C07D 409/12 , C07B 61/00

Ipc: C07D 333/54 (2006.01), C07D 409/12 (2006.01), A61P

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/07/2012, OBSERVADAS AS CONDICOES LEGAIS