BR112013024059B1 - Compostos de bis(fluoroalquil)-1,4-benzodiazepinona, combinação e uso de ditos compostos - Google Patents

Compostos de bis(fluoroalquil)-1,4-benzodiazepinona, combinação e uso de ditos compostos Download PDF

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Publication number
BR112013024059B1
BR112013024059B1 BR112013024059-8A BR112013024059A BR112013024059B1 BR 112013024059 B1 BR112013024059 B1 BR 112013024059B1 BR 112013024059 A BR112013024059 A BR 112013024059A BR 112013024059 B1 BR112013024059 B1 BR 112013024059B1
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compound
trifluoropropyl
phenyl
benzodiazepin
oxo
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BR112013024059-8A
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English (en)
Portuguese (pt)
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BR112013024059A2 (pt
Inventor
Claude Quesnelle
Soong-Hoon Kim
Francis Y. Lee
Ashvinikumar Gavai
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Bristol-Myers Squibb Company
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Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of BR112013024059A2 publication Critical patent/BR112013024059A2/pt
Publication of BR112013024059B1 publication Critical patent/BR112013024059B1/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
BR112013024059-8A 2011-03-22 2012-03-22 Compostos de bis(fluoroalquil)-1,4-benzodiazepinona, combinação e uso de ditos compostos BR112013024059B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161466238P 2011-03-22 2011-03-22
US61/466,238 2011-03-22
PCT/US2012/030021 WO2012129353A1 (en) 2011-03-22 2012-03-22 Bis(fluoroalkyl)-1,4-benzodiazepinone compounds

Publications (2)

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BR112013024059A2 BR112013024059A2 (pt) 2016-12-06
BR112013024059B1 true BR112013024059B1 (pt) 2022-01-25

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US (2) US8629136B2 (https=)
EP (1) EP2688873B1 (https=)
JP (1) JP5873923B2 (https=)
KR (1) KR101948347B1 (https=)
CN (1) CN103717576B (https=)
AR (2) AR085471A1 (https=)
AU (1) AU2012230904B2 (https=)
BR (1) BR112013024059B1 (https=)
CA (1) CA2830902C (https=)
CL (1) CL2013002690A1 (https=)
CO (1) CO6771446A2 (https=)
CY (1) CY1116423T1 (https=)
DK (1) DK2688873T3 (https=)
EA (1) EA022530B1 (https=)
ES (1) ES2534080T3 (https=)
HR (1) HRP20150273T1 (https=)
IL (1) IL228534A (https=)
MA (1) MA35036B1 (https=)
MX (1) MX2013010420A (https=)
MY (1) MY161233A (https=)
PE (1) PE20140626A1 (https=)
PH (1) PH12013501738B1 (https=)
PL (1) PL2688873T3 (https=)
PT (1) PT2688873E (https=)
RS (1) RS53843B1 (https=)
SG (1) SG193555A1 (https=)
SI (1) SI2688873T1 (https=)
SM (1) SMT201500091B (https=)
TN (1) TN2013000372A1 (https=)
TW (1) TWI530489B (https=)
UY (1) UY33961A (https=)
WO (1) WO2012129353A1 (https=)

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DK2688873T3 (en) 2015-04-27
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KR20140027956A (ko) 2014-03-07
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JP2014511840A (ja) 2014-05-19
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