BR112012020372A2 - "naticorpo que se liga ao csf- 1r humano, composição farmaceutica acido nucleico vetoresde expressão, célula hospedeira e método para a produção de um anticorpo recobinante - Google Patents
"naticorpo que se liga ao csf- 1r humano, composição farmaceutica acido nucleico vetoresde expressão, célula hospedeira e método para a produção de um anticorpo recobinanteInfo
- Publication number
- BR112012020372A2 BR112012020372A2 BR112012020372A BR112012020372A BR112012020372A2 BR 112012020372 A2 BR112012020372 A2 BR 112012020372A2 BR 112012020372 A BR112012020372 A BR 112012020372A BR 112012020372 A BR112012020372 A BR 112012020372A BR 112012020372 A2 BR112012020372 A2 BR 112012020372A2
- Authority
- BR
- Brazil
- Prior art keywords
- producing
- nucleic acid
- pharmaceutical composition
- host cell
- expression vectors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
abstract not avaible
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10002268 | 2010-03-05 | ||
PCT/EP2011/053214 WO2011107553A1 (en) | 2010-03-05 | 2011-03-03 | Antibodies against human csf-1r and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112012020372A2 true BR112012020372A2 (pt) | 2017-01-10 |
BR112012020372A8 BR112012020372A8 (pt) | 2018-01-02 |
Family
ID=42664747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012020372A BR112012020372A8 (pt) | 2010-03-05 | 2011-03-03 | anticorpo que se liga ao csf-1r humano, composição farmacêutica, ácido nucleico, vetores de expressão, célula hospedeira e método para a produção de um anticorpo recombinante |
Country Status (11)
Country | Link |
---|---|
US (5) | US9169323B2 (pt) |
EP (1) | EP2542587A1 (pt) |
JP (2) | JP2013521765A (pt) |
KR (1) | KR101656548B1 (pt) |
CN (1) | CN102918060B (pt) |
BR (1) | BR112012020372A8 (pt) |
CA (1) | CA2789076C (pt) |
HK (1) | HK1176948A1 (pt) |
MX (1) | MX2012010014A (pt) |
RU (1) | RU2617971C2 (pt) |
WO (1) | WO2011107553A1 (pt) |
Families Citing this family (200)
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KR101656548B1 (ko) | 2010-03-05 | 2016-09-09 | 에프. 호프만-라 로슈 아게 | 인간 csf-1r에 대한 항체 및 이의 용도 |
EP2542588A1 (en) | 2010-03-05 | 2013-01-09 | F. Hoffmann-La Roche AG | Antibodies against human csf-1r and uses thereof |
TWI713942B (zh) | 2010-05-04 | 2020-12-21 | 美商戊瑞治療有限公司 | 與集落刺激因子1受體(csf1r)結合之抗體類 |
DK2734547T3 (en) | 2011-07-18 | 2017-04-03 | Univ Melbourne | USE OF C-FMS ANTIBODIES |
RU2658603C2 (ru) * | 2011-12-15 | 2018-06-21 | Ф.Хоффманн-Ля Рош Аг | Антитела против человеческого csf-1r и их применения |
AR090263A1 (es) * | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
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BR112015025622A2 (pt) | 2013-04-12 | 2017-07-18 | Morphosys Ag | anticorpo ou fragmento de anticorpo isolado, composição farmacêutica, ácido nucleico, vetor, e célula hospedeira isolada |
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JP2011515497A (ja) | 2008-03-26 | 2011-05-19 | セレラント セラピューティクス インコーポレイテッド | 骨髄性血液学的増殖性疾患と関連する免疫グロブリンおよび/またはToll様受容体タンパク質ならびにその使用 |
CA2759146C (en) | 2009-04-20 | 2017-06-13 | Kyowa Hakko Kirin Co., Ltd. | Agonist anti-cd40 antibody |
RS58693B1 (sr) | 2009-12-10 | 2019-06-28 | Hoffmann La Roche | Antitela koja poželjno vezuju ekstracelularni domen 4 humanog csf1r, i njihova primena |
EP2542588A1 (en) | 2010-03-05 | 2013-01-09 | F. Hoffmann-La Roche AG | Antibodies against human csf-1r and uses thereof |
KR101656548B1 (ko) | 2010-03-05 | 2016-09-09 | 에프. 호프만-라 로슈 아게 | 인간 csf-1r에 대한 항체 및 이의 용도 |
TWI426920B (zh) | 2010-03-26 | 2014-02-21 | Hoffmann La Roche | 雙專一性、雙價抗-vegf/抗-ang-2抗體 |
AR080698A1 (es) | 2010-04-01 | 2012-05-02 | Imclone Llc | Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e |
TWI713942B (zh) | 2010-05-04 | 2020-12-21 | 美商戊瑞治療有限公司 | 與集落刺激因子1受體(csf1r)結合之抗體類 |
JP5798404B2 (ja) | 2010-08-31 | 2015-10-21 | 日東電工株式会社 | 極板保護用粘着テープ |
RU2658603C2 (ru) | 2011-12-15 | 2018-06-21 | Ф.Хоффманн-Ля Рош Аг | Антитела против человеческого csf-1r и их применения |
AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
-
2011
- 2011-03-03 KR KR1020127025972A patent/KR101656548B1/ko active IP Right Grant
- 2011-03-03 CA CA2789076A patent/CA2789076C/en not_active Expired - Fee Related
- 2011-03-03 BR BR112012020372A patent/BR112012020372A8/pt not_active Application Discontinuation
- 2011-03-03 CN CN201180011736.3A patent/CN102918060B/zh not_active Expired - Fee Related
- 2011-03-03 RU RU2012142231A patent/RU2617971C2/ru not_active IP Right Cessation
- 2011-03-03 US US13/582,964 patent/US9169323B2/en not_active Expired - Fee Related
- 2011-03-03 MX MX2012010014A patent/MX2012010014A/es active IP Right Grant
- 2011-03-03 WO PCT/EP2011/053214 patent/WO2011107553A1/en active Application Filing
- 2011-03-03 JP JP2012555430A patent/JP2013521765A/ja not_active Ceased
- 2011-03-03 EP EP11706266A patent/EP2542587A1/en not_active Withdrawn
-
2013
- 2013-04-10 HK HK13104333.3A patent/HK1176948A1/zh not_active IP Right Cessation
-
2014
- 2014-11-24 US US14/551,660 patent/US20150080556A1/en not_active Abandoned
-
2015
- 2015-03-09 US US14/642,101 patent/US9617342B2/en active Active
- 2015-10-27 JP JP2015211184A patent/JP6005825B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-04 US US15/285,183 patent/US10030073B2/en not_active Expired - Fee Related
- 2016-10-04 US US15/285,120 patent/US9988458B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
RU2012142231A (ru) | 2014-04-10 |
EP2542587A1 (en) | 2013-01-09 |
JP2013521765A (ja) | 2013-06-13 |
US9988458B2 (en) | 2018-06-05 |
US9169323B2 (en) | 2015-10-27 |
KR101656548B1 (ko) | 2016-09-09 |
RU2617971C2 (ru) | 2017-04-28 |
US20150080556A1 (en) | 2015-03-19 |
BR112012020372A8 (pt) | 2018-01-02 |
US20150175696A1 (en) | 2015-06-25 |
US20120329997A1 (en) | 2012-12-27 |
CA2789076A1 (en) | 2011-09-09 |
US10030073B2 (en) | 2018-07-24 |
WO2011107553A1 (en) | 2011-09-09 |
HK1176948A1 (zh) | 2013-08-09 |
KR20120138801A (ko) | 2012-12-26 |
JP2016065065A (ja) | 2016-04-28 |
CN102918060A (zh) | 2013-02-06 |
CA2789076C (en) | 2017-11-21 |
US20170015752A1 (en) | 2017-01-19 |
JP6005825B2 (ja) | 2016-10-12 |
US20170114139A1 (en) | 2017-04-27 |
MX2012010014A (es) | 2012-09-21 |
CN102918060B (zh) | 2016-04-06 |
US9617342B2 (en) | 2017-04-11 |
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