|
US4057685A
(en)
|
1972-02-02 |
1977-11-08 |
Abbott Laboratories |
Chemically modified endotoxin immunizing agent
|
|
DE2848965A1
(de)
|
1978-11-11 |
1980-05-22 |
Behringwerke Ag |
Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine
|
|
AU545912B2
(en)
|
1980-03-10 |
1985-08-08 |
Cetus Corporation |
Cloned heterologous jive products in bacillies
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
NO821391L
(no)
|
1981-04-29 |
1982-11-01 |
Biogen Nv |
Kloningsvektorer, rekombinante dna-molekyler samt bakterieverter transformert med disse
|
|
US4551433A
(en)
|
1981-05-18 |
1985-11-05 |
Genentech, Inc. |
Microbial hybrid promoters
|
|
US4356170A
(en)
|
1981-05-27 |
1982-10-26 |
Canadian Patents & Development Ltd. |
Immunogenic polysaccharide-protein conjugates
|
|
US4673574A
(en)
|
1981-08-31 |
1987-06-16 |
Anderson Porter W |
Immunogenic conjugates
|
|
SE8205892D0
(sv)
|
1982-10-18 |
1982-10-18 |
Bror Morein |
Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
|
|
US4459286A
(en)
|
1983-01-31 |
1984-07-10 |
Merck & Co., Inc. |
Coupled H. influenzae type B vaccine
|
|
JPS59166086A
(ja)
|
1983-03-09 |
1984-09-19 |
Teruhiko Beppu |
新規な発現型プラスミドとそれらを用いて仔牛プロキモシン遺伝子を大腸菌内で発現させる方法
|
|
US4663160A
(en)
|
1983-03-14 |
1987-05-05 |
Miles Laboratories, Inc. |
Vaccines for gram-negative bacteria
|
|
JPS59205983A
(ja)
|
1983-04-28 |
1984-11-21 |
ジエネツクス・コ−ポレイシヨン |
異種遺伝子を原核微生物で発現させる方法
|
|
US4663280A
(en)
|
1983-05-19 |
1987-05-05 |
Public Health Research Institute Of The City Of New York |
Expression and secretion vectors and method of constructing vectors
|
|
US4761283A
(en)
|
1983-07-05 |
1988-08-02 |
The University Of Rochester |
Immunogenic conjugates
|
|
US4689406A
(en)
|
1983-08-10 |
1987-08-25 |
Amgen |
Enhancement of microbial expression of polypeptides
|
|
JPS6054685A
(ja)
|
1983-09-02 |
1985-03-29 |
Suntory Ltd |
改良発現ベクタ−およびその利用
|
|
EP0136907A3
(en)
|
1983-10-03 |
1986-12-30 |
Genentech, Inc. |
A xenogeneic expression control system, a method of using it, expression vectors containing it, cells transformed thereby and heterologous proteins produced therefrom
|
|
US6090406A
(en)
|
1984-04-12 |
2000-07-18 |
The Liposome Company, Inc. |
Potentiation of immune responses with liposomal adjuvants
|
|
US5916588A
(en)
|
1984-04-12 |
1999-06-29 |
The Liposome Company, Inc. |
Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
|
|
US4882317A
(en)
|
1984-05-10 |
1989-11-21 |
Merck & Co., Inc. |
Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency
|
|
US4695624A
(en)
|
1984-05-10 |
1987-09-22 |
Merck & Co., Inc. |
Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
|
|
US4808700A
(en)
|
1984-07-09 |
1989-02-28 |
Praxis Biologics, Inc. |
Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
|
|
US4738921A
(en)
|
1984-09-27 |
1988-04-19 |
Eli Lilly And Company |
Derivative of the tryptophan operon for expression of fused gene products
|
|
US4745056A
(en)
|
1984-10-23 |
1988-05-17 |
Biotechnica International, Inc. |
Streptomyces secretion vector
|
|
IT1187753B
(it)
|
1985-07-05 |
1987-12-23 |
Sclavo Spa |
Coniugati glicoproteici ad attivita' immunogenica trivalente
|
|
US4865974A
(en)
|
1985-09-20 |
1989-09-12 |
Cetus Corporation |
Bacterial methionine N-terminal peptidase
|
|
JPS63123383A
(ja)
|
1986-11-11 |
1988-05-27 |
Mitsubishi Kasei Corp |
ハイブリツドプロモ−タ−、発現調節dna配列および発現ベクタ−
|
|
US5057540A
(en)
|
1987-05-29 |
1991-10-15 |
Cambridge Biotech Corporation |
Saponin adjuvant
|
|
RU2023448C1
(ru)
|
1987-07-30 |
1994-11-30 |
Сентро Насьональ Де Биопрепарадос |
Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в
|
|
NL8802046A
(nl)
|
1988-08-18 |
1990-03-16 |
Gen Electric |
Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen.
|
|
AU627226B2
(en)
|
1988-08-25 |
1992-08-20 |
Liposome Company, Inc., The |
Influenza vaccine and novel adjuvants
|
|
DE3841091A1
(de)
|
1988-12-07 |
1990-06-13 |
Behringwerke Ag |
Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
|
|
AU640118B2
(en)
|
1988-12-19 |
1993-08-19 |
De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur |
Meningococcal class 1 outer-membrane protein vaccine
|
|
DE68907045T2
(de)
|
1989-01-17 |
1993-12-02 |
Eniricerche Spa |
Synthetische Peptide und deren Verwendung als allgemeine Träger für die Herstellung von immunogenischen Konjugaten, die für die Entwicklung von synthetischen Impfstoffen geeignet sind.
|
|
CA2017507C
(en)
|
1989-05-25 |
1996-11-12 |
Gary Van Nest |
Adjuvant formulation comprising a submicron oil droplet emulsion
|
|
JPH04506662A
(ja)
|
1989-07-14 |
1992-11-19 |
アメリカン・サイアナミド・カンパニー |
接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー
|
|
IT1237764B
(it)
|
1989-11-10 |
1993-06-17 |
Eniricerche Spa |
Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
|
|
SE466259B
(sv)
|
1990-05-31 |
1992-01-20 |
Arne Forsgren |
Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
|
|
IL98715A0
(en)
|
1990-08-13 |
1992-07-15 |
American Cyanamid Co |
Filamentous hemaglutinin of bodetella pertussis as a carrier molecule for conjugate vaccines
|
|
IT1262896B
(it)
|
1992-03-06 |
1996-07-22 |
|
Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
|
|
KR100278157B1
(ko)
|
1992-06-25 |
2001-01-15 |
장 스테판느 |
보조약을 함유하는 백신 조성물
|
|
IL102687A
(en)
|
1992-07-30 |
1997-06-10 |
Yeda Res & Dev |
Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
|
|
NL9201716A
(nl)
|
1992-10-02 |
1994-05-02 |
Nederlanden Staat |
Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat.
|
|
SK117395A3
(en)
|
1993-03-23 |
1996-11-06 |
Smithkline Beecham Biolog |
Vaccine composition and manufacturing process thereof
|
|
ES2210262T3
(es)
|
1993-09-22 |
2004-07-01 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Procedimiento que permite activar un glucido soluble con la ayuda de nuevos reactivos cianilantes para producir estructuras inmunogenas.
|
|
GB9326174D0
(en)
|
1993-12-22 |
1994-02-23 |
Biocine Sclavo |
Mucosal adjuvant
|
|
GB9326253D0
(en)
|
1993-12-23 |
1994-02-23 |
Smithkline Beecham Biolog |
Vaccines
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6429199B1
(en)
|
1994-07-15 |
2002-08-06 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules for activating dendritic cells
|
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
AUPM873294A0
(en)
|
1994-10-12 |
1994-11-03 |
Csl Limited |
Saponin preparations and use thereof in iscoms
|
|
IL117483A
(en)
|
1995-03-17 |
2008-03-20 |
Bernard Brodeur |
MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K.
|
|
UA56132C2
(uk)
|
1995-04-25 |
2003-05-15 |
Смітклайн Бічем Байолоджікалс С.А. |
Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
|
|
US6180111B1
(en)
|
1995-05-18 |
2001-01-30 |
University Of Maryland |
Vaccine delivery system
|
|
GB9513261D0
(en)
|
1995-06-29 |
1995-09-06 |
Smithkline Beecham Biolog |
Vaccines
|
|
US6558677B2
(en)
|
1996-10-15 |
2003-05-06 |
Wendell D. Zollinger |
Vaccine against gram negative bacteria
|
|
DE69841122D1
(de)
|
1997-03-10 |
2009-10-15 |
Coley Pharm Gmbh |
Verwendung von nicht-methyliertem CpG Dinukleotid in Kombination mit Aluminium als Adjuvantien
|
|
US6818222B1
(en)
|
1997-03-21 |
2004-11-16 |
Chiron Corporation |
Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
|
|
GB9711964D0
(en)
|
1997-06-09 |
1997-08-06 |
Medical Res Council |
Live attenuated vaccines
|
|
GB9712347D0
(en)
|
1997-06-14 |
1997-08-13 |
Smithkline Beecham Biolog |
Vaccine
|
|
GB9713156D0
(en)
|
1997-06-20 |
1997-08-27 |
Microbiological Res Authority |
Vaccines
|
|
JP2001514001A
(ja)
|
1997-08-21 |
2001-09-11 |
オランダ国 |
グラム陰性粘膜細菌の新規突然変異株及びそのワクチンにおける応用
|
|
DE69815692T2
(de)
|
1997-09-05 |
2004-04-29 |
Glaxosmithkline Biologicals S.A. |
Öl in wasser emulsionen mit saponinen
|
|
EP1900818A3
(en)
|
1997-11-06 |
2008-06-11 |
Novartis Vaccines and Diagnostics S.r.l. |
Neisserial antigens
|
|
GB9725084D0
(en)
|
1997-11-28 |
1998-01-28 |
Medeva Europ Ltd |
Vaccine compositions
|
|
JP4399112B2
(ja)
|
1998-01-14 |
2010-01-13 |
カイロン ソチエタ ア レスポンサビリタ リミタータ |
NeisseriaMeningitidis抗原
|
|
EP1053015A2
(en)
|
1998-02-12 |
2000-11-22 |
American Cyanamid Company |
Pneumococcal and meningococcal vaccines formulated with interleukin-12
|
|
US6303114B1
(en)
|
1998-03-05 |
2001-10-16 |
The Medical College Of Ohio |
IL-12 enhancement of immune responses to T-independent antigens
|
|
KR20010042573A
(ko)
|
1998-04-09 |
2001-05-25 |
장 스테판느 |
애쥬번트 조성물
|
|
EP2261350A3
(en)
|
1998-05-01 |
2012-01-04 |
Novartis Vaccines and Diagnostics, Inc. |
Neisseria meningitidis antigens and compositions
|
|
US6562798B1
(en)
|
1998-06-05 |
2003-05-13 |
Dynavax Technologies Corp. |
Immunostimulatory oligonucleotides with modified bases and methods of use thereof
|
|
GB9817052D0
(en)
|
1998-08-05 |
1998-09-30 |
Smithkline Beecham Biolog |
Vaccine
|
|
DE69941574D1
(de)
|
1998-08-19 |
2009-12-03 |
Baxter Healthcare Sa |
Immunogenes beta-propionamido-gebundenes polysaccharid-protein konjugat geeignet als impfstoff und hergestellt bei verwendung von n-acryloyliertem polysaccharid
|
|
IL142395A0
(en)
|
1998-10-16 |
2002-03-10 |
Smithkline Beecham Biolog |
Adjuvant systems and vaccines
|
|
DK1535928T3
(da)
|
1998-10-22 |
2008-10-20 |
Univ Montana |
Vaccinesammensætninger indeholdende Omp85-proteiner af Neisseria gonorrhoeae og Neisseria meningitidis
|
|
GB9823978D0
(en)
|
1998-11-02 |
1998-12-30 |
Microbiological Res Authority |
Multicomponent meningococcal vaccine
|
|
WO2000033882A1
(en)
|
1998-12-04 |
2000-06-15 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
A vi-repa conjugate vaccine for immunization against salmonella typhi
|
|
ATE346608T1
(de)
|
1999-03-19 |
2006-12-15 |
Glaxosmithkline Biolog Sa |
Impstoff gegen streptococcus pneumoniae
|
|
JP2002541808A
(ja)
|
1999-04-09 |
2002-12-10 |
テクラブ, インコーポレイテッド |
ポリサッカリド結合体ワクチンのための組換えトキシンaタンパク質キャリア
|
|
GB9918319D0
(en)
|
1999-08-03 |
1999-10-06 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
MXPA02003067A
(es)
|
1999-09-24 |
2002-09-30 |
Smithkline Beecham Biolog |
Uso de combinacion de ester sorbitano de polioxietileno y octoxinol como adjuvante y su uso en vacunas.
|
|
MXPA02003068A
(es)
|
1999-09-24 |
2002-09-30 |
Smithkline Beecham Biolog |
Adyuvante que comprende un eter o ester alquilo de polioxietileno y al menos un tensioactivo no ionico..
|
|
GB9925559D0
(en)
|
1999-10-28 |
1999-12-29 |
Smithkline Beecham Biolog |
Novel method
|
|
JP3701826B2
(ja)
|
1999-11-12 |
2005-10-05 |
株式会社村上開明堂 |
有色防曇鏡
|
|
AU1917501A
(en)
|
1999-11-12 |
2001-06-06 |
University Of Iowa Research Foundation, The |
Control of neisserial membrane synthesis
|
|
RU2002117308A
(ru)
|
1999-11-29 |
2004-03-10 |
Чирон Спа (It) |
85 кДа АНТИГЕН NEISSERIA
|
|
DK2289545T3
(en)
|
2000-01-17 |
2016-09-05 |
Glaxosmithkline Biologicals Sa |
Supplemented OMV vaccine against meningococcus
|
|
WO2001095935A1
(en)
|
2000-01-20 |
2001-12-20 |
Ottawa Health Research Institute |
Immunostimulatory nucleic acids for inducing a th2 immune response
|
|
BR0107857A
(pt)
|
2000-01-25 |
2002-10-29 |
Univ Queensland |
Proteìnas compreendendo regiões conservadas de antìgeno nhha de superfìcie de neisseria meningitidis
|
|
EP1261723B1
(en)
|
2000-02-28 |
2008-02-27 |
Novartis Vaccines and Diagnostics S.r.l. |
Hybrid expression of neisserial proteins
|
|
GB0007432D0
(en)
|
2000-03-27 |
2000-05-17 |
Microbiological Res Authority |
Proteins for use as carriers in conjugate vaccines
|
|
NO20002828D0
(no)
|
2000-06-02 |
2000-06-02 |
Statens Inst For Folkehelse |
Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
|
|
AU2001280883A1
(en)
|
2000-07-27 |
2002-02-13 |
The Children's Hospital & Research Center At Oakland |
Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis
|
|
GB0103170D0
(en)
|
2001-02-08 |
2001-03-28 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
JP2004509970A
(ja)
|
2000-09-26 |
2004-04-02 |
ハイブリドン・インコーポレイテッド |
位置的化学変化による免疫刺激オリゴヌクレオチドアナログの免疫刺激活性の調節
|
|
NZ540544A
(en)
|
2000-10-27 |
2007-08-31 |
Inst Genomic Research |
Nucleic acids and proteins from streptococcus groups A & B
|
|
GB0103169D0
(en)
|
2001-02-08 |
2001-03-28 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
GB0103171D0
(en)
|
2001-02-08 |
2001-03-28 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
US20030035806A1
(en)
|
2001-05-11 |
2003-02-20 |
D'ambra Anello J. |
Novel meningitis conjugate vaccine
|
|
GB0115176D0
(en)
|
2001-06-20 |
2001-08-15 |
Chiron Spa |
Capular polysaccharide solubilisation and combination vaccines
|
|
RU2323002C2
(ru)
|
2001-07-26 |
2008-04-27 |
Чирон Срл. |
Вакцины, содержащие алюминиевые адъюванты и гистидин
|
|
GB0121591D0
(en)
|
2001-09-06 |
2001-10-24 |
Chiron Spa |
Hybrid and tandem expression of neisserial proteins
|
|
EP1450856B1
(en)
|
2001-09-14 |
2009-11-11 |
Cytos Biotechnology AG |
Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use
|
|
JP4360906B2
(ja)
|
2001-09-14 |
2009-11-11 |
サイトス バイオテクノロジー アーゲー |
ウィルス様粒子によって誘導される免疫応答を高めるための、抗原提示細胞のインビボでの活性化
|
|
MX339524B
(es)
|
2001-10-11 |
2016-05-30 |
Wyeth Corp |
Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
|
|
WO2003035836A2
(en)
|
2001-10-24 |
2003-05-01 |
Hybridon Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
|
|
GB0130123D0
(en)
|
2001-12-17 |
2002-02-06 |
Microbiological Res Agency |
Outer membrane vesicle vaccine and its preparation
|
|
BR0308768A
(pt)
|
2002-03-26 |
2005-02-15 |
Chiron Srl |
Sacarìdeos modificados possuindo estabilidade melhorada em água
|
|
DE20321889U1
(de)
|
2002-08-02 |
2012-03-12 |
Glaxosmithkline Biologicals S.A. |
Impfstoffzusammensetzung
|
|
GB0220194D0
(en)
|
2002-08-30 |
2002-10-09 |
Chiron Spa |
Improved vesicles
|
|
NZ562998A
(en)
|
2002-10-11 |
2008-05-30 |
Novartis Vaccines & Diagnostic |
Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages
|
|
CA2506318C
(en)
|
2002-11-15 |
2011-07-12 |
Chiron Srl |
Unexpected surface proteins in neisseria meningitidis
|
|
GB0227346D0
(en)
|
2002-11-22 |
2002-12-31 |
Chiron Spa |
741
|
|
CN1867354A
(zh)
|
2003-04-16 |
2006-11-22 |
惠氏控股有限公司 |
预防和治疗脑膜炎球菌疾病的新颖免疫原性组合物
|
|
GB0316560D0
(en)
|
2003-07-15 |
2003-08-20 |
Chiron Srl |
Vesicle filtration
|
|
GB0419408D0
(en)
|
2004-09-01 |
2004-10-06 |
Chiron Srl |
741 chimeric polypeptides
|
|
EP2682126B1
(en)
*
|
2005-01-27 |
2016-11-23 |
Children's Hospital & Research Center at Oakland |
GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis
|
|
GB0524066D0
(en)
*
|
2005-11-25 |
2006-01-04 |
Chiron Srl |
741 ii
|
|
WO2008001224A2
(en)
*
|
2006-06-29 |
2008-01-03 |
Novartis Ag |
Polypeptides from neisseria meningitidis
|
|
WO2009104097A2
(en)
*
|
2008-02-21 |
2009-08-27 |
Novartis Ag |
Meningococcal fhbp polypeptides
|
|
WO2010028096A2
(en)
*
|
2008-09-03 |
2010-03-11 |
Children's Hospital & Research Center At Oakland |
Peptides presenting an epitope of an a domain of factor h binding protein and methods of use
|
|
GB0819633D0
(en)
*
|
2008-10-25 |
2008-12-03 |
Isis Innovation |
Composition
|