BR112012008142A2 - conjugados de peptídeo/ polietilenoglicol liga dos a dissulfeto para a transfecção de ácidos nucleicos - Google Patents
conjugados de peptídeo/ polietilenoglicol liga dos a dissulfeto para a transfecção de ácidos nucleicosInfo
- Publication number
- BR112012008142A2 BR112012008142A2 BR112012008142A BR112012008142A BR112012008142A2 BR 112012008142 A2 BR112012008142 A2 BR 112012008142A2 BR 112012008142 A BR112012008142 A BR 112012008142A BR 112012008142 A BR112012008142 A BR 112012008142A BR 112012008142 A2 BR112012008142 A2 BR 112012008142A2
- Authority
- BR
- Brazil
- Prior art keywords
- inventive carrier
- disulfide
- nucleic acid
- polyethylene glycol
- linked peptide
- Prior art date
Links
- 108020004707 nucleic acids Proteins 0.000 title abstract 4
- 150000007523 nucleic acids Chemical class 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 4
- 238000001890 transfection Methods 0.000 title abstract 3
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 title abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Pulmonology (AREA)
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- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
Abstract
conjugados de peptídeo/ polietilenoglicol liga dos a dissulfeto para a transfecção de ácidos nucleicos. a presente invenção refere-se a molécula polimérica veículo inventiva de acordo com a fórmula geral (i) e suas variações, a qual permite a transfecção eficiente de ácidos nucleicos em células in vivo e in vitro, um complexo de carga veículo polimérico formado por meio de um ácido nucleico e por meio da molécula polimérica veículo inventive, mas também aos métodos de preparação dessa molécula polimérica veículo inventiva e do complexo de carga veículo polimérico inventivo. a presente invenção também refere-se métodos de aplicação e uso desta molécula polimérica veículo inventiva e o complexo carga veículo polimérico inventivo como um medicamento, para o tratamento de várias doenças, e na preparação de uma composição farmacêutica para o tratamento de tais doenças.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/553,559 US20110053829A1 (en) | 2009-09-03 | 2009-09-03 | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
PCT/EP2010/005438 WO2011026641A1 (en) | 2009-09-03 | 2010-09-03 | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112012008142A2 true BR112012008142A2 (pt) | 2016-03-01 |
BR112012008142A8 BR112012008142A8 (pt) | 2016-10-11 |
Family
ID=42752368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012008142A BR112012008142A8 (pt) | 2009-09-03 | 2010-09-03 | conjugados de peptídeo/ polietilenoglicol ligados a dissulfeto para a transfecção de ácidos nucleicos |
Country Status (15)
Country | Link |
---|---|
US (6) | US20110053829A1 (pt) |
EP (2) | EP2810661A3 (pt) |
JP (1) | JP5813642B2 (pt) |
KR (3) | KR101572249B1 (pt) |
CN (1) | CN102573919B (pt) |
AU (1) | AU2010291499B2 (pt) |
BR (1) | BR112012008142A8 (pt) |
CA (1) | CA2765421C (pt) |
DK (1) | DK2331138T3 (pt) |
ES (1) | ES2526055T3 (pt) |
MX (1) | MX2012002502A (pt) |
PL (1) | PL2331138T3 (pt) |
RU (1) | RU2552352C2 (pt) |
SG (1) | SG178013A1 (pt) |
WO (1) | WO2011026641A1 (pt) |
Families Citing this family (227)
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WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
WO2009046738A1 (en) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition for treating lung cancer, particularly of non-small lung cancers (nsclc) |
WO2009046739A1 (en) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition for treating prostate cancer (pca) |
CN102014937A (zh) | 2008-03-03 | 2011-04-13 | 迈阿密大学 | 基于异基因癌细胞的免疫治疗 |
WO2010037408A1 (en) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
WO2011069529A1 (en) | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids |
EP2449113B8 (en) * | 2010-07-30 | 2015-11-25 | CureVac AG | Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation |
US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
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