BR0115312A - Derivados heterociclilalquil piperidina, sua preparação e as composições que os contêm - Google Patents

Derivados heterociclilalquil piperidina, sua preparação e as composições que os contêm

Info

Publication number
BR0115312A
BR0115312A BR0115312-9A BR0115312A BR0115312A BR 0115312 A BR0115312 A BR 0115312A BR 0115312 A BR0115312 A BR 0115312A BR 0115312 A BR0115312 A BR 0115312A
Authority
BR
Brazil
Prior art keywords
piperidine derivatives
preparation
compositions containing
phenyl
heterocyclylalkyl
Prior art date
Application number
BR0115312-9A
Other languages
English (en)
Inventor
Eric Bacque
Serge Mignani
Guy Pantel
Michel Tabart
Fabrice Viviani
Jean-Christophe Carry
Youssef El-Ahmad
Michel Evers
Philippe Hubert
Jean-Luc Malleron
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BR0115312A publication Critical patent/BR0115312A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

"DERIVADOS HETEROCICLILALQUIL PIPERIDINA, SUA PREPARAçãO E AS COMPOSIçõES QUE OS CONTêM". A invenção refere-se aos derivados heterociclilalquil piperidina de fórmula geral (I) para os quais: X~ 1~, X~ 2~, X~ 3~, X~ 4~ e X~ 5~ são >C-R'~ 1~ a >C-R'~ 5~, ou então pelo menos um entre estes representa N, R~ 2~ é COOH, alquiloxicarbonila, cicloalquiloxicarbonila, CN, -CONRaRb ou R~ 2~ é CH~ 2~OH, alquila substituída ou R~ 2~ é -CF~ 2~-Rc, -C(CH~ 3~)~ 2~-Rc, -CO-Rc, -CHOH-Rc, -C(cicloalquila)-Rc ou -CH=CH-Rc, R~ 3~ é fenila, heterociclila, alk-R^ O^~ 3~, Y representa >CH-Re ou um radical difluorometileno, carbonila, hidroxiiminometileno, alquiloxiiminometileno, cicloalquiloxiiminometileno, ou um radical cicloalquileno-1,1, e n = 0 a 4 ficando entendido que os radicais ou porções fenila ou heterociclila mencionados acima podem ser eventualmente substituídos, sob suas formas enantioméricas ou diaestereoisoméricas ou as misturas dessas formas, e/ou se for o caso sob sua forma sin ou anti ou sua mistura assim como seus sais.
BR0115312-9A 2000-11-15 2001-11-14 Derivados heterociclilalquil piperidina, sua preparação e as composições que os contêm BR0115312A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0014738A FR2816618B1 (fr) 2000-11-15 2000-11-15 Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
PCT/FR2001/003559 WO2002040474A2 (fr) 2000-11-15 2001-11-14 Derives heterocyclylalcoyl piperidine et leur application comme antimicrobiens

Publications (1)

Publication Number Publication Date
BR0115312A true BR0115312A (pt) 2003-09-23

Family

ID=8856503

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115312-9A BR0115312A (pt) 2000-11-15 2001-11-14 Derivados heterociclilalquil piperidina, sua preparação e as composições que os contêm

Country Status (28)

Country Link
EP (2) EP1337529B1 (pt)
JP (1) JP2004514661A (pt)
KR (1) KR100849608B1 (pt)
CN (1) CN1483031A (pt)
AR (1) AR034006A1 (pt)
AT (1) ATE337311T1 (pt)
AU (2) AU2002218365B2 (pt)
BG (1) BG107793A (pt)
BR (1) BR0115312A (pt)
CA (1) CA2429311A1 (pt)
CZ (1) CZ20031316A3 (pt)
DE (1) DE60122567T2 (pt)
DK (1) DK1337529T3 (pt)
EA (1) EA200300568A1 (pt)
EE (1) EE200300207A (pt)
ES (1) ES2271119T3 (pt)
FR (1) FR2816618B1 (pt)
HR (1) HRP20030379A2 (pt)
HU (1) HUP0303758A3 (pt)
IL (1) IL155841A0 (pt)
NO (2) NO20032187L (pt)
PL (1) PL363004A1 (pt)
PT (1) PT1337529E (pt)
SK (1) SK5822003A3 (pt)
TN (1) TNSN01160A1 (pt)
WO (1) WO2002040474A2 (pt)
YU (1) YU46803A (pt)
ZA (1) ZA200303794B (pt)

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EP1305308B1 (en) 2000-07-26 2006-12-20 Smithkline Beecham Plc Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0118238D0 (en) * 2001-07-26 2001-09-19 Smithkline Beecham Plc Medicaments
WO2003064431A2 (en) 2002-01-29 2003-08-07 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
JP4445753B2 (ja) 2002-01-29 2010-04-07 グラクソ グループ リミテッド アミノピペリジン誘導体
AR040335A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
FR2842807A1 (fr) 2002-07-23 2004-01-30 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant
GB0217294D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicaments
FR2844270B1 (fr) * 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
DE10256405A1 (de) * 2002-12-02 2004-06-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Topoisomerase IV inhibieren
WO2004096982A2 (en) 2002-11-05 2004-11-11 Smithkline Beecham Corporation Antibacterial agents
US7491714B2 (en) 2002-12-04 2009-02-17 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
FR2852954B1 (fr) * 2003-03-28 2006-07-14 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
US7232833B2 (en) 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
FR2862301B1 (fr) * 2003-11-17 2007-12-21 Aventis Pharma Sa Nouveau procede de preparation de quinoleines 3-fluorees
FR2867472B1 (fr) * 2004-03-12 2008-07-18 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
EP1846416A4 (en) 2005-01-25 2009-07-01 Glaxo Group Ltd ANTIBACTERIAL AGENTS
JP2008528587A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP2008528588A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
WO2006081264A1 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
EP1853566A1 (en) 2005-03-01 2007-11-14 Wyeth Cinnoline compounds and their use as liver x receptor modulators
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
CA2635126A1 (en) 2006-01-26 2007-08-02 Actelion Pharmaceuticals Ltd Tetrahydropyrane antibiotics
DE602007009205D1 (de) 2006-04-06 2010-10-28 Glaxo Group Ltd Pyrrolochinoxalinonderivate als antibakterielle mittel
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
ATE520687T1 (de) 2007-06-15 2011-09-15 Actelion Pharmaceuticals Ltd 3-amino-6-(1-amino-ethyl)-tetrahydropyranderiva e
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
US20110275661A1 (en) 2008-10-17 2011-11-10 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
ES2561631T3 (es) 2009-01-15 2016-02-29 Glaxo Group Limited Compuestos de naftiridin-2(1H)-ona útiles como agentes antibacterianos
KR20150043465A (ko) * 2012-08-15 2015-04-22 글락소 그룹 리미티드 화학 공정
JP6546654B2 (ja) 2014-08-22 2019-07-17 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 淋菌感染を治療するための三環式含窒素化合物
WO2016138988A1 (en) * 2015-03-02 2016-09-09 University Of Copenhagen Piperazine inhibitors of bacterial gyrase and topoisomerase iv
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物

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Publication number Priority date Publication date Assignee Title
NL7908031A (nl) 1979-11-01 1981-06-01 Acf Chemiefarma Nv Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.
JPH0239546A (ja) 1988-07-29 1990-02-08 Origin Electric Co Ltd 混成集積回路の製造方法
NZ232091A (en) 1989-01-16 1990-12-21 Bellon Labor Sa Roger 7-fluoro-8-(piperazin-1-yl)-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof
EP1051413B1 (en) * 1998-01-26 2003-06-04 SmithKline Beecham plc Quinoline derivatives as antibacterials
AU2437900A (en) * 1999-01-20 2000-08-07 Smithkline Beecham Plc Piperidinylquinolines as protein tyrosine kinase inhibitors
FR2852954B1 (fr) * 2003-03-28 2006-07-14 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
AR034006A1 (es) 2004-01-21
NO20032187L (no) 2003-06-26
ATE337311T1 (de) 2006-09-15
AU2002218365B2 (en) 2007-07-05
EP1337529B1 (fr) 2006-08-23
DK1337529T3 (da) 2006-12-18
PL363004A1 (en) 2004-11-15
EP1337529A2 (fr) 2003-08-27
KR20030060934A (ko) 2003-07-16
HRP20030379A2 (en) 2005-04-30
EA200300568A1 (ru) 2003-12-25
NO20032187D0 (no) 2003-05-14
DE60122567T2 (de) 2007-08-23
YU46803A (sh) 2006-05-25
CA2429311A1 (en) 2002-05-23
NO20072142L (no) 2007-04-25
DE60122567D1 (de) 2006-10-05
AU1836502A (en) 2002-05-27
BG107793A (bg) 2004-08-31
CZ20031316A3 (cs) 2003-10-15
ES2271119T3 (es) 2007-04-16
WO2002040474A3 (fr) 2002-10-31
JP2004514661A (ja) 2004-05-20
KR100849608B1 (ko) 2008-07-31
HUP0303758A3 (en) 2009-08-28
SK5822003A3 (en) 2004-06-08
EE200300207A (et) 2003-08-15
TNSN01160A1 (fr) 2005-11-10
ZA200303794B (en) 2004-06-29
HUP0303758A2 (hu) 2004-03-01
EP1695964A1 (fr) 2006-08-30
IL155841A0 (en) 2003-12-23
FR2816618B1 (fr) 2002-12-27
PT1337529E (pt) 2006-12-29
CN1483031A (zh) 2004-03-17
FR2816618A1 (fr) 2002-05-17
WO2002040474A2 (fr) 2002-05-23

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]