YU46803A - Heterociklilalkil piperidin derivati, njihova priprema i njihovi farmaceutski oblici - Google Patents
Heterociklilalkil piperidin derivati, njihova priprema i njihovi farmaceutski obliciInfo
- Publication number
- YU46803A YU46803A YU46803A YUP46803A YU46803A YU 46803 A YU46803 A YU 46803A YU 46803 A YU46803 A YU 46803A YU P46803 A YUP46803 A YU P46803A YU 46803 A YU46803 A YU 46803A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- piperidine derivatives
- preparation
- compositions containing
- containing same
- radical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Pronalazak se odnosi na heterocikloalkil piperidin derivate opšte formule (I), gde X1, X2, X3, X4, i X5 su >C-R'5 do >C-R'5 gde jedan ili više njih je N; R2 je COOH alkiloksikarbonil, cikloalkiloksikarbonil, CN, -CONRaRb ili R2 je CH2OH, alkil supstituisani -CH=CH-Rc; R3 je fenil, heterociklil, alk-R03; Y predstavlja >CH-Re ili difluormetilen, karbonil, hidroksiiminometilen, alkiloksiimonometilen, cikloalkiloksiiminometilen radikal, ili cikloalkilen-1,1 radikal; i n=o do 4 gde se podrazumeva da radikali ili fenil ili heterociklične grupe koje su gore spomenute opcionalno mogu biti zamenjene, u enantiomernim ili diastereoizomernim oblicima ili njihovim smešama, i/ili kao što može biti slučaj u njihovim sin ili anti formama ili njihovim smešama i njihovim solima.[The invention concerns heterocyclylalkyl piperidine derivatives of general formula (I), wherein X1, X2, X3, X4 and X5 are >C-R'1 to >C-R'5 or one at most represents N; R2 is COOH, alkyloxycarbonyl, cycloalkyloxycarbonyl, CN, -CONRaRb or R2 is CH2OH, alkyl substituted or R2 is -CF2-Rc, -C(CH3)2-Rc, -CO-Rc, -CHOH-Rc, -C(cycloalkyl)-Rc or -CH=CH-Rc; R3 is phenyl, heterocyclyl. alk-RГє3; Y represents >CH-Re or a difluoromethylene, carbonyl, hydroxyiminomethylene, alkyloxyiminomethylene, cycloalkyloxyiminomethylene radical, or a cycloalkylene-1,1 radical; and n = 0 to 4 provided that the radicals or phenyl or heterocyclyl portions mentioned above can optionally be substituted, in the enantiomeric or diastereoisomeric forms or mixtures thereof, and/or as the case may be in their syn or anti form or mixture thereof and their salts.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0014738A FR2816618B1 (fr) | 2000-11-15 | 2000-11-15 | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU46803A true YU46803A (sh) | 2006-05-25 |
Family
ID=8856503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU46803A YU46803A (sh) | 2000-11-15 | 2001-11-14 | Heterociklilalkil piperidin derivati, njihova priprema i njihovi farmaceutski oblici |
Country Status (28)
| Country | Link |
|---|---|
| EP (2) | EP1695964A1 (sh) |
| JP (1) | JP2004514661A (sh) |
| KR (1) | KR100849608B1 (sh) |
| CN (1) | CN1483031A (sh) |
| AR (1) | AR034006A1 (sh) |
| AT (1) | ATE337311T1 (sh) |
| AU (2) | AU1836502A (sh) |
| BG (1) | BG107793A (sh) |
| BR (1) | BR0115312A (sh) |
| CA (1) | CA2429311A1 (sh) |
| CZ (1) | CZ20031316A3 (sh) |
| DE (1) | DE60122567T2 (sh) |
| DK (1) | DK1337529T3 (sh) |
| EA (1) | EA200300568A1 (sh) |
| EE (1) | EE200300207A (sh) |
| ES (1) | ES2271119T3 (sh) |
| FR (1) | FR2816618B1 (sh) |
| HR (1) | HRP20030379A2 (sh) |
| HU (1) | HUP0303758A3 (sh) |
| IL (1) | IL155841A0 (sh) |
| NO (2) | NO20032187L (sh) |
| PL (1) | PL363004A1 (sh) |
| PT (1) | PT1337529E (sh) |
| SK (1) | SK5822003A3 (sh) |
| TN (1) | TNSN01160A1 (sh) |
| WO (1) | WO2002040474A2 (sh) |
| YU (1) | YU46803A (sh) |
| ZA (1) | ZA200303794B (sh) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030019621A (ko) | 2000-07-26 | 2003-03-06 | 스미스클라인비이참피이엘시이 | 항균 활성을 갖는 아미노피페리딘 퀴놀린 및 그의아자이소스테릭 유사체 |
| GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| AR038240A1 (es) | 2002-01-29 | 2005-01-05 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para su preparacion |
| JP4508650B2 (ja) | 2002-01-29 | 2010-07-21 | グラクソ グループ リミテッド | アミノピペリジン化合物、当該化合物の製法および当該化合物を含有する医薬組成物 |
| TW200406413A (en) | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
| AR040336A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| FR2842807A1 (fr) | 2002-07-23 | 2004-01-30 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant |
| GB0217294D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicaments |
| FR2844270B1 (fr) | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
| FR2844268B1 (fr) * | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| DE10256405A1 (de) * | 2002-12-02 | 2004-06-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen, die Topoisomerase IV inhibieren |
| JP4704755B2 (ja) | 2002-11-05 | 2011-06-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
| ES2312839T3 (es) | 2002-12-04 | 2009-03-01 | Glaxo Group Limited | Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos. |
| US7232833B2 (en) | 2003-03-28 | 2007-06-19 | Novexel | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
| FR2852954B1 (fr) * | 2003-03-28 | 2006-07-14 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2862301B1 (fr) * | 2003-11-17 | 2007-12-21 | Aventis Pharma Sa | Nouveau procede de preparation de quinoleines 3-fluorees |
| FR2867472B1 (fr) * | 2004-03-12 | 2008-07-18 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| US7709472B2 (en) | 2005-01-25 | 2010-05-04 | Glaxo Group Limited | Antibacterial agents |
| WO2006081264A1 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| EP1846418A4 (en) | 2005-01-25 | 2009-12-23 | Glaxo Group Ltd | ANTIBACTERIAL ACTIVE SUBSTANCES |
| EP1846416A4 (en) | 2005-01-25 | 2009-07-01 | Glaxo Group Ltd | ANTIBACTERIAL AGENTS |
| JP2008531709A (ja) | 2005-03-01 | 2008-08-14 | ワイス | シンノリン化合物および肝臓ｘ受容体調節物質としてのそれらの使用 |
| MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| CA2635126A1 (en) | 2006-01-26 | 2007-08-02 | Actelion Pharmaceuticals Ltd | Tetrahydropyrane antibiotics |
| WO2007115947A1 (en) | 2006-04-06 | 2007-10-18 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| MX2009013254A (es) | 2007-06-15 | 2010-01-25 | Actelion Pharmaceuticals Ltd | Derivados 3-amino-6(1-amino-etil)-tetrahidropirano. |
| EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
| US20110275661A1 (en) | 2008-10-17 | 2011-11-10 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
| US8318940B2 (en) | 2009-01-15 | 2012-11-27 | Glaxo Group Limited | Naphthyridin-2 (1 H)-one compounds useful as antibacterials |
| US9273001B2 (en) * | 2012-08-15 | 2016-03-01 | Glaxo Group Limited | Chemical process |
| MX2017002321A (es) | 2014-08-22 | 2017-08-02 | Glaxosmithkline Ip Dev Ltd | Compuestos que contienen nitrogeno triciclico para tratar infeccion por neisseria gonorrhoeae. |
| WO2016138988A1 (en) * | 2015-03-02 | 2016-09-09 | University Of Copenhagen | Piperazine inhibitors of bacterial gyrase and topoisomerase iv |
| UY36851A (es) | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7908031A (nl) | 1979-11-01 | 1981-06-01 | Acf Chemiefarma Nv | Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen. |
| JPH0239546A (ja) | 1988-07-29 | 1990-02-08 | Origin Electric Co Ltd | 混成集積回路の製造方法 |
| NZ232091A (en) | 1989-01-16 | 1990-12-21 | Bellon Labor Sa Roger | 7-fluoro-8-(piperazin-1-yl)-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof |
| WO1999037635A1 (en) * | 1998-01-26 | 1999-07-29 | Smithkline Beecham Plc | Quinoline derivatives as antibacterials |
| EP1144404A1 (en) * | 1999-01-20 | 2001-10-17 | Smithkline Beecham Plc | Piperidinylquinolines as protein tyrosine kinase inhibitors |
| FR2852954B1 (fr) * | 2003-03-28 | 2006-07-14 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
-
2000
- 2000-11-15 FR FR0014738A patent/FR2816618B1/fr not_active Expired - Fee Related
-
2001
- 2001-11-13 AR ARP010105289A patent/AR034006A1/es unknown
- 2001-11-14 EP EP06010725A patent/EP1695964A1/fr not_active Withdrawn
- 2001-11-14 ES ES01996538T patent/ES2271119T3/es not_active Expired - Lifetime
- 2001-11-14 EE EEP200300207A patent/EE200300207A/xx unknown
- 2001-11-14 DE DE60122567T patent/DE60122567T2/de not_active Expired - Fee Related
- 2001-11-14 EP EP01996538A patent/EP1337529B1/fr not_active Expired - Lifetime
- 2001-11-14 PL PL01363004A patent/PL363004A1/xx not_active Application Discontinuation
- 2001-11-14 CZ CZ20031316A patent/CZ20031316A3/cs unknown
- 2001-11-14 BR BR0115312-9A patent/BR0115312A/pt not_active Application Discontinuation
- 2001-11-14 TN TNTNSN01160A patent/TNSN01160A1/fr unknown
- 2001-11-14 CA CA002429311A patent/CA2429311A1/en not_active Abandoned
- 2001-11-14 SK SK582-2003A patent/SK5822003A3/sk unknown
- 2001-11-14 PT PT01996538T patent/PT1337529E/pt unknown
- 2001-11-14 AU AU1836502A patent/AU1836502A/xx active Pending
- 2001-11-14 KR KR1020037006600A patent/KR100849608B1/ko not_active IP Right Cessation
- 2001-11-14 HU HU0303758A patent/HUP0303758A3/hu unknown
- 2001-11-14 YU YU46803A patent/YU46803A/sh unknown
- 2001-11-14 DK DK01996538T patent/DK1337529T3/da active
- 2001-11-14 CN CNA018210996A patent/CN1483031A/zh active Pending
- 2001-11-14 IL IL15584101A patent/IL155841A0/xx unknown
- 2001-11-14 EA EA200300568A patent/EA200300568A1/ru unknown
- 2001-11-14 JP JP2002543484A patent/JP2004514661A/ja active Pending
- 2001-11-14 AT AT01996538T patent/ATE337311T1/de not_active IP Right Cessation
- 2001-11-14 WO PCT/FR2001/003559 patent/WO2002040474A2/fr active IP Right Grant
- 2001-11-14 AU AU2002218365A patent/AU2002218365B2/en not_active Ceased
-
2003
- 2003-05-09 BG BG107793A patent/BG107793A/bg unknown
- 2003-05-13 HR HR20030379A patent/HRP20030379A2/hr not_active Application Discontinuation
- 2003-05-14 NO NO20032187A patent/NO20032187L/no unknown
- 2003-05-15 ZA ZA200303794A patent/ZA200303794B/xx unknown
-
2007
- 2007-04-25 NO NO20072142A patent/NO20072142L/no not_active Application Discontinuation
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