DE3881489D1 - Peptide mit collagenase hemmender wirkung. - Google Patents

Peptide mit collagenase hemmender wirkung.

Info

Publication number
DE3881489D1
DE3881489D1 DE8888310492T DE3881489T DE3881489D1 DE 3881489 D1 DE3881489 D1 DE 3881489D1 DE 8888310492 T DE8888310492 T DE 8888310492T DE 3881489 T DE3881489 T DE 3881489T DE 3881489 D1 DE3881489 D1 DE 3881489D1
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
peptides
inhibiting effect
collagenase inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888310492T
Other languages
English (en)
Other versions
DE3881489T2 (de
Inventor
David James Beecham Pha Hunter
Roger Edward Beecham Markwell
Robert William Beecham Ph Ward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of DE3881489D1 publication Critical patent/DE3881489D1/de
Application granted granted Critical
Publication of DE3881489T2 publication Critical patent/DE3881489T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE8888310492T 1987-11-14 1988-11-08 Peptide mit collagenase hemmender wirkung. Expired - Fee Related DE3881489T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878726714A GB8726714D0 (en) 1987-11-14 1987-11-14 Compounds

Publications (2)

Publication Number Publication Date
DE3881489D1 true DE3881489D1 (de) 1993-07-08
DE3881489T2 DE3881489T2 (de) 1993-09-16

Family

ID=10626975

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888310492T Expired - Fee Related DE3881489T2 (de) 1987-11-14 1988-11-08 Peptide mit collagenase hemmender wirkung.

Country Status (15)

Country Link
US (1) US4935404A (de)
EP (1) EP0320118B1 (de)
JP (1) JPH01160992A (de)
KR (1) KR890008155A (de)
AT (1) ATE90107T1 (de)
AU (1) AU609900B2 (de)
CA (1) CA1322076C (de)
DE (1) DE3881489T2 (de)
DK (1) DK633088A (de)
ES (1) ES2054826T3 (de)
GB (1) GB8726714D0 (de)
IE (1) IE883391L (de)
NZ (1) NZ226930A (de)
PT (1) PT88992B (de)
ZA (1) ZA888448B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212163A (en) * 1989-04-13 1993-05-18 Beecham Group P.L.C. Compounds
EP0401963A1 (de) * 1989-04-13 1990-12-12 Beecham Group p.l.c. Phosphonopeptide mit kollagenase-inhibitierender Wirkung
GB8921326D0 (en) * 1989-09-21 1989-11-08 Beecham Group Plc Novel treatment
FR2654430B1 (fr) * 1989-11-15 1995-01-06 Commissariat Energie Atomique Nouveaux derives de peptides, utilisables comme inhibiteurs des collagenases bacteriennes.
GB9008065D0 (en) * 1990-04-10 1990-06-06 Beecham Group Plc Novel compounds
GB9008078D0 (en) * 1990-04-10 1990-06-06 Beecham Group Plc Novel compounds
US5155100A (en) * 1991-05-01 1992-10-13 Ciba-Geigy Corporation Phosphono/biaryl substituted dipeptide derivatives
US5294632A (en) * 1991-05-01 1994-03-15 Ciba-Geigy Corporation Phosphono/biaryl substituted dipetide derivatives
EP0520573A1 (de) * 1991-06-27 1992-12-30 Glaxo Inc. Derivate von cyclischen Imiden
US5250522A (en) * 1992-10-09 1993-10-05 Ciba-Geigy Corporation Phosphono/biaryl substituted amino acid derivatives
GB9122859D0 (en) * 1991-10-28 1991-12-11 Smithkline Beecham Plc Novel compounds
JPH05148277A (ja) * 1991-11-05 1993-06-15 Banyu Pharmaceut Co Ltd アミノホスホン酸誘導体
US5504070A (en) * 1991-12-05 1996-04-02 Berlex Laboratories, Inc. Inhibitors of the conversion of big endothelin to endothelin
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
CA2126687A1 (en) * 1992-01-15 1993-07-22 Charles G. Caldwell Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents
AU4267293A (en) * 1992-05-01 1993-11-29 British Biotech Pharmaceuticals Limited Use of MMP inhibitors
US5326760A (en) * 1992-06-29 1994-07-05 Glaxo, Inc. Aminobutanoic acid compounds having metalloprotease inhibiting properties
AU5292193A (en) * 1992-10-02 1994-04-26 Merck & Co., Inc. N-(mercaptoacyl)peptidyl derivatives as antidegenerative agents
US6090785A (en) * 1992-10-15 2000-07-18 Merck & Co., Inc. Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents
WO1994012169A1 (en) * 1992-11-25 1994-06-09 Merck & Co., Inc. Carboxy-peptidyl derivatives as antidegenerative active agents
US5608078A (en) * 1993-03-30 1997-03-04 Merrell Pharmaceuticals Inc. Phosphonomethyldipeptides and process for preparation thereof
EP0618224A1 (de) * 1993-03-30 1994-10-05 Merrell Dow Pharmaceuticals Inc. Phosophonomethyldipeptide
CA2160139A1 (en) * 1993-04-07 1994-10-13 Richard Edward Galardy Synthetic matrix metalloprotease inhibitors and uses thereof
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US6117841A (en) * 1997-05-30 2000-09-12 Warner-Lambert Company Substituted peptidylamine calcium channel blockers
EP0922702A1 (de) * 1997-12-13 1999-06-16 Roche Diagnostics GmbH Neue Azulenderivate und diese enthaltende Arzneimittel
AR033651A1 (es) 1999-10-01 2004-01-07 Hoffmann La Roche Derivados de pirimidina-2,4,6-triona, composiciones farmaceuticas que contienen dichos compuestos y el empleo de los mismos para la manufactura de un medicamento
US6716845B2 (en) 2001-03-30 2004-04-06 Hoffmann-La Roche Inc. Barbituric acid derivatives
US7420000B2 (en) * 2003-09-10 2008-09-02 University Of Southern California Amino phosphonate and amino bis-phosphonate derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950402A (en) * 1972-05-31 1976-04-13 Monsanto Company Process for producing N-phosphonomethyl glycine
IL48835A (en) * 1975-01-27 1979-05-31 Sparamedica Ag Amino acyl and peptidyl derivatives of phophonic acids, their preparation and pharmaceutical compositions containingthem
EP0002039A1 (de) * 1977-11-19 1979-05-30 Ciba-Geigy Ag Phosphonigsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung in der Mikroorganismenbekämpfung
US4331591A (en) * 1978-10-05 1982-05-25 Ciba-Geigy Corporation Chemical process for the production of α-aminophosphonic acids and peptide derivatives
US4389349A (en) * 1982-01-25 1983-06-21 Cho Hung H Process for preparing of N-phosphenomethyl glycine
US4661298A (en) * 1983-08-31 1987-04-28 Stauffer Chemical Company Process for the formation of phosphonoalkylated amino acids
US4804500A (en) * 1985-04-22 1989-02-14 Monsanto Company Amine dealkylation process

Also Published As

Publication number Publication date
AU2507088A (en) 1989-05-25
ES2054826T3 (es) 1994-08-16
EP0320118B1 (de) 1993-06-02
JPH01160992A (ja) 1989-06-23
GB8726714D0 (en) 1987-12-16
EP0320118A2 (de) 1989-06-14
PT88992A (pt) 1988-12-01
KR890008155A (ko) 1989-07-10
ZA888448B (en) 1989-10-25
IE883391L (en) 1989-05-14
DK633088D0 (da) 1988-11-11
NZ226930A (en) 1991-07-26
PT88992B (pt) 1993-02-26
CA1322076C (en) 1993-09-07
ATE90107T1 (de) 1993-06-15
DE3881489T2 (de) 1993-09-16
EP0320118A3 (en) 1990-07-04
AU609900B2 (en) 1991-05-09
US4935404A (en) 1990-06-19
DK633088A (da) 1989-05-15

Similar Documents

Publication Publication Date Title
DE3881489D1 (de) Peptide mit collagenase hemmender wirkung.
DK114783A (da) Hidtil ukendte forbindelser, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
DE3776880D1 (de) Neue substituierte alkandiphosphonsaeuren.
ES8506001A1 (es) Un procedimiento para preparar compuestos de imidazol fusionados
TW368501B (en) 7-(2-aminoethyl)-benzothiazolones
ES2058531T3 (es) Amidas de mercapto-fenilalcanoilaminoacidos, su preparacion y su uso como inhibidores de colagenasa.
FI101301B1 (fi) Menetelmä terapeuttisesti käyttökelpoisten, N-substituoitujen heksahydroatsepiinijohdannaisten valmistamiseksi
PL243132A1 (en) Process for manufacturing novel muramyl peptides
PT91607A (pt) Process for the preparation of substituted beta-diketones and of pharmaceutical compositions containing them
GR3006821T3 (de)
NO873564D0 (no) Nye tyroninderivater.
ES8703433A1 (es) Un procedimiento para preparar un derivado triciclico de pi-ridazinona
AU9035491A (en) Chiral hydantoin resolution
ES2040223T3 (es) Derivados de la tiadiazolilacetamida, procedimiento para su fabricacion y su utilizacion.
DE3788369D1 (de) Verfahren zur Herstellung von Cephalosporinderivaten.
EA200100163A1 (ru) Новые производные 6-деоксиэритромицина, способ их получения и их применение в качестве лекарственных средств
FI863897A (fi) Kemiskt foerfarande.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee