BG64624B1 - (бензодиоксанови, бензофуранови или бензопиранови) производни, притежаващи фундусни релаксиращи свойства - Google Patents
(бензодиоксанови, бензофуранови или бензопиранови) производни, притежаващи фундусни релаксиращи свойства Download PDFInfo
- Publication number
- BG64624B1 BG64624B1 BG104372A BG10437200A BG64624B1 BG 64624 B1 BG64624 B1 BG 64624B1 BG 104372 A BG104372 A BG 104372A BG 10437200 A BG10437200 A BG 10437200A BG 64624 B1 BG64624 B1 BG 64624B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- formula
- alkyl
- hydrogen
- radical
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97203808 | 1997-12-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
BG104372A BG104372A (en) | 2000-12-29 |
BG64624B1 true BG64624B1 (bg) | 2005-09-30 |
Family
ID=8229014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG104372A BG64624B1 (bg) | 1997-12-05 | 2000-04-24 | (бензодиоксанови, бензофуранови или бензопиранови) производни, притежаващи фундусни релаксиращи свойства |
Country Status (32)
Country | Link |
---|---|
US (4) | US6133277A (es) |
EP (1) | EP1036073B8 (es) |
JP (1) | JP2001525407A (es) |
KR (1) | KR100591605B1 (es) |
CN (1) | CN1155597C (es) |
AR (1) | AR017195A1 (es) |
AT (1) | ATE334125T1 (es) |
AU (1) | AU748669B2 (es) |
BG (1) | BG64624B1 (es) |
BR (1) | BR9814256A (es) |
CA (1) | CA2311669C (es) |
CO (1) | CO5011114A1 (es) |
CZ (1) | CZ297895B6 (es) |
DE (1) | DE69835372T2 (es) |
EA (1) | EA003365B1 (es) |
EE (1) | EE04438B1 (es) |
ES (1) | ES2270541T3 (es) |
HK (1) | HK1028400A1 (es) |
HR (1) | HRP20000340B1 (es) |
HU (1) | HU224813B1 (es) |
ID (1) | ID24616A (es) |
IL (1) | IL136529A (es) |
MY (1) | MY124586A (es) |
NO (1) | NO320727B1 (es) |
NZ (1) | NZ503603A (es) |
PL (1) | PL191144B1 (es) |
SK (1) | SK286268B6 (es) |
TR (1) | TR200001542T2 (es) |
TW (1) | TW577886B (es) |
UA (1) | UA70308C2 (es) |
WO (1) | WO1999029687A1 (es) |
ZA (1) | ZA9811081B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6133277A (en) | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
PL198532B1 (pl) * | 1999-06-02 | 2008-06-30 | Janssen Pharmaceutica Nv | Pochodna benzopiranu podstawiona pirolidynylem, piperydynylem lub homopiperydynylem i sposób jej otrzymywania oraz kompozycja farmaceutyczna i sposób jej otrzymywania |
DK1187829T3 (da) * | 1999-06-02 | 2004-04-13 | Janssen Pharmaceutica Nv | Aminoalkylsubstituerede (benzodioxan, benzofuran eller benzopyran) derivater |
JO2352B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
JO2409B1 (en) * | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
US6688079B2 (en) | 2001-04-18 | 2004-02-10 | Kraft Foods Holdings, Inc. | Method for manufacturing flexible packages having slide closures |
US20050014818A1 (en) * | 2001-11-09 | 2005-01-20 | Masaru Mitsuda | Process for producing optically active chroman derivative and intermediate |
ES2199086B1 (es) | 2002-07-31 | 2005-06-01 | Cepa Schwarz Pharma Sl | Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas. |
US7071821B2 (en) * | 2003-05-14 | 2006-07-04 | Bellsouth Intellectual Property Corporation | Method and system for alerting a person to a situation |
ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
WO2005032544A1 (en) | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | Treatment of mitochondrial diseases |
EP1687277B1 (en) | 2003-11-20 | 2018-04-04 | Janssen Pharmaceutica NV | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
CN1882549B (zh) | 2003-11-20 | 2011-02-23 | 詹森药业有限公司 | 用作聚(adp-核糖)聚合酶抑制剂的7-苯基烷基取代的2-喹啉酮和2-喹喔啉酮 |
ES2238015B1 (es) * | 2004-01-30 | 2006-11-01 | Cepa Schwarz Pharma, S.L. | Derivados de cicloalcanodionas con actividad neuroprotectora. |
EP1771175B1 (en) | 2004-06-30 | 2015-12-23 | Janssen Pharmaceutica NV | Phthalazine derivatives as parp inhibitors |
NZ551801A (en) * | 2004-06-30 | 2009-11-27 | Janssen Pharmaceutica Nv | Quinazolinedione derivatives as PARP inhibitors |
AU2005259188B2 (en) | 2004-06-30 | 2011-03-31 | Janssen Pharmaceutica N.V. | Quinazolinone derivatives as PARP inhibitors |
DE102004032277A1 (de) * | 2004-07-02 | 2006-01-19 | Basell Polyolefine Gmbh | Verfahren zur racemoselektiven Synthese von ansa-Metallocenen |
JP2008530229A (ja) | 2005-02-17 | 2008-08-07 | ワイス | シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体 |
RU2007139541A (ru) * | 2005-04-22 | 2009-05-27 | Вайет (Us) | Производные хромана и хромена и их применение |
WO2008015538A2 (en) * | 2006-07-31 | 2008-02-07 | Schwarz Pharma S.L. | Use of diaza- and thiaza-cycloalkanediones for preventing and/or treating pain and /or migraine |
US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
US8503431B2 (en) * | 2006-08-25 | 2013-08-06 | Wireless Wonders Ltd. | Mobile phone related indirect communication system and method |
DK2134691T3 (da) | 2007-03-08 | 2012-05-07 | Janssen Pharmaceutica Nv | Quinolinonderivativer som parp- og tank-inhibitorer |
JP5017703B2 (ja) * | 2007-05-16 | 2012-09-05 | 住友ゴム工業株式会社 | ビードエイペックスおよびタイヤ |
ES2448870T3 (es) | 2007-10-26 | 2014-03-17 | Janssen Pharmaceutica, N.V. | Derivados de quinolina como inhibidores de PARP |
ATE513818T1 (de) | 2008-03-27 | 2011-07-15 | Janssen Pharmaceutica Nv | Chinazolinonderivate als tubulinpolymerisationshemmer |
EP2271626B1 (en) | 2008-03-27 | 2014-11-26 | Janssen Pharmaceutica, N.V. | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors |
RS59172B1 (sr) | 2012-02-24 | 2019-10-31 | Lupin Ltd | Supstituisana jedinjenja hromana kao modulatori receptora osetljivog na kalcijum |
US9040533B2 (en) | 2012-12-27 | 2015-05-26 | Purdue Pharma L.P. | Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators |
DE102013207163B4 (de) | 2013-04-19 | 2022-09-22 | Adidas Ag | Schuhoberteil |
DE102014220087B4 (de) | 2014-10-02 | 2016-05-12 | Adidas Ag | Flachgestricktes Schuhoberteil für Sportschuhe |
WO2017115372A1 (en) | 2015-12-30 | 2017-07-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Pt(IV) PRODRUGS |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2400094A1 (de) * | 1973-01-04 | 1974-07-18 | Janssen Pharmaceutica Nv | 1-geschweifte klammer auf 1- eckige klammer auf 2-(1,4-benzodioxan-2-yl) -2-hydroxyaethyl eckige klammer zu -4-piperidyl geschweifte klammer zu -2-benzimidazolinone, verfahren zu iherer herstellung und arzneimittel |
US5137901A (en) * | 1988-07-28 | 1992-08-11 | Bayer Aktiengesellschaft | Substituted aminomethyltetralins and their heterocyclic analogues |
EP0546388A1 (de) * | 1991-12-09 | 1993-06-16 | Bayer Ag | Azaheterocyclylmethyl-chromane als Wirkstoffe zur Behandlung von Erkrankungen des Zentralnervensystems |
WO1993017017A1 (en) * | 1992-02-27 | 1993-09-02 | Janssen Pharmaceutica N.V. | [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors |
WO1995005383A1 (en) * | 1993-08-19 | 1995-02-23 | Janssen Pharmaceutica N.V. | Vasocontrictive dihydrobenzopyran derivatives |
US5541199A (en) * | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
WO1997028157A1 (fr) * | 1996-02-01 | 1997-08-07 | Pierre Fabre Medicament | Nouveaux derives de la piperidine substitues en position 4 par un groupe imidazolidin-2-on-1-yl-ethyl, tetrahydropyrimidin-2-on-1-yl-ethyl, et 1,3-dia-zepin-2-on-1-yl-ethyl, et leurs applications comme antagonistes des recepteurs alpha-2 adrenergiques |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3929801A (en) * | 1973-11-20 | 1975-12-30 | Janssen Pharmaceutica Nv | 2-Benzimidazolinones |
GB1599296A (en) * | 1977-07-06 | 1981-09-30 | Brewster D L | Ice making machine |
GR71865B (es) * | 1978-03-20 | 1983-07-07 | Ciba Geigy | |
DE2852945A1 (de) * | 1978-12-07 | 1980-06-26 | Boehringer Sohn Ingelheim | Benzodioxanyl-hydroxyaethylpiperidyl- imidazolidinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
US4329348A (en) * | 1979-02-26 | 1982-05-11 | Ciba-Geigy Corporation | N-Oxacyclic-alkylpiperidines as psychostimulants |
US4239348A (en) * | 1979-11-30 | 1980-12-16 | Hughes Aircraft Company | High resolution AC silicon MOS light-valve substrate |
DE4319038A1 (de) * | 1993-06-08 | 1994-12-15 | Bayer Ag | Verwendung von teilweise bekannten substituierten Chromanen als Arzneimittel, neue Wirkstoffe und Verfahren zu ihrer Herstellung |
US5696653A (en) * | 1996-12-13 | 1997-12-09 | Phase Metrics | Tooling for holding a head gimbal assembly |
US6133277A (en) * | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
-
1998
- 1998-11-16 US US09/192,686 patent/US6133277A/en not_active Expired - Lifetime
- 1998-11-25 TW TW087119526A patent/TW577886B/zh not_active IP Right Cessation
- 1998-11-27 SK SK803-2000A patent/SK286268B6/sk not_active IP Right Cessation
- 1998-11-27 TR TR2000/01542T patent/TR200001542T2/xx unknown
- 1998-11-27 PL PL341007A patent/PL191144B1/pl not_active IP Right Cessation
- 1998-11-27 ID IDW20001041D patent/ID24616A/id unknown
- 1998-11-27 CZ CZ20002018A patent/CZ297895B6/cs not_active IP Right Cessation
- 1998-11-27 IL IL13652998A patent/IL136529A/xx not_active IP Right Cessation
- 1998-11-27 UA UA2000053031A patent/UA70308C2/uk unknown
- 1998-11-27 ES ES98966603T patent/ES2270541T3/es not_active Expired - Lifetime
- 1998-11-27 AU AU24127/99A patent/AU748669B2/en not_active Ceased
- 1998-11-27 AT AT98966603T patent/ATE334125T1/de not_active IP Right Cessation
- 1998-11-27 EP EP98966603A patent/EP1036073B8/en not_active Expired - Lifetime
- 1998-11-27 JP JP2000524281A patent/JP2001525407A/ja active Pending
- 1998-11-27 BR BR9814256-9A patent/BR9814256A/pt not_active Application Discontinuation
- 1998-11-27 HU HU0004492A patent/HU224813B1/hu not_active IP Right Cessation
- 1998-11-27 EA EA200000616A patent/EA003365B1/ru not_active IP Right Cessation
- 1998-11-27 WO PCT/EP1998/007771 patent/WO1999029687A1/en active IP Right Grant
- 1998-11-27 CA CA2311669A patent/CA2311669C/en not_active Expired - Lifetime
- 1998-11-27 NZ NZ503603A patent/NZ503603A/en unknown
- 1998-11-27 DE DE69835372T patent/DE69835372T2/de not_active Expired - Lifetime
- 1998-11-27 EE EEP200000328A patent/EE04438B1/xx not_active IP Right Cessation
- 1998-11-27 KR KR1020007003796A patent/KR100591605B1/ko not_active IP Right Cessation
- 1998-11-27 CN CNB988118319A patent/CN1155597C/zh not_active Expired - Fee Related
- 1998-12-01 CO CO98071204A patent/CO5011114A1/es unknown
- 1998-12-01 MY MYPI98005442A patent/MY124586A/en unknown
- 1998-12-03 ZA ZA9811081A patent/ZA9811081B/xx unknown
- 1998-12-04 AR ARP980106182A patent/AR017195A1/es active IP Right Grant
-
2000
- 2000-04-19 NO NO20002074A patent/NO320727B1/no not_active IP Right Cessation
- 2000-04-24 BG BG104372A patent/BG64624B1/bg unknown
- 2000-05-25 HR HR20000340A patent/HRP20000340B1/xx not_active IP Right Cessation
- 2000-08-18 US US09/641,485 patent/US6495547B1/en not_active Expired - Lifetime
- 2000-12-07 HK HK00107845A patent/HK1028400A1/xx not_active IP Right Cessation
-
2002
- 2002-04-03 US US10/116,590 patent/US6747045B2/en not_active Expired - Lifetime
- 2002-09-05 US US10/235,623 patent/US6852714B2/en not_active Expired - Lifetime
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2400094A1 (de) * | 1973-01-04 | 1974-07-18 | Janssen Pharmaceutica Nv | 1-geschweifte klammer auf 1- eckige klammer auf 2-(1,4-benzodioxan-2-yl) -2-hydroxyaethyl eckige klammer zu -4-piperidyl geschweifte klammer zu -2-benzimidazolinone, verfahren zu iherer herstellung und arzneimittel |
US5137901A (en) * | 1988-07-28 | 1992-08-11 | Bayer Aktiengesellschaft | Substituted aminomethyltetralins and their heterocyclic analogues |
EP0546388A1 (de) * | 1991-12-09 | 1993-06-16 | Bayer Ag | Azaheterocyclylmethyl-chromane als Wirkstoffe zur Behandlung von Erkrankungen des Zentralnervensystems |
WO1993017017A1 (en) * | 1992-02-27 | 1993-09-02 | Janssen Pharmaceutica N.V. | [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors |
WO1995005383A1 (en) * | 1993-08-19 | 1995-02-23 | Janssen Pharmaceutica N.V. | Vasocontrictive dihydrobenzopyran derivatives |
US5541199A (en) * | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
WO1997028157A1 (fr) * | 1996-02-01 | 1997-08-07 | Pierre Fabre Medicament | Nouveaux derives de la piperidine substitues en position 4 par un groupe imidazolidin-2-on-1-yl-ethyl, tetrahydropyrimidin-2-on-1-yl-ethyl, et 1,3-dia-zepin-2-on-1-yl-ethyl, et leurs applications comme antagonistes des recepteurs alpha-2 adrenergiques |
Also Published As
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BG64624B1 (bg) | (бензодиоксанови, бензофуранови или бензопиранови) производни, притежаващи фундусни релаксиращи свойства | |
EP1187829B1 (en) | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives | |
EP1187831B1 (en) | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives | |
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