EA200000616A1 - Производные (бензодиоксана, бензофурана или бензопирана), обеспечивающие релаксацию мускулатуры дна желудка - Google Patents

Производные (бензодиоксана, бензофурана или бензопирана), обеспечивающие релаксацию мускулатуры дна желудка

Info

Publication number
EA200000616A1
EA200000616A1 EA200000616A EA200000616A EA200000616A1 EA 200000616 A1 EA200000616 A1 EA 200000616A1 EA 200000616 A EA200000616 A EA 200000616A EA 200000616 A EA200000616 A EA 200000616A EA 200000616 A1 EA200000616 A1 EA 200000616A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
hydrogen
equal
bivalent radical
cycloalkyl
Prior art date
Application number
EA200000616A
Other languages
English (en)
Other versions
EA003365B1 (ru
Inventor
Пит Том Берт Поль Вигеринк
Вим Гастон Версхейрен
Марк Франсис Жозефин Шровен
Марк Франс Леопольд Де Брюйн
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200000616A1 publication Critical patent/EA200000616A1/ru
Publication of EA003365B1 publication Critical patent/EA003365B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I), их стереохимически изомерным формам, их N-оксидной форме или фармацевтически пригодной соли присоединения кислоты, где Alkявляется Cалкандиилом, необязательно замещенным гидрокси, Cалкилокси или Cалкилкарбонилокси; -Z-Z-бивалентным радикалом; R, Rи R, каждый независимо, выбран из водорода, Cалкила, гидрокси, галоида и т.п.; или когда Rи Rприсоединены к смежным углеродным атомам, Rи Rмогут вместе образовывать бивалентный радикал; Rявляется водородом или Cалкилом; A представляет собой бивалентный радикал формулы -NR-Alk-(b-1) или -N-пиперидинил-(CH)(b-2), где m равно 0 или 1; Rпредставляет собой радикал формулы (A), где n равно 1 или 2; pравно 0, а pравно 1 или 2; или pравно 1 или 2, а pравно 0; X является кислородом, серой или =NR; Y является кислородом или серой; Rпредставляет собой водород, Cалкил, Cциклоалкил, фенил или фенилметил; Rпредставляет собой Cалкил, Cциклоалкил, фенил или фенилметил; Rявляется циано, Cалкилом, Cциклоалкилом, Cалкилоксикарбонилом или аминокарбонилом; Rявляется водородом или Cалкилом, a Q - бивалентный радикал. Описываются способы получения указанных соединений, составы, включающие указанные соединения, и их применение в качестве лекарственных средств, в частности, для лечения состояний, связанных с ухудшенной релаксацией мускулатуры дна желудка.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000616A 1997-12-05 1998-11-27 Производные аминоалкилхроманов, обеспечивающие релаксацию мускулатуры дна желудка EA003365B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97203808 1997-12-05
PCT/EP1998/007771 WO1999029687A1 (en) 1997-12-05 1998-11-27 (benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties

Publications (2)

Publication Number Publication Date
EA200000616A1 true EA200000616A1 (ru) 2000-12-25
EA003365B1 EA003365B1 (ru) 2003-04-24

Family

ID=8229014

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000616A EA003365B1 (ru) 1997-12-05 1998-11-27 Производные аминоалкилхроманов, обеспечивающие релаксацию мускулатуры дна желудка

Country Status (32)

Country Link
US (4) US6133277A (ru)
EP (1) EP1036073B8 (ru)
JP (1) JP2001525407A (ru)
KR (1) KR100591605B1 (ru)
CN (1) CN1155597C (ru)
AR (1) AR017195A1 (ru)
AT (1) ATE334125T1 (ru)
AU (1) AU748669B2 (ru)
BG (1) BG64624B1 (ru)
BR (1) BR9814256A (ru)
CA (1) CA2311669C (ru)
CO (1) CO5011114A1 (ru)
CZ (1) CZ297895B6 (ru)
DE (1) DE69835372T2 (ru)
EA (1) EA003365B1 (ru)
EE (1) EE04438B1 (ru)
ES (1) ES2270541T3 (ru)
HK (1) HK1028400A1 (ru)
HR (1) HRP20000340B1 (ru)
HU (1) HU224813B1 (ru)
ID (1) ID24616A (ru)
IL (1) IL136529A (ru)
MY (1) MY124586A (ru)
NO (1) NO320727B1 (ru)
NZ (1) NZ503603A (ru)
PL (1) PL191144B1 (ru)
SK (1) SK286268B6 (ru)
TR (1) TR200001542T2 (ru)
TW (1) TW577886B (ru)
UA (1) UA70308C2 (ru)
WO (1) WO1999029687A1 (ru)
ZA (1) ZA9811081B (ru)

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JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
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US7071821B2 (en) * 2003-05-14 2006-07-04 Bellsouth Intellectual Property Corporation Method and system for alerting a person to a situation
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WO2005032544A1 (en) * 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. Treatment of mitochondrial diseases
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US7928104B2 (en) 2003-11-20 2011-04-19 Dominique Jean-Pierre Mabire 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
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EP2134691B1 (en) 2007-03-08 2012-01-25 Janssen Pharmaceutica, N.V. Quinolinone derivatives as parp and tank inhibitors
JP5017703B2 (ja) * 2007-05-16 2012-09-05 住友ゴム工業株式会社 ビードエイペックスおよびタイヤ
PL2215075T3 (pl) 2007-10-26 2014-04-30 Janssen Pharmaceutica Nv Pochodne chinolinonu jako inhibitory PARP
AU2009228945B2 (en) 2008-03-27 2013-05-02 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
WO2009118382A1 (en) 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors
SI2817299T1 (sl) 2012-02-24 2019-10-30 Lupin Ltd Substituirane kroman spojine kot modulatorji na kalcij občutljivega receptorja
WO2014102592A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Oxime/substituted quinoxaline-type piperidine compounds and uses thereof
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DE102014220087B4 (de) 2014-10-02 2016-05-12 Adidas Ag Flachgestricktes Schuhoberteil für Sportschuhe
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Also Published As

Publication number Publication date
AU748669B2 (en) 2002-06-06
ZA9811081B (en) 2000-06-22
HU224813B1 (en) 2006-02-28
HK1028400A1 (en) 2001-02-16
WO1999029687A1 (en) 1999-06-17
NZ503603A (en) 2001-10-26
EP1036073B8 (en) 2006-11-15
US20030149093A1 (en) 2003-08-07
BG64624B1 (bg) 2005-09-30
EP1036073A1 (en) 2000-09-20
US6133277A (en) 2000-10-17
NO20002074L (no) 2000-06-02
ATE334125T1 (de) 2006-08-15
CZ297895B6 (cs) 2007-04-25
HRP20000340A2 (en) 2001-04-30
US6852714B2 (en) 2005-02-08
PL341007A1 (en) 2001-03-12
HUP0004492A2 (hu) 2002-03-28
AU2412799A (en) 1999-06-28
CZ20002018A3 (cs) 2000-10-11
SK8032000A3 (en) 2001-02-12
US20030083365A1 (en) 2003-05-01
IL136529A (en) 2003-03-12
BR9814256A (pt) 2000-10-03
PL191144B1 (pl) 2006-03-31
DE69835372T2 (de) 2007-08-09
TW577886B (en) 2004-03-01
HUP0004492A3 (en) 2002-04-29
EE04438B1 (et) 2005-02-15
CN1155597C (zh) 2004-06-30
US6747045B2 (en) 2004-06-08
NO320727B1 (no) 2006-01-23
BG104372A (en) 2000-12-29
IL136529A0 (en) 2001-06-14
CA2311669A1 (en) 1999-06-17
ES2270541T3 (es) 2007-04-01
SK286268B6 (sk) 2008-06-06
TR200001542T2 (tr) 2001-01-22
CN1280577A (zh) 2001-01-17
EP1036073B1 (en) 2006-07-26
CO5011114A1 (es) 2001-02-28
HRP20000340B1 (en) 2008-12-31
DE69835372D1 (de) 2006-09-07
UA70308C2 (ru) 2004-10-15
EE200000328A (et) 2001-08-15
KR20010031010A (ko) 2001-04-16
KR100591605B1 (ko) 2006-06-20
US6495547B1 (en) 2002-12-17
CA2311669C (en) 2010-04-27
MY124586A (en) 2006-06-30
EA003365B1 (ru) 2003-04-24
ID24616A (id) 2000-07-27
JP2001525407A (ja) 2001-12-11
AR017195A1 (es) 2001-08-22
WO1999029687A8 (en) 2000-04-13
NO20002074D0 (no) 2000-04-19

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