EA200101236A1 - Аминоалкилзамещенные (бензодиоксан, бензофуран или бензопиран) производные - Google Patents
Аминоалкилзамещенные (бензодиоксан, бензофуран или бензопиран) производныеInfo
- Publication number
- EA200101236A1 EA200101236A1 EA200101236A EA200101236A EA200101236A1 EA 200101236 A1 EA200101236 A1 EA 200101236A1 EA 200101236 A EA200101236 A EA 200101236A EA 200101236 A EA200101236 A EA 200101236A EA 200101236 A1 EA200101236 A1 EA 200101236A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- hydrogen
- equal
- phenylmethyl
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
Abstract
Настоящее изобретение относится к соединениям формулы (I), их стереохимически изомерным формам, их N-оксидным формам, их фармацевтически приемлемым кислотно-аддитивным солям, где -Z-Z- представляет двухвалентный радикал; R, Rи R, каждый независимо, выбран из водорода, Cалкила, гидрокси, галогена и т.п.; или, когда Rи Rнаходятся на смежных атомах углерода, Rи R, взятые вместе, могут образовывать двухвалентный радикал формулы; Alkи Alkпредставляют необязательно замещенный Cалкандиил; Rпредставляет водород или фенилметил; Rпредставляет радикал формулы (с-1), (с-2), (с-3), (с-4), (с-5); где n равно 1 или 2; рравно 0 и рравно 1 или 2; или рравно 1 или 2, а рравно 0; Х представляет кислород, серу или NR; Y представляет кислород или серу; Rпредставляет водород, Cалкил, Сциклоалкил, фенил или фенилметил; Rпредставляет Cалкил, Сциклоалкил, фенил или фенилметил; Rпредставляет циано, Cалкил, Сциклоалкил, Cалкилоксикарбонил или аминокарбонил; Rпредставляет водород или Cалкил; и Q представляет двухвалентный радикал. Раскрыты способы получения указанных продуктов, композиции, включающие указанные продукты, и их применение в качестве лекарственных средств, в частности, для лечения состояний, связанных с нарушением релаксации дна желудка.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99201747 | 1999-06-02 | ||
PCT/EP2000/004746 WO2000075136A1 (en) | 1999-06-02 | 2000-05-23 | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200101236A1 true EA200101236A1 (ru) | 2002-08-29 |
EA004645B1 EA004645B1 (ru) | 2004-06-24 |
Family
ID=8240260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200101236A EA004645B1 (ru) | 1999-06-02 | 2000-05-23 | Аминоалкилзамещенные производные бензопирана |
Country Status (33)
Country | Link |
---|---|
US (2) | US6864273B1 (ru) |
EP (1) | EP1187829B1 (ru) |
JP (1) | JP2003501427A (ru) |
KR (1) | KR100699512B1 (ru) |
CN (1) | CN1150191C (ru) |
AR (1) | AR033334A1 (ru) |
AT (1) | ATE256125T1 (ru) |
AU (1) | AU773773B2 (ru) |
BG (1) | BG65269B1 (ru) |
BR (1) | BR0011237A (ru) |
CA (1) | CA2374902C (ru) |
CZ (1) | CZ20014177A3 (ru) |
DE (1) | DE60007124T2 (ru) |
DK (1) | DK1187829T3 (ru) |
EA (1) | EA004645B1 (ru) |
EE (1) | EE04780B1 (ru) |
ES (1) | ES2212774T3 (ru) |
HR (1) | HRP20010868A2 (ru) |
HU (1) | HUP0201404A3 (ru) |
IL (2) | IL146840A0 (ru) |
MX (1) | MXPA01012330A (ru) |
MY (1) | MY120618A (ru) |
NO (1) | NO319953B1 (ru) |
NZ (1) | NZ514993A (ru) |
PL (1) | PL198552B1 (ru) |
PT (1) | PT1187829E (ru) |
SI (1) | SI1187829T1 (ru) |
SK (1) | SK285619B6 (ru) |
TR (1) | TR200103430T2 (ru) |
TW (1) | TWI289559B (ru) |
UA (1) | UA73122C2 (ru) |
WO (1) | WO2000075136A1 (ru) |
ZA (1) | ZA200109860B (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL198532B1 (pl) | 1999-06-02 | 2008-06-30 | Janssen Pharmaceutica Nv | Pochodna benzopiranu podstawiona pirolidynylem, piperydynylem lub homopiperydynylem i sposób jej otrzymywania oraz kompozycja farmaceutyczna i sposób jej otrzymywania |
JO2352B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
KR20120037035A (ko) * | 2002-04-08 | 2012-04-18 | 제리아 신야쿠 고교 가부시키 가이샤 | 위 음식물 수용능 장해 치료약 |
JP2008530229A (ja) | 2005-02-17 | 2008-08-07 | ワイス | シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体 |
JP5731718B2 (ja) | 2011-11-11 | 2015-06-10 | ファイザー・インク | 2−チオピリミジノン |
MA42035A (fr) | 2015-05-05 | 2018-03-14 | Pfizer | 2-thiopyrimidinones |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3910930A (en) | 1973-01-04 | 1975-10-07 | Janssen Pharmaceutica Nv | 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones |
US3929801A (en) | 1973-11-20 | 1975-12-30 | Janssen Pharmaceutica Nv | 2-Benzimidazolinones |
GR71865B (ru) | 1978-03-20 | 1983-07-07 | Ciba Geigy | |
DE2852945A1 (de) | 1978-12-07 | 1980-06-26 | Boehringer Sohn Ingelheim | Benzodioxanyl-hydroxyaethylpiperidyl- imidazolidinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
US4329348A (en) | 1979-02-26 | 1982-05-11 | Ciba-Geigy Corporation | N-Oxacyclic-alkylpiperidines as psychostimulants |
DE3124366A1 (de) | 1981-06-20 | 1982-12-30 | Hoechst Ag, 6000 Frankfurt | N-oxacyclyl-alkylpiperidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und deren verwendung |
FR2533584B1 (fr) | 1982-09-28 | 1986-03-21 | Pasteur Institut | Procede de detection du pouvoir mutagene de substances, susceptibles d'induire la deterioration d'adn cellulaires, mettant en jeu la production d'une reponse sos |
DE3901814A1 (de) | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
DE4140540A1 (de) | 1991-12-09 | 1993-06-17 | Bayer Ag | Neue azaheterocyclylmethyl-chromane |
SI9300097B (en) | 1992-02-27 | 2001-12-31 | Janssen Pharmaceutica Nv | (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines |
DE4319038A1 (de) | 1993-06-08 | 1994-12-15 | Bayer Ag | Verwendung von teilweise bekannten substituierten Chromanen als Arzneimittel, neue Wirkstoffe und Verfahren zu ihrer Herstellung |
CN1052006C (zh) | 1993-08-19 | 2000-05-03 | 詹森药业有限公司 | 血管收缩剂二氢苯并吡喃衍生物,制备方法和用途 |
US5541199A (en) | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
FR2744451B1 (fr) | 1996-02-01 | 1998-04-24 | Pf Medicament | Nouvelles imidazolidinones, pyrimidinones, et 1,3-diazepin-2 -ones, leur preparation et leurs applications en therapeutique |
US6133277A (en) * | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
PL198532B1 (pl) | 1999-06-02 | 2008-06-30 | Janssen Pharmaceutica Nv | Pochodna benzopiranu podstawiona pirolidynylem, piperydynylem lub homopiperydynylem i sposób jej otrzymywania oraz kompozycja farmaceutyczna i sposób jej otrzymywania |
JO2352B1 (en) | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
-
2000
- 2000-05-23 DK DK00940267T patent/DK1187829T3/da active
- 2000-05-23 PL PL352112A patent/PL198552B1/pl not_active IP Right Cessation
- 2000-05-23 TR TR2001/03430T patent/TR200103430T2/xx unknown
- 2000-05-23 UA UA2001128825A patent/UA73122C2/uk unknown
- 2000-05-23 AT AT00940267T patent/ATE256125T1/de not_active IP Right Cessation
- 2000-05-23 BR BR0011237-2A patent/BR0011237A/pt not_active Application Discontinuation
- 2000-05-23 ES ES00940267T patent/ES2212774T3/es not_active Expired - Lifetime
- 2000-05-23 NZ NZ514993A patent/NZ514993A/en unknown
- 2000-05-23 EE EEP200100639A patent/EE04780B1/xx not_active IP Right Cessation
- 2000-05-23 CZ CZ20014177A patent/CZ20014177A3/cs unknown
- 2000-05-23 KR KR1020017013659A patent/KR100699512B1/ko not_active IP Right Cessation
- 2000-05-23 JP JP2001502419A patent/JP2003501427A/ja not_active Withdrawn
- 2000-05-23 HU HU0201404A patent/HUP0201404A3/hu unknown
- 2000-05-23 CN CNB008083185A patent/CN1150191C/zh not_active Expired - Fee Related
- 2000-05-23 MX MXPA01012330A patent/MXPA01012330A/es unknown
- 2000-05-23 IL IL14684000A patent/IL146840A0/xx active IP Right Grant
- 2000-05-23 CA CA002374902A patent/CA2374902C/en not_active Expired - Lifetime
- 2000-05-23 US US09/980,452 patent/US6864273B1/en not_active Expired - Lifetime
- 2000-05-23 DE DE60007124T patent/DE60007124T2/de not_active Expired - Lifetime
- 2000-05-23 SK SK1703-2001A patent/SK285619B6/sk not_active IP Right Cessation
- 2000-05-23 EA EA200101236A patent/EA004645B1/ru not_active IP Right Cessation
- 2000-05-23 WO PCT/EP2000/004746 patent/WO2000075136A1/en active IP Right Grant
- 2000-05-23 PT PT00940267T patent/PT1187829E/pt unknown
- 2000-05-23 EP EP00940267A patent/EP1187829B1/en not_active Expired - Lifetime
- 2000-05-23 SI SI200030293T patent/SI1187829T1/xx unknown
- 2000-05-23 AU AU55256/00A patent/AU773773B2/en not_active Ceased
- 2000-05-24 TW TW089109971A patent/TWI289559B/zh not_active IP Right Cessation
- 2000-05-30 MY MYPI20002411A patent/MY120618A/en unknown
- 2000-06-01 AR ARP000102714A patent/AR033334A1/es unknown
-
2001
- 2001-11-22 HR HR20010868A patent/HRP20010868A2/hr not_active Application Discontinuation
- 2001-11-28 BG BG106156A patent/BG65269B1/bg unknown
- 2001-11-29 IL IL146840A patent/IL146840A/en not_active IP Right Cessation
- 2001-11-29 ZA ZA200109860A patent/ZA200109860B/xx unknown
- 2001-12-03 NO NO20015903A patent/NO319953B1/no not_active IP Right Cessation
-
2004
- 2004-11-29 US US10/999,187 patent/US7273862B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |