BG64522B1 - Средство за лечение на вирусни инфекциозни заболявания - Google Patents
Средство за лечение на вирусни инфекциозни заболявания Download PDFInfo
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- BG64522B1 BG64522B1 BG102984A BG10298498A BG64522B1 BG 64522 B1 BG64522 B1 BG 64522B1 BG 102984 A BG102984 A BG 102984A BG 10298498 A BG10298498 A BG 10298498A BG 64522 B1 BG64522 B1 BG 64522B1
- Authority
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- Bulgaria
- Prior art keywords
- echinacea
- drug
- acid
- virus
- hsv
- Prior art date
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Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Immunology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/646,988 US6355684B1 (en) | 1990-10-11 | 1996-05-08 | Antimicrobial treatment for herpes simplex virus and other infectious diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG102984A BG102984A (en) | 1999-09-30 |
| BG64522B1 true BG64522B1 (bg) | 2005-06-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102984A BG64522B1 (bg) | 1996-05-08 | 1998-12-02 | Средство за лечение на вирусни инфекциозни заболявания |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US6355684B1 (de) |
| EP (1) | EP0918458B1 (de) |
| JP (1) | JP2001505546A (de) |
| KR (1) | KR100347651B1 (de) |
| CN (1) | CN1113599C (de) |
| AP (1) | AP1356A (de) |
| AT (1) | ATE349159T1 (de) |
| AU (1) | AU716247B2 (de) |
| BG (1) | BG64522B1 (de) |
| BR (1) | BR9711086A (de) |
| CA (1) | CA2253736C (de) |
| CZ (1) | CZ295869B6 (de) |
| DE (1) | DE69737144T2 (de) |
| DK (1) | DK0918458T3 (de) |
| EA (1) | EA001339B1 (de) |
| EE (1) | EE04605B1 (de) |
| ES (1) | ES2278393T3 (de) |
| GE (1) | GEP20002132B (de) |
| HU (1) | HU229230B1 (de) |
| IL (2) | IL126924A (de) |
| IS (1) | IS4888A (de) |
| NO (1) | NO326139B1 (de) |
| NZ (1) | NZ332650A (de) |
| OA (1) | OA10917A (de) |
| PL (1) | PL188470B1 (de) |
| RS (1) | RS49721B (de) |
| SK (1) | SK285361B6 (de) |
| TR (1) | TR199802251T2 (de) |
| UA (1) | UA65537C2 (de) |
| WO (1) | WO1998011778A1 (de) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6355684B1 (en) * | 1990-10-11 | 2002-03-12 | Meryl J. Squires | Antimicrobial treatment for herpes simplex virus and other infectious diseases |
| US6350784B1 (en) * | 1996-02-12 | 2002-02-26 | Meryl J. Squires | Antimicrobial prevention and treatment of human immunedeficiency virus and other infectious diseases |
| US9662360B2 (en) * | 2008-10-09 | 2017-05-30 | Meritus Corporation | Treatment of herpes, pseudomonas, staph, and hepatitis |
| CN1087608C (zh) * | 1996-08-29 | 2002-07-17 | 中国人民解放军军事医学科学院放射医学研究所 | 二咖啡酰奎宁酸在治疗乙型肝炎及与逆转录病毒有关疾病中的用途及新咖啡酰奎宁酸衍生物 |
| AU9578898A (en) | 1997-09-24 | 1999-04-12 | Geoffrey N Richards | Composition and method for reducing pathogenic bacteria in food products |
| US6248343B1 (en) * | 1998-01-20 | 2001-06-19 | Ethicon, Inc. | Therapeutic antimicrobial compositions |
| DE19814725A1 (de) * | 1998-04-02 | 1999-10-07 | Michael O Ruepp | Verwendung von Echinacea-pallida und Echinacea angustifolia-Extrakten; Löwenzahn-/Taraxacum)-Extrakten; Spitzwegerich-(Plantago)-Extrakten |
| DE19814905A1 (de) * | 1998-04-02 | 1999-10-07 | Michael O Ruepp Aar Pharma | Verwendung von Bärentraubenblätter (Arctostaphylos uva ursi)-, Birkenblätter (Betula)-, Schachtelhalmkraut (Equisetum)- und Brennessel (Urtica)-Extrakten |
| EP1076547A4 (de) | 1998-04-27 | 2001-09-26 | Larex Inc | Arabinogalactanderivate und zusammenstellungen die diese enthalten |
| US6162393A (en) * | 1998-08-06 | 2000-12-19 | Ndt, Inc. | Contact lens and ophthalmic solutions |
| US6211243B1 (en) | 1999-09-22 | 2001-04-03 | B. Ron Johnson | Methods for treating cold sores with anti-infective compositions |
| US8173709B2 (en) * | 1999-09-22 | 2012-05-08 | Quadex Pharmaceuticals, Llc | Anti-infective methods for treating pathogen-induced disordered tissues |
| US6759434B2 (en) | 1999-09-22 | 2004-07-06 | B. Ron Johnson | Anti-infective compositions, methods and systems for treating disordered tissue |
| CA2379581C (en) * | 1999-09-30 | 2011-03-22 | Factors R & D Technologies Ltd. | Echinacea supplement and method of manufacture |
| US6306443B1 (en) | 2000-06-20 | 2001-10-23 | Amway Corporation | Method of increasing concentrations of caffeic acid derivatives and alkylamides and compositions containing the same |
| US6589513B2 (en) | 2000-09-20 | 2003-07-08 | Lesko-Care, L.L.C. | Oral hygiene formulation and method of use |
| US6632459B2 (en) * | 2000-12-11 | 2003-10-14 | Nutricia N.V. | Chlorogenic acid and an analog thereof for immune system stimulation |
| JP4280888B2 (ja) * | 2001-03-23 | 2009-06-17 | 独立行政法人産業技術総合研究所 | 生分解性多価カルボン酸エステル・カルボン酸の製造方法 |
| US6635679B2 (en) * | 2001-05-14 | 2003-10-21 | Akzo Nobel N.V. | Methods and compositions for inactivating viruses |
| IL143318A0 (en) | 2001-05-23 | 2002-04-21 | Herbal Synthesis Corp | Herbal compositions for the treatment of mucosal lesions |
| US6767546B1 (en) * | 2001-08-17 | 2004-07-27 | The United States Of America As Represented By The Secretary Of Agriculture | Use of echinacea as a feed additive to enhance protection against coccidiosis |
| ITMI20021691A1 (it) * | 2002-07-30 | 2004-01-30 | Indena Spa | Estratti di echinacea angustifolia |
| US7585523B2 (en) * | 2002-08-27 | 2009-09-08 | Targeted Medical Pharma | Composition and method to augment and sustain neurotransmitter production |
| DE10341579A1 (de) * | 2003-09-09 | 2005-04-07 | Bionorica Ag | Verwendung von Extrakten aus Gentiana lutea als antimikrobiell wirkendes Mittel |
| GB0326520D0 (en) * | 2003-11-13 | 2003-12-17 | Compton Developments Ltd | Molluscicidal and anti-barnacle compounds |
| DE102004005788A1 (de) * | 2004-02-06 | 2005-09-01 | Riemser Arzneimittel Ag | Zubereitungen enthaltend Echinacea-Auszüge und Thiocyanat |
| AU2005259854C1 (en) * | 2004-07-07 | 2011-06-02 | Integria Healthcare (Australia) PTY LTD | An Echinacea formulation |
| GB2432788C (en) * | 2004-07-07 | 2018-06-27 | Integria Healthcare Australia Pty Ltd | An echinacea formulation |
| FR2877576B1 (fr) * | 2004-11-08 | 2007-03-09 | Ahmed Kadri | Composition pharmaceutique utilisee pour stimuler la proliferation et l'activation des mastocytes |
| US7619008B2 (en) * | 2004-11-12 | 2009-11-17 | Kimberly-Clark Worldwide, Inc. | Xylitol for treatment of vaginal infections |
| EP1671535A1 (de) * | 2004-12-16 | 2006-06-21 | Stiftung Caesar Center of Advanced European Studies and Research | Verfahren zur Änderung des Gehaltes phenolischer Verbindungen in Pflanzenzellen |
| US20060217443A1 (en) * | 2005-03-28 | 2006-09-28 | Kimberly-Clark Worldwide, Inc. | Method for preventing and/or treating vaginal and vulval infections |
| US8809283B2 (en) | 2005-05-20 | 2014-08-19 | Natuderm, Llc | Proteasome inhibitors and uses thereof |
| US7786176B2 (en) * | 2005-07-29 | 2010-08-31 | Kimberly-Clark Worldwide, Inc. | Vaginal treatment composition containing xylitol |
| JP5513111B2 (ja) * | 2006-07-20 | 2014-06-04 | イズン ファーマシューティカルズ コーポレイション | フィルム送達リンス |
| KR100791282B1 (ko) | 2007-02-27 | 2008-01-04 | 재단법인 제주하이테크산업진흥원 | 미백활성을 나타내는 노루참나물 추출물 |
| US20080241290A1 (en) * | 2007-03-30 | 2008-10-02 | Wayne Jeffrey Perry | Sinus relief composition and method of producing the same |
| US7850998B2 (en) * | 2007-07-18 | 2010-12-14 | Kiani Iraj E | Method of treating viral conditions |
| US7700137B1 (en) | 2007-07-18 | 2010-04-20 | Kiani Iraj E | Anti-viral compositions and method |
| US8637094B2 (en) * | 2007-07-18 | 2014-01-28 | Iraj E. Kiani | Composition and method for treating viral conditions |
| US20090069446A1 (en) * | 2007-09-06 | 2009-03-12 | Wayne Jeffrey Perry | Dendritic salt therapeutic agent delivery system |
| US20090069433A1 (en) * | 2007-09-10 | 2009-03-12 | Wayne Jeffrey Perry | Nasal rinse additive |
| ITMI20080395A1 (it) | 2008-03-10 | 2009-09-11 | Indena Spa | Formulazioni per il trattamento delle verruche e delle placche psoriatiche |
| EP2278971A1 (de) * | 2008-04-24 | 2011-02-02 | Indena S.p.A. | Zusammensetzungen zur behandlung von vaginalen infektionen mit chronischer entzündung |
| EP2320920B1 (de) | 2008-07-22 | 2015-04-22 | Izun Pharmaceuticals Corporation | Topische entzündungshemmende kombination |
| ITRE20090011A1 (it) * | 2009-02-11 | 2010-08-12 | Gianni Magnanini | Composizione terapeutica per il trattamento dell'herpes labialis |
| GB0917086D0 (en) * | 2009-09-29 | 2009-11-11 | Union Of Agricultural Cooperat | Compositon of botanical extracts and their use |
| WO2011064292A2 (en) * | 2009-11-25 | 2011-06-03 | Dsm Ip Assets B.V. | Polyester amide foamers |
| CN102844041A (zh) * | 2010-01-11 | 2012-12-26 | 维托生物有限责任公司 | 用于治疗局部病毒感染的新协同组合物 |
| US20110229537A1 (en) * | 2010-03-17 | 2011-09-22 | Arbonne International Llc | Oral supplement |
| FR2969926B1 (fr) | 2011-01-04 | 2017-03-10 | Elicityl | Arabinogalactanes, apiogalacturonanes et heteroglycanes sulfates pour le traitement des maladies causees par les virus influenza |
| US8846725B2 (en) | 2011-01-24 | 2014-09-30 | Quadex Pharmaceuticals, Llc | Highly penetrating compositions and methods for treating pathogen-induced disordered tissues |
| EP2573085A1 (de) * | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamidmesylat-Monohydrat mit einem spezifischen Teilchengrößenverteilungsbereich und einem spezifischen Oberflächenbereich |
| CN103070918A (zh) * | 2012-11-14 | 2013-05-01 | 翟立冬 | 一种可以清除hpv病毒的润体油及其制备方法 |
| US9549930B2 (en) | 2013-03-14 | 2017-01-24 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered and/or prodromal stage tissue |
| US9463180B2 (en) | 2013-03-14 | 2016-10-11 | Quadex Pharmaceuticals, Llc | Treatment of molluscum contagiosum |
| US9125911B2 (en) | 2013-03-14 | 2015-09-08 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered tissues |
| CN104138422A (zh) * | 2013-05-09 | 2014-11-12 | 杨东天 | 一种治疗带状疱疹的中药制剂 |
| CA2955981C (en) | 2014-07-22 | 2022-10-25 | Ralco Nutrition, Inc. | Antiviral compositions comprising one or more essential oils |
| EP3034129A1 (de) | 2014-12-16 | 2016-06-22 | Agon Pharma GmbH | Verfahren zur Herstellung eines Echinacea purpura Trockenpresssaftes und Verwendung desselben zur Behandlung von Equinem Sarkoid |
| CN105284945B (zh) * | 2015-11-20 | 2018-12-04 | 黄乃宁 | 一种防治甘蔗凤梨病的方法 |
| KR102670487B1 (ko) * | 2016-11-17 | 2024-05-30 | 주식회사 엘지생활건강 | 시나린을 포함하는 구강질환 예방 또는 치료용 조성물 |
| CN107898903A (zh) * | 2017-10-12 | 2018-04-13 | 深圳职业技术学院 | 一种抗疱疹病毒的脂质体乳膏及其制备方法 |
| WO2019108973A2 (en) * | 2017-11-30 | 2019-06-06 | Duke University | Compositions and methods for ablating niche cells in testis and other epithelial cells and methods relating thereto |
| CN108030796A (zh) * | 2017-12-18 | 2018-05-15 | 王秀兰 | 一种抗流感病毒的蒙药及其制备方法 |
| US10478407B2 (en) | 2018-02-23 | 2019-11-19 | The Administrators Of The Tulane Educational Fund | Pharmaceutical composition for viral infections |
| EA036150B1 (ru) * | 2018-07-17 | 2020-10-05 | Рамида Вагиф Кызы Шадлинская | Средство для лечения и профилактики заболевания пародонта и слизистой ротовой полости |
| CZ307717B6 (cs) * | 2018-08-01 | 2019-03-13 | Fakultní nemocnice Hradec Králové | 1-Alkyl-3-(2-hydroxyethyl)imidazolium-halogenid jako dezinfekční činidlo a dezinfekční kompozice, která jej obsahuje |
| US11931333B1 (en) | 2019-05-28 | 2024-03-19 | Peter Van Horn | Topical treatment of herpes infections |
| CN114821176B (zh) * | 2022-04-28 | 2022-11-01 | 浙江大学 | 一种儿童脑部mr图像病毒性脑炎分类系统 |
| KR20240087518A (ko) | 2022-12-01 | 2024-06-19 | 서울여자대학교 산학협력단 | 카페산을 포함하는 식물바이러스 방제용 조성물 및 이를 이용한 식물바이러스 방제 방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4935448A (en) | 1983-01-10 | 1990-06-19 | Baldone Joseph A | Treatment of diseases caused by herpes viruses |
| US4760079A (en) | 1983-01-10 | 1988-07-26 | Baltech, Inc. | Treatment of diseases caused by herpes viruses |
| US4661354A (en) | 1984-06-21 | 1987-04-28 | Finnerty Edmund F | Topical treatment of herpes simplex with a zinc sulfate-camphor water solution |
| US4797420A (en) * | 1984-08-14 | 1989-01-10 | Jabco Manufacturing, Inc. | Disinfectant formulation and method of use |
| US4585656A (en) | 1984-08-20 | 1986-04-29 | Rosenthal Harold R | Treatment of herpes |
| EP0213099A3 (de) | 1985-08-23 | 1989-07-19 | Cederroth Nordic Aktiebolag | Mittel mit antiphlogistischer, immunstimulierender und zytoprotektiver Wirkung, ihre Herstellung und pharmazeutische Verwendungen |
| FR2620698B1 (fr) * | 1987-09-23 | 1990-08-10 | Atlantic Pharma Prod | Fluorure d'ammonium quaternaire et son application dans une substance inhibitrice ou destructrice d'etres vivants unicellulaires |
| US5149529A (en) | 1988-04-08 | 1992-09-22 | Board Of Trustees Of Leland Chiron Corporation | Compositions and treatment for herpes simplex |
| DE4017091A1 (de) | 1990-05-27 | 1991-11-28 | Walter Dr Mach | Molekuelverbundsystem zur kontra-eskalativen therapie viraler infektionskrankheiten |
| US6348503B1 (en) * | 1996-02-12 | 2002-02-19 | Meryl J. Squires | Method and topical treatment composition for herpesvirus hominis |
| US6355684B1 (en) * | 1990-10-11 | 2002-03-12 | Meryl J. Squires | Antimicrobial treatment for herpes simplex virus and other infectious diseases |
| US5461029A (en) | 1992-04-24 | 1995-10-24 | American Cyanamid Company | Method of treating herpes viral infections using HBNF and MK proteins |
| US5455033A (en) * | 1993-05-21 | 1995-10-03 | Degree/Silverman M.D. Inc. | Medicinal composition for treatment of inflammation |
| NL9500216A (nl) | 1995-02-06 | 1996-09-02 | Bio Pharma Sciences Bv | Farmaceutische samenstelling voor de behandeling van herpes. |
-
1996
- 1996-05-08 US US08/646,988 patent/US6355684B1/en not_active Expired - Lifetime
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1997
- 1997-03-12 CA CA002253736A patent/CA2253736C/en not_active Expired - Lifetime
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- 1997-03-12 KR KR1019980708990A patent/KR100347651B1/ko not_active IP Right Cessation
- 1997-03-12 IL IL12692497A patent/IL126924A/xx not_active IP Right Cessation
- 1997-03-12 CN CN97195836A patent/CN1113599C/zh not_active Expired - Lifetime
- 1997-03-12 JP JP51463098A patent/JP2001505546A/ja active Pending
- 1997-03-12 EP EP97933985A patent/EP0918458B1/de not_active Expired - Lifetime
- 1997-03-12 AT AT97933985T patent/ATE349159T1/de not_active IP Right Cessation
- 1997-03-12 IL IL165980A patent/IL165980A/en not_active IP Right Cessation
- 1997-03-12 EE EE9800382A patent/EE04605B1/xx not_active IP Right Cessation
- 1997-03-12 BR BR9711086-8A patent/BR9711086A/pt not_active Application Discontinuation
- 1997-03-12 AU AU37153/97A patent/AU716247B2/en not_active Ceased
- 1997-03-12 GE GEAP19974587A patent/GEP20002132B/en unknown
- 1997-03-12 NZ NZ332650A patent/NZ332650A/xx unknown
- 1997-03-12 ES ES97933985T patent/ES2278393T3/es not_active Expired - Lifetime
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- 1997-03-12 HU HU9902055A patent/HU229230B1/hu active IP Right Revival
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- 1997-03-12 WO PCT/US1997/002468 patent/WO1998011778A1/en active IP Right Grant
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- 1997-03-12 SK SK1533-98A patent/SK285361B6/sk not_active IP Right Cessation
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- 1997-03-12 DK DK97933985T patent/DK0918458T3/da active
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