BG63944B1 - Производни на хидроксиламина, които се използват за повишаване продуцирането на молекулен чаперон исъстав - Google Patents

Производни на хидроксиламина, които се използват за повишаване продуцирането на молекулен чаперон исъстав Download PDF

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Publication number
BG63944B1
BG63944B1 BG101713A BG10171397A BG63944B1 BG 63944 B1 BG63944 B1 BG 63944B1 BG 101713 A BG101713 A BG 101713A BG 10171397 A BG10171397 A BG 10171397A BG 63944 B1 BG63944 B1 BG 63944B1
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BG
Bulgaria
Prior art keywords
alkyl
phenyl
substituted
group
unsubstituted
Prior art date
Application number
BG101713A
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Bulgarian (bg)
English (en)
Other versions
BG101713A (en
Inventor
Laszlo Vigh
Nagy Peter Literati
Jenoe Szilbereky
Laszlo Ueroegdi
Andrea Jednakovits
Laszlo Jaszlits
Katalin Biro
Ede Marvanyos
Mihaly Barabas
Erzsebet Hegedues
Laszlo Koranyi
Maria Kuerthy
Gabor Balogh
Ibolya Horvath
Zsolt Toeroek
Eva Udvardy
Gyoergy Dorman
Denes Medzihradszky
Bea Mezes
Eszter Kovacs
Ernoe Duda
Beatrix Farkas
Attila Glatz
Original Assignee
Biorex Kutato Es Fejlesztoe Rt.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27270113&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG63944(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biorex Kutato Es Fejlesztoe Rt. filed Critical Biorex Kutato Es Fejlesztoe Rt.
Publication of BG101713A publication Critical patent/BG101713A/xx
Publication of BG63944B1 publication Critical patent/BG63944B1/bg

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    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
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    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
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    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
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    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Neurology (AREA)
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  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
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  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG101713A 1995-11-02 1997-07-01 Производни на хидроксиламина, които се използват за повишаване продуцирането на молекулен чаперон исъстав BG63944B1 (bg)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU9503141A HU222994B1 (hu) 1995-11-02 1995-11-02 Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HU9603919 1996-02-09
HU9629820 1996-10-04
PCT/HU1996/000064 WO1997016439A1 (en) 1995-11-02 1996-11-01 Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof

Publications (2)

Publication Number Publication Date
BG101713A BG101713A (en) 1998-03-31
BG63944B1 true BG63944B1 (bg) 2003-07-31

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BG101713A BG63944B1 (bg) 1995-11-02 1997-07-01 Производни на хидроксиламина, които се използват за повишаване продуцирането на молекулен чаперон исъстав

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US (4) US6653326B1 (de)
EP (1) EP0801649B1 (de)
JP (2) JP4531865B2 (de)
KR (1) KR19980700976A (de)
CN (1) CN1152871C (de)
AT (1) ATE221880T1 (de)
AU (1) AU720195B2 (de)
BG (1) BG63944B1 (de)
BR (1) BR9607565B1 (de)
CA (1) CA2209167C (de)
CZ (1) CZ295562B6 (de)
DE (1) DE69622840T2 (de)
DK (1) DK0801649T3 (de)
EE (1) EE04239B1 (de)
ES (1) ES2176502T3 (de)
HR (1) HRP960508B1 (de)
HU (1) HU222994B1 (de)
IL (1) IL121126A (de)
MX (1) MX9704988A (de)
NO (1) NO321140B1 (de)
NZ (1) NZ320523A (de)
PL (1) PL195634B1 (de)
PT (1) PT801649E (de)
RS (1) RS49981B (de)
RU (1) RU2206320C2 (de)
SI (1) SI0801649T1 (de)
SK (1) SK284823B6 (de)
TR (1) TR199700574T1 (de)
UA (1) UA61050C2 (de)
WO (1) WO1997016439A1 (de)
ZA (1) ZA969249B (de)

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UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells
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