BG63874B1 - Производни на индол-2,3-дион-3-оксим - Google Patents
Производни на индол-2,3-дион-3-оксим Download PDFInfo
- Publication number
- BG63874B1 BG63874B1 BG102489A BG10248998A BG63874B1 BG 63874 B1 BG63874 B1 BG 63874B1 BG 102489 A BG102489 A BG 102489A BG 10248998 A BG10248998 A BG 10248998A BG 63874 B1 BG63874 B1 BG 63874B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- methyl
- dione
- phenyl
- oxime
- isoquinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK106996 | 1996-10-01 | ||
| DK127796 | 1996-11-13 | ||
| PCT/DK1997/000418 WO1998014447A1 (en) | 1996-10-01 | 1997-10-01 | Novel indole-2,3-dione-3-oxime derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG102489A BG102489A (en) | 1999-04-30 |
| BG63874B1 true BG63874B1 (bg) | 2003-04-30 |
Family
ID=26065167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102489A BG63874B1 (bg) | 1996-10-01 | 1998-05-26 | Производни на индол-2,3-дион-3-оксим |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US6124285A (cs) |
| EP (1) | EP0869958B1 (cs) |
| JP (1) | JP3319762B2 (cs) |
| KR (1) | KR100492052B1 (cs) |
| CN (1) | CN1093859C (cs) |
| AT (1) | ATE286052T1 (cs) |
| AU (1) | AU716435B2 (cs) |
| BG (1) | BG63874B1 (cs) |
| BR (1) | BR9706765A (cs) |
| CA (1) | CA2238410C (cs) |
| CZ (1) | CZ297938B6 (cs) |
| DE (1) | DE69732090T2 (cs) |
| DK (1) | DK0869958T3 (cs) |
| EE (1) | EE9800144A (cs) |
| ES (1) | ES2235253T3 (cs) |
| HK (1) | HK1017682A1 (cs) |
| HU (1) | HU225145B1 (cs) |
| IL (1) | IL124563A (cs) |
| IS (1) | IS2123B (cs) |
| NO (1) | NO310722B1 (cs) |
| NZ (1) | NZ330456A (cs) |
| PL (1) | PL193041B1 (cs) |
| PT (1) | PT869958E (cs) |
| RU (1) | RU2190612C2 (cs) |
| SI (1) | SI0869958T1 (cs) |
| SK (1) | SK282729B6 (cs) |
| TR (1) | TR199800956T1 (cs) |
| UA (1) | UA54403C2 (cs) |
| WO (1) | WO1998014447A1 (cs) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA54403C2 (uk) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
| NZ507259A (en) * | 1998-03-31 | 2003-07-25 | Neurosearch As | Indole-2,3-dione-3-oxime derivatives for therapeutic use |
| CA2369746A1 (en) | 1999-05-19 | 2000-11-30 | Neurosearch A/S | Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
| CN1298704C (zh) * | 2000-01-24 | 2007-02-07 | 神经研究公司 | 具有神经营养活性的靛红衍生物 |
| IT1318636B1 (it) * | 2000-07-21 | 2003-08-27 | Roberto Pellicciari | Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato. |
| EP1361878A1 (en) * | 2001-02-15 | 2003-11-19 | Neurosearch A/S | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity |
| WO2003006466A1 (en) | 2001-07-13 | 2003-01-23 | Pharmacia & Upjohn Company | Hexahydroazepino (4, 5-g) indoles and indolines as 5-ht receptor ligands |
| US7632948B2 (en) | 2002-08-22 | 2009-12-15 | Neurosearch A/S | Method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| US7718641B2 (en) | 2005-11-23 | 2010-05-18 | Aros Pharma Aps | Pyrrolo [3,4-H] isoquinoline compounds and methods for modulating gated ion channels |
| US20080021034A1 (en) * | 2006-04-10 | 2008-01-24 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| CA2652307A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| EP2066323A2 (en) * | 2006-09-12 | 2009-06-10 | NeuroSearch AS | Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein |
| US20080108603A1 (en) * | 2006-10-19 | 2008-05-08 | Eisenach James C | Combination therapy for the treatment of pain |
| US20080108622A1 (en) * | 2006-10-19 | 2008-05-08 | Eisenach James C | Combination therapy for the treatment of pain |
| WO2010104324A2 (ko) * | 2009-03-10 | 2010-09-16 | 한국과학기술연구원 | 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도 |
| CN102653538A (zh) * | 2011-03-04 | 2012-09-05 | 爱斯医药科技(南京)有限公司 | Spd-502的制备方法 |
| CN107635970B (zh) | 2015-04-29 | 2021-03-12 | 詹森药业有限公司 | 苯并咪唑酮和苯并噻唑酮化合物以及它们作为ampa受体调节剂的用途 |
| CN107750250B (zh) * | 2015-04-29 | 2021-09-07 | 詹森药业有限公司 | 吲哚酮化合物及其作为ampa受体调节剂的用途 |
| SG11201708190UA (en) | 2015-04-29 | 2017-11-29 | Janssen Pharmaceutica Nv | Azabenzimidazoles and their use as ampa receptor modulators |
| AU2016255431B2 (en) | 2015-04-29 | 2020-05-07 | Janssen Pharmaceutica Nv | Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9204914A (es) * | 1991-08-28 | 1993-07-01 | Frank Watjen | Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende. |
| US5721230A (en) | 1993-05-10 | 1998-02-24 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| DE69407407T2 (de) * | 1993-05-13 | 1998-04-09 | Neurosearch As | Ampa antagonisten und behandlungsmethode |
| DK81593D0 (da) * | 1993-07-07 | 1993-07-07 | Neurosearch As | Nye isatinoximderivater, deres fremstilling og anvendelse |
| JP3164371B2 (ja) * | 1994-09-14 | 2001-05-08 | ノイロサーチ アクティーゼルスカブ | インドール−２，３−ジオン−３−オキシム誘導体、その製造および使用 |
| NZ293266A (en) * | 1994-09-14 | 1998-01-26 | Neurosearch As | Fused indole and quinoxaline dione and dione oxime derivatives, preparation and pharmaceutical compositions |
| UA54403C2 (uk) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
-
1997
- 1997-01-10 UA UA98052752A patent/UA54403C2/uk unknown
- 1997-10-01 KR KR10-1998-0704103A patent/KR100492052B1/ko not_active IP Right Cessation
- 1997-10-01 AU AU43768/97A patent/AU716435B2/en not_active Ceased
- 1997-10-01 HU HU9901630A patent/HU225145B1/hu not_active IP Right Cessation
- 1997-10-01 US US09/077,554 patent/US6124285A/en not_active Expired - Lifetime
- 1997-10-01 EE EE9800144A patent/EE9800144A/xx unknown
- 1997-10-01 SK SK676-98A patent/SK282729B6/sk not_active IP Right Cessation
- 1997-10-01 AT AT97941880T patent/ATE286052T1/de not_active IP Right Cessation
- 1997-10-01 PL PL327073A patent/PL193041B1/pl not_active IP Right Cessation
- 1997-10-01 RU RU98112237/04A patent/RU2190612C2/ru not_active IP Right Cessation
- 1997-10-01 PT PT97941880T patent/PT869958E/pt unknown
- 1997-10-01 NZ NZ330456A patent/NZ330456A/en unknown
- 1997-10-01 WO PCT/DK1997/000418 patent/WO1998014447A1/en active IP Right Grant
- 1997-10-01 DE DE69732090T patent/DE69732090T2/de not_active Expired - Lifetime
- 1997-10-01 ES ES97941880T patent/ES2235253T3/es not_active Expired - Lifetime
- 1997-10-01 DK DK97941880T patent/DK0869958T3/da active
- 1997-10-01 CA CA002238410A patent/CA2238410C/en not_active Expired - Fee Related
- 1997-10-01 EP EP97941880A patent/EP0869958B1/en not_active Expired - Lifetime
- 1997-10-01 SI SI9730698T patent/SI0869958T1/xx unknown
- 1997-10-01 TR TR1998/00956T patent/TR199800956T1/xx unknown
- 1997-10-01 IL IL12456397A patent/IL124563A/xx not_active IP Right Cessation
- 1997-10-01 BR BR9706765-2A patent/BR9706765A/pt not_active Application Discontinuation
- 1997-10-01 CZ CZ0160698A patent/CZ297938B6/cs not_active IP Right Cessation
- 1997-10-01 US US09/956,892 patent/USRE38200E1/en not_active Expired - Fee Related
- 1997-10-01 JP JP51615898A patent/JP3319762B2/ja not_active Expired - Fee Related
- 1997-10-01 CN CN97191602A patent/CN1093859C/zh not_active Expired - Fee Related
-
1998
- 1998-05-18 IS IS4748A patent/IS2123B/xx unknown
- 1998-05-26 BG BG102489A patent/BG63874B1/bg unknown
- 1998-05-29 NO NO19982466A patent/NO310722B1/no not_active IP Right Cessation
-
1999
- 1999-06-30 HK HK99102769A patent/HK1017682A1/xx not_active IP Right Cessation
-
2000
- 2000-05-31 US US09/584,117 patent/US6693111B1/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG63874B1 (bg) | Производни на индол-2,3-дион-3-оксим | |
| DK174161B1 (da) | Anellerede indolderivater, fremgangsmåde til deres fremstilling og fremgangsmåde til fremstilling af farmaceutisk præparat indeholdende dem | |
| WO2007005887A2 (en) | Androgen receptor modulator compounds, compositions and uses thereof | |
| US7595336B2 (en) | Isatine derivatives with neurotrophic activity | |
| JPH08510221A (ja) | Ａｍｐａ拮抗薬およびそれを用いての治療方法 | |
| JPH03200786A (ja) | ラクタム誘導体 | |
| EP1066037B1 (en) | Use of indole-2,3-dione-3-oxime derivatives as ampa antagonists | |
| WO2000040565A1 (en) | Tetrahydroindazole derivatives as ligands for gaba-a alpha 5 receptors | |
| NZ293265A (en) | 5-aryl-isoquinoline-2-one-3-acyloxime derivatives fused with a n-heterocyclic ring | |
| MXPA98004365A (en) | Novel indole-2,3-dione-3-oxime derivatives |