IL124563A - 5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparation - Google Patents
5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparationInfo
- Publication number
- IL124563A IL124563A IL12456397A IL12456397A IL124563A IL 124563 A IL124563 A IL 124563A IL 12456397 A IL12456397 A IL 12456397A IL 12456397 A IL12456397 A IL 12456397A IL 124563 A IL124563 A IL 124563A
- Authority
- IL
- Israel
- Prior art keywords
- het
- phenyl
- pyrrolo
- isoquinoline
- preparation
- Prior art date
Links
- 125000005646 oximino group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- ZVGOSMLEXKUSJZ-UHFFFAOYSA-N pyrrolo[3,2-h]isoquinolin-2-one Chemical class N=1C(C=C2C=CC=3C=CN=CC=3C2=1)=O ZVGOSMLEXKUSJZ-UHFFFAOYSA-N 0.000 title 1
- LNMAXZZQNSPQSR-UHFFFAOYSA-N 3-(hydroxyamino)indol-2-one Chemical class C1=CC=CC2=NC(=O)C(NO)=C21 LNMAXZZQNSPQSR-UHFFFAOYSA-N 0.000 abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005225 alkynyloxycarbonyl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003257 excitatory amino acid Substances 0.000 abstract 1
- 230000002461 excitatory amino acid Effects 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- -1 hydroxy, carboxy Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK106996 | 1996-10-01 | ||
| DK127796 | 1996-11-13 | ||
| PCT/DK1997/000418 WO1998014447A1 (en) | 1996-10-01 | 1997-10-01 | Novel indole-2,3-dione-3-oxime derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL124563A0 IL124563A0 (en) | 1998-12-06 |
| IL124563A true IL124563A (en) | 2005-05-17 |
Family
ID=26065167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12456397A IL124563A (en) | 1996-10-01 | 1997-10-01 | 5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparation |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US6124285A (cs) |
| EP (1) | EP0869958B1 (cs) |
| JP (1) | JP3319762B2 (cs) |
| KR (1) | KR100492052B1 (cs) |
| CN (1) | CN1093859C (cs) |
| AT (1) | ATE286052T1 (cs) |
| AU (1) | AU716435B2 (cs) |
| BG (1) | BG63874B1 (cs) |
| BR (1) | BR9706765A (cs) |
| CA (1) | CA2238410C (cs) |
| CZ (1) | CZ297938B6 (cs) |
| DE (1) | DE69732090T2 (cs) |
| DK (1) | DK0869958T3 (cs) |
| EE (1) | EE9800144A (cs) |
| ES (1) | ES2235253T3 (cs) |
| HU (1) | HU225145B1 (cs) |
| IL (1) | IL124563A (cs) |
| IS (1) | IS2123B (cs) |
| NO (1) | NO310722B1 (cs) |
| NZ (1) | NZ330456A (cs) |
| PL (1) | PL193041B1 (cs) |
| PT (1) | PT869958E (cs) |
| RU (1) | RU2190612C2 (cs) |
| SI (1) | SI0869958T1 (cs) |
| SK (1) | SK282729B6 (cs) |
| TR (1) | TR199800956T1 (cs) |
| UA (1) | UA54403C2 (cs) |
| WO (1) | WO1998014447A1 (cs) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA54403C2 (uk) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
| CA2326576A1 (en) | 1998-03-31 | 1999-10-07 | Neurosearch A/S | Indole-2,3-dione-3-oxime derivatives for therapeutic use |
| WO2000071102A2 (en) * | 1999-05-19 | 2000-11-30 | Neurosearch A/S | Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
| US7282511B2 (en) | 2000-01-24 | 2007-10-16 | Neurosearch A/S | Isatine derivatives with neurotrophic activity |
| IT1318636B1 (it) * | 2000-07-21 | 2003-08-27 | Roberto Pellicciari | Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato. |
| EP1361878A1 (en) * | 2001-02-15 | 2003-11-19 | Neurosearch A/S | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity |
| MXPA04000358A (es) | 2001-07-13 | 2004-05-04 | Pharmacia & Up John Company | Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht. |
| CA2493244A1 (en) | 2002-08-22 | 2004-03-04 | Neurosearch A/S | A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| WO2007059608A1 (en) | 2005-11-23 | 2007-05-31 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| WO2007115403A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| US20080004282A1 (en) * | 2006-04-10 | 2008-01-03 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| EP2066323A2 (en) * | 2006-09-12 | 2009-06-10 | NeuroSearch AS | Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein |
| US20080108603A1 (en) * | 2006-10-19 | 2008-05-08 | Eisenach James C | Combination therapy for the treatment of pain |
| US20080108622A1 (en) * | 2006-10-19 | 2008-05-08 | Eisenach James C | Combination therapy for the treatment of pain |
| WO2010104324A2 (ko) * | 2009-03-10 | 2010-09-16 | 한국과학기술연구원 | 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도 |
| CN102653538A (zh) * | 2011-03-04 | 2012-09-05 | 爱斯医药科技(南京)有限公司 | Spd-502的制备方法 |
| EA033281B1 (ru) | 2015-04-29 | 2019-09-30 | Янссен Фармацевтика Нв | Азабензимидазолы и их применение в качестве модуляторов рецептора ampa |
| ES2759348T3 (es) | 2015-04-29 | 2020-05-08 | Janssen Pharmaceutica Nv | Imidazopirazinas y pirazolopirimidinas y su utilización como moduladores de receptores AMPA |
| KR20170141769A (ko) * | 2015-04-29 | 2017-12-26 | 얀센 파마슈티카 엔.브이. | 인돌론 화합물 및 ampa 수용체 조절제로서의 이의 용도 |
| KR20170141767A (ko) | 2015-04-29 | 2017-12-26 | 얀센 파마슈티카 엔.브이. | 벤즈이미다졸론 및 벤조티아졸론 화합물 및 ampa 수용체 조절제로서의 이들의 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE69677B1 (en) * | 1989-12-11 | 1996-10-02 | Neurosearch As | Isatine derivatives their preparation and use |
| MX9204914A (es) * | 1991-08-28 | 1993-07-01 | Frank Watjen | Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende. |
| TW281669B (cs) * | 1993-02-17 | 1996-07-21 | Chugai Pharmaceutical Co Ltd | |
| US5721230A (en) | 1993-05-10 | 1998-02-24 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| AU679075B2 (en) | 1993-05-13 | 1997-06-19 | Neurosearch A/S | Ampa antagonists and a method of treatment therewith |
| DK81593D0 (da) * | 1993-07-07 | 1993-07-07 | Neurosearch As | Nye isatinoximderivater, deres fremstilling og anvendelse |
| CA2199613C (en) * | 1994-09-14 | 2000-02-29 | Peter Moldt | Indole-2,3-dione-3-oxime derivatives, their preparation and use |
| NZ293266A (en) * | 1994-09-14 | 1998-01-26 | Neurosearch As | Fused indole and quinoxaline dione and dione oxime derivatives, preparation and pharmaceutical compositions |
| UA54403C2 (uk) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
-
1997
- 1997-01-10 UA UA98052752A patent/UA54403C2/uk unknown
- 1997-10-01 AT AT97941880T patent/ATE286052T1/de not_active IP Right Cessation
- 1997-10-01 KR KR10-1998-0704103A patent/KR100492052B1/ko not_active Expired - Fee Related
- 1997-10-01 HU HU9901630A patent/HU225145B1/hu not_active IP Right Cessation
- 1997-10-01 TR TR1998/00956T patent/TR199800956T1/xx unknown
- 1997-10-01 JP JP51615898A patent/JP3319762B2/ja not_active Expired - Fee Related
- 1997-10-01 CN CN97191602A patent/CN1093859C/zh not_active Expired - Fee Related
- 1997-10-01 DE DE69732090T patent/DE69732090T2/de not_active Expired - Lifetime
- 1997-10-01 CA CA002238410A patent/CA2238410C/en not_active Expired - Fee Related
- 1997-10-01 PT PT97941880T patent/PT869958E/pt unknown
- 1997-10-01 DK DK97941880T patent/DK0869958T3/da active
- 1997-10-01 BR BR9706765-2A patent/BR9706765A/pt not_active Application Discontinuation
- 1997-10-01 US US09/077,554 patent/US6124285A/en not_active Expired - Lifetime
- 1997-10-01 ES ES97941880T patent/ES2235253T3/es not_active Expired - Lifetime
- 1997-10-01 IL IL12456397A patent/IL124563A/xx not_active IP Right Cessation
- 1997-10-01 WO PCT/DK1997/000418 patent/WO1998014447A1/en active IP Right Grant
- 1997-10-01 RU RU98112237/04A patent/RU2190612C2/ru not_active IP Right Cessation
- 1997-10-01 PL PL327073A patent/PL193041B1/pl not_active IP Right Cessation
- 1997-10-01 AU AU43768/97A patent/AU716435B2/en not_active Ceased
- 1997-10-01 EE EE9800144A patent/EE9800144A/xx unknown
- 1997-10-01 US US09/956,892 patent/USRE38200E1/en not_active Expired - Fee Related
- 1997-10-01 SI SI9730698T patent/SI0869958T1/xx unknown
- 1997-10-01 NZ NZ330456A patent/NZ330456A/en unknown
- 1997-10-01 CZ CZ0160698A patent/CZ297938B6/cs not_active IP Right Cessation
- 1997-10-01 SK SK676-98A patent/SK282729B6/sk not_active IP Right Cessation
- 1997-10-01 EP EP97941880A patent/EP0869958B1/en not_active Expired - Lifetime
-
1998
- 1998-05-18 IS IS4748A patent/IS2123B/xx unknown
- 1998-05-26 BG BG102489A patent/BG63874B1/bg unknown
- 1998-05-29 NO NO19982466A patent/NO310722B1/no not_active IP Right Cessation
-
2000
- 2000-05-31 US US09/584,117 patent/US6693111B1/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |