BG63205B1 - МЕТОД ЗА ПОЛУЧАВАНЕ НА ПИРАЗОЛ[4,3-d]ПИРИМИДИН-7-ОНИ И МЕЖДИННИ СЪЕДИНЕНИЯ ЗА ТЯХ - Google Patents

МЕТОД ЗА ПОЛУЧАВАНЕ НА ПИРАЗОЛ[4,3-d]ПИРИМИДИН-7-ОНИ И МЕЖДИННИ СЪЕДИНЕНИЯ ЗА ТЯХ Download PDF

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Publication number
BG63205B1
BG63205B1 BG103794A BG10379499A BG63205B1 BG 63205 B1 BG63205 B1 BG 63205B1 BG 103794 A BG103794 A BG 103794A BG 10379499 A BG10379499 A BG 10379499A BG 63205 B1 BG63205 B1 BG 63205B1
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BG
Bulgaria
Prior art keywords
compound
tertiary
alkanol
preparation
additional base
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Application number
BG103794A
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Bulgarian (bg)
English (en)
Other versions
BG103794A (en
Inventor
Peter Dunn
Philip LEVETT
Original Assignee
Pfizer Research And Development Company, N.V./S.A.
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG63205(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Research And Development Company, N.V./S.A. filed Critical Pfizer Research And Development Company, N.V./S.A.
Publication of BG103794A publication Critical patent/BG103794A/xx
Publication of BG63205B1 publication Critical patent/BG63205B1/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
BG103794A 1998-10-12 1999-10-11 МЕТОД ЗА ПОЛУЧАВАНЕ НА ПИРАЗОЛ[4,3-d]ПИРИМИДИН-7-ОНИ И МЕЖДИННИ СЪЕДИНЕНИЯ ЗА ТЯХ BG63205B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (2)

Publication Number Publication Date
BG103794A BG103794A (en) 2000-09-29
BG63205B1 true BG63205B1 (bg) 2001-06-29

Family

ID=10840421

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103794A BG63205B1 (bg) 1998-10-12 1999-10-11 МЕТОД ЗА ПОЛУЧАВАНЕ НА ПИРАЗОЛ[4,3-d]ПИРИМИДИН-7-ОНИ И МЕЖДИННИ СЪЕДИНЕНИЯ ЗА ТЯХ

Country Status (49)

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US (3) US6207829B1 (cs)
EP (1) EP0994115B1 (cs)
JP (1) JP3721021B2 (cs)
KR (1) KR100380954B1 (cs)
CN (2) CN1473831A (cs)
AP (1) AP1233A (cs)
AR (1) AR019244A1 (cs)
AT (1) ATE290003T1 (cs)
AU (1) AU756463B2 (cs)
BG (1) BG63205B1 (cs)
BR (1) BR9905092A (cs)
CA (1) CA2285733C (cs)
CO (1) CO5150214A1 (cs)
CR (1) CR6118A (cs)
CU (1) CU22928A3 (cs)
CZ (1) CZ296816B6 (cs)
DE (1) DE69923906T2 (cs)
DK (1) DK0994115T3 (cs)
DZ (1) DZ2912A1 (cs)
EA (1) EA003774B1 (cs)
EE (1) EE04192B1 (cs)
EG (1) EG22630A (cs)
ES (1) ES2237049T3 (cs)
GB (1) GB9822238D0 (cs)
GE (1) GEP20022700B (cs)
GT (1) GT199900172A (cs)
HK (1) HK1027559A1 (cs)
HR (1) HRP990318B1 (cs)
HU (1) HU226162B1 (cs)
ID (1) ID23351A (cs)
IL (11) IL152927A (cs)
IS (1) IS1951B (cs)
MA (1) MA25007A1 (cs)
MY (1) MY124620A (cs)
NO (1) NO313700B1 (cs)
OA (1) OA11165A (cs)
PE (1) PE20001086A1 (cs)
PL (1) PL198150B1 (cs)
PT (1) PT994115E (cs)
RS (1) RS49762B (cs)
SG (1) SG118060A1 (cs)
SI (1) SI0994115T1 (cs)
SK (1) SK285215B6 (cs)
TN (1) TNSN99189A1 (cs)
TR (1) TR199902541A2 (cs)
TW (1) TW589314B (cs)
UA (1) UA66787C2 (cs)
UY (1) UY25750A1 (cs)
ZA (1) ZA996412B (cs)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
YU93902A (sh) * 2000-06-22 2005-11-28 Pfizer Products Inc. Postupak za pripremanje pirazolopirimidinona
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
YU51701A (sh) * 2000-07-28 2003-12-31 Pfizer Inc. Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
EP1458679B1 (en) 2001-12-20 2010-01-20 Merck Serono SA Pyrrolidine derivatives as prostaglandin modulators
CA2470427C (en) * 2001-12-21 2012-07-10 Cytokinetics, Incorporated Compositions and methods for treating heart failure
EP1719772A1 (en) 2002-05-31 2006-11-08 Schering Corporation Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
ES2378620T3 (es) * 2003-03-27 2012-04-16 Cytokinetics, Inc. Sulfonamidas para el tratamiento de insuficiencia cardiaca congestiva, sus composiciones y usos.
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
EP2024369A4 (en) * 2006-06-05 2010-10-27 Matrix Lab Ltd NEW PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
WO1998049166A1 (en) * 1997-04-25 1998-11-05 Pfizer Limited PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION

Also Published As

Publication number Publication date
HU226162B1 (en) 2008-05-28
IL152923A0 (en) 2003-06-24
IL152927A (en) 2004-06-01
IL132273A0 (en) 2001-03-19
SI0994115T1 (cs) 2005-08-31
HU9903469D0 (en) 1999-12-28
SG118060A1 (en) 2006-01-27
CA2285733C (en) 2004-08-24
CR6118A (es) 2005-09-16
GEP20022700B (en) 2002-05-27
NO313700B1 (no) 2002-11-18
IS5209A (is) 2000-04-13
IL152926A (en) 2004-02-19
SK138599A3 (en) 2000-05-16
GT199900172A (es) 2001-03-28
US20010009962A1 (en) 2001-07-26
IL152928A (en) 2007-07-04
RS49762B (sr) 2008-04-04
JP2000119273A (ja) 2000-04-25
CU22928A3 (es) 2004-02-20
IL152927A0 (en) 2003-06-24
HUP9903469A3 (en) 2000-10-30
PL198150B1 (pl) 2008-05-30
CN1473831A (zh) 2004-02-11
ES2237049T3 (es) 2005-07-16
TNSN99189A1 (fr) 2005-11-10
SK285215B6 (sk) 2006-09-07
CZ353299A3 (cs) 2000-05-17
IL152924A (en) 2004-02-19
BR9905092A (pt) 2000-08-08
MA25007A1 (fr) 2000-07-01
ZA996412B (en) 2001-04-11
EP0994115A2 (en) 2000-04-19
JP3721021B2 (ja) 2005-11-30
MY124620A (en) 2006-06-30
EA199900822A3 (ru) 2000-08-28
EP0994115A3 (en) 2000-05-24
CO5150214A1 (es) 2002-04-29
IL152923A (en) 2004-02-08
PL335959A1 (en) 2000-04-25
IS1951B (is) 2004-10-13
PT994115E (pt) 2005-06-30
UA66787C2 (en) 2004-06-15
DZ2912A1 (fr) 2004-03-01
US20030069422A1 (en) 2003-04-10
CN1255497A (zh) 2000-06-07
YU48999A (sh) 2002-06-19
AU5358199A (en) 2000-04-13
IL132273A (en) 2004-06-20
EA199900822A2 (ru) 2000-04-24
EE04192B1 (et) 2003-12-15
EA003774B1 (ru) 2003-08-28
ID23351A (id) 2000-04-13
AR019244A1 (es) 2001-12-26
US6207829B1 (en) 2001-03-27
TW589314B (en) 2004-06-01
KR100380954B1 (ko) 2003-04-21
EP0994115B1 (en) 2005-03-02
CA2285733A1 (en) 2000-04-12
NO994943D0 (no) 1999-10-11
OA11165A (en) 2003-04-22
IL152926A0 (en) 2003-06-24
CZ296816B6 (cs) 2006-06-14
EG22630A (en) 2003-05-31
HUP9903469A2 (hu) 2000-08-28
IL152928A0 (en) 2003-06-24
NO994943L (no) 2000-04-13
AU756463B2 (en) 2003-01-16
HRP990318A2 (en) 2000-06-30
HK1027559A1 (en) 2001-01-19
TR199902541A2 (xx) 2000-07-21
GB9822238D0 (en) 1998-12-09
PE20001086A1 (es) 2000-10-18
CN1207295C (zh) 2005-06-22
KR20000028987A (ko) 2000-05-25
AP1233A (en) 2003-12-18
HRP990318B1 (en) 2004-06-30
IL152924A0 (en) 2003-06-24
AP9901672A0 (en) 1999-12-31
EE9900507A (et) 2000-06-15
BG103794A (en) 2000-09-29
DE69923906T2 (de) 2006-04-06
DK0994115T3 (da) 2005-06-20
ATE290003T1 (de) 2005-03-15
UY25750A1 (es) 2001-08-27
DE69923906D1 (de) 2005-04-07

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BG63205B1 (bg) МЕТОД ЗА ПОЛУЧАВАНЕ НА ПИРАЗОЛ[4,3-d]ПИРИМИДИН-7-ОНИ И МЕЖДИННИ СЪЕДИНЕНИЯ ЗА ТЯХ
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