SG118060A1 - Process for preparation of pyrazoloÄ4,3-dÜpyrimidin-7-ones and intermediates thereof - Google Patents

Process for preparation of pyrazoloÄ4,3-dÜpyrimidin-7-ones and intermediates thereof

Info

Publication number
SG118060A1
SG118060A1 SG1999005097A SG1999005097A SG118060A1 SG 118060 A1 SG118060 A1 SG 118060A1 SG 1999005097 A SG1999005097 A SG 1999005097A SG 1999005097 A SG1999005097 A SG 1999005097A SG 118060 A1 SG118060 A1 SG 118060A1
Authority
SG
Singapore
Prior art keywords
düpyrimidin
intermediates
ones
preparation
Prior art date
Application number
SG1999005097A
Other languages
English (en)
Inventor
James Dunn Peter
Charles Levett Philip
Original Assignee
Pfizer Ireland Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG118060(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
Publication of SG118060A1 publication Critical patent/SG118060A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG1999005097A 1998-10-12 1999-10-12 Process for preparation of pyrazoloÄ4,3-dÜpyrimidin-7-ones and intermediates thereof SG118060A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (1)

Publication Number Publication Date
SG118060A1 true SG118060A1 (en) 2006-01-27

Family

ID=10840421

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1999005097A SG118060A1 (en) 1998-10-12 1999-10-12 Process for preparation of pyrazoloÄ4,3-dÜpyrimidin-7-ones and intermediates thereof

Country Status (48)

Country Link
US (3) US6207829B1 (cs)
EP (1) EP0994115B1 (cs)
JP (1) JP3721021B2 (cs)
KR (1) KR100380954B1 (cs)
CN (2) CN1473831A (cs)
AP (1) AP1233A (cs)
AR (1) AR019244A1 (cs)
AT (1) ATE290003T1 (cs)
AU (1) AU756463B2 (cs)
BG (1) BG63205B1 (cs)
BR (1) BR9905092A (cs)
CA (1) CA2285733C (cs)
CO (1) CO5150214A1 (cs)
CR (1) CR6118A (cs)
CU (1) CU22928A3 (cs)
CZ (1) CZ296816B6 (cs)
DE (1) DE69923906T2 (cs)
DK (1) DK0994115T3 (cs)
DZ (1) DZ2912A1 (cs)
EA (1) EA003774B1 (cs)
EE (1) EE04192B1 (cs)
EG (1) EG22630A (cs)
ES (1) ES2237049T3 (cs)
GB (1) GB9822238D0 (cs)
GE (1) GEP20022700B (cs)
GT (1) GT199900172A (cs)
HR (1) HRP990318B1 (cs)
HU (1) HU226162B1 (cs)
ID (1) ID23351A (cs)
IL (11) IL152923A (cs)
IS (1) IS1951B (cs)
MA (1) MA25007A1 (cs)
MY (1) MY124620A (cs)
NO (1) NO313700B1 (cs)
OA (1) OA11165A (cs)
PE (1) PE20001086A1 (cs)
PL (1) PL198150B1 (cs)
PT (1) PT994115E (cs)
RS (1) RS49762B (cs)
SG (1) SG118060A1 (cs)
SI (1) SI0994115T1 (cs)
SK (1) SK285215B6 (cs)
TN (1) TNSN99189A1 (cs)
TR (1) TR199902541A2 (cs)
TW (1) TW589314B (cs)
UA (1) UA66787C2 (cs)
UY (1) UY25750A1 (cs)
ZA (1) ZA996412B (cs)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078760A1 (fr) * 1999-06-21 2000-12-28 The Biochemical Pharmaceutical Factory Of Zhuhai Sez Procede de preparation de sildenafil, agent et procede d'obtention d'un comprime mixte a base de sildenafil et de chlorhydrate d'apomorphine
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
IL153532A0 (en) * 2000-06-22 2003-07-06 Pfizer Process for the preparation of pyrazolopyrimidinones
EP1176147A1 (en) * 2000-07-28 2002-01-30 Pfizer Limited Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
IL162602A0 (en) 2001-12-20 2005-11-20 Applied Research Systems Pyrrolidine derivatives as prostaglandin modulators
AU2002367023A1 (en) * 2001-12-21 2003-07-30 Cytokinetics, Inc. Compositions and methods for treating heart failure
EP1719772A1 (en) 2002-05-31 2006-11-08 Schering Corporation Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
EP1605752B1 (en) * 2003-03-27 2011-09-14 Cytokinetics, Inc. Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
WO2007141805A2 (en) * 2006-06-05 2007-12-13 Matrix Laboratories Limited Novel process for the preparation of sildenafil citrate
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
EP0812845A1 (en) * 1996-06-14 1997-12-17 Pfizer Limited Process for preparing sildenafil
WO1998049166A1 (en) * 1997-04-25 1998-11-05 Pfizer Limited PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
EP0812845A1 (en) * 1996-06-14 1997-12-17 Pfizer Limited Process for preparing sildenafil
WO1998049166A1 (en) * 1997-04-25 1998-11-05 Pfizer Limited PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION

Also Published As

Publication number Publication date
ZA996412B (en) 2001-04-11
SK285215B6 (sk) 2006-09-07
IS5209A (is) 2000-04-13
DE69923906T2 (de) 2006-04-06
YU48999A (sh) 2002-06-19
KR100380954B1 (ko) 2003-04-21
US20030069422A1 (en) 2003-04-10
IL152924A0 (en) 2003-06-24
UA66787C2 (en) 2004-06-15
UY25750A1 (es) 2001-08-27
HUP9903469A2 (hu) 2000-08-28
CA2285733C (en) 2004-08-24
MA25007A1 (fr) 2000-07-01
SI0994115T1 (cs) 2005-08-31
EP0994115A3 (en) 2000-05-24
HU226162B1 (en) 2008-05-28
IL152924A (en) 2004-02-19
AU756463B2 (en) 2003-01-16
PL198150B1 (pl) 2008-05-30
CU22928A3 (es) 2004-02-20
IL152926A (en) 2004-02-19
JP3721021B2 (ja) 2005-11-30
IL152923A0 (en) 2003-06-24
IL152927A (en) 2004-06-01
TW589314B (en) 2004-06-01
NO313700B1 (no) 2002-11-18
HU9903469D0 (en) 1999-12-28
DZ2912A1 (fr) 2004-03-01
CN1207295C (zh) 2005-06-22
KR20000028987A (ko) 2000-05-25
IL132273A0 (en) 2001-03-19
HRP990318A2 (en) 2000-06-30
SK138599A3 (en) 2000-05-16
JP2000119273A (ja) 2000-04-25
HUP9903469A3 (en) 2000-10-30
IL152926A0 (en) 2003-06-24
ATE290003T1 (de) 2005-03-15
PE20001086A1 (es) 2000-10-18
ES2237049T3 (es) 2005-07-16
CZ353299A3 (cs) 2000-05-17
TNSN99189A1 (fr) 2005-11-10
EE04192B1 (et) 2003-12-15
EG22630A (en) 2003-05-31
OA11165A (en) 2003-04-22
HK1027559A1 (en) 2001-01-19
AR019244A1 (es) 2001-12-26
CZ296816B6 (cs) 2006-06-14
IL152927A0 (en) 2003-06-24
DE69923906D1 (de) 2005-04-07
PL335959A1 (en) 2000-04-25
BG63205B1 (bg) 2001-06-29
GT199900172A (es) 2001-03-28
NO994943D0 (no) 1999-10-11
HRP990318B1 (en) 2004-06-30
BG103794A (en) 2000-09-29
IS1951B (is) 2004-10-13
DK0994115T3 (da) 2005-06-20
AP9901672A0 (en) 1999-12-31
EP0994115A2 (en) 2000-04-19
IL132273A (en) 2004-06-20
AP1233A (en) 2003-12-18
ID23351A (id) 2000-04-13
IL152923A (en) 2004-02-08
EP0994115B1 (en) 2005-03-02
MY124620A (en) 2006-06-30
CN1255497A (zh) 2000-06-07
IL152928A (en) 2007-07-04
GB9822238D0 (en) 1998-12-09
US6207829B1 (en) 2001-03-27
GEP20022700B (en) 2002-05-27
NO994943L (no) 2000-04-13
AU5358199A (en) 2000-04-13
IL152928A0 (en) 2003-06-24
CN1473831A (zh) 2004-02-11
EA199900822A3 (ru) 2000-08-28
TR199902541A2 (xx) 2000-07-21
RS49762B (sr) 2008-04-04
CA2285733A1 (en) 2000-04-12
CO5150214A1 (es) 2002-04-29
PT994115E (pt) 2005-06-30
BR9905092A (pt) 2000-08-08
US20010009962A1 (en) 2001-07-26
CR6118A (es) 2005-09-16
EA003774B1 (ru) 2003-08-28
EA199900822A2 (ru) 2000-04-24
EE9900507A (et) 2000-06-15

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