BG62850B1 - Метод за получаване на антагонисти на левкотриена - Google Patents

Метод за получаване на антагонисти на левкотриена Download PDF

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Publication number
BG62850B1
BG62850B1 BG100638A BG10063896A BG62850B1 BG 62850 B1 BG62850 B1 BG 62850B1 BG 100638 A BG100638 A BG 100638A BG 10063896 A BG10063896 A BG 10063896A BG 62850 B1 BG62850 B1 BG 62850B1
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BG
Bulgaria
Prior art keywords
solution
compound
toluene
formula
added
Prior art date
Application number
BG100638A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG100638A (bg
Inventor
Mahadevan Bhupathy
James M. Mcnamara
Daniel R. Sidler
Ralph P. Volante
James J. Bergan
Original Assignee
Merck & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26870681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG62850(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co. filed Critical Merck & Co.
Publication of BG100638A publication Critical patent/BG100638A/bg
Publication of BG62850B1 publication Critical patent/BG62850B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/53—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
BG100638A 1993-12-28 1996-06-06 Метод за получаване на антагонисти на левкотриена BG62850B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17493193A 1993-12-28 1993-12-28
US35042894A 1994-12-09 1994-12-09
PCT/US1994/014858 WO1995018107A1 (fr) 1993-12-28 1994-12-22 Procede de preparation d'antagonistes des leukotrienes

Publications (2)

Publication Number Publication Date
BG100638A BG100638A (bg) 1997-03-31
BG62850B1 true BG62850B1 (bg) 2000-09-29

Family

ID=26870681

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100638A BG62850B1 (bg) 1993-12-28 1996-06-06 Метод за получаване на антагонисти на левкотриена

Country Status (29)

Country Link
US (2) US5614632A (fr)
EP (1) EP0737186B1 (fr)
JP (1) JP3640962B2 (fr)
KR (1) KR100319336B1 (fr)
CN (3) CN101081834B (fr)
AT (1) ATE169906T1 (fr)
AU (1) AU686303B2 (fr)
BG (1) BG62850B1 (fr)
BR (1) BR9408452A (fr)
CA (1) CA2179407C (fr)
CY (1) CY2104B1 (fr)
CZ (1) CZ286079B6 (fr)
DE (1) DE69412644T2 (fr)
DK (1) DK0737186T3 (fr)
ES (1) ES2122534T3 (fr)
FI (1) FI113045B (fr)
GE (1) GEP20012387B (fr)
HK (1) HK1009269A1 (fr)
HR (1) HRP941022B1 (fr)
HU (1) HU226394B1 (fr)
LV (1) LV12313B (fr)
NZ (1) NZ278263A (fr)
PL (1) PL178671B1 (fr)
RO (1) RO119018B1 (fr)
RU (2) RU2140909C1 (fr)
TW (2) TW448160B (fr)
UA (1) UA44724C2 (fr)
WO (1) WO1995018107A1 (fr)
YU (1) YU49412B (fr)

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CN102633683B (zh) * 2012-04-06 2014-05-21 盐城市晶华化工有限公司 一种1-羟甲基环丙基乙腈合成方法
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CN103539714A (zh) * 2012-07-16 2014-01-29 上海朴颐化学科技有限公司 1-巯甲基环丙基乙酸及其中间体的制备方法
WO2014012954A1 (fr) 2012-07-18 2014-01-23 Takeda Gmbh Traitement de l'asthme sévère partiellement régulé ou non régulé
WO2014081616A1 (fr) * 2012-11-21 2014-05-30 Merck Sharp & Dohme Corp. Préparation de précurseurs d'antagonistes de leucotriène
WO2014118796A1 (fr) * 2013-01-31 2014-08-07 Melody Healthcare Pvt. Ltd. Procédé in situ pour la préparation de montélukast sodique hautement pur
CN103570618A (zh) * 2013-09-30 2014-02-12 浙江车头制药股份有限公司 一种孟鲁司特钠盐的制备方法
JP2017503814A (ja) 2014-01-22 2017-02-02 タケダ ゲー・エム・ベー・ハーＴａｋｅｄａ ＧｍｂＨ 部分的コントロール状態の重症喘息またはコントロール不良状態の重症喘息のｐｄｅ４インヒビターを用いた（およびロイコトリエン調節薬と組み合わせて用いた）治療
CN104119270A (zh) * 2014-08-12 2014-10-29 牡丹江恒远药业有限公司 一种孟鲁司特钠的制备方法
CN105085391B (zh) * 2015-06-10 2017-08-22 广东默泰同创医药科技有限公司 用作白三烯受体拮抗剂的环丙基不饱和喹啉化合物及应用
CN105541786B (zh) * 2016-01-06 2017-08-08 鲁南贝特制药有限公司 一种孟鲁司特钠侧链中间体及其制备方法
CN109503476A (zh) * 2018-12-26 2019-03-22 哈尔滨珍宝制药有限公司 一种孟鲁司特钠的合成工艺
CN111170939A (zh) * 2019-12-20 2020-05-19 牡丹江恒远药业股份有限公司 一种高纯度孟鲁司特钠及其中间体的制备方法

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CA2111372C (fr) * 1992-12-22 2007-01-16 Robert N. Young Acides heterocycliques diaryliques condenses en 5,6, antagonistes de la leucotriene
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EP0737186A1 (fr) 1996-10-16
AU1444895A (en) 1995-07-17
DK0737186T3 (da) 1999-02-08
US5614632A (en) 1997-03-25
CZ286079B6 (cs) 2000-01-12
BR9408452A (pt) 1997-08-05
EP0737186B1 (fr) 1998-08-19
CY2104B1 (en) 2002-04-05
HU226394B1 (en) 2008-11-28
BG100638A (bg) 1997-03-31
JPH09507235A (ja) 1997-07-22
HUT76279A (en) 1997-07-28
PL315155A1 (en) 1996-10-14
LV12313B (en) 1999-11-20
CN1139429A (zh) 1997-01-01
PL178671B1 (pl) 2000-05-31
YU49412B (sh) 2006-01-16
CZ187896A3 (en) 1996-12-11
RU2140909C1 (ru) 1999-11-10
CA2179407A1 (fr) 1995-07-06
FI113045B (fi) 2004-02-27
UA44724C2 (uk) 2002-03-15
WO1995018107A1 (fr) 1995-07-06
HRP941022A2 (en) 1997-06-30
CN1219535A (zh) 1999-06-16
NZ278263A (en) 1998-04-27
US6320052B1 (en) 2001-11-20
CA2179407C (fr) 2009-03-17
RO119018B1 (ro) 2004-02-27
CN101081834B (zh) 2011-08-24
CN101081834A (zh) 2007-12-05
ATE169906T1 (de) 1998-09-15
DE69412644T2 (de) 1999-02-11
AU686303B2 (en) 1998-02-05
CN1046712C (zh) 1999-11-24
TW416948B (en) 2001-01-01
CN1326837C (zh) 2007-07-18
ES2122534T3 (es) 1998-12-16
DE69412644D1 (de) 1998-09-24
JP3640962B2 (ja) 2005-04-20
HRP941022B1 (en) 1999-12-31
FI962641A0 (fi) 1996-06-26
HU9601775D0 (en) 1996-09-30
GEP20012387B (en) 2001-03-25
LV12313A (lv) 1999-07-20
YU77594A (sh) 1997-09-30
FI962641A (fi) 1996-06-26
KR100319336B1 (ko) 2002-04-22
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RU2225398C2 (ru) 2004-03-10
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