ATE528294T1 - Montelukast-benzhydryl-piperazin-salze und verfahren zu ihrer herstellung - Google Patents

Montelukast-benzhydryl-piperazin-salze und verfahren zu ihrer herstellung

Info

Publication number
ATE528294T1
ATE528294T1 AT09719393T AT09719393T ATE528294T1 AT E528294 T1 ATE528294 T1 AT E528294T1 AT 09719393 T AT09719393 T AT 09719393T AT 09719393 T AT09719393 T AT 09719393T AT E528294 T1 ATE528294 T1 AT E528294T1
Authority
AT
Austria
Prior art keywords
phenyl
montelukast
piperazine salts
production
benzhydryl piperazine
Prior art date
Application number
AT09719393T
Other languages
English (en)
Inventor
Nitin Shimpi
Mahendra Lakkad
Sunil Nadkarni
V V Srinivasa A
Original Assignee
Torrent Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticals Ltd filed Critical Torrent Pharmaceuticals Ltd
Application granted granted Critical
Publication of ATE528294T1 publication Critical patent/ATE528294T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT09719393T 2008-01-07 2009-01-05 Montelukast-benzhydryl-piperazin-salze und verfahren zu ihrer herstellung ATE528294T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN38MU2008 2008-01-07
PCT/IN2009/000011 WO2009113087A1 (en) 2008-01-07 2009-01-05 Montelukast benzhydryl piperazine salts and process for preparation thereof

Publications (1)

Publication Number Publication Date
ATE528294T1 true ATE528294T1 (de) 2011-10-15

Family

ID=40908540

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09719393T ATE528294T1 (de) 2008-01-07 2009-01-05 Montelukast-benzhydryl-piperazin-salze und verfahren zu ihrer herstellung

Country Status (4)

Country Link
US (1) US20100292251A1 (de)
EP (1) EP2231613B1 (de)
AT (1) ATE528294T1 (de)
WO (1) WO2009113087A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011121091A1 (en) 2010-03-31 2011-10-06 Krka, D.D., Novo Mesto Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
WO2012077133A1 (en) * 2010-12-07 2012-06-14 Ind-Swift Laboratories Limited Processes for preparation of montelukast sodium and purification of diol intermediate
CN105585525B (zh) * 2016-02-29 2018-08-14 山东新时代药业有限公司 一种孟鲁司特钠的合成方法
WO2023088319A1 (zh) * 2021-11-16 2023-05-25 温州医科大学附属眼视光医院 孟鲁斯特酸小檗碱类季铵盐化合物、复盐组合物及其合成方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW448160B (en) * 1993-12-28 2001-08-01 Merck & Co Inc Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
US20050107612A1 (en) * 2002-12-30 2005-05-19 Dr. Reddy's Laboratories Limited Process for preparation of montelukast and its salts
US7189853B2 (en) * 2004-04-15 2007-03-13 Dr. Reddy's Laboratories Limited Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts
JP2009526047A (ja) * 2006-02-09 2009-07-16 テバ ファーマシューティカル インダストリーズ リミティド モンテルカストナトリウムの安定な医薬製剤
IL181485A0 (en) * 2006-02-21 2007-07-04 Chemagis Ltd Processes for preparing novel montelukast salts

Also Published As

Publication number Publication date
EP2231613B1 (de) 2011-10-12
US20100292251A1 (en) 2010-11-18
WO2009113087A1 (en) 2009-09-17
EP2231613A1 (de) 2010-09-29

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