ATE528294T1 - Montelukast-benzhydryl-piperazin-salze und verfahren zu ihrer herstellung - Google Patents
Montelukast-benzhydryl-piperazin-salze und verfahren zu ihrer herstellungInfo
- Publication number
- ATE528294T1 ATE528294T1 AT09719393T AT09719393T ATE528294T1 AT E528294 T1 ATE528294 T1 AT E528294T1 AT 09719393 T AT09719393 T AT 09719393T AT 09719393 T AT09719393 T AT 09719393T AT E528294 T1 ATE528294 T1 AT E528294T1
- Authority
- AT
- Austria
- Prior art keywords
- phenyl
- montelukast
- piperazine salts
- production
- benzhydryl piperazine
- Prior art date
Links
- -1 MONTELUKAST BENZHYDRYL PIPERAZINE SALTS Chemical class 0.000 title 1
- 229960005127 montelukast Drugs 0.000 title 1
- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical class CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 abstract 3
- 150000008640 diphenylmethylpiperazines Chemical class 0.000 abstract 2
- 150000001447 alkali salts Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN38MU2008 | 2008-01-07 | ||
| PCT/IN2009/000011 WO2009113087A1 (en) | 2008-01-07 | 2009-01-05 | Montelukast benzhydryl piperazine salts and process for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE528294T1 true ATE528294T1 (de) | 2011-10-15 |
Family
ID=40908540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09719393T ATE528294T1 (de) | 2008-01-07 | 2009-01-05 | Montelukast-benzhydryl-piperazin-salze und verfahren zu ihrer herstellung |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100292251A1 (de) |
| EP (1) | EP2231613B1 (de) |
| AT (1) | ATE528294T1 (de) |
| WO (1) | WO2009113087A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011121091A1 (en) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
| WO2012077133A1 (en) * | 2010-12-07 | 2012-06-14 | Ind-Swift Laboratories Limited | Processes for preparation of montelukast sodium and purification of diol intermediate |
| CN105585525B (zh) * | 2016-02-29 | 2018-08-14 | 山东新时代药业有限公司 | 一种孟鲁司特钠的合成方法 |
| US12221418B2 (en) | 2021-11-16 | 2025-02-11 | Eye Hospital, Wenzhou Medical University | Montelukast berberine quaternary ammonium salt compound and double salt composition, and synthesis method therefor and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW448160B (en) * | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
| US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
| US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
| CN101365450A (zh) * | 2006-02-09 | 2009-02-11 | 特瓦制药工业有限公司 | 孟鲁司特钠的稳定药物制剂 |
| JP2009529495A (ja) * | 2006-02-21 | 2009-08-20 | ケマジス・リミテッド | モンテルカストアンモニウム塩の新規な多形体およびその調製方法 |
-
2009
- 2009-01-05 US US12/810,736 patent/US20100292251A1/en not_active Abandoned
- 2009-01-05 WO PCT/IN2009/000011 patent/WO2009113087A1/en not_active Ceased
- 2009-01-05 EP EP09719393A patent/EP2231613B1/de not_active Not-in-force
- 2009-01-05 AT AT09719393T patent/ATE528294T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20100292251A1 (en) | 2010-11-18 |
| WO2009113087A1 (en) | 2009-09-17 |
| EP2231613B1 (de) | 2011-10-12 |
| EP2231613A1 (de) | 2010-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |