WO2014188453A3 - Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid - Google Patents

Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid Download PDF

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Publication number
WO2014188453A3
WO2014188453A3 PCT/IN2014/000353 IN2014000353W WO2014188453A3 WO 2014188453 A3 WO2014188453 A3 WO 2014188453A3 IN 2014000353 W IN2014000353 W IN 2014000353W WO 2014188453 A3 WO2014188453 A3 WO 2014188453A3
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WO
WIPO (PCT)
Prior art keywords
preparation
benzimidazol
ethoxyethyl
piperidinyl
phenyl
Prior art date
Application number
PCT/IN2014/000353
Other languages
French (fr)
Other versions
WO2014188453A2 (en
Inventor
Srinivasan Thirumalai Rajan
Sajja Eswaraiah
Ghojala Venkat Reddy
Original Assignee
Msn Laboratories Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Private Limited filed Critical Msn Laboratories Private Limited
Priority claimed from IN5394CH2013 external-priority patent/IN2013CH05394A/en
Publication of WO2014188453A2 publication Critical patent/WO2014188453A2/en
Publication of WO2014188453A3 publication Critical patent/WO2014188453A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to novel process for the preparation of 2-[4-(2-{4-[l-(2- ethoxyethyl)-lH-benzimidazol-2-yl]-l-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid represented by the following structural formula- 1. Formula- 1 The present invention also provides novel intermediate compounds useful for the preparation of compound of formula- 1.
PCT/IN2014/000353 2013-05-24 2014-05-26 Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid WO2014188453A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2276/CHE/2013 2013-05-24
IN2276CH2013 2013-05-24
IN5394/CHE/2013 2013-11-22
IN5394CH2013 IN2013CH05394A (en) 2013-11-22 2014-05-26

Publications (2)

Publication Number Publication Date
WO2014188453A2 WO2014188453A2 (en) 2014-11-27
WO2014188453A3 true WO2014188453A3 (en) 2015-02-26

Family

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PCT/IN2014/000353 WO2014188453A2 (en) 2013-05-24 2014-05-26 Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid

Country Status (1)

Country Link
WO (1) WO2014188453A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106699728A (en) * 2015-07-13 2017-05-24 南京长澳医药科技有限公司 Bilastine intermediate impurity and preparation method thereof
CN105254579A (en) * 2015-09-19 2016-01-20 万全万特制药江苏有限公司 Method for preparing bilastine intermediate through one-kettle process
WO2018042305A1 (en) * 2016-08-29 2018-03-08 Symed Labs Limited Improved processes for preparation of bilastine using novel intermediates
CN106631687B (en) * 2016-12-21 2019-08-30 山东新和成药业有限公司 A method of with synthesizing leaf alcohol under silane-Lewis acid catalytic systems
CN107365298A (en) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 A kind of preparation method of the benzyl propionate derivant of 2 methyl 2 '
CN109810093A (en) * 2017-11-20 2019-05-28 重庆华邦胜凯制药有限公司 A kind of preparation method of bilastine intermediate
EP3599235A1 (en) 2018-07-24 2020-01-29 Faes Farma, S.A. Process and intermediates for the preparation of bilastine
CN110950837A (en) * 2018-09-27 2020-04-03 上海天慈中商药业有限公司 Preparation method of bilastine
CN111039784A (en) * 2019-12-18 2020-04-21 厦门云凡医药科技有限公司 Preparation method of bilastine intermediate
CN111039922A (en) * 2019-12-27 2020-04-21 山东罗欣药业集团恒欣药业有限公司 Preparation process of bilastine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877187A (en) * 1996-06-04 1999-03-02 Fabrica Espanola De Productos Quimicos Y Farmaceuticos S.A. (Faes) Benzimidazole derivatives with antihistaminic activity
US7612095B2 (en) * 2002-04-19 2009-11-03 Faes Farma, S.A. Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-yl]-1-piperidinyl]ethyl]-αα-dimethyl-benzeneacetic acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877187A (en) * 1996-06-04 1999-03-02 Fabrica Espanola De Productos Quimicos Y Farmaceuticos S.A. (Faes) Benzimidazole derivatives with antihistaminic activity
US7612095B2 (en) * 2002-04-19 2009-11-03 Faes Farma, S.A. Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-yl]-1-piperidinyl]ethyl]-αα-dimethyl-benzeneacetic acid

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WO2014188453A2 (en) 2014-11-27

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