SA113340696B1 - تصنيع 2-(5-برومو-4-(4-سيكلو بروبيل نافثالين-1-يل)-4 h-1، 2، 4- ترازول-3- يل ثيو) حمض أسيتيك - Google Patents

تصنيع 2-(5-برومو-4-(4-سيكلو بروبيل نافثالين-1-يل)-4 h-1، 2، 4- ترازول-3- يل ثيو) حمض أسيتيك

Info

Publication number
SA113340696B1
SA113340696B1 SA113340696A SA113340696A SA113340696B1 SA 113340696 B1 SA113340696 B1 SA 113340696B1 SA 113340696 A SA113340696 A SA 113340696A SA 113340696 A SA113340696 A SA 113340696A SA 113340696 B1 SA113340696 B1 SA 113340696B1
Authority
SA
Saudi Arabia
Prior art keywords
cyclopropylnaphthalen
ylthio
triazol
bromo
manufacture
Prior art date
Application number
SA113340696A
Other languages
English (en)
Inventor
جونيك إسمير
جالفين جابريل
Original Assignee
ارديا بيوساينسيز، انك.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ارديا بيوساينسيز، انك. filed Critical ارديا بيوساينسيز، انك.
Publication of SA113340696B1 publication Critical patent/SA113340696B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

يتعلق الاختراع الحالي بعمليات عملية لتحضير المركب 4 : (المركب 4). تشتمل على ملامسة مركب له الصيغة (III): الصيغة (III)؛ حيث R عبارة عن C1-C20 alkyl ، C1-C20 alkenyl ، C3-C10 cycloalkyl ، أو C3-C10 cycloalkenyl ؛ مع محلول sodium hydroxide . شكل 1.
SA113340696A 2012-07-03 2013-07-03 تصنيع 2-(5-برومو-4-(4-سيكلو بروبيل نافثالين-1-يل)-4 h-1، 2، 4- ترازول-3- يل ثيو) حمض أسيتيك SA113340696B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261667922P 2012-07-03 2012-07-03

Publications (1)

Publication Number Publication Date
SA113340696B1 true SA113340696B1 (ar) 2016-03-06

Family

ID=49882471

Family Applications (2)

Application Number Title Priority Date Filing Date
SA115360678A SA115360678B1 (ar) 2012-07-03 2013-07-03 تصنيع حمض 2-(5-برومو-4-(4-سيكلو بروبيل نافثالين-1-يل)-4 h-1، 2، 4- ترازول-3- يل ثيو) أسيتيك
SA113340696A SA113340696B1 (ar) 2012-07-03 2013-07-03 تصنيع 2-(5-برومو-4-(4-سيكلو بروبيل نافثالين-1-يل)-4 h-1، 2، 4- ترازول-3- يل ثيو) حمض أسيتيك

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SA115360678A SA115360678B1 (ar) 2012-07-03 2013-07-03 تصنيع حمض 2-(5-برومو-4-(4-سيكلو بروبيل نافثالين-1-يل)-4 h-1، 2، 4- ترازول-3- يل ثيو) أسيتيك

Country Status (26)

Country Link
US (2) US9296709B2 (ar)
EP (1) EP2870142B1 (ar)
JP (1) JP6124226B2 (ar)
KR (1) KR20150028992A (ar)
CN (1) CN104736522B (ar)
AR (1) AR091651A1 (ar)
AU (1) AU2013286739B2 (ar)
BR (1) BR112015000160A2 (ar)
CA (1) CA2878027A1 (ar)
CO (1) CO7170165A2 (ar)
ES (1) ES2609595T3 (ar)
HK (1) HK1206359A1 (ar)
HU (1) HUE031416T2 (ar)
IL (1) IL236413A (ar)
MX (1) MX352812B (ar)
MY (1) MY174629A (ar)
NZ (1) NZ631044A (ar)
PL (1) PL2870142T3 (ar)
PT (1) PT2870142T (ar)
RU (1) RU2666549C2 (ar)
SA (2) SA115360678B1 (ar)
SG (1) SG11201408800VA (ar)
SI (1) SI2870142T1 (ar)
TW (2) TWI634110B (ar)
WO (1) WO2014008295A1 (ar)
ZA (1) ZA201409489B (ar)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR091651A1 (es) 2012-07-03 2015-02-18 Ardea Biosciences Inc Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico
WO2014198241A1 (en) * 2013-06-14 2014-12-18 Sunshine Lake Pharma Co., Ltd. Thio-1,2,4-triazole derivatives and method for preparing the same
CN103524440B (zh) * 2013-10-15 2015-09-09 苏州鹏旭医药科技有限公司 痛风治疗药Lesinurad的制备方法及Lesinurad中间体
US10351536B2 (en) * 2013-11-22 2019-07-16 Crystal Pharmatech Co., Ltd. Crystalline forms of lesinurad and its sodium salt
US10117840B2 (en) * 2014-06-06 2018-11-06 The Scripps Research Institute Sulfur(VI) fluoride compounds and methods for the preparation thereof
CN105294585B (zh) * 2014-07-02 2019-02-12 成都海创药业有限公司 一种治疗痛风的化合物
CN105315218A (zh) * 2014-07-17 2016-02-10 天津药物研究院 一种制备lesinurad中间体1-萘基三唑硫酮的方法
CN104341361B (zh) * 2014-10-27 2017-01-11 张远强 一种腈基取代三氮唑亚磺酰丙二酸类化合物、其制备方法及用途
CN104326999B (zh) * 2014-10-27 2017-01-18 张远强 烷氧基取代的三氮唑亚磺酰丙二酸类化合物、其制备方法及用途
CN104311498B (zh) * 2014-10-27 2016-04-06 张远强 烷氧基取代的三氮唑磺酰丙二酸类化合物、其制备方法及用途
CN105820130B (zh) * 2015-01-08 2018-06-22 天津药物研究院有限公司 三氮唑正丙酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途
CN105985296B (zh) * 2015-02-13 2018-10-16 天津药物研究院有限公司 一种可以工业化的lesinurad中间体1-萘基三唑硫酮的精制工艺
CN109053608A (zh) * 2015-02-17 2018-12-21 华润赛科药业有限责任公司 一种旋光纯的硫代乙酸类化合物、其药物组合物和用途
CN104788318A (zh) * 2015-03-23 2015-07-22 爱斯特（成都）生物制药有限公司 一种4-硝基-环丙基萘的制备方法
CN105622531A (zh) * 2015-04-03 2016-06-01 南京明德新药研发股份有限公司 轴手性异构体及其制备方法和制药用途
CN104817509B (zh) * 2015-04-13 2019-05-17 安徽省逸欣铭医药科技有限公司 Lesinurad类似物及其制备方法和医药用途
CN106187926B (zh) * 2015-04-30 2018-11-27 天津药物研究院有限公司 含二芳基甲烷结构的羧酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途
EP3112334A1 (en) 2015-06-29 2017-01-04 DPx Fine Chemicals Austria GmbH & CoKG Process for manufacturing 1-cyclopropyl-naphthalenes
CN104987311A (zh) * 2015-06-30 2015-10-21 安徽万邦医药科技有限公司 一种[4-(4-环丙基萘-1-基)-5-硝基- 4h-[1,2,4]三唑-3-基硫烷基]-乙酸乙酯的制备方法及其中间体(5-硝基-4h-[1,2,4]三唑-3-基硫基)-乙酸乙酯
CN105017168A (zh) * 2015-07-01 2015-11-04 安徽万邦医药科技有限公司 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法
WO2017036884A1 (en) 2015-08-28 2017-03-09 Sandoz Ag A lesinurad, free form / lesinurad ethyl ester co-crystal
CN105175348A (zh) * 2015-10-16 2015-12-23 北京康立生医药技术开发有限公司 一种乐司尼达的制备方法
CN105399694B (zh) * 2015-12-11 2017-09-15 浙江京新药业股份有限公司 药物Lesinurad轴手性对映体
WO2017147270A1 (en) * 2016-02-24 2017-08-31 Ardea Biosciences, Inc. Atropisomers of triazole derivative
CN105906576B (zh) * 2016-06-12 2018-04-17 成都百裕制药股份有限公司 一种来司诺雷中间体的制备方法
CN106083680B (zh) * 2016-06-21 2018-11-02 山东川成医药股份有限公司 一种4-环丙基-1-萘基异硫氰酸酯的制备方法
CN106220577A (zh) * 2016-07-26 2016-12-14 苏州明锐医药科技有限公司 利新洛德的制备方法
CN106187927B (zh) * 2016-07-26 2020-02-04 山东川成医药股份有限公司 一种Lesinurad中间体的制备方法
EP3281941B1 (en) 2016-08-11 2019-07-24 Zentiva K.S. Process for preparing 2-(5-bromo-4-(1-cyclopropylnaphthalen-4-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid
CN106632108A (zh) * 2016-12-14 2017-05-10 湖南欧亚生物有限公司 一种来司诺雷的制备方法
EP3372592A1 (en) 2017-03-07 2018-09-12 Zentiva, k.s. Solid forms of lesinurad amine salts
US10351537B2 (en) 2017-03-10 2019-07-16 Apotex Inc. Processes for the preparation of lesinurad and intermediates thereof
EP3315494A1 (en) 2017-04-19 2018-05-02 Química Sintética, S.A. Amorphous form of lesinurad and processes for its preparation
CN108947919B (zh) 2017-05-17 2023-05-02 上海奥博生物医药股份有限公司 一种抗痛风药Lesinurad的新型制备方法及其关键中间体
CN109206323A (zh) * 2017-07-07 2019-01-15 上海现代制药股份有限公司 一种萘胺药物中间体的制备方法
CN107739344A (zh) * 2017-10-10 2018-02-27 浙江新东港药业股份有限公司 制备Lesinurd的方法及其中间体
EP3498697A1 (en) 2017-12-12 2019-06-19 Química Sintética, S.A. Novel salts and polymorphs of lesinurad
CN109970667A (zh) * 2017-12-27 2019-07-05 徐州万邦金桥制药有限公司 一种雷西纳德的精制方法
CN108047148A (zh) * 2017-12-28 2018-05-18 北京沃邦医药科技有限公司 一种雷西纳德杂质的制备方法
CN110878045A (zh) * 2018-09-05 2020-03-13 江西同和药业股份有限公司 一种化合物及其制备方法和应用
CN111116501B (zh) * 2019-12-30 2021-03-12 北京鑫开元医药科技有限公司海南分公司 一种有效降低杂质含量的雷西纳德中间体的合成方法
CN111116500B (zh) * 2019-12-30 2021-06-08 北京鑫开元医药科技有限公司海南分公司 一种雷西纳德关键中间体的纯化方法
CN112778223A (zh) * 2021-01-25 2021-05-11 海南鑫开源医药科技有限公司 一种雷西纳德氧化杂质的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05002070A (es) 2002-08-23 2005-07-05 Ribapharm Inc Inhibidores no nucleosidicos de la transcriptasa inversa.
WO2007050087A1 (en) 2004-08-25 2007-05-03 Ardea Biosciences, Inc. N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS
ES2380604T3 (es) * 2004-08-25 2012-05-16 Ardea Biosciences, Inc. S-triazolil alfa-mercaptoacetanilidas como inhibidores de la transcriptasa inversa del VIH
EP2842948A1 (en) 2007-11-27 2015-03-04 Ardea Biosciences, Inc. Novel compounds and compositions and methods of use
US8242154B2 (en) 2008-09-04 2012-08-14 Ardea Biosciences, Inc. Compounds, compositions and methods of using same for modulating uric acid levels
MX2011002449A (es) 2008-09-04 2011-05-25 Ardea Biosciences Inc Compuestos, composiciones y métodos para utilizar los mismos para modular niveles de ácido úrico.
US8173690B2 (en) * 2008-09-04 2012-05-08 Ardea Biosciences, Inc. Compounds, compositions and methods of using same for modulating uric acid levels
AU2011203708B2 (en) 2010-01-08 2013-08-01 Ardea Biosciences, Inc. Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate, and uses thereof
EP2560642A4 (en) 2010-03-30 2013-12-18 Ardea Biosciences Inc TREATMENT OF GICHT
LT2582683T (lt) 2010-06-15 2018-06-11 Ardea Biosciences, Inc. Podagros ir hiperuricemijos gydymas
CN106176736A (zh) 2010-10-15 2016-12-07 阿迪亚生命科学公司 用于治疗高尿酸血症及相关疾病的方法
MX2013007505A (es) 2010-12-30 2013-08-01 Ardea Biosciences Inc Formas polimorficas de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1 -il)-4h-1,2,4-triazol-3-iltio)acetico y usos de los mismos.
AR091651A1 (es) 2012-07-03 2015-02-18 Ardea Biosciences Inc Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico

Also Published As

Publication number Publication date
BR112015000160A2 (pt) 2017-06-27
US20150252010A1 (en) 2015-09-10
MX352812B (es) 2017-12-08
CN104736522B (zh) 2018-10-09
MX2015000082A (es) 2015-09-04
WO2014008295A1 (en) 2014-01-09
AU2013286739B2 (en) 2017-02-23
CN104736522A (zh) 2015-06-24
TW201604186A (zh) 2016-02-01
JP2015525749A (ja) 2015-09-07
RU2666549C2 (ru) 2018-09-18
EP2870142A1 (en) 2015-05-13
AU2013286739A1 (en) 2015-01-22
PL2870142T3 (pl) 2017-04-28
TWI634110B (zh) 2018-09-01
TW201406734A (zh) 2014-02-16
IL236413A0 (en) 2015-02-26
ES2609595T3 (es) 2017-04-21
HUE031416T2 (en) 2017-07-28
NZ631044A (en) 2015-12-24
IL236413A (en) 2016-11-30
SA115360678B1 (ar) 2016-09-08
AR091651A1 (es) 2015-02-18
ZA201409489B (en) 2019-01-30
EP2870142B1 (en) 2016-10-19
CO7170165A2 (es) 2015-01-28
HK1206359A1 (en) 2016-01-08
EP2870142A4 (en) 2016-01-06
MY174629A (en) 2020-05-03
US20160214947A1 (en) 2016-07-28
SG11201408800VA (en) 2015-01-29
CA2878027A1 (en) 2014-01-09
SI2870142T1 (sl) 2017-02-28
JP6124226B2 (ja) 2017-05-10
RU2015102723A (ru) 2016-08-20
KR20150028992A (ko) 2015-03-17
TWI621615B (zh) 2018-04-21
US9296709B2 (en) 2016-03-29
WO2014008295A8 (en) 2015-01-08
PT2870142T (pt) 2016-12-27

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