HK1206359A1 - Manufacture of 2- (5- bromo-4- (4-cyclopropylnaphthalen-1-yl) -4h- 1,2,4-triazol-3-ylthio) acetic acid 2-(5--4(--1-)-4h-124--3-) - Google Patents
Manufacture of 2- (5- bromo-4- (4-cyclopropylnaphthalen-1-yl) -4h- 1,2,4-triazol-3-ylthio) acetic acid 2-(5--4(--1-)-4h-124--3-)Info
- Publication number
- HK1206359A1 HK1206359A1 HK15107090.7A HK15107090A HK1206359A1 HK 1206359 A1 HK1206359 A1 HK 1206359A1 HK 15107090 A HK15107090 A HK 15107090A HK 1206359 A1 HK1206359 A1 HK 1206359A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cyclopropylnaphthalen
- ylthio
- triazol
- bromo
- manufacture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261667922P | 2012-07-03 | 2012-07-03 | |
| PCT/US2013/049135 WO2014008295A1 (en) | 2012-07-03 | 2013-07-02 | Manufacture of 2- (5- bromo-4 (-cyclopropylnaphthalen-1-yl) -4h-1,2,4-triazol-3-ylthio) acetic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1206359A1 true HK1206359A1 (en) | 2016-01-08 |
Family
ID=49882471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15107090.7A HK1206359A1 (en) | 2012-07-03 | 2015-07-24 | Manufacture of 2- (5- bromo-4- (4-cyclopropylnaphthalen-1-yl) -4h- 1,2,4-triazol-3-ylthio) acetic acid 2-(5--4(--1-)-4h-124--3-) |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9296709B2 (xx) |
| EP (1) | EP2870142B1 (xx) |
| JP (1) | JP6124226B2 (xx) |
| KR (1) | KR20150028992A (xx) |
| CN (1) | CN104736522B (xx) |
| AR (1) | AR091651A1 (xx) |
| AU (1) | AU2013286739B2 (xx) |
| BR (1) | BR112015000160A2 (xx) |
| CA (1) | CA2878027A1 (xx) |
| CO (1) | CO7170165A2 (xx) |
| ES (1) | ES2609595T3 (xx) |
| HK (1) | HK1206359A1 (xx) |
| HU (1) | HUE031416T2 (xx) |
| IL (1) | IL236413A (xx) |
| MX (1) | MX352812B (xx) |
| MY (1) | MY174629A (xx) |
| NZ (1) | NZ631044A (xx) |
| PL (1) | PL2870142T3 (xx) |
| PT (1) | PT2870142T (xx) |
| RU (1) | RU2666549C2 (xx) |
| SA (2) | SA115360678B1 (xx) |
| SG (1) | SG11201408800VA (xx) |
| SI (1) | SI2870142T1 (xx) |
| TW (2) | TWI634110B (xx) |
| WO (1) | WO2014008295A1 (xx) |
| ZA (1) | ZA201409489B (xx) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR091651A1 (es) | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
| CN105263913B (zh) * | 2013-06-14 | 2017-12-15 | 广东东阳光药业有限公司 | 硫代1,2,4‑三唑衍生物及其制备方法 |
| CN103524440B (zh) * | 2013-10-15 | 2015-09-09 | 苏州鹏旭医药科技有限公司 | 痛风治疗药Lesinurad的制备方法及Lesinurad中间体 |
| EP3071554B1 (en) * | 2013-11-22 | 2018-10-03 | Crystal Pharmatech Co., Ltd. | Crystalline forms of lesinurad |
| AU2015269198B2 (en) * | 2014-06-06 | 2020-12-10 | The Scripps Research Institute | Sulfur(VI) fluoride compounds and methods for the preparation thereof |
| CN105294585B (zh) * | 2014-07-02 | 2019-02-12 | 成都海创药业有限公司 | 一种治疗痛风的化合物 |
| CN105315218A (zh) * | 2014-07-17 | 2016-02-10 | 天津药物研究院 | 一种制备lesinurad中间体1-萘基三唑硫酮的方法 |
| CN104311498B (zh) * | 2014-10-27 | 2016-04-06 | 张远强 | 烷氧基取代的三氮唑磺酰丙二酸类化合物、其制备方法及用途 |
| CN104341361B (zh) * | 2014-10-27 | 2017-01-11 | 张远强 | 一种腈基取代三氮唑亚磺酰丙二酸类化合物、其制备方法及用途 |
| CN104326999B (zh) * | 2014-10-27 | 2017-01-18 | 张远强 | 烷氧基取代的三氮唑亚磺酰丙二酸类化合物、其制备方法及用途 |
| CN105820130B (zh) * | 2015-01-08 | 2018-06-22 | 天津药物研究院有限公司 | 三氮唑正丙酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途 |
| CN105985296B (zh) * | 2015-02-13 | 2018-10-16 | 天津药物研究院有限公司 | 一种可以工业化的lesinurad中间体1-萘基三唑硫酮的精制工艺 |
| CN109053608A (zh) * | 2015-02-17 | 2018-12-21 | 华润赛科药业有限责任公司 | 一种旋光纯的硫代乙酸类化合物、其药物组合物和用途 |
| CN104788318A (zh) * | 2015-03-23 | 2015-07-22 | 爱斯特（成都）生物制药有限公司 | 一种4-硝基-环丙基萘的制备方法 |
| CN105622531A (zh) | 2015-04-03 | 2016-06-01 | 南京明德新药研发股份有限公司 | 轴手性异构体及其制备方法和制药用途 |
| CN104817509B (zh) * | 2015-04-13 | 2019-05-17 | 安徽省逸欣铭医药科技有限公司 | Lesinurad类似物及其制备方法和医药用途 |
| CN106187926B (zh) | 2015-04-30 | 2018-11-27 | 天津药物研究院有限公司 | 含二芳基甲烷结构的羧酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途 |
| EP3112334A1 (en) | 2015-06-29 | 2017-01-04 | DPx Fine Chemicals Austria GmbH & CoKG | Process for manufacturing 1-cyclopropyl-naphthalenes |
| CN104987311A (zh) * | 2015-06-30 | 2015-10-21 | 安徽万邦医药科技有限公司 | 一种[4-(4-环丙基萘-1-基)-5-硝基- 4h-[1,2,4]三唑-3-基硫烷基]-乙酸乙酯的制备方法及其中间体(5-硝基-4h-[1,2,4]三唑-3-基硫基)-乙酸乙酯 |
| CN105017168A (zh) * | 2015-07-01 | 2015-11-04 | 安徽万邦医药科技有限公司 | 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法 |
| WO2017036884A1 (en) | 2015-08-28 | 2017-03-09 | Sandoz Ag | A lesinurad, free form / lesinurad ethyl ester co-crystal |
| CN105175348A (zh) * | 2015-10-16 | 2015-12-23 | 北京康立生医药技术开发有限公司 | 一种乐司尼达的制备方法 |
| CN105399694B (zh) * | 2015-12-11 | 2017-09-15 | 浙江京新药业股份有限公司 | 药物Lesinurad轴手性对映体 |
| WO2017147270A1 (en) * | 2016-02-24 | 2017-08-31 | Ardea Biosciences, Inc. | Atropisomers of triazole derivative |
| CN105906576B (zh) * | 2016-06-12 | 2018-04-17 | 成都百裕制药股份有限公司 | 一种来司诺雷中间体的制备方法 |
| CN106083680B (zh) * | 2016-06-21 | 2018-11-02 | 山东川成医药股份有限公司 | 一种4-环丙基-1-萘基异硫氰酸酯的制备方法 |
| CN106187927B (zh) * | 2016-07-26 | 2020-02-04 | 山东川成医药股份有限公司 | 一种Lesinurad中间体的制备方法 |
| CN106220577A (zh) * | 2016-07-26 | 2016-12-14 | 苏州明锐医药科技有限公司 | 利新洛德的制备方法 |
| EP3281941B1 (en) | 2016-08-11 | 2019-07-24 | Zentiva K.S. | Process for preparing 2-(5-bromo-4-(1-cyclopropylnaphthalen-4-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid |
| CN106632108A (zh) * | 2016-12-14 | 2017-05-10 | 湖南欧亚生物有限公司 | 一种来司诺雷的制备方法 |
| EP3372592A1 (en) | 2017-03-07 | 2018-09-12 | Zentiva, k.s. | Solid forms of lesinurad amine salts |
| US10351537B2 (en) | 2017-03-10 | 2019-07-16 | Apotex Inc. | Processes for the preparation of lesinurad and intermediates thereof |
| EP3315494A1 (en) | 2017-04-19 | 2018-05-02 | Química Sintética, S.A. | Amorphous form of lesinurad and processes for its preparation |
| CN108947919B (zh) | 2017-05-17 | 2023-05-02 | 上海奥博生物医药股份有限公司 | 一种抗痛风药Lesinurad的新型制备方法及其关键中间体 |
| CN109206323A (zh) * | 2017-07-07 | 2019-01-15 | 上海现代制药股份有限公司 | 一种萘胺药物中间体的制备方法 |
| CN107739344A (zh) * | 2017-10-10 | 2018-02-27 | 浙江新东港药业股份有限公司 | 制备Lesinurd的方法及其中间体 |
| EP3498697A1 (en) | 2017-12-12 | 2019-06-19 | Química Sintética, S.A. | Novel salts and polymorphs of lesinurad |
| CN109970667A (zh) * | 2017-12-27 | 2019-07-05 | 徐州万邦金桥制药有限公司 | 一种雷西纳德的精制方法 |
| CN108047148A (zh) * | 2017-12-28 | 2018-05-18 | 北京沃邦医药科技有限公司 | 一种雷西纳德杂质的制备方法 |
| CN110878045A (zh) * | 2018-09-05 | 2020-03-13 | 江西同和药业股份有限公司 | 一种化合物及其制备方法和应用 |
| CN111116500B (zh) * | 2019-12-30 | 2021-06-08 | 北京鑫开元医药科技有限公司海南分公司 | 一种雷西纳德关键中间体的纯化方法 |
| CN111116501B (zh) * | 2019-12-30 | 2021-03-12 | 北京鑫开元医药科技有限公司海南分公司 | 一种有效降低杂质含量的雷西纳德中间体的合成方法 |
| CN112778223A (zh) * | 2021-01-25 | 2021-05-11 | 海南鑫开源医药科技有限公司 | 一种雷西纳德氧化杂质的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05002070A (es) | 2002-08-23 | 2005-07-05 | Ribapharm Inc | Inhibidores no nucleosidicos de la transcriptasa inversa. |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| MX2007002236A (es) | 2004-08-25 | 2007-07-09 | Ardea Biosciences Inc | S-triazolil-alfa-mercaptoacetanilidas como inhibidores de transcriptasa inversa de virus de inmunodeficiencia humana. |
| TWI415840B (zh) | 2007-11-27 | 2013-11-21 | Ardea Biosciences Inc | 新穎化合物、組合物及使用方法 |
| US8173690B2 (en) * | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| EP2328879A4 (en) * | 2008-09-04 | 2012-05-09 | Ardea Biosciences Inc | CORRESPONDING COMPOUNDS, COMPOSITIONS, AND METHODS OF USE FOR MODULATING URIC ACID RATES |
| US8242154B2 (en) | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| CA2785200C (en) | 2010-01-08 | 2015-02-24 | Ardea Biosciences, Inc. | Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetate, and uses thereof |
| EP3659601A1 (en) | 2010-03-30 | 2020-06-03 | Ardea Biosciences, Inc. | Treatment of gout |
| US9216179B2 (en) | 2010-06-15 | 2015-12-22 | Ardea Biosciences, Inc. | Treatment of gout and hyperuricemia |
| CN106176736A (zh) | 2010-10-15 | 2016-12-07 | 阿迪亚生命科学公司 | 用于治疗高尿酸血症及相关疾病的方法 |
| CA2817249C (en) | 2010-12-30 | 2015-02-10 | Ardea Biosciences, Inc. | Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid and uses thereof |
| AR091651A1 (es) | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
-
2013
- 2013-07-01 AR ARP130102354 patent/AR091651A1/es unknown
- 2013-07-02 SI SI201330470A patent/SI2870142T1/sl unknown
- 2013-07-02 SG SG11201408800VA patent/SG11201408800VA/en unknown
- 2013-07-02 ES ES13813122.2T patent/ES2609595T3/es active Active
- 2013-07-02 MY MYPI2015000009A patent/MY174629A/en unknown
- 2013-07-02 KR KR20157001430A patent/KR20150028992A/ko not_active Application Discontinuation
- 2013-07-02 JP JP2015520662A patent/JP6124226B2/ja active Active
- 2013-07-02 CA CA2878027A patent/CA2878027A1/en not_active Abandoned
- 2013-07-02 MX MX2015000082A patent/MX352812B/es active IP Right Grant
- 2013-07-02 CN CN201380045807.0A patent/CN104736522B/zh not_active Expired - Fee Related
- 2013-07-02 EP EP13813122.2A patent/EP2870142B1/en active Active
- 2013-07-02 BR BR112015000160A patent/BR112015000160A2/pt not_active IP Right Cessation
- 2013-07-02 AU AU2013286739A patent/AU2013286739B2/en not_active Ceased
- 2013-07-02 RU RU2015102723A patent/RU2666549C2/ru not_active IP Right Cessation
- 2013-07-02 HU HUE13813122A patent/HUE031416T2/en unknown
- 2013-07-02 PT PT138131222T patent/PT2870142T/pt unknown
- 2013-07-02 WO PCT/US2013/049135 patent/WO2014008295A1/en active Application Filing
- 2013-07-02 US US14/409,806 patent/US9296709B2/en not_active Expired - Fee Related
- 2013-07-02 NZ NZ631044A patent/NZ631044A/en not_active IP Right Cessation
- 2013-07-02 PL PL13813122T patent/PL2870142T3/pl unknown
- 2013-07-03 TW TW104135665A patent/TWI634110B/zh not_active IP Right Cessation
- 2013-07-03 SA SA115360678A patent/SA115360678B1/ar unknown
- 2013-07-03 SA SA113340696A patent/SA113340696B1/ar unknown
- 2013-07-03 TW TW102123881A patent/TWI621615B/zh not_active IP Right Cessation
-
2014
- 2014-12-23 IL IL236413A patent/IL236413A/en active IP Right Grant
- 2014-12-23 ZA ZA2014/09489A patent/ZA201409489B/en unknown
-
2015
- 2015-01-15 CO CO15007371A patent/CO7170165A2/es unknown
- 2015-07-24 HK HK15107090.7A patent/HK1206359A1/xx not_active IP Right Cessation
-
2016
- 2016-02-19 US US15/048,110 patent/US20160214947A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20210701 |