CO7170165A2 - Fabricación de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético - Google Patents

Fabricación de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético

Info

Publication number
CO7170165A2
CO7170165A2 CO15007371A CO15007371A CO7170165A2 CO 7170165 A2 CO7170165 A2 CO 7170165A2 CO 15007371 A CO15007371 A CO 15007371A CO 15007371 A CO15007371 A CO 15007371A CO 7170165 A2 CO7170165 A2 CO 7170165A2
Authority
CO
Colombia
Prior art keywords
ylthium
cyclopropylnaphthalen
triazol
bromo
manufacture
Prior art date
Application number
CO15007371A
Other languages
English (en)
Inventor
Esmir Gunic
Gabriel Galvin
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of CO7170165A2 publication Critical patent/CO7170165A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)

Abstract

En el presente documento, se describen ciertos procesos de síntesis decompuestos de Fórmula (I)
CO15007371A 2012-07-03 2015-01-15 Fabricación de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético CO7170165A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261667922P 2012-07-03 2012-07-03

Publications (1)

Publication Number Publication Date
CO7170165A2 true CO7170165A2 (es) 2015-01-28

Family

ID=49882471

Family Applications (1)

Application Number Title Priority Date Filing Date
CO15007371A CO7170165A2 (es) 2012-07-03 2015-01-15 Fabricación de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético

Country Status (26)

Country Link
US (2) US9296709B2 (es)
EP (1) EP2870142B1 (es)
JP (1) JP6124226B2 (es)
KR (1) KR20150028992A (es)
CN (1) CN104736522B (es)
AR (1) AR091651A1 (es)
AU (1) AU2013286739B2 (es)
BR (1) BR112015000160A2 (es)
CA (1) CA2878027A1 (es)
CO (1) CO7170165A2 (es)
ES (1) ES2609595T3 (es)
HK (1) HK1206359A1 (es)
HU (1) HUE031416T2 (es)
IL (1) IL236413A (es)
MX (1) MX352812B (es)
MY (1) MY174629A (es)
NZ (1) NZ631044A (es)
PL (1) PL2870142T3 (es)
PT (1) PT2870142T (es)
RU (1) RU2666549C2 (es)
SA (2) SA115360678B1 (es)
SG (1) SG11201408800VA (es)
SI (1) SI2870142T1 (es)
TW (2) TWI634110B (es)
WO (1) WO2014008295A1 (es)
ZA (1) ZA201409489B (es)

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EP3112334A1 (en) 2015-06-29 2017-01-04 DPx Fine Chemicals Austria GmbH & CoKG Process for manufacturing 1-cyclopropyl-naphthalenes
CN104987311A (zh) * 2015-06-30 2015-10-21 安徽万邦医药科技有限公司 一种[4-(4-环丙基萘-1-基)-5-硝基- 4h-[1,2,4]三唑-3-基硫烷基]-乙酸乙酯的制备方法及其中间体(5-硝基-4h-[1,2,4]三唑-3-基硫基)-乙酸乙酯
CN105017168A (zh) * 2015-07-01 2015-11-04 安徽万邦医药科技有限公司 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法
WO2017036884A1 (en) 2015-08-28 2017-03-09 Sandoz Ag A lesinurad, free form / lesinurad ethyl ester co-crystal
CN105175348A (zh) * 2015-10-16 2015-12-23 北京康立生医药技术开发有限公司 一种乐司尼达的制备方法
CN105399694B (zh) * 2015-12-11 2017-09-15 浙江京新药业股份有限公司 药物Lesinurad轴手性对映体
WO2017147270A1 (en) * 2016-02-24 2017-08-31 Ardea Biosciences, Inc. Atropisomers of triazole derivative
CN105906576B (zh) * 2016-06-12 2018-04-17 成都百裕制药股份有限公司 一种来司诺雷中间体的制备方法
CN106083680B (zh) * 2016-06-21 2018-11-02 山东川成医药股份有限公司 一种4-环丙基-1-萘基异硫氰酸酯的制备方法
CN106187927B (zh) * 2016-07-26 2020-02-04 山东川成医药股份有限公司 一种Lesinurad中间体的制备方法
CN106220577A (zh) * 2016-07-26 2016-12-14 苏州明锐医药科技有限公司 利新洛德的制备方法
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CN109206323A (zh) * 2017-07-07 2019-01-15 上海现代制药股份有限公司 一种萘胺药物中间体的制备方法
CN107739344A (zh) * 2017-10-10 2018-02-27 浙江新东港药业股份有限公司 制备Lesinurd的方法及其中间体
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CN109970667A (zh) * 2017-12-27 2019-07-05 徐州万邦金桥制药有限公司 一种雷西纳德的精制方法
CN108047148A (zh) * 2017-12-28 2018-05-18 北京沃邦医药科技有限公司 一种雷西纳德杂质的制备方法
CN110878045A (zh) * 2018-09-05 2020-03-13 江西同和药业股份有限公司 一种化合物及其制备方法和应用
CN111116500B (zh) * 2019-12-30 2021-06-08 北京鑫开元医药科技有限公司海南分公司 一种雷西纳德关键中间体的纯化方法
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Also Published As

Publication number Publication date
EP2870142A1 (en) 2015-05-13
ZA201409489B (en) 2019-01-30
JP2015525749A (ja) 2015-09-07
AR091651A1 (es) 2015-02-18
PT2870142T (pt) 2016-12-27
SI2870142T1 (sl) 2017-02-28
TWI621615B (zh) 2018-04-21
CA2878027A1 (en) 2014-01-09
AU2013286739A1 (en) 2015-01-22
PL2870142T3 (pl) 2017-04-28
SG11201408800VA (en) 2015-01-29
CN104736522B (zh) 2018-10-09
SA113340696B1 (ar) 2016-03-06
TW201406734A (zh) 2014-02-16
CN104736522A (zh) 2015-06-24
MX352812B (es) 2017-12-08
TWI634110B (zh) 2018-09-01
SA115360678B1 (ar) 2016-09-08
ES2609595T3 (es) 2017-04-21
HUE031416T2 (en) 2017-07-28
WO2014008295A1 (en) 2014-01-09
HK1206359A1 (en) 2016-01-08
IL236413A (en) 2016-11-30
EP2870142A4 (en) 2016-01-06
MX2015000082A (es) 2015-09-04
AU2013286739B2 (en) 2017-02-23
JP6124226B2 (ja) 2017-05-10
EP2870142B1 (en) 2016-10-19
US20160214947A1 (en) 2016-07-28
RU2015102723A (ru) 2016-08-20
TW201604186A (zh) 2016-02-01
WO2014008295A8 (en) 2015-01-08
IL236413A0 (en) 2015-02-26
NZ631044A (en) 2015-12-24
RU2666549C2 (ru) 2018-09-18
KR20150028992A (ko) 2015-03-17
BR112015000160A2 (pt) 2017-06-27
US20150252010A1 (en) 2015-09-10
MY174629A (en) 2020-05-03
US9296709B2 (en) 2016-03-29

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