CR20150028A - Derivados de ariletinilo - Google Patents

Derivados de ariletinilo

Info

Publication number
CR20150028A
CR20150028A CR20150028A CR20150028A CR20150028A CR 20150028 A CR20150028 A CR 20150028A CR 20150028 A CR20150028 A CR 20150028A CR 20150028 A CR20150028 A CR 20150028A CR 20150028 A CR20150028 A CR 20150028A
Authority
CR
Costa Rica
Prior art keywords
derivatives
aryletinyl
formula
relates
present
Prior art date
Application number
CR20150028A
Other languages
English (en)
Inventor
Georg Jaeschke
Lothar Lindemann
Heinz Stadler
Eric Vieira
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20150028A publication Critical patent/CR20150028A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a derivados de etinilo de la fórmula I.
CR20150028A 2012-08-13 2015-01-22 Derivados de ariletinilo CR20150028A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12180209 2012-08-13
PCT/EP2013/066443 WO2014026880A1 (en) 2012-08-13 2013-08-06 Arylethynyl pyrimidines

Publications (1)

Publication Number Publication Date
CR20150028A true CR20150028A (es) 2015-02-27

Family

ID=46851291

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20150028A CR20150028A (es) 2012-08-13 2015-01-22 Derivados de ariletinilo

Country Status (36)

Country Link
US (1) US9199971B2 (es)
EP (1) EP2882742B1 (es)
JP (1) JP5974179B2 (es)
KR (1) KR101747005B1 (es)
CN (1) CN104540815B (es)
AR (1) AR092097A1 (es)
AU (1) AU2013304212B2 (es)
BR (1) BR112015002921A2 (es)
CA (1) CA2880257C (es)
CL (1) CL2015000290A1 (es)
CO (1) CO7180198A2 (es)
CR (1) CR20150028A (es)
CY (1) CY1118595T1 (es)
DK (1) DK2882742T3 (es)
EA (1) EA025165B1 (es)
ES (1) ES2601511T3 (es)
HK (1) HK1207378A1 (es)
HR (1) HRP20161692T1 (es)
HU (1) HUE030237T2 (es)
IL (1) IL237015A (es)
LT (1) LT2882742T (es)
MA (1) MA37895B1 (es)
MX (1) MX358011B (es)
MY (1) MY170255A (es)
NZ (1) NZ704858A (es)
PE (1) PE20150685A1 (es)
PH (1) PH12015500261B1 (es)
PL (1) PL2882742T3 (es)
PT (1) PT2882742T (es)
RS (1) RS55397B1 (es)
SG (1) SG11201501055SA (es)
SI (1) SI2882742T1 (es)
TW (1) TWI501958B (es)
UA (1) UA113223C2 (es)
WO (1) WO2014026880A1 (es)
ZA (1) ZA201500582B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8729263B2 (en) 2012-08-13 2014-05-20 Novartis Ag 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
CN104603110B (zh) * 2012-10-18 2016-08-31 霍夫曼-拉罗奇有限公司 作为mGluR5受体活性的调节剂的乙炔基衍生物
AU2016273751B2 (en) * 2015-06-03 2020-04-02 F. Hoffmann-La Roche Ag Ethynyl derivatives

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005118568A1 (en) * 2004-06-01 2005-12-15 F. Hoffmann-La Roche Ag Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
EP1809620B1 (en) 2004-11-04 2010-12-29 Addex Pharma SA Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0503646D0 (en) * 2005-02-22 2005-03-30 Novartis Ag Organic compounds
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
TW200811157A (en) * 2006-05-05 2008-03-01 Astrazeneca Ab mGluR5 modulators I
KR20100033981A (ko) 2007-06-03 2010-03-31 벤더르빌트 유니버시티 벤즈아미드 대사성 글루타민산염 수용체5 양성 알로스테릭 조절자 및 이의 제조 및 사용방법
EP2212316A4 (en) * 2007-10-26 2012-06-27 Astrazeneca Ab DERIVATIVES OF AMINO1,2,4-TRIAZOLES AS MODULATORS OF MGLUR5
US8334287B2 (en) * 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US8389536B2 (en) * 2009-10-27 2013-03-05 Hoffmann-La Roche Inc. Positive allosteric modulators (PAM)
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
ES2492694T3 (es) * 2010-07-09 2014-09-10 Recordati Ireland Limited Nuevos compuestos espiroheterocíclicos como antagonistas de mGlu5
JPWO2012015024A1 (ja) * 2010-07-29 2013-09-12 大正製薬株式会社 エチニル−ピラゾール誘導体
ES2580333T3 (es) * 2011-04-26 2016-08-23 F. Hoffmann-La Roche Ag Derivados de pirazolidin-3-ona
US20130123254A1 (en) * 2011-09-30 2013-05-16 Barbara Biemans Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification
UA110995C2 (uk) * 2011-10-07 2016-03-10 Ф. Хоффманн-Ля Рош Аг Етинільні похідні як модулятори метаботропного глутаматного рецептора
UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
MY167810A (en) * 2012-07-17 2018-09-26 Hoffmann La Roche Arylethynyl derivatives
EP2900659B1 (en) * 2012-09-27 2016-08-24 F. Hoffmann-La Roche AG Arylethynyl derivatives

Also Published As

Publication number Publication date
ES2601511T3 (es) 2017-02-15
LT2882742T (lt) 2016-12-12
NZ704858A (en) 2018-02-23
HK1207378A1 (en) 2016-01-29
CA2880257A1 (en) 2014-02-20
CL2015000290A1 (es) 2015-07-03
CA2880257C (en) 2020-07-21
CY1118595T1 (el) 2017-07-12
MX358011B (es) 2018-08-02
US20150158848A1 (en) 2015-06-11
TW201410671A (zh) 2014-03-16
MX2015001599A (es) 2015-05-11
KR101747005B1 (ko) 2017-06-27
AU2013304212A1 (en) 2015-02-12
AR092097A1 (es) 2015-03-25
PH12015500261A1 (en) 2015-03-30
UA113223C2 (xx) 2016-12-26
PH12015500261B1 (en) 2015-03-30
JP5974179B2 (ja) 2016-08-23
IL237015A (en) 2016-11-30
MA37895A1 (fr) 2016-12-30
TWI501958B (zh) 2015-10-01
EA025165B1 (ru) 2016-11-30
PE20150685A1 (es) 2015-05-11
CN104540815A (zh) 2015-04-22
RS55397B1 (sr) 2017-04-28
DK2882742T3 (en) 2016-12-12
AU2013304212B2 (en) 2017-03-09
SG11201501055SA (en) 2015-03-30
PT2882742T (pt) 2016-11-16
EA201590252A1 (ru) 2015-06-30
ZA201500582B (en) 2016-08-31
HRP20161692T1 (hr) 2017-02-24
PL2882742T3 (pl) 2017-03-31
MA37895B1 (fr) 2017-08-31
CN104540815B (zh) 2016-10-19
HUE030237T2 (en) 2017-04-28
WO2014026880A1 (en) 2014-02-20
EP2882742A1 (en) 2015-06-17
SI2882742T1 (sl) 2017-01-31
BR112015002921A2 (pt) 2019-07-30
EP2882742B1 (en) 2016-09-21
CO7180198A2 (es) 2015-02-09
MY170255A (en) 2019-07-13
KR20150041132A (ko) 2015-04-15
JP2015528824A (ja) 2015-10-01
US9199971B2 (en) 2015-12-01

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