ATE524444T1 - Verbessertes verfahren zur herstellung von montelukast-natrium - Google Patents
Verbessertes verfahren zur herstellung von montelukast-natriumInfo
- Publication number
- ATE524444T1 ATE524444T1 AT06808904T AT06808904T ATE524444T1 AT E524444 T1 ATE524444 T1 AT E524444T1 AT 06808904 T AT06808904 T AT 06808904T AT 06808904 T AT06808904 T AT 06808904T AT E524444 T1 ATE524444 T1 AT E524444T1
- Authority
- AT
- Austria
- Prior art keywords
- phenyl
- metal salt
- sodium
- montelukast sodium
- iii
- Prior art date
Links
- 229960001951 montelukast sodium Drugs 0.000 title abstract 3
- LBFBRXGCXUHRJY-HKHDRNBDSA-M montelukast sodium Chemical compound [Na+].CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC([O-])=O)CC1 LBFBRXGCXUHRJY-HKHDRNBDSA-M 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 4
- 239000002184 metal Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- UOPMCTRPKWKMSA-REFCXTLYSA-N acetic acid;2-[2-[(3r)-3-[3-[(e)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-(cyclopropylmethylsulfanyl)propyl]phenyl]propan-2-ol Chemical class CC(O)=O.CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1CC1 UOPMCTRPKWKMSA-REFCXTLYSA-N 0.000 abstract 2
- 238000011065 in-situ storage Methods 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- 239000011734 sodium Chemical class 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- -1 amine salt Chemical class 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
- 229910000000 metal hydroxide Inorganic materials 0.000 abstract 1
- 150000004692 metal hydroxides Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- JRHLVNAWLWIHDN-UHFFFAOYSA-N methyl 2-[1-(sulfanylmethyl)cyclopropyl]acetate Chemical compound COC(=O)CC1(CS)CC1 JRHLVNAWLWIHDN-UHFFFAOYSA-N 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN574MU2006 | 2006-04-12 | ||
| PCT/IB2006/002690 WO2007116240A1 (en) | 2006-04-12 | 2006-09-28 | An improved process for the manufacture of montelukast sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE524444T1 true ATE524444T1 (de) | 2011-09-15 |
Family
ID=38580734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06808904T ATE524444T1 (de) | 2006-04-12 | 2006-09-28 | Verbessertes verfahren zur herstellung von montelukast-natrium |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090281323A1 (de) |
| EP (1) | EP2004608B1 (de) |
| AT (1) | ATE524444T1 (de) |
| CA (1) | CA2649189A1 (de) |
| WO (1) | WO2007116240A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101213177A (zh) | 2005-07-05 | 2008-07-02 | 特瓦制药工业有限公司 | 孟鲁司特的纯化 |
| EP1968943B1 (de) | 2005-12-13 | 2013-01-23 | MSN Laboratories Limited | Verbessertes verfahren zur herstellung von montelukast und dessen pharmazeutisch unbedenklichen salze |
| EP1886998A1 (de) | 2006-08-09 | 2008-02-13 | Esteve Quimica, S.A. | Verfahren zur Reinigung von Montelukast und dessen Aminesalzen |
| WO2008062478A2 (en) * | 2006-11-20 | 2008-05-29 | Manne Satyanarayana Reddy | Improved process for pure montelukast sodium through pure intermediates as well as novel amine salts |
| EP2287154A1 (de) | 2009-07-14 | 2011-02-23 | KRKA, D.D., Novo Mesto | Effiziente Synthese zur Herstellung von Montelukast |
| AU2009357276A1 (en) * | 2009-12-23 | 2012-08-09 | Pharmathen S.A. | Improved process for the preparation of Montelukast and salts thereof |
| WO2011121091A1 (en) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
| KR100990046B1 (ko) * | 2010-07-30 | 2010-10-26 | 동국제약 주식회사 | 신규한 몬테루카스트 4-할로 벤질아민염 및 이를 이용한 몬테루카스트 나트륨염의 제조방법 |
| WO2014001860A1 (en) * | 2012-05-18 | 2014-01-03 | Laurus Labs Private Limited | Process for preparation of montelukast sodium |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2114882T3 (es) | 1990-10-12 | 1998-06-16 | Merck Frosst Canada Inc | Acidos hidroxialquilquinolinos insaturados como antagonistas de leucotrienos. |
| TW416948B (en) * | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
| US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
| PT1631550E (pt) * | 2003-06-06 | 2012-04-19 | Morepen Lab Ltd | Um método melhorado para a preparação do ácido montelucaste e do seu sal de sódio na forma amorfa |
| JP2007520546A (ja) | 2004-02-03 | 2007-07-26 | ケマジス リミティド | モンテルカストナトリウムの安定な非晶質性形態 |
| ATE500225T1 (de) * | 2004-07-19 | 2011-03-15 | Matrix Lab Ltd | Verfahren zur herstellung von montelukast und salzen davon |
| EP1817289A1 (de) * | 2004-11-30 | 2007-08-15 | Medichem, S.A. | Neues verfahren zur herstellung einesleukotrienantagonisten |
| WO2006064269A2 (en) * | 2004-12-17 | 2006-06-22 | Cipla Limited | Salts of leukotriene antagonist montelukast |
-
2006
- 2006-09-28 US US12/296,644 patent/US20090281323A1/en not_active Abandoned
- 2006-09-28 AT AT06808904T patent/ATE524444T1/de not_active IP Right Cessation
- 2006-09-28 EP EP06808904A patent/EP2004608B1/de not_active Not-in-force
- 2006-09-28 CA CA002649189A patent/CA2649189A1/en not_active Abandoned
- 2006-09-28 WO PCT/IB2006/002690 patent/WO2007116240A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP2004608A4 (de) | 2010-03-24 |
| CA2649189A1 (en) | 2007-10-18 |
| US20090281323A1 (en) | 2009-11-12 |
| WO2007116240A1 (en) | 2007-10-18 |
| EP2004608B1 (de) | 2011-09-14 |
| EP2004608A1 (de) | 2008-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |