ATE540926T1 - Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form - Google Patents
Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher formInfo
- Publication number
- ATE540926T1 ATE540926T1 AT03817134T AT03817134T ATE540926T1 AT E540926 T1 ATE540926 T1 AT E540926T1 AT 03817134 T AT03817134 T AT 03817134T AT 03817134 T AT03817134 T AT 03817134T AT E540926 T1 ATE540926 T1 AT E540926T1
- Authority
- AT
- Austria
- Prior art keywords
- acid
- sodium salt
- crude
- montelucastic
- producing
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 title 1
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical class C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 abstract 4
- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 abstract 4
- 229960005127 montelukast Drugs 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- VFAXPOVKNPTBTM-UHFFFAOYSA-N 2-[1-(sulfanylmethyl)cyclopropyl]acetic acid Chemical compound OC(=O)CC1(CS)CC1 VFAXPOVKNPTBTM-UHFFFAOYSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 abstract 1
- -1 alkyl lithium Chemical compound 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- SMBQBQBNOXIFSF-UHFFFAOYSA-N dilithium Chemical compound [Li][Li] SMBQBQBNOXIFSF-UHFFFAOYSA-N 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000003586 protic polar solvent Substances 0.000 abstract 1
- 229910001415 sodium ion Inorganic materials 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2003/000214 WO2004108679A1 (en) | 2003-06-06 | 2003-06-06 | An improved method for the preparation of montelukast acid and sodium salt thereof in amorphous form |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE540926T1 true ATE540926T1 (de) | 2012-01-15 |
Family
ID=33495847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03817134T ATE540926T1 (de) | 2003-06-06 | 2003-06-06 | Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8450491B2 (de) |
| EP (1) | EP1631550B1 (de) |
| AT (1) | ATE540926T1 (de) |
| AU (1) | AU2003253247A1 (de) |
| CA (1) | CA2528228C (de) |
| PT (1) | PT1631550E (de) |
| WO (1) | WO2004108679A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
| IL174758A (en) | 2003-10-10 | 2012-09-24 | Synthon Bv | Crystalline form of montelukast, pharmaceutical composition comprising it, process for the preparation thereof and uses thereof as a medicament |
| EP1709001A2 (de) * | 2004-01-28 | 2006-10-11 | Pliva Istrazivanje i Razvoj d.o.o. | Feste formen von montelukastsäure |
| US20050187244A1 (en) * | 2004-01-30 | 2005-08-25 | Entire Interest. | Montelukast sodium polymorphs |
| EP1708708A1 (de) * | 2004-01-30 | 2006-10-11 | Teva Pharmaceutical Industries Ltd. | Montelukast-freie säure-polymorphen |
| EP1760077A1 (de) * | 2004-01-30 | 2007-03-07 | Teva Pharmaceutical Industries Ltd. | Polymorphe Formen vonMontelukast freie Säure |
| EP1711166A1 (de) | 2004-02-03 | 2006-10-18 | Chemagis Ltd. | Stabile amorphe formen von montelukast natrium |
| CA2563776A1 (en) | 2004-04-21 | 2005-11-10 | Teva Pharmaceutical Industries Ltd. | Processes for preparing montelukast sodium |
| US20080214822A1 (en) * | 2004-11-30 | 2008-09-04 | Medichem, S.A. | Process For the Preparation of a Leukotriene Antagonist |
| WO2007004237A2 (en) * | 2005-07-05 | 2007-01-11 | Matrix Laboratories Ltd | A process for the preparation of montelukast |
| US7812168B2 (en) * | 2005-07-05 | 2010-10-12 | Teva Pharmaceutical Industries Ltd. | Purification of montelukast |
| WO2007059325A2 (en) * | 2005-11-16 | 2007-05-24 | Teva Pharmaceutical Industries Ltd. | Drying methods of montelukast sodium by azeotropic removal of the solvent |
| ES2403067T3 (es) * | 2005-12-13 | 2013-05-13 | Msn Laboratories Limited | Un procedimiento mejorado para la preparación de montelukast y sus sales farmaceúticamente aceptables |
| WO2007072114A1 (en) * | 2005-12-23 | 2007-06-28 | Glade Organics Private Limited | An improved process for the manufacture of montelukast sodium |
| PL1976522T5 (pl) | 2005-12-30 | 2019-12-31 | Krka Tovarna Zdravil, D.D., Novo Mesto | Kompozycja farmaceutyczna zawierająca montelukast |
| EP1996552A1 (de) | 2006-03-17 | 2008-12-03 | Synthon B.V. | Montelukast-amantadin-salz |
| US20090281323A1 (en) * | 2006-04-12 | 2009-11-12 | Glade Organics Private Limited | Process for the manufacture of montelukast sodium |
| EP1886998A1 (de) | 2006-08-09 | 2008-02-13 | Esteve Quimica, S.A. | Verfahren zur Reinigung von Montelukast und dessen Aminesalzen |
| WO2008023044A1 (en) * | 2006-08-23 | 2008-02-28 | Sandoz Ag | Process for the preparation of montelukast free acid and its amine salts |
| US8115004B2 (en) | 2006-11-20 | 2012-02-14 | Msn Laboratories Limited | Process for pure montelukast sodium through pure intermediates as well as amine salts |
| CZ302518B6 (cs) * | 2007-07-09 | 2011-06-29 | Zentiva, A. S. | Zpusob izolace a cištení montelukastu |
| WO2009144742A2 (en) * | 2008-05-26 | 2009-12-03 | Aptuit Laurus Pvt Limited | An improved process for preparing montelukast and salts thereof |
| WO2010148209A2 (en) * | 2009-06-19 | 2010-12-23 | Dr. Reddy's Laboratories Ltd. | Preparation of montelukast |
| EP2287154A1 (de) | 2009-07-14 | 2011-02-23 | KRKA, D.D., Novo Mesto | Effiziente Synthese zur Herstellung von Montelukast |
| EP2552892A1 (de) | 2010-03-31 | 2013-02-06 | KRKA, D.D., Novo Mesto | Effiziente synthese zur herstellung von montelukast und neue kristalline form von zwischenprodukten darin |
| WO2014012954A1 (en) | 2012-07-18 | 2014-01-23 | Takeda Gmbh | Treatment of partly controlled or uncontrolled severe asthma |
| WO2014118796A1 (en) | 2013-01-31 | 2014-08-07 | Melody Healthcare Pvt. Ltd. | An in-situ process for the preparation of highly pure montelukast sodium |
| JP2015007000A (ja) * | 2013-06-24 | 2015-01-15 | 株式会社トクヤマ | モンテルカスト遊離酸の結晶を製造する方法 |
| JP6173864B2 (ja) * | 2013-10-01 | 2017-08-02 | 株式会社トクヤマ | モンテルカストナトリウムのアモルファスを製造する方法 |
| CN103570619B (zh) * | 2013-11-08 | 2015-12-09 | 南京靖龙药物研发有限公司 | 一种孟鲁司特钠衍生物的制备方法 |
| JP2017503814A (ja) | 2014-01-22 | 2017-02-02 | タケダ ゲー・エム・ベー・ハーＴａｋｅｄａ ＧｍｂＨ | 部分的コントロール状態の重症喘息またはコントロール不良状態の重症喘息のｐｄｅ４インヒビターを用いた（およびロイコトリエン調節薬と組み合わせて用いた）治療 |
| CN105585524B (zh) * | 2016-02-29 | 2018-03-02 | 山东新时代药业有限公司 | 一种由孟鲁司特酸制备孟鲁司特钠的方法 |
| CN105924392B (zh) * | 2016-02-29 | 2018-03-02 | 山东新时代药业有限公司 | 一种孟鲁司特钠制备方法 |
| CN107162969A (zh) * | 2017-07-05 | 2017-09-15 | 成都亿知科技有限公司 | 孟鲁司特钠晶体及其制备方法和药物组合物 |
| ES2876292T3 (es) * | 2017-07-24 | 2021-11-12 | Interquim Sa | Procedimiento de preparación y purificación del antagonista de LFA-1 lifitegrast |
| CN112789037A (zh) | 2018-09-06 | 2021-05-11 | 创新药物筛选有限公司 | 用于治疗哮喘或帕金森病的方法和药物组合物 |
| IT201900008340A1 (it) | 2019-06-07 | 2020-12-07 | Genetic S P A | Sali di montelukast e loro composizioni farmaceutiche |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565473A (en) * | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| HU222344B1 (hu) | 1990-10-12 | 2003-06-28 | Merck Frosst Canada & Co. | Eljárás telítetlen hidroxi-alkil-kinolinsavak, és ezeket tartalmazó gyógyszerkészítmények előállítására |
| TW416948B (en) * | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
| AU2003209043A1 (en) * | 2002-02-07 | 2003-09-02 | Dr. Reddy's Laboratories Ltd. | Novel anhydrous amorphous forms of montelukast sodium salt |
-
2003
- 2003-06-06 WO PCT/IN2003/000214 patent/WO2004108679A1/en not_active Ceased
- 2003-06-06 PT PT03817134T patent/PT1631550E/pt unknown
- 2003-06-06 AU AU2003253247A patent/AU2003253247A1/en not_active Abandoned
- 2003-06-06 US US10/576,971 patent/US8450491B2/en not_active Expired - Fee Related
- 2003-06-06 AT AT03817134T patent/ATE540926T1/de active
- 2003-06-06 CA CA2528228A patent/CA2528228C/en not_active Expired - Lifetime
- 2003-06-06 EP EP03817134A patent/EP1631550B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2528228A1 (en) | 2004-12-16 |
| AU2003253247A1 (en) | 2005-01-04 |
| CA2528228C (en) | 2011-09-20 |
| EP1631550B1 (de) | 2012-01-11 |
| PT1631550E (pt) | 2012-04-19 |
| US8450491B2 (en) | 2013-05-28 |
| WO2004108679A1 (en) | 2004-12-16 |
| EP1631550A1 (de) | 2006-03-08 |
| US20070082925A1 (en) | 2007-04-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE540926T1 (de) | Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form | |
| US20100063291A1 (en) | Process for preparation of solid montelukast | |
| CN110256403B (zh) | 一种人工合成尼古丁的制备方法 | |
| ATE366725T1 (de) | Verfahren zur herstellung von gereinigten 1,3- substituierten imidazoliumsalzen | |
| EG25480A (en) | Method for preparation of optionally 2-substituted1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids | |
| WO2008062478A3 (en) | Improved process for pure montelukast sodium through pure intermediates as well as novel amine salts | |
| WO2009047313A3 (en) | Method of producing 2' -deoxy-5-azacytidine (decitabine) | |
| NZ577081A (en) | Synthesis of compounds useful as modulators of amyloid-beta production | |
| US20100029945A1 (en) | Process for the purification of Montelukast | |
| EP2004608B1 (de) | Verbessertes verfahren zur herstellung von montelukast-natrium | |
| ATE297933T1 (de) | Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil | |
| ATE418541T1 (de) | Verfahren zur herstellung von carvedilol | |
| TW200611901A (en) | Method for producing 1, 3-dioxolan-4, 6-dione compound | |
| DE602005021461D1 (de) | Verfahren zur herstellung von cabergolin | |
| NO20100848L (no) | Fremgangsmate for isolering av ARN syrer | |
| WO2000052012A8 (en) | A method for synthesizing porphyrin compounds | |
| ATE412640T1 (de) | Verfahren zur gewinnung eines zur gewinnung von valsartan nützlichen valsartan-salzes | |
| WO2010076252A3 (de) | Verfahren zur reinigung wässriger glyoxal-lösungen | |
| Bell | Kinetic Resolution in the Reaction of (2R, 3R)-2, 3-Diacetoxy-and (2R, 3R)-2, 3-Dibenzoyloxy-succinic Anhydrides with Racemic Alcohols | |
| JPH02164A (ja) | レチナールの製造方法 | |
| WO2008062471A3 (en) | A mild method for the production of di-n-propylacetic acid (valproic acid) | |
| WO2008102671A1 (ja) | ４－ヒドロキシイソロイシンの精製方法 | |
| DD202000A5 (de) | Verfahren zur herstellung neuer terpen-derivate | |
| JPH0543692B2 (de) | ||
| WO2009133572A3 (en) | Process for the preparation of amorphous raberazole sodium |