ATE544749T1 - Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer - Google Patents
Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmerInfo
- Publication number
- ATE544749T1 ATE544749T1 AT07863800T AT07863800T ATE544749T1 AT E544749 T1 ATE544749 T1 AT E544749T1 AT 07863800 T AT07863800 T AT 07863800T AT 07863800 T AT07863800 T AT 07863800T AT E544749 T1 ATE544749 T1 AT E544749T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitor
- factor
- pharmaceutical salts
- synthesizing pharmaceutical
- synthesizing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/90—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having more than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86414506P | 2006-11-02 | 2006-11-02 | |
PCT/US2007/083394 WO2008057972A1 (en) | 2006-11-02 | 2007-11-01 | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE544749T1 true ATE544749T1 (de) | 2012-02-15 |
Family
ID=39167635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07863800T ATE544749T1 (de) | 2006-11-02 | 2007-11-01 | Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer |
Country Status (10)
Country | Link |
---|---|
US (2) | US8524907B2 (de) |
EP (2) | EP2077995B1 (de) |
CN (1) | CN101595092B (de) |
AT (1) | ATE544749T1 (de) |
AU (1) | AU2007317376B2 (de) |
CA (1) | CA2667488C (de) |
ES (2) | ES2382055T3 (de) |
HK (2) | HK1133258A1 (de) |
PT (2) | PT2404906E (de) |
WO (1) | WO2008057972A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7696352B2 (en) * | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
JP5227178B2 (ja) | 2005-11-08 | 2013-07-03 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | N−(5−クロロ−2−ピリジニル)−2−[[4−[(ジメチルアミノ)イミノメチル]ベンゾイル]アミノ]−5−メトキシ−ベンズアミド、第Xa因子阻害剤の薬学的な塩および多形体 |
EA015942B1 (ru) | 2006-05-05 | 2011-12-30 | Милленниум Фамэсьютикэлс, Инк. | Замещенные имидазолы, композиция на их основе, способ профилактики или лечения нежелательного тромбообразования с их помощью и способ ингибирования коагуляции образцов крови |
ES2382055T3 (es) * | 2006-11-02 | 2012-06-04 | Millennium Pharmaceuticals, Inc. | Métodos para sintetizar sales farmacéuticas de un inhibidor del factor Xa |
EP2591783A1 (de) | 2007-04-13 | 2013-05-15 | Millennium Pharmaceuticals, Inc. | Gerinnungshemmende Kombinationstherapie mit einer Verbindung als Faktor-Xa-Hemmer |
US8530501B2 (en) * | 2009-12-17 | 2013-09-10 | Millennium Pharmaceuticals, Inc. | Salts and crystalline forms of a factor Xa inhibitor |
US8742120B2 (en) * | 2009-12-17 | 2014-06-03 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
JP5766204B2 (ja) | 2009-12-17 | 2015-08-19 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 第Xa因子阻害剤の合成方法 |
AR082804A1 (es) | 2010-09-01 | 2013-01-09 | Portola Pharm Inc | Formas cristalinas de un inhibidor del factor xa |
US9200268B2 (en) | 2012-12-27 | 2015-12-01 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
US20140346397A1 (en) | 2012-12-27 | 2014-11-27 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
CN104341343B (zh) * | 2013-07-24 | 2018-09-28 | 四川海思科制药有限公司 | 贝曲西班的晶型及其制备方法和用途 |
CN104693114B (zh) * | 2013-12-10 | 2019-08-16 | 四川海思科制药有限公司 | 一种贝曲西班的改进的制备方法 |
CN105085387A (zh) * | 2014-05-20 | 2015-11-25 | 四川海思科制药有限公司 | 贝曲西班盐及其制备方法和用途 |
EP3078378B1 (de) | 2015-04-08 | 2020-06-24 | Vaiomer | Verwendung von faktor-xa-inhibitoren zur regulierung von glykämie |
WO2017091757A1 (en) | 2015-11-24 | 2017-06-01 | Portola Pharmaceuticals, Inc. | Isotopically enriched betrixaban |
CN105348187B (zh) * | 2015-12-02 | 2017-12-08 | 安徽省逸欣铭医药科技有限公司 | 一种贝曲西班结构类似物及其制备方法和用途 |
CN105732490A (zh) * | 2016-03-25 | 2016-07-06 | 重庆医科大学 | 一种贝曲西班的制备方法 |
EP3293174A1 (de) * | 2016-09-09 | 2018-03-14 | Sandoz Ag | Kristalline formen von betrixaban |
WO2018229796A2 (en) * | 2017-06-14 | 2018-12-20 | Mylan Laboratories Limited | A process for betrixaban hydrochloride and betrixaban maleate salt |
CN108570003A (zh) * | 2018-06-01 | 2018-09-25 | 浙江宏元药业股份有限公司 | 一种贝曲西班马来酸盐的一水无定形及其制备方法 |
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KR101195801B1 (ko) * | 2004-06-18 | 2012-11-05 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Xa 인자 억제제 |
JP5227178B2 (ja) * | 2005-11-08 | 2013-07-03 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | N−(5−クロロ−2−ピリジニル)−2−[[4−[(ジメチルアミノ)イミノメチル]ベンゾイル]アミノ]−5−メトキシ−ベンズアミド、第Xa因子阻害剤の薬学的な塩および多形体 |
WO2007112367A2 (en) * | 2006-03-27 | 2007-10-04 | Portola Pharmaceuticals, Inc. | Potassium channel modulators and platelet procoagulant activity |
EA015942B1 (ru) * | 2006-05-05 | 2011-12-30 | Милленниум Фамэсьютикэлс, Инк. | Замещенные имидазолы, композиция на их основе, способ профилактики или лечения нежелательного тромбообразования с их помощью и способ ингибирования коагуляции образцов крови |
ES2382055T3 (es) * | 2006-11-02 | 2012-06-04 | Millennium Pharmaceuticals, Inc. | Métodos para sintetizar sales farmacéuticas de un inhibidor del factor Xa |
KR101472765B1 (ko) * | 2006-12-08 | 2014-12-15 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 경구용 Xa 인자 억제제를 포함하는 단위 용량 제형 및 경구용 Xa 인자 억제제를 사용하는 혈전증의 치료 방법 |
JP2010515691A (ja) * | 2007-01-05 | 2010-05-13 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 第Xa因子阻害剤 |
EP2591783A1 (de) * | 2007-04-13 | 2013-05-15 | Millennium Pharmaceuticals, Inc. | Gerinnungshemmende Kombinationstherapie mit einer Verbindung als Faktor-Xa-Hemmer |
PT2146705E (pt) * | 2007-05-02 | 2014-05-23 | Portola Pharm Inc | Terapia de combinação com um composto que atua como inibidor do recetor de adp de plaquetas |
JP5766204B2 (ja) * | 2009-12-17 | 2015-08-19 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 第Xa因子阻害剤の合成方法 |
-
2007
- 2007-11-01 ES ES07863800T patent/ES2382055T3/es active Active
- 2007-11-01 EP EP07863800A patent/EP2077995B1/de active Active
- 2007-11-01 CN CN2007800399575A patent/CN101595092B/zh active Active
- 2007-11-01 WO PCT/US2007/083394 patent/WO2008057972A1/en active Application Filing
- 2007-11-01 CA CA2667488A patent/CA2667488C/en not_active Expired - Fee Related
- 2007-11-01 AT AT07863800T patent/ATE544749T1/de active
- 2007-11-01 ES ES11183853.8T patent/ES2550057T3/es active Active
- 2007-11-01 PT PT111838538T patent/PT2404906E/pt unknown
- 2007-11-01 AU AU2007317376A patent/AU2007317376B2/en not_active Ceased
- 2007-11-01 US US12/446,954 patent/US8524907B2/en active Active
- 2007-11-01 PT PT07863800T patent/PT2077995E/pt unknown
- 2007-11-01 EP EP11183853.8A patent/EP2404906B1/de active Active
-
2010
- 2010-01-11 HK HK10100268.3A patent/HK1133258A1/xx not_active IP Right Cessation
-
2012
- 2012-06-29 HK HK12106397.2A patent/HK1165426A1/xx not_active IP Right Cessation
-
2013
- 2013-08-08 US US13/962,819 patent/US9221758B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
PT2404906E (pt) | 2015-11-02 |
US9221758B2 (en) | 2015-12-29 |
US20100197929A1 (en) | 2010-08-05 |
WO2008057972A1 (en) | 2008-05-15 |
AU2007317376B2 (en) | 2013-01-17 |
EP2077995B1 (de) | 2012-02-08 |
PT2077995E (pt) | 2012-05-10 |
US20140046071A1 (en) | 2014-02-13 |
CN101595092A (zh) | 2009-12-02 |
ES2550057T3 (es) | 2015-11-04 |
CA2667488C (en) | 2015-07-07 |
ES2382055T3 (es) | 2012-06-04 |
EP2404906A1 (de) | 2012-01-11 |
CN101595092B (zh) | 2012-02-01 |
US8524907B2 (en) | 2013-09-03 |
EP2404906B1 (de) | 2015-07-15 |
AU2007317376A1 (en) | 2008-05-15 |
HK1133258A1 (en) | 2010-03-19 |
CA2667488A1 (en) | 2008-05-15 |
HK1165426A1 (en) | 2012-10-05 |
EP2077995A1 (de) | 2009-07-15 |
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