BR9408452A - Processo para preparação de um composto e composto obtido - Google Patents
Processo para preparação de um composto e composto obtidoInfo
- Publication number
- BR9408452A BR9408452A BR9408452A BR9408452A BR9408452A BR 9408452 A BR9408452 A BR 9408452A BR 9408452 A BR9408452 A BR 9408452A BR 9408452 A BR9408452 A BR 9408452A BR 9408452 A BR9408452 A BR 9408452A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- formula
- preparing
- het
- compound obtained
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/53—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17493193A | 1993-12-28 | 1993-12-28 | |
US35042894A | 1994-12-09 | 1994-12-09 | |
PCT/US1994/014858 WO1995018107A1 (en) | 1993-12-28 | 1994-12-22 | Process for the preparation of leukotriene antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9408452A true BR9408452A (pt) | 1997-08-05 |
Family
ID=26870681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9408452A BR9408452A (pt) | 1993-12-28 | 1994-12-22 | Processo para preparação de um composto e composto obtido |
Country Status (29)
Country | Link |
---|---|
US (2) | US5614632A (pt) |
EP (1) | EP0737186B1 (pt) |
JP (1) | JP3640962B2 (pt) |
KR (1) | KR100319336B1 (pt) |
CN (3) | CN1046712C (pt) |
AT (1) | ATE169906T1 (pt) |
AU (1) | AU686303B2 (pt) |
BG (1) | BG62850B1 (pt) |
BR (1) | BR9408452A (pt) |
CA (1) | CA2179407C (pt) |
CY (1) | CY2104B1 (pt) |
CZ (1) | CZ286079B6 (pt) |
DE (1) | DE69412644T2 (pt) |
DK (1) | DK0737186T3 (pt) |
ES (1) | ES2122534T3 (pt) |
FI (1) | FI113045B (pt) |
GE (1) | GEP20012387B (pt) |
HK (1) | HK1009269A1 (pt) |
HR (1) | HRP941022B1 (pt) |
HU (1) | HU226394B1 (pt) |
LV (1) | LV12313B (pt) |
NZ (1) | NZ278263A (pt) |
PL (1) | PL178671B1 (pt) |
RO (1) | RO119018B1 (pt) |
RU (2) | RU2140909C1 (pt) |
TW (2) | TW448160B (pt) |
UA (1) | UA44724C2 (pt) |
WO (1) | WO1995018107A1 (pt) |
YU (1) | YU49412B (pt) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5523477A (en) * | 1995-01-23 | 1996-06-04 | Merck & Co., Inc. | Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid |
CA2395834A1 (en) * | 1999-12-28 | 2001-07-05 | Tetsuo Kawaguchi | Tricyclic compounds |
CN1318400C (zh) * | 2002-02-06 | 2007-05-30 | 戴尔玛化学品股份有限公司 | 制备1-(巯基甲基)-环丙烷乙酸的方法 |
AU2003209043A1 (en) * | 2002-02-07 | 2003-09-02 | Dr. Reddy's Laboratories Ltd. | Novel anhydrous amorphous forms of montelukast sodium salt |
US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
US7560559B2 (en) * | 2003-04-15 | 2009-07-14 | Merck & Co., Inc. | Polymorphic form of montelukast sodium |
AU2004234235A1 (en) | 2003-04-25 | 2004-11-11 | Nippon Chemiphar Co., Ltd. | Salt of (2s,3s)-3-[[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid |
US8450491B2 (en) * | 2003-06-06 | 2013-05-28 | Morepen Laboratories Limited | Method for the preparation of montelukast acid and sodium salt thereof in amorphous form |
EP1678139B1 (en) | 2003-10-10 | 2011-08-31 | Synhton B.V. | Solid-state montelukast |
US20050187243A1 (en) * | 2004-01-30 | 2005-08-25 | Valerie Niddam-Hildesheim | Montelukast free acid polymorphs |
EP1760077A1 (en) * | 2004-01-30 | 2007-03-07 | Teva Pharmaceutical Industries Ltd. | Montelukast free acid polymorphs |
WO2005075427A2 (en) * | 2004-01-30 | 2005-08-18 | Teva Pharmaceutical Industries Ltd. | Montelukast sodium polymorphs |
BRPI0506610A (pt) | 2004-02-03 | 2007-05-02 | Chemagis Ltd | montelucaste sódico amorfo, processo de preparação de montelucaste sódico amorfo, composição farmacêutica, método de tratamento utilizando a administração de montelucaste sódico amorfo, co-precipitado amorfo de montelucaste sódico e processo de preparação de co-precipitado amorfo de montelucaste sódico |
US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
MXPA06012220A (es) * | 2004-04-21 | 2007-07-18 | Teva Pharma | Procesos para preparar sodio de montelukast. |
US7501517B2 (en) | 2004-04-30 | 2009-03-10 | Synthon Ip, Inc. | Process for making montelukast and intermediates therefor |
US7829716B2 (en) | 2004-04-30 | 2010-11-09 | Synthon Pharmaceuticals, Inc. | Process for making montelukast and intermediates therefor |
US20090143590A1 (en) * | 2004-07-19 | 2009-06-04 | Matrix Laboratories Ltd. | Process for the Preparation of Montelukast and its Salts |
WO2006008750A2 (en) * | 2004-07-19 | 2006-01-26 | Matrix Laboratories Ltd | Methyl 2-[(3s)-[3-[(2e)-(7-chloro quinolin-2-yl) ethenyl] phenyl]-3-halopropyl] benzoates |
WO2006021974A1 (en) * | 2004-08-23 | 2006-03-02 | Morepen Laboratories Limited | A process for synthesizing diol (viii)-an intermediate of montelukast sodium |
PL205637B1 (pl) * | 2004-10-22 | 2010-05-31 | Inst Farmaceutyczny | Sposób wytwarzania kwasu (R,E)-(1-{1-{3-[2-(7-chlorochinolin-2-ylo)etenylo]fenylo}-3-[2-(1-hydroksy-1-metyloetylo)fenylo] propylosulfanylometylo}cyklopropylo)octowego i/lub jego farmaceutycznie dopuszczalnych soli |
WO2006054317A1 (en) * | 2004-11-19 | 2006-05-26 | Matrix Laboratories Ltd | Process for the preparation of novel amorphous montelukast sodium |
US20080214822A1 (en) * | 2004-11-30 | 2008-09-04 | Medichem, S.A. | Process For the Preparation of a Leukotriene Antagonist |
ITMI20050247A1 (it) * | 2005-02-18 | 2006-08-19 | Chemi Spa | Processo per la preparazione di montelukast |
US7812168B2 (en) * | 2005-07-05 | 2010-10-12 | Teva Pharmaceutical Industries Ltd. | Purification of montelukast |
EP1912499A4 (en) * | 2005-07-20 | 2010-03-31 | Reddys Lab Ltd Dr | PREPARATION OF MONTELUKAST |
EP1783117A1 (en) * | 2005-11-04 | 2007-05-09 | Esteve Quimica, S.A. | Process for the preparation of a leukotriene antagonist and intermediates thereof |
US20070161796A1 (en) * | 2005-11-16 | 2007-07-12 | Ilan Kor-Sade | Drying methods of montelukast sodium by azeotropic removal of the solvent |
AR057908A1 (es) | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast e intermediarios del mismo |
EP1968943B1 (en) * | 2005-12-13 | 2013-01-23 | MSN Laboratories Limited | An improved process for the preparation of montelukast and its pharmaceutically acceptable salts |
CA2632954A1 (en) * | 2005-12-23 | 2007-06-28 | Glade Organics Private Limited | An improved process for the manufacture of montelukast sodium |
EP1976522B2 (en) | 2005-12-30 | 2019-07-03 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition containing montelukast |
US7572930B2 (en) * | 2006-02-02 | 2009-08-11 | Chemagis Ltd. | Process for preparing 1-(mercaptomethyl)cyclopropaneacetic acid, a useful intermediate in the preparation of montelukast and salts thereof |
WO2007092031A1 (en) * | 2006-02-09 | 2007-08-16 | Teva Pharmaceutical Industries Ltd. | Stable pharmaceutical formulations of montelukast sodium |
CA2643228A1 (en) * | 2006-02-21 | 2007-08-30 | Chemagis Ltd. | Novel polymorphs of montelukast ammonium salts and processes for preparation therefor |
WO2007096889A2 (en) * | 2006-02-27 | 2007-08-30 | Chemagis Ltd. | Process for preparing montelukast and salts thereof |
EP1996552A1 (en) | 2006-03-17 | 2008-12-03 | Synthon B.V. | Montelukast amantadine salt |
CA2649189A1 (en) * | 2006-04-12 | 2007-10-18 | Glade Organics Private Limited | An improved process for the manufacture of montelukast sodium |
WO2008001213A1 (en) * | 2006-06-26 | 2008-01-03 | Aurobindo Pharma Limited | An improved process for the preparation of leukotriene receptor antagonist (montelukast sodium) |
GB0614485D0 (en) * | 2006-07-21 | 2006-09-27 | Pliva Istrazivanje I Razvoj D | Process |
EP2069307A4 (en) * | 2006-08-04 | 2010-03-03 | Matrix Lab Ltd | PROCESS FOR THE PREPARATION OF MONTELUKAST AND ITS SALTS |
EP1886998A1 (en) * | 2006-08-09 | 2008-02-13 | Esteve Quimica, S.A. | Purification process of montelukast and its amine salts |
KR20090080038A (ko) * | 2006-09-15 | 2009-07-23 | 씨아이피엘에이 엘티디. | 몬테루카스트의 제조방법 및 그의 중간체 |
GB0618703D0 (en) * | 2006-09-22 | 2006-11-01 | Almac Sciences Ltd | Synthesis of leikotriene compounds |
US7700776B2 (en) | 2006-10-24 | 2010-04-20 | Formosa Laboratories, Inc. | Compounds and preparation for montelukast sodium |
WO2008058118A2 (en) * | 2006-11-06 | 2008-05-15 | Dr. Reddy's Labortories, Ltd. | Preparation of montelukast and its salts |
WO2008062478A2 (en) * | 2006-11-20 | 2008-05-29 | Manne Satyanarayana Reddy | Improved process for pure montelukast sodium through pure intermediates as well as novel amine salts |
KR100774088B1 (ko) * | 2006-12-14 | 2007-11-06 | 한미약품 주식회사 | 몬테루카스트의 제조방법 및 이에 사용되는 중간체 |
US7271268B1 (en) | 2006-12-22 | 2007-09-18 | Formosa Laboratories Inc. | Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives |
US20080188664A1 (en) * | 2007-01-15 | 2008-08-07 | Chemagis Ltd. | Process for preparing montelukast sodium containing controlled levels of impurities |
EP1958936A1 (en) * | 2007-02-14 | 2008-08-20 | Inke, S.A. | Process for obtaining montelukast |
WO2008126075A1 (en) * | 2007-04-12 | 2008-10-23 | Chemagis Ltd. | Process for preparing montelukast and salts thereof using optically impure 2-(2-(3(s)-(3-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl-2-propanol |
PL205444B1 (pl) * | 2007-05-02 | 2010-04-30 | Zak & Lstrok Ady Farmaceutyczn | Sposób wytwarzania soli sodowej kwasu 1-(((1(R)-(3-(2-(7--chloro-2- chinolinylo)-etenylo)fenylo)-3-(2-(1-hydroksy-1- metyloetylo)fenylo)propylo)sulfanylo)metylo)-cyklopropanooctowego |
WO2008135966A1 (en) * | 2007-05-02 | 2008-11-13 | Chemagis Ltd. | Process for the purification of optically impure 2-(2-(3(s)-(3-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxy-propyl)phenyl-2-propanol |
CZ302518B6 (cs) * | 2007-07-09 | 2011-06-29 | Zentiva, A. S. | Zpusob izolace a cištení montelukastu |
EP2014633A1 (en) | 2007-07-13 | 2009-01-14 | Lonza Ag | Process for the production of tertiary alcohols |
ES2320077B1 (es) | 2007-07-31 | 2010-02-26 | Moehs Iberica, S.L. | Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo. |
WO2009027990A1 (en) * | 2007-08-29 | 2009-03-05 | Morepen Laboratories Limited | Salts of montelukast and process therefor |
KR101072896B1 (ko) | 2007-10-09 | 2011-10-17 | 한미홀딩스 주식회사 | 이온성 액체 매개체를 이용한 몬테루카스트산의 제조 방법 |
US20100305080A1 (en) * | 2007-10-25 | 2010-12-02 | O'shea Paul | Novel Crystalline Salts of Montelukast |
EP2053043A1 (en) | 2007-10-26 | 2009-04-29 | Inke, S.A. | Crystalline salt of montelukast |
DE102007061630B4 (de) | 2007-12-20 | 2013-07-04 | Formosa Laboratories, Inc. | Neue Verbindungen und Herstellung von Montelukast-Natrium |
US20100292251A1 (en) * | 2008-01-07 | 2010-11-18 | Torrent Pharmaceuticals Limited | Montelukast benzhydryl piperazine salts and process for preparation thereof |
CN101817818B (zh) * | 2008-03-06 | 2011-10-26 | 台耀化学股份有限公司 | 一种用于制备孟鲁司特钠的化合物 |
CN101323589B (zh) * | 2008-03-06 | 2010-10-06 | 台耀化学股份有限公司 | 化合物及孟鲁司特钠的制备方法 |
EP2265586A4 (en) * | 2008-03-17 | 2012-10-03 | Reddys Lab Ltd Dr | PREPARATION OF MONTELUKAST AND ITS SALTS |
EP2276739A1 (en) * | 2008-04-25 | 2011-01-26 | Synthon B.V. | Process for making montelukast intermediates |
US9004752B2 (en) * | 2008-05-05 | 2015-04-14 | Abbvie, Inc. | Method for evaluating the solubility of a crystalline substance in a polymer |
ES2605473T3 (es) * | 2008-05-26 | 2017-03-14 | Laurus Labs Private Limited | Un procedimiento mejorado para la preparación de Montelukast y sus sales |
KR101123292B1 (ko) * | 2008-09-26 | 2012-03-19 | 주식회사 엘지생명과학 | 몬테루카스트 나트륨염의 제조방법 |
WO2010064109A2 (en) | 2008-12-02 | 2010-06-10 | Mayuka Labs Private Limited | An improved process for the preparation of montelukast sodium and its intermediates |
WO2010148209A2 (en) * | 2009-06-19 | 2010-12-23 | Dr. Reddy's Laboratories Ltd. | Preparation of montelukast |
WO2011004298A1 (en) | 2009-07-09 | 2011-01-13 | Alembic Limited | Montelukast hexamethylenediamine salt and its use for the preparation of montelukast sodium |
EP2287154A1 (en) | 2009-07-14 | 2011-02-23 | KRKA, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast |
CN101638381B (zh) | 2009-09-02 | 2012-08-29 | 鲁南制药集团股份有限公司 | 孟鲁司特钠中间体的合成方法 |
WO2011033470A1 (en) | 2009-09-16 | 2011-03-24 | Ranbaxy Laboratories Limited | Crystalline form of montelukast sodium |
EP2486015A1 (en) * | 2009-10-09 | 2012-08-15 | DSM IP Assets B.V. | Sythesis of optically active intermediate for the preparation of montelukast |
US20120259121A1 (en) | 2009-12-23 | 2012-10-11 | Pharmathen S.A. | Process for the preparation of montelukast and salts thereof |
WO2011121091A1 (en) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
HUP1000425A2 (en) | 2010-08-11 | 2012-03-28 | Richter Gedeon Nyrt | Process for the production of montelukast sodium |
US8471030B2 (en) | 2010-12-06 | 2013-06-25 | Orochem Technologies Inc. | Purification of montelukast using simulated moving bed |
EP2502910A1 (en) | 2011-03-15 | 2012-09-26 | Laboratorios Lesvi, S.L. | Camphorsulfonic salt of a key Montelukast intermediate |
CN102633683B (zh) * | 2012-04-06 | 2014-05-21 | 盐城市晶华化工有限公司 | 一种1-羟甲基环丙基乙腈合成方法 |
EP2850064B1 (en) * | 2012-05-18 | 2018-11-07 | Laurus Labs Limited | Process for preparation of montelukast sodium |
CN103539714A (zh) * | 2012-07-16 | 2014-01-29 | 上海朴颐化学科技有限公司 | 1-巯甲基环丙基乙酸及其中间体的制备方法 |
WO2014012954A1 (en) | 2012-07-18 | 2014-01-23 | Takeda Gmbh | Treatment of partly controlled or uncontrolled severe asthma |
WO2014081616A1 (en) * | 2012-11-21 | 2014-05-30 | Merck Sharp & Dohme Corp. | Preparation of precursors for leukotriene antagonists |
WO2014118796A1 (en) * | 2013-01-31 | 2014-08-07 | Melody Healthcare Pvt. Ltd. | An in-situ process for the preparation of highly pure montelukast sodium |
CN103570618A (zh) * | 2013-09-30 | 2014-02-12 | 浙江车头制药股份有限公司 | 一种孟鲁司特钠盐的制备方法 |
EP3096760A1 (en) | 2014-01-22 | 2016-11-30 | Takeda GmbH | Treatment of partly controlled or uncontrolled severe asthma with a pde4 inhibitor (and in combination with a leukotriene modifier) |
CN104119270A (zh) * | 2014-08-12 | 2014-10-29 | 牡丹江恒远药业有限公司 | 一种孟鲁司特钠的制备方法 |
CN105085391B (zh) | 2015-06-10 | 2017-08-22 | 广东默泰同创医药科技有限公司 | 用作白三烯受体拮抗剂的环丙基不饱和喹啉化合物及应用 |
CN105541786B (zh) * | 2016-01-06 | 2017-08-08 | 鲁南贝特制药有限公司 | 一种孟鲁司特钠侧链中间体及其制备方法 |
CN109503476A (zh) * | 2018-12-26 | 2019-03-22 | 哈尔滨珍宝制药有限公司 | 一种孟鲁司特钠的合成工艺 |
CN111170939A (zh) * | 2019-12-20 | 2020-05-19 | 牡丹江恒远药业股份有限公司 | 一种高纯度孟鲁司特钠及其中间体的制备方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5256675A (en) * | 1989-08-07 | 1993-10-26 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same |
FR2665159B1 (fr) * | 1990-07-24 | 1992-11-13 | Rhone Poulenc Sante | Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent. |
EP0480717B1 (en) * | 1990-10-12 | 1998-04-15 | Merck Frosst Canada Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
EP0480716A1 (en) * | 1990-10-12 | 1992-04-15 | Merck Frosst Canada Inc. | Saturated hydroxyalkylquinoline acids as leukotriene antagonists |
US5270324A (en) * | 1992-04-10 | 1993-12-14 | Merck Frosst Canada, Inc. | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists |
US5358946A (en) * | 1992-05-29 | 1994-10-25 | The Du Pont Merck Pharmaceutical Company | Heterocycle-substituted amides, carbamates and ureas as agents for the treatment of atherosclerosis |
US5270234A (en) * | 1992-10-30 | 1993-12-14 | International Business Machines Corporation | Deep submicron transistor fabrication method |
CA2111372C (en) * | 1992-12-22 | 2007-01-16 | Robert N. Young | Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists |
US5371096A (en) * | 1993-08-27 | 1994-12-06 | Ciba-Geigy Corporation | (3-pyridyl)tetrafuran-2-yl substituted carboxylic acids |
-
1994
- 1994-12-21 TW TW089114101A patent/TW448160B/zh not_active IP Right Cessation
- 1994-12-21 TW TW083111982A patent/TW416948B/zh not_active IP Right Cessation
- 1994-12-22 RU RU96113796A patent/RU2140909C1/ru active
- 1994-12-22 JP JP51815295A patent/JP3640962B2/ja not_active Expired - Lifetime
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- 1994-12-22 CN CN94194671A patent/CN1046712C/zh not_active Expired - Lifetime
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- 1994-12-22 KR KR1019960703483A patent/KR100319336B1/ko not_active IP Right Cessation
- 1994-12-22 PL PL94315155A patent/PL178671B1/pl unknown
- 1994-12-22 AT AT95906106T patent/ATE169906T1/de active
- 1994-12-22 DK DK95906106T patent/DK0737186T3/da active
- 1994-12-22 AU AU14448/95A patent/AU686303B2/en not_active Expired
- 1994-12-22 WO PCT/US1994/014858 patent/WO1995018107A1/en active IP Right Grant
- 1994-12-22 CA CA002179407A patent/CA2179407C/en not_active Expired - Lifetime
- 1994-12-22 ES ES95906106T patent/ES2122534T3/es not_active Expired - Lifetime
- 1994-12-22 RU RU99110880/04A patent/RU2225398C2/ru active
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- 1994-12-22 UA UA96072985A patent/UA44724C2/uk unknown
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- 1994-12-22 DE DE69412644T patent/DE69412644T2/de not_active Expired - Lifetime
- 1994-12-22 CN CN200610094487XA patent/CN101081834B/zh not_active Expired - Lifetime
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- 1994-12-22 BR BR9408452A patent/BR9408452A/pt not_active Application Discontinuation
- 1994-12-27 YU YU77594A patent/YU49412B/sh unknown
- 1994-12-28 HR HR08/350,428A patent/HRP941022B1/xx not_active IP Right Cessation
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1995
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1996
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1998
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1999
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