AR240822A2 - Un procedimiento para la preparacion de una trans-octahidro-oxazolo[4,5-g!quinolina y sus sales - Google Patents
Un procedimiento para la preparacion de una trans-octahidro-oxazolo[4,5-g!quinolina y sus salesInfo
- Publication number
- AR240822A2 AR240822A2 AR30115786A AR30115786A AR240822A2 AR 240822 A2 AR240822 A2 AR 240822A2 AR 30115786 A AR30115786 A AR 30115786A AR 30115786 A AR30115786 A AR 30115786A AR 240822 A2 AR240822 A2 AR 240822A2
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- alcoxy
- formula
- iii
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
UN PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE TRANS-OCTAHIDRO-OXAZOLO[4,5-G!QUINOLINA DE FORMULA (I) EN LA QUE R ES ALQUILO RECTO O RAMIFICADO Y R1 ES H, ALQUILO, ALCOXI, HALOGENO, HIDROXILO, AMINO O DIALQUIL AMINO, ESTANDO LOS ATOMOS DE HIDROGENO DE LAS POSICIONES 4A Y 8A EN RELACION TRANS, Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, POR QUE SE CICLIZA UN COMPUESTO DE FORMULA (II), EN LA QUE R TIENE VALORES INDICADOS Y R10 ES H, ALQUILO O ALCOXI OBTENIENDO LOS COMPUESTOS DE FORMULA (III), DONDE R Y R10 TIENEN LOS VALORES INDICADOS, EN PRESENCIA DE UN AGENTE DESHIDRATANTE OBTENIENDOSE A): LOS COMPUESTOS (I) EN LOS QUE R1 ES AMINO O DIALQUIL AMINO HACIENDO REACCIONAR LOS COMPUESTOS (III) EN LOS QUE R10 ES ALCOXI CON AMONIACO O DIALQUILAMINO; B) LOS COMPUESTOS (I) EN LOS QUE R1 ES HIDROXI, HACIENDO REACCIONAR LOS COMPUESTOS (III) EN LOS QUE R10 ES ALCOXI CON HCL O HBR (G); C) LOS COMPUESTOS (I) EN LOS QUE R1 ES HALO, HACIENDO REACCIONAR LOS COMPUESTOS (I) EN LOS QUE R1 ES HIDROXI CON PENTA O TRIHALURO DE FOSFORO O UN OXIHALURO DE FOSFORO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63723284A | 1984-08-02 | 1984-08-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AR240822A1 AR240822A1 (es) | 1991-02-28 |
| AR240822A2 true AR240822A2 (es) | 1991-02-28 |
Family
ID=24555086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR301157A AR240822A1 (es) | 1984-08-02 | 1986-08-01 | Un procedimiento para la preparacion de una trans-octahidro-oxazolo|4,5-g¨quinolina y sus sales |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0172697B1 (es) |
| JP (1) | JPH0670063B2 (es) |
| KR (1) | KR880001430B1 (es) |
| AR (1) | AR240822A1 (es) |
| AT (1) | ATE67766T1 (es) |
| AU (1) | AU569406B2 (es) |
| CA (1) | CA1292742C (es) |
| DE (1) | DE3584205D1 (es) |
| DK (1) | DK349185A (es) |
| ES (2) | ES8704499A1 (es) |
| GR (1) | GR851895B (es) |
| HU (1) | HU193338B (es) |
| IE (1) | IE58695B1 (es) |
| IL (1) | IL75991A0 (es) |
| NZ (1) | NZ212946A (es) |
| PH (1) | PH22541A (es) |
| PT (1) | PT80899B (es) |
| SU (1) | SU1421258A3 (es) |
| ZA (1) | ZA855830B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826986A (en) * | 1986-06-16 | 1989-05-02 | Eli Lilly And Company | 6-Oxo-trans-octa- and decahydroquinolines |
| US4762843A (en) * | 1986-09-15 | 1988-08-09 | Warner-Lambert Company | Hetero [f] fused carbocyclic pyridines as dopaminergic agents |
| US4939259A (en) * | 1989-07-24 | 1990-07-03 | Eli Lilly And Company | 2-oxo-pyrido[2,3-g]quinoline derivatives |
| US6395744B1 (en) | 1994-04-22 | 2002-05-28 | Queen's University At Kingston | Method and compositions for the treatment or amelioration of female sexual dysfunction |
| CA2334550A1 (en) * | 1998-06-22 | 1999-12-29 | Queen's University At Kingston | Method and compositions for the treatment or amelioration of female sexual dysfunction |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4198415A (en) * | 1979-01-22 | 1980-04-15 | Eli Lilly And Company | Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines |
| FI852975L (fi) * | 1984-08-03 | 1986-02-04 | Lilly Co Eli | Tricykliska kinolinderivat. |
| US4826986A (en) * | 1986-06-16 | 1989-05-02 | Eli Lilly And Company | 6-Oxo-trans-octa- and decahydroquinolines |
-
1985
- 1985-08-01 DK DK349185A patent/DK349185A/da not_active Application Discontinuation
- 1985-08-01 CA CA000487985A patent/CA1292742C/en not_active Expired - Lifetime
- 1985-08-01 HU HU852964A patent/HU193338B/hu not_active IP Right Cessation
- 1985-08-01 IE IE192185A patent/IE58695B1/en not_active IP Right Cessation
- 1985-08-01 ZA ZA855830A patent/ZA855830B/xx unknown
- 1985-08-01 GR GR851895A patent/GR851895B/el unknown
- 1985-08-01 JP JP60170980A patent/JPH0670063B2/ja not_active Expired - Lifetime
- 1985-08-01 NZ NZ212946A patent/NZ212946A/xx unknown
- 1985-08-01 PT PT80899A patent/PT80899B/pt not_active IP Right Cessation
- 1985-08-01 IL IL75991A patent/IL75991A0/xx not_active IP Right Cessation
- 1985-08-01 PH PH32596A patent/PH22541A/en unknown
- 1985-08-01 SU SU853932559A patent/SU1421258A3/ru active
- 1985-08-01 KR KR1019850005554A patent/KR880001430B1/ko not_active IP Right Cessation
- 1985-08-02 DE DE8585305538T patent/DE3584205D1/de not_active Expired - Lifetime
- 1985-08-02 AU AU45737/85A patent/AU569406B2/en not_active Ceased
- 1985-08-02 AT AT85305538T patent/ATE67766T1/de not_active IP Right Cessation
- 1985-08-02 ES ES545859A patent/ES8704499A1/es not_active Expired
- 1985-08-02 EP EP85305538A patent/EP0172697B1/en not_active Expired - Lifetime
-
1986
- 1986-02-13 ES ES551964A patent/ES8800231A1/es not_active Expired
- 1986-08-01 AR AR301157A patent/AR240822A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| DE3584205D1 (de) | 1991-10-31 |
| JPS6147487A (ja) | 1986-03-07 |
| GR851895B (es) | 1985-12-03 |
| EP0172697A3 (en) | 1986-03-12 |
| DK349185A (da) | 1986-02-03 |
| ES8800231A1 (es) | 1987-10-16 |
| IL75991A0 (en) | 1985-12-31 |
| JPH0670063B2 (ja) | 1994-09-07 |
| ES545859A0 (es) | 1987-04-01 |
| NZ212946A (en) | 1988-07-28 |
| KR860001815A (ko) | 1986-03-22 |
| IE58695B1 (en) | 1993-11-03 |
| ZA855830B (en) | 1987-03-25 |
| EP0172697A2 (en) | 1986-02-26 |
| SU1421258A3 (ru) | 1988-08-30 |
| ES551964A0 (es) | 1987-10-16 |
| PT80899A (en) | 1985-09-01 |
| ATE67766T1 (de) | 1991-10-15 |
| CA1292742C (en) | 1991-12-03 |
| AU4573785A (en) | 1986-02-06 |
| AR240822A1 (es) | 1991-02-28 |
| PT80899B (pt) | 1987-12-30 |
| ES8704499A1 (es) | 1987-04-01 |
| KR880001430B1 (ko) | 1988-08-08 |
| PH22541A (en) | 1988-10-17 |
| HU193338B (en) | 1987-09-28 |
| DK349185D0 (da) | 1985-08-01 |
| AU569406B2 (en) | 1988-01-28 |
| EP0172697B1 (en) | 1991-09-25 |
| HUT38348A (en) | 1986-05-28 |
| IE851921L (en) | 1986-02-02 |
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